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Biological Process List
IDStructureTitle
IID00005MDM4/USP7Crystal Structure of the USP7:HdmX(AHSS) complex
IID00007AXIN1/GSK3BCrystal structure of GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide
IID00013ESR1/SMYD2Structural Basis of Estrogen Receptor Alpha Methylation Mediated by Histone Methyltransferase SmyD2
IID00013ESR1/ESR1/calm1Solution NMR-derived structure of calmodulin bound with ER alpha peptides
IID00013ESR1/SETD7SET7/9-ER-AdoHcy complex
IID00013ESR1/SFN14-3-3 protein interaction with Estrogen Receptor Alpha provides a novel drug target interface
IID00015TP53/EP300Structural Basis for the Regulation of p53 Function by p300
IID00015TP53/CREBBPNMR Structure of CBP Bromodomain in complex with p53 peptide
IID00015TP53/SETD7Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
IID00015TP53/SMYD2Structure of SMYD2 in complex with p53 and SAH
IID00015TP53/HMGB1HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail
IID00015TP53/GTF2H1Solution structure of the complex between p53 transactivation domain 2 and TFIIH p62 PH domain
IID00015TP53/MDM2Crystal Structure of an MDM2/P53 Peptide Complex
IID00015TP53/MDM4Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
IID00015TP53/S100BSOLUTION STRUCTURE OF THE C-TERMINAL NEGATIVE REGULATORY DOMAIN OF P53 IN A COMPLEX WITH CA2+-BOUND S100B(BB)
IID00015TP53/CCNA2 /CDK2CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
IID00015TP53/SFNCrystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide
IID00015TP53/TP53BP1Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide
IID00017RB1/E2F1/TFDP1Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
IID00017RB1/CCNA1/CDK2CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein
IID00017RB1/PPP1CACrystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1
IID00023XRCC6/XRCC5/NHEJ1Complex of XLF and heterodimer Ku bound to DNA
IID00027H2AX/MDC1Crystal structure of the MDC1 brct repeat in complex with the histone tail of gamma-H2AX
IID00027H2AX/MCPH1STRUCTURE OF HUMAN MICROCEPHALIN (MCPH1) TANDEM BRCT DOMAINS IN COMPLEX WITH A GAMMA-H2AX PHOSPHOPEPTIDE
IID00027H2AX/MCPH1Structure of human microcephalin (MCPH1) tandem BRCT domains in complex with an H2A.X peptide phosphorylated at Ser139 and Tyr142
IID00035APC/CTNNB1Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment
IID00037AKT2/GSK3BStructure of activated form of PKB kinase domain S474D with GSK3 peptide and AMP-PNP
IID00039CTNNB1/BTRC/SKP1Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase
IID00043CDKN1A/PCNAHuman PCNA
IID00046STAT1/CREBBPNMR structure of the CBP-TAZ2/STAT1-TAD complex
IID00047STAT6/NCOA1Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6
IID00048MSH2/MSH6/DNAhuman MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair
IID00048MSH2/MSH3/DNAHuman MutSbeta complexed with an IDL of 4 bases (Loop4) and ADP
IID00049CDKN1B/SKP1/SKP2/CKS1BCrystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide
IID00049CDKN1BActivation of Akt results in phosphorylation p27, which are then transported to the cytoplasm with 14-3-3.
IID00052GSK3B/AKT1Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor
IID00053STAT2/CrebbpNMR structure of the CBP-TAZ1/STAT2-TAD complex
IID00062H3C1/YWHAZMolecular basis for the recognitionof phosphorylated and phosphoacetylatedhistone H3 by 14-3-3
IID00064E2F1/CCNA2/CDK2CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F
IID00064E2F1/RB1Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide
IID00066PRKCE/YWHAZRecognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon
IID00069PPP3CA/CALM1Structure of calmodulin bound to its recognition site from calcineurin
IID00069PPP3CA/RCAN1Structure of Calcineurin bound to RCAN1
IID00076TFDP1/GTF2H1Solution structure of the complex between DP1 acidic region and TFIIH p62 PH domain
IID00079IRF3/DNACrystal Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-B enhancer
IID00080POLD3/PCNACrystal structure of hPCNA bound to residues 452-466 of the DNA polymerase-delta-p66 subunit
IID00083NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment
IID00085HIF1A/VHL/ELOB/ELOCCrystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex
IID00085HIF1A/HIF1ANFactor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide
IID00085HIF1A/EP300NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex
IID00092CREBBP/NCOA3Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins
IID00092CREBBP/IRF3Crystal structure of human phosphorylated IRF-3 bound to CBP
IID00110NCOA3/CREBBPStructure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins
IID00110NCOA3/ARCrystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3
IID00112ZFYVE9/SMAD2CRYSTAL STRUCTURE OF SMAD2 MH2 DOMAIN BOUND TO THE SMAD-BINDING DOMAIN OF SARA
IID00112ZFYVE9/SMAD3SMAD3 SBD complex
IID00113SMAD3/SMAD3/SMAD4Crystal Structure of the phosphorylated Smad3/Smad4 heterotrimeric complex
IID00113SMAD3/NEDD4LStructure of the second domain of human Nedd4L in complex with a phosphorylated pTPY motif derived from human Smad3
IID00127SMAD2/SMAD2/SMAD4Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex
IID00130RBL1/E2F5/TFDP1Crystal structure of the E2F5-DP1-p107ternary complex
IID00135SMAD7/SMURF2Solution structure of Smurf2 WW3 domain-Smad7 PY peptide complex
IID00137ANXA1An engineered cyclic peptide alleviates symptoms of inflammation in a murine model of inflammatory bowel disease
IID00137ANXA1/S100A11S100C (S100A11),OR CALGIZZARIN, IN COMPLEX WITH ANNEXIN I N-TERMINUS
IID00163MDM2/USP7The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with mdm2 peptide 147-150
IID00163MDM2NMR structure of unliganded MDM2
IID00163MDM2/MDM4Crystal Structure of the MDM2-MDMX RING Domain Heterodimer
IID00164XPC/CETN2Solution structure of the C-terminal domain (T94-Y172) of the human centrin 2 in complex with a 17 residues peptide (P1-XPC) from xeroderma pigmentosum group C protein
IID00164XPC/GTF2H1Solution structure of the complex between XPC acidic domain and TFIIH p62 PH domain
IID00165MXD1/Sin3bStructure of the complex of the Mad1-Sin3B interaction domains
IID00169REST/CTDSP1Structure of Scp1 D96N bound to REST-pS861/4 peptide
IID00169REST/Sin3bSolution structure of the NRSF/REST-mSin3B PAH1 complex
IID00171E2F2/RB1Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2
IID00174SMAD1/YAP1Structure of the first WW domain of human YAP in complex with a phosphorylated human Smad1 derived peptide
IID00174SMAD1/STUB1Crystal structure of the TPR domain of CHIP complexed with phosphorylated Smad1 peptide
IID00175POU2AF1/POU2F1/DNACRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT
IID00179CITED2/EP300Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2
IID00181BRIP1/BRCA1Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase
IID00187PQBP1/TXNL4ACrystal structure of U5-15kD in a complex with PQBP1
IID00196XPA/ERCC1Solution structure of a ERCC1-XPA heterodimer
IID00237BRCA2/RAD51Crystal structure of a RAD51-BRCA2 BRC repeat complex
IID00249PALB2/BRCA2Crystal Structure of a PALB2 / BRCA2 complex
IID00250EHMT2/CBX3Crystal structure of the complex of human chromobox homolog 3 (CBX3) with peptide
IID00262EGFR/CBLCrystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
IID00277PAK1Crystal structure of PAK1 kinase domain with ruthenium complex lambda-FL172
IID00286ERRFI1/EGFRcrystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
IID00286ERRFI1/EGFRCrystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
IID00292RAF1/YWHAZHuman 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A
IID00293ERBB2/PTPN18PTPN18 in complex with HER2-pY1248 phosphor-peptides
IID00293ERBB2/ERBINThe Structure of ERBIN PDZ domain bound to the Carboxy-terminal tail of the ErbB2 Receptor
IID00293ERBB2/PLCG1Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase ErbB2
IID00293ERBB2/GRB7Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139
IID00293ERBB2/PTPN18Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites
IID00294APP/APBB1Crystal structure of theintracellular domain of human APP in complex with Fe65-PTB2
IID00304YAP1/SFN14-3-3 sigma in complex with YAP pS127-peptide
IID00326PHF12/MORF4L1Structural Basis for Molecular Interactions Involving MRG Domains: Implications in Chromatin Biology
IID00327UHRF1/USP7Crystal structure of USP7 in complex with UHRF1
IID00327UHRF1Crystal structure of UHRF1 TTD domain in complex with the polybasic region
IID00332MBD1/DNASolution Structure of the Methyl-CpG-Binding Domain of Human MBD1 in Complex with Methylated DNA
IID00348OPTN/MAP1LC3BLC3B OPTN-LIR Ptotcomplex structure
IID00398DAXX/SUMO1Phosphorylation of SUMO-interacting motif by CK2 enhances Daxx SUMO binding activity
IID00410S100B/S100BCALCIUM FORM OF HUMAN S100B, NMR, 20 STRUCTURES
IID00427RFXANK/FRX5Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human RFXANK
IID00433FOXO3/YWHAECrystal Structure of 14-3-3 epsilon with FOXO3a peptide
IID00435NFATC1/PPP3CA/PPP3R1Structure of Calcineurin in complex with NFATc1 LxVP peptide
IID00442CREB1/CRBBP/KMT2AAllosteric communication in the KIXdomain proceeds through dynamic re-packing of the hydrophobic core
IID00457HDAC4/YWHAGCrystal structure of 14-3-3 GAMMA
IID00457HDAC4/ANKRA2Crystal Structure of the Peptide Bound Complex of the Ankyrin Repeat Domains of Human ANKRA2
IID00457HDAC4/RFXANKCrystal structure of RFXANK
IID00458MLF1/YWHAECrystal structure of 14-3-3 epsilon with Mlf1 peptide
IID00460FOXO4Stress signals in FOXO regulation
IID00464FOXO1/SFN14-3-3 sigma in complex with FOXO1 pT24 peptide
IID00466NEATC3/MAPK8Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4
IID00470NFATC2/FOXP3/DNAStructure of a domain-swapped FOXP3 dimer
IID00470NFATC2/FOXP2/DNAStructure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA.
IID00470NFATC2/FOS/JUN/DNASTRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA
IID00484FANCM/CENPS/CENPXThe crystal structure of FANCM bound MHF complex
IID00484FANCM/RMI1/RMI2Crystal structure of the RMI core complex with MM2 peptide from FANCM
IID00522GAB2/GRB2Grb2 SH3C (3)
IID00528SPRY2/CBLCrystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2
IID00532DKK1/LRP6The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide
IID00532DKK1/LRP6/KREMEN1Wnt modulator Kremen in complex with DKK1 (CRD2) and LRP6 (PE3PE4)
IID00540CFTR/YWHAZCrystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768
IID00540CFTR/GOPCPDZ Domain of CAL (Cystic Fibrosis Transmembrane Regulator-Associated Ligand)
IID00563MTA1/HDAC1The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex
IID00565HDAC1/RBL1p107 pocket domain complexed with HDAC1 peptide
IID00584SOST/LRP6The structure of a beta propeller domain in complex with peptide S
IID00596CYBA/NCF1Solution Structure Of The P22Phox-P47Phox Complex
IID00598MTOR/MLST8/AKT1S1Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex
IID00613STK11/CAB39/STRADAStructure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex
IID00613STK11/YWHAZStructure of the LKB1 and 14-3-3 complex
IID00615ITGA4/YWHAZ14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
IID00615ITGA4/Ap2m1Mu2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with Integrin alpha4 internalisation peptide QYKSILQE
IID00616ITGB7/ FLNACrystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide
IID00626SOX2/POU2F1/DNATERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
IID00626SOX2/KPNA4SOX2 bound to Importin-alpha 3
IID00641SUPT5H/RTF1Crystal Structure of Human Rtf1 Plus3 Domain in Complex with Spt5 CTR Phosphopeptide
IID00661PRKAA2/PRKAB1/PRKAG1Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
IID00669BECN1/BCL2L1Solution structure of the Bcl-xL/Beclin-1complex
IID00690TERT/KPNA1The crystal structure of human Importin alpha 5 with TERT NLS peptide
IID00698FYNFyn SH2 domain in complex with thenatural inhibitory phosphotyrosinepeptide
IID00700ANXA2/S100A4Crystal structure of Annexin A2 complexed with S100A4
IID00700ANXA2/S100A10P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS
IID00700ANXA2Crystal structure of Tyr24 phosphorylated Annexin A2 at 2.9 A resolution
IID00704MET/GRB2DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX
IID00704MET/HGFCryo-EM structure of 2:2 c-MET/HGF holo-complex
IID00704MET/CBLCrystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met
IID00708SRCCRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP
IID00714SYK/CBLCrystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk
IID00724HLTF/S100A10/ANXA2Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide
IID00725SUZ12/RBBP4/PHF19/JARID2Crystal Structure of a SUZ12-RBBP4-PHF19-JARID2 Heterotetrameric Complex
IID00726RPS6KA1/MAPK1Heterodimeric structure of ERK2 and RSK1
IID00726RPS6KA1/S100BS100B-RSK1 crystal structure C
IID00727EZH2/EED/SUZ12/H3C1/JARID2Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide
IID00736CCDC8/ANKRA2Crystalstructure of ANKRA2-CCDC8 complex
IID50003Cdh1/Ctnnb1BETA-CATENIN/E-CADHERIN COMPLEX
IID50004Creb1/CrebbpKIX DOMAIN OF MOUSE CBP (CREB BINDING PROTEIN) IN COMPLEX WITH PHOSPHORYLATED KINASE INDUCIBLE DOMAIN (PKID) OF RAT CREB (CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN), NMR 17 STRUCTURES
IID50008Crebbp/NCOA3Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR
IID50008Crebbp/TP53Structure of CBP nuclear coactivator binding domain in complex with p53 TAD
IID50013AANAT/YWHAZCRYSTALSTRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX
IID50019s100b/s100bCa2+-S100B, refined with RDCs
IID50022S100B/S100BTHE 2.0 A STRUCTURE OF HOLO S100B FROM BOVINE BRAIN
IID50054Camk1/CALM1Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of calmodulin kinase I
IID50077mdm2NMR Structure of a Complex Between MDM2 and a Small Molecule Inhibitor
IID50084Ncoa1/ESR1Crystal structure of ERa LBDin complex with RU100132
IID50088Sap25/Sin3aSolution structure of the mSin3A PAH1-SAP25 SID complex
IID50094mdm4/TP53Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
IID50097Hbp1/Sin3aSolution Structure of HBP1 SID-mSin3A PAH2 Complex
IID50197MYLK2/CALM1SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR
IID50223SWR1/HTZ1/HTB1Crystal structure of yeast Swr1-Z domain in complex with H2A.Z-H2B dimer
IID50236Gsk3bAKT1 protein kinase phosphorylates and deactivates GSK3B
IID50239nbs1/rad32Crystal structure of an unfused Mre11-Nbs1 complex with two manganese ions per active site
IID50247RHO/SAGNMR structures of phosphorylated carboxy terminus of bovine rhodopsin in arrestin-bound state
IID50261Sox2/POU2F1/DNACrystal structure of a POU/HMG/DNA ternary complex
IID50275SIC1/SKP1/CDC4Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex
IID50275SIC1/CDC14Structure of Cdc14 bound to SIC1 PxL motif
IID50281Yap1/Tead4Structural basis of YAP recognition by TEAD4 in the Hippo pathway
IID50297CTHT_0053230/CTHT_0029920/CTHT_0006210/H3C1/H3C1Structure of ctPRC2 in complex with H3K27me3 and H3K27M
IID50311ANXA1X-RAY STRUCTURE OF FULL-LENGTH ANNEXIN 1
IID50313SPT16/HTB1/HTA1SPT16-H2A-H2B FACT HISTONE Complex
IID50341Fanci/Fancd2Structure of the FANCI-FANCD2 complex
IID90002LT_SV40/Kpna2MOUSE IMPORTIN ALPHA-SV40 LARGE T ANTIGEN NLS PEPTIDE COMPLEX
IID90002LT_SV40/RB1RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN
IID90003E1A_ADE05/RB1Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain
IID90003E1A_ADE05/CREBBPNMR structure of CBP TAZ2 and adenoviral E1A complex
IID90040cas9/RNA/DNACrystal structure of catalytically-active Streptococcus pyogenes CRISPR-Cas9 in complex with single-guided RNA and double-stranded DNA primed for target DNA cleavage
IID90040cas9/RNA/acrIIA4Crystal structure of SpyCas9-sgRNA-AcrIIA4 ternary complex