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IID00003
 UniprotO14646
ProteinChromodomain-helicase-DNA-binding protein 1
GeneCHD1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1710
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 268-443 Hetero tetramer : IID00062Complex
 Evidence X-RAY 2b2v C Reference
       Region 2b2v C 268-270 disorder
       Region 2b2v C 271-355 order
       Region 2b2v C 356-373 disorder
 Evidence X-RAY 2b2u C Reference
       Region 2b2u C 268-270 disorder
       Region 2b2u C 271-357 order
       Region 2b2u C 358-373 disorder
 Evidence X-RAY 2b2v B Reference
       Region 2b2v B 268-270 disorder
       Region 2b2v B 271-401 order
       Region 2b2v B 402-404 disorder
       Region 2b2v B 405-443 order
 Evidence X-RAY 2b2v A Reference
       Region 2b2v A 268-269 disorder
       Region 2b2v A 270-443 order
 Evidence X-RAY 2b2u B Reference
       Region 2b2u B 268-268 disorder
       Region 2b2u B 269-309 order
       Region 2b2u B 310-310 disorder
       Region 2b2u B 311-401 order
       Region 2b2u B 402-403 disorder
       Region 2b2u B 404-443 order
 Evidence X-RAY 2b2u A Reference
       Region 2b2u A 268-270 disorder
       Region 2b2u A 271-308 order
       Region 2b2u A 309-310 disorder
       Region 2b2u A 311-443 order
Seq 268-443 Hetero dimer : IID90024Complex
 Evidence X-RAY 4o42 A Reference
       Region 4o42 A 268-269 disorder
       Region 4o42 A 270-442 order
       Region 4o42 A 443-443 disorder
Seq 268-443 Hetero dimer : P03495
 Evidence X-RAY 4nw2 C Reference
       Region 4nw2 C 268-269 disorder
       Region 4nw2 C 270-442 order
       Region 4nw2 C 443-443 disorder
 Evidence X-RAY 4nw2 A Reference
       Region 4nw2 A 268-269 disorder
       Region 4nw2 A 270-442 order
       Region 4nw2 A 443-443 disorder
Seq 268-443 Hetero trimer :
 Evidence X-RAY 2b2y C This complex is hetero trimer in the automatic decision, but is actually homo trimer. Reference
       Region 2b2y C 268-268 disorder
       Region 2b2y C 269-354 order
       Region 2b2y C 355-373 disorder
 Evidence X-RAY 2b2y B This complex is hetero trimer in the automatic decision, but is actually homo trimer. Reference
       Region 2b2y B 268-268 disorder
       Region 2b2y B 269-309 order
       Region 2b2y B 310-310 disorder
       Region 2b2y B 311-399 order
       Region 2b2y B 400-405 disorder
       Region 2b2y B 406-443 order
 Evidence X-RAY 2b2y A This complex is hetero trimer in the automatic decision, but is actually homo trimer. Reference
       Region 2b2y A 268-269 disorder
       Region 2b2y A 270-308 order
       Region 2b2y A 309-309 disorder
       Region 2b2y A 310-443 order
Seq 268-443 Hetero tetramer : IID00062Complex
 Evidence X-RAY 2b2w C Reference
       Region 2b2w C 268-268 disorder
       Region 2b2w C 269-354 order
       Region 2b2w C 355-373 disorder
 Evidence X-RAY 2b2t C Reference
       Region 2b2t C 268-269 disorder
       Region 2b2t C 270-355 order
       Region 2b2t C 356-373 disorder
 Evidence X-RAY 2b2w B Reference
       Region 2b2w B 268-268 disorder
       Region 2b2w B 269-309 order
       Region 2b2w B 310-310 disorder
       Region 2b2w B 311-443 order
 Evidence X-RAY 2b2w A Reference
       Region 2b2w A 268-268 disorder
       Region 2b2w A 269-443 order
 Evidence X-RAY 2b2t B Reference
       Region 2b2t B 268-309 order
       Region 2b2t B 310-310 disorder
       Region 2b2t B 311-402 order
       Region 2b2t B 403-404 disorder
       Region 2b2t B 405-443 order
 Evidence X-RAY 2b2t A Reference
       Region 2b2t A 268-268 disorder
       Region 2b2t A 269-443 order
Seq 270-443 Hetero dimer : IID00009Complex
 Evidence X-RAY 5afw A Reference
       Region 5afw A 270-362 order
       Region 5afw A 363-373 disorder
       Region 5afw A 374-443 order
Seq 1119-1327 Homo dimer :
 Evidence X-RAY 4b4c A Reference
       Region 4b4c A 1119-1123 disorder
       Region 4b4c A 1124-1181 order
       Region 4b4c A 1182-1198 disorder
       Region 4b4c A 1199-1327 order
Seq 1409-1511 Monomer :
 Evidence NMR 2n39 A Reference
       Region 2n39 A 1409-1511 order
       Region 2n39 A 1506-1511 high_rmsd
Seqphosphorylation
    1688-1688 Phosphoserine
    1689-1689 Phosphoserine
    1677-1677 Phosphoserine
    1622-1622 Phosphoserine
    1373-1373 Phosphoserine
    1371-1371 Phosphoserine
    1363-1363 Phosphoserine
    1356-1356 Phosphoserine
    1360-1360 Phosphoserine
    1355-1355 Phosphoserine
    1353-1353 Phosphoserine
    1161-1161 Phosphoserine
    1102-1102 Phosphoserine
    1100-1100 Phosphoserine
    1098-1098 Phosphoserine
    1096-1096 Phosphoserine
    1085-1085 Phosphoserine
    1081-1081 Phosphoserine
    1040-1040 Phosphoserine
    1025-1025 Phosphoserine
    471-471 Phosphoserine
    252-252 Phosphoserine
    250-250 Phosphothreonine
    241-241 Phosphoserine
    237-237 Phosphothreonine
    216-216 Phosphoserine
    215-215 Phosphoserine
 
Prediction
NeProc
Disorder 1-281,286-291,299-309,451-456,949-961,970-1120,1186-1196,1292-1298,1304-1424,1431-1436,1494-1710
Order 282-285,292-298,310-450,457-948,962-969,1121-1185,1197-1291,1299-1303,1425-1430,1437-1493
ProS 82-102,147-150,238-245,255-264,271-281,299-309,451-456,970-980,987-1004,1013-1027,1041-1070,1078-1082,1089-1096,1292-1298,1304-1318,1402-1424,1431-1436,1494-1502,1564-1569,1577-1590,1596-1620,1627-1646,1658-1710
AlphaFold
Disorder 1-271,305-312,367-373,376-376,402-404,451-455,474-477,578-582,645-649,674-685,687-687,703-703,734-749,768-775,840-840,868-870,930-991,995-1124,1183-1199,1323-1408,1433-1438,1508-1710
Order 272-304,313-366,374-375,377-401,405-450,456-473,478-577,583-644,650-673,686-686,688-702,704-733,750-767,776-839,841-867,871-929,992-994,1125-1182,1200-1322,1409-1432,1439-1507
Pfam Hmmer
PF00385 272-355 2.1e-08
PF00385 389-443 5.1e-15
PF00176 484-765 1e-144
PF00271 823-902 8e-25
SEG 13-67 ,105-115 ,117-138 ,152-179 ,214-228 ,267-275 ,789-801 ,974-989 ,1049-1066 ,1084-1116 ,1328-1344 ,1352-1376 ,1507-1516 ,1537-1548 ,1625-1647
Function
Function in SwissProt
ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3 (PubMed:18042460, PubMed:28866611). Required for maintaining open chromatin and pluripotency in embryonic stem cells (By similarity).
Biological Process
See also
Diagram with PDB data
H3C1/YWHAZMolecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3