IL.39

N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE

PDB

The ligand-free form

2dul_AA [Alignment: 1 2]

The ligand-bound form

2ytz_AB[Alignment: 1 2]

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the structural change



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Function

EC*1

CSA distance*2

2.1.1.32

*1 Enzyme commission number.
*2 The distance between the active site annotated in CSA23 and the ligand-binding sites.

Ligand

PDB*1

Full name

2xSAH

2x(S-ADENOSYL-L-HOMOCYSTEINE)

*1 Ligand name designated by the PDB identifiers.

Segments

Component No.

Fixed*1

Moving*1

Motion type

Ligand binding

Coupled motion type

1

D1(5A-16A,25A-251A,258A-315A,5B-16B,23B-250B,260B-321B,356B-358B,361B-363B)

L3(17A-24A)

Local

Independent

2

D2(252A-257A,316A-329A,337A-366A)

L4(330A-336A)

Local

Independent

*1 The location of the fixed and moving segments indicated by the residue number assigned in the ligand-bound form. The background color of characters indicates the corresponding segment in the structure. The colored segments not described in the Table are: 1) a part of component in which the motion is small (< 1.0 A), or, 2) a part of a protomer of homodimers, for which a corresponding part of the other protomer is shown in the Table.

Displacement and disorder

Component No.

RMSD*1

Displacement*2

Disorder-order transition*3

Disorder residue*4

Helix-Coil*5

1

Yes

+8

2

Yes

-5

*1 The root-mean-square displacement of a component of motion calculated for the domain motions.
*2 The mean displacement of a component of motion calculated for the local motions.
*3 Order-disorder transition: Whether the open form contains the disordered structure.
*4 The number of disordered residues.
*5 The number of residues exhibiting the alpha-helix to coil transition.

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