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IID00001
 UniprotO00482
ProteinNuclear receptor subfamily 5 group A member 2
GeneNR5A2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
541
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 79-187 Monomer :
 Evidence X-RAY 5l0m A Reference
       Region 5l0m A 79-82 disorder
       Region 5l0m A 83-178 order
       Region 5l0m A 179-187 disorder
 Evidence X-RAY 2a66 A Reference
       Region 2a66 A 79-83 disorder
       Region 2a66 A 84-178 order
       Region 2a66 A 179-187 disorder
Seq 191-541 Hetero dimer : IID00039Complex
 Evidence X-RAY 3tx7 B Reference
       Region 3tx7 B 191-298 disorder
       Region 3tx7 B 299-331 order
       Region 3tx7 B 332-337 disorder
       Region 3tx7 B 338-363 order
       Region 3tx7 B 364-373 disorder
       Region 3tx7 B 374-461 order
       Region 3tx7 B 462-467 disorder
       Region 3tx7 B 468-538 order
       Region 3tx7 B 539-541 disorder
Seq 290-541 Hetero dimer : IID00081Complex
 Evidence X-RAY 1yuc B Reference
       Region 1yuc B 290-299 disorder
       Region 1yuc B 300-539 order
       Region 1yuc B 540-541 disorder
 Evidence X-RAY 1yuc A Reference
       Region 1yuc A 290-298 disorder
       Region 1yuc A 299-538 order
       Region 1yuc A 539-541 disorder
 Evidence X-RAY 4oni B Reference
       Region 4oni B 291-299 disorder
       Region 4oni B 300-541 order
 Evidence X-RAY 4oni A Reference
       Region 4oni A 291-298 disorder
       Region 4oni A 299-539 order
       Region 4oni A 540-541 disorder
 Evidence X-RAY 4dor B Reference
       Region 4dor B 290-299 disorder
       Region 4dor B 300-539 order
       Region 4dor B 540-541 disorder
 Evidence X-RAY 4dor A Reference
       Region 4dor A 290-299 disorder
       Region 4dor A 300-397 order
       Region 4dor A 398-420 disorder
       Region 4dor A 421-538 order
       Region 4dor A 539-541 disorder
Seq 294-541 Hetero dimer : P51843
 Evidence X-RAY 4rwv A Reference
       Region 4rwv A 294-296 disorder
       Region 4rwv A 297-539 order
       Region 4rwv A 540-541 disorder
Seq 297-541 Hetero trimer : IID00082Complex
 Evidence X-RAY 1zdu A Reference
       Region 1zdu A 297-298 disorder
       Region 1zdu A 299-330 order
       Region 1zdu A 331-337 disorder
       Region 1zdu A 338-538 order
       Region 1zdu A 539-541 disorder
Seq 297-541 Hetero dimer : IID00082Complex
 Evidence X-RAY 5syz A Reference
       Region 5syz A 297-299 disorder
       Region 5syz A 300-527 order
       Region 5syz A 528-529 disorder
       Region 5syz A 530-538 order
 Evidence X-RAY 4ple G Reference
       Region 4ple G 301-538 order
       Region 4ple G 539-541 disorder
 Evidence X-RAY 4ple E Reference
       Region 4ple E 301-537 order
       Region 4ple E 538-541 disorder
 Evidence X-RAY 4ple C Reference
       Region 4ple C 301-462 order
       Region 4ple C 463-463 disorder
       Region 4ple C 464-538 order
       Region 4ple C 539-541 disorder
 Evidence X-RAY 4ple A Reference
       Region 4ple A 301-538 order
       Region 4ple A 539-541 disorder
 Evidence X-RAY 4pld A Reference
       Region 4pld A 301-538 order
       Region 4pld A 539-541 disorder
 Evidence X-RAY 3plz B Reference
       Region 3plz B 300-333 order
       Region 3plz B 334-334 disorder
       Region 3plz B 335-540 order
       Region 3plz B 541-541 disorder
 Evidence X-RAY 3plz A Reference
       Region 3plz A 300-329 order
       Region 3plz A 330-337 disorder
       Region 3plz A 338-538 order
       Region 3plz A 539-541 disorder
 Evidence X-RAY 5l11 A Reference
       Region 5l11 A 299-299 disorder
       Region 5l11 A 300-526 order
       Region 5l11 A 527-529 disorder
       Region 5l11 A 530-536 order
       Region 5l11 A 537-541 disorder
Seq 299-541 Hetero dimer : IID00103Complex
 Evidence X-RAY 5unj A Reference
       Region 5unj A 299-299 disorder
       Region 5unj A 300-328 order
       Region 5unj A 329-338 disorder
       Region 5unj A 339-461 order
       Region 5unj A 462-463 disorder
       Region 5unj A 464-538 order
       Region 5unj A 539-541 disorder
Seq 299-541 Hetero trimer : IID00082Complex
 Evidence X-RAY 1yok A Reference
       Region 1yok A 300-334 order
       Region 1yok A 335-337 disorder
       Region 1yok A 338-538 order
       Region 1yok A 539-541 disorder
 Evidence X-RAY 4dos A Reference
       Region 4dos A 299-538 order
Seq 300-538 Monomer :
 Evidence X-RAY 4is8 B Reference
       Region 4is8 B 300-331 order
       Region 4is8 B 332-337 disorder
       Region 4is8 B 338-527 order
       Region 4is8 B 528-530 disorder
       Region 4is8 B 531-538 order
 Evidence X-RAY 4is8 A Reference
       Region 4is8 A 300-331 order
       Region 4is8 A 332-337 disorder
       Region 4is8 A 338-527 order
       Region 4is8 A 528-530 disorder
       Region 4is8 A 531-538 order
SeqProS possible 152-167 This region is described to be disordered in the absence of DNA (PubMed=16289203). :
       Region 2a66 A 84-178 order
 
Prediction
NeProc
Disorder 1-81,156-338
Order 82-155,339-541
ProS 6-13,156-176,205-208,232-239,261-275,302-327
AlphaFold
Disorder 1-83,190-299,334-337,419-420
Order 84-189,300-333,338-418,421-541
Pfam Hmmer
PF00105 84-159 1e-52
PF00104 350-535 1.1e-56
Function
Function in SwissProt
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity).