O.8

HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR

PDB

The ligand-free form

1iz3_AA [Alignment: 1 2]

The ligand-bound form

3d8c_AA[Alignment: 1 2]

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Function

EC*1

CSA distance*2

1.14.11.16

*1 Enzyme commission number.
*2 The distance between the active site annotated in CSA23 and the ligand-binding sites.

Ligand

PDB*1

Full name

2xPEPT(QLTSYDCEVNAPI),2xZN,2xAKG

2x(Peptide(QLTSYDCEVNAPI)),2x(ZINC ION),2x(2-OXOGLUTARIC ACID)

*1 Ligand name designated by the PDB identifiers.

Segments

Component No.

Fixed*1

Moving*1

Motion type

Ligand binding

Coupled motion type

1

D1(347A-349A,12A-13A,37A-40A,52A-54A,57A-60A,97A-120A,195A-200A,215A-219A,224A-260A,274A-279A,340A-342A)

D2(33A-36A,72A-96A,121A-147A,155A-155A,157A-157A,164A-164A,191A-194A,212A-214A,280A-282A)

Other/ domain-like

Coupled

*1 The location of the fixed and moving segments indicated by the residue number assigned in the ligand-bound form. The background color of characters indicates the corresponding segment in the structure. The colored segments not described in the Table are: 1) a part of component in which the motion is small (< 1.0 A), or, 2) a part of a protomer of homodimers, for which a corresponding part of the other protomer is shown in the Table.

Displacement and disorder

Component No.

RMSD*1

Displacement*2

Disorder-order transition*3

Disorder residue*4

Helix-Coil*5

1

1

*1 The root-mean-square displacement of a component of motion calculated for the domain motions.
*2 The mean displacement of a component of motion calculated for the local motions.
*3 Order-disorder transition: Whether the open form contains the disordered structure.
*4 The number of disordered residues.
*5 The number of residues exhibiting the alpha-helix to coil transition.

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