N.98

DIHYDROFOLATE REDUCTASE

PDB

The ligand-free form

1cz3_AB [Alignment: 1 2]

The ligand-bound form

1d1g_AB[Alignment: 1 2]

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Function

EC*1

CSA distance*2

1.5.1.3

2.7

*1 Enzyme commission number.
*2 The distance between the active site annotated in CSA23 and the ligand-binding sites.

Ligand

PDB*1

Full name

2xMTX,2xNDP

2x(METHOTREXATE),2x(NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHTE)

*1 Ligand name designated by the PDB identifiers.

Segments

Component No.

Fixed*1

Moving*1

Motion type

Ligand binding

Coupled motion type

1

No significant

*1 The location of the fixed and moving segments indicated by the residue number assigned in the ligand-bound form. The background color of characters indicates the corresponding segment in the structure. The colored segments not described in the Table are: 1) a part of component in which the motion is small (< 1.0 A), or, 2) a part of a protomer of homodimers, for which a corresponding part of the other protomer is shown in the Table.

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