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IID00005
 UniprotO15151
ProteinProtein Mdm4
GeneMDM4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
490
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 14-111 Monomer :
 Evidence X-RAY 3fe7 A Reference
       Region 3fe7 A 14-25 disorder
       Region 3fe7 A 26-108 order
       Region 3fe7 A 109-111 disorder
 Evidence X-RAY 3lbj E Reference
       Region 3lbj E 23-24 disorder
       Region 3lbj E 25-107 order
       Region 3lbj E 108-111 disorder
 Evidence NMR 2n06 A Reference
       Region 2n06 A 23-111 order
       Region 2n06 A 109-111 high_rmsd
 Evidence NMR 2n0u A Reference
       Region 2n0u A 23-111 order
       Region 2n0u A 111-111 high_rmsd
 Evidence NMR 2n0w A Reference
       Region 2n0w A 23-111 order
 Evidence NMR 2n14 A Reference
       Region 2n14 A 23-111 order
       Region 2n14 A 111-111 high_rmsd
 Evidence X-RAY 5vk1 A Reference
       Region 5vk1 A 24-24 disorder
       Region 5vk1 A 25-107 order
       Region 5vk1 A 108-108 disorder
 Evidence X-RAY 5vk1 C Reference
       Region 5vk1 C 24-24 disorder
       Region 5vk1 C 25-106 order
       Region 5vk1 C 107-108 disorder
 Evidence X-RAY 5vk1 E Reference
       Region 5vk1 E 24-24 disorder
       Region 5vk1 E 25-107 order
       Region 5vk1 E 108-108 disorder
 Evidence X-RAY 5vk1 G Reference
       Region 5vk1 G 24-24 disorder
       Region 5vk1 G 25-106 order
       Region 5vk1 G 107-108 disorder
 Evidence X-RAY 5vk1 I Reference
       Region 5vk1 I 24-25 disorder
       Region 5vk1 I 26-107 order
       Region 5vk1 I 108-108 disorder
 Evidence X-RAY 5vk1 K Reference
       Region 5vk1 K 24-25 disorder
       Region 5vk1 K 26-107 order
       Region 5vk1 K 108-108 disorder
 Evidence X-RAY 5vk1 M Reference
       Region 5vk1 M 24-24 disorder
       Region 5vk1 M 25-106 order
       Region 5vk1 M 107-108 disorder
 Evidence X-RAY 5vk1 O Reference
       Region 5vk1 O 24-24 disorder
       Region 5vk1 O 25-106 order
       Region 5vk1 O 107-108 disorder
 Evidence X-RAY 7c3q A Reference
       Region 7c3q A 23-108 order
 Evidence X-RAY 7c3y A Reference
       Region 7c3y A 23-108 order
 Evidence X-RAY 7c44 A Reference
       Region 7c44 A 23-108 order
 Evidence X-RAY 3fea A Reference
       Region 3fea A 14-25 disorder
       Region 3fea A 26-108 order
       Region 3fea A 109-111 disorder
 Evidence X-RAY 7kjn A Reference
       Region 7kjn A 24-108 order
 Evidence X-RAY 6q9u A Reference
       Region 6q9u A 14-23 disorder
       Region 6q9u A 24-109 order
       Region 6q9u A 110-111 disorder
Seq 14-111 Homo dimer :
 Evidence X-RAY 3u15 A Reference
       Region 3u15 A 14-25 disorder
       Region 3u15 A 26-107 order
       Region 3u15 A 108-111 disorder
 Evidence X-RAY 3u15 B Reference
       Region 3u15 B 14-25 disorder
       Region 3u15 B 26-107 order
       Region 3u15 B 108-111 disorder
 Evidence X-RAY 3u15 C Reference
       Region 3u15 C 14-25 disorder
       Region 3u15 C 26-107 order
       Region 3u15 C 108-111 disorder
 Evidence X-RAY 3u15 D Reference
       Region 3u15 D 14-25 disorder
       Region 3u15 D 26-106 order
       Region 3u15 D 107-111 disorder
 Evidence X-RAY 6q9y A Reference
       Region 6q9y A 14-25 disorder
       Region 6q9y A 26-110 order
       Region 6q9y A 111-111 disorder
 Evidence X-RAY 6q9y B Reference
       Region 6q9y B 14-22 disorder
       Region 6q9y B 23-110 order
       Region 6q9y B 111-111 disorder
Seq 14-111 Homo dimer :
 Evidence X-RAY 6q9w B Reference
       Region 6q9w B 14-24 disorder
       Region 6q9w B 25-108 order
       Region 6q9w B 109-111 disorder
 Evidence X-RAY 6q9w A Reference
       Region 6q9w A 14-24 disorder
       Region 6q9w A 25-110 order
       Region 6q9w A 111-111 disorder
Seq 14-111 Homo tetramer :
 Evidence X-RAY 6q9q D Reference
       Region 6q9q D 14-24 disorder
       Region 6q9q D 25-108 order
       Region 6q9q D 109-111 disorder
 Evidence X-RAY 6q9q C Reference
       Region 6q9q C 14-24 disorder
       Region 6q9q C 25-107 order
       Region 6q9q C 108-111 disorder
 Evidence X-RAY 6q9q B Reference
       Region 6q9q B 14-24 disorder
       Region 6q9q B 25-108 order
       Region 6q9q B 109-111 disorder
 Evidence X-RAY 6q9q A Reference
       Region 6q9q A 14-24 disorder
       Region 6q9q A 25-108 order
       Region 6q9q A 109-111 disorder
 Evidence X-RAY 8hdg D Reference
       Region 8hdg D 23-109 order
       Region 8hdg D 110-111 disorder
 Evidence X-RAY 8hdg C Reference
       Region 8hdg C 23-109 order
       Region 8hdg C 110-111 disorder
 Evidence X-RAY 8hdg B Reference
       Region 8hdg B 23-109 order
       Region 8hdg B 110-111 disorder
 Evidence X-RAY 8hdg A Reference
       Region 8hdg A 23-109 order
       Region 8hdg A 110-111 disorder
Seq 14-111 Homo trimer :
 Evidence X-RAY 6q9s C Reference
       Region 6q9s C 14-21 disorder
       Region 6q9s C 22-109 order
       Region 6q9s C 110-111 disorder
 Evidence X-RAY 6q9s B Reference
       Region 6q9s B 14-24 disorder
       Region 6q9s B 25-110 order
       Region 6q9s B 111-111 disorder
 Evidence X-RAY 6q9s A Reference
       Region 6q9s A 14-21 disorder
       Region 6q9s A 22-108 order
       Region 6q9s A 109-111 disorder
Seq 16-116 Hetero dodecamer :
 Evidence X-RAY 2vyr D This region binds to an antibody. Reference
       Region 2vyr D 16-24 disorder
       Region 2vyr D 25-109 order
       Region 2vyr D 110-116 disorder
 Evidence X-RAY 2vyr C This region binds to an antibody. Reference
       Region 2vyr C 16-24 disorder
       Region 2vyr C 25-109 order
       Region 2vyr C 110-116 disorder
 Evidence X-RAY 2vyr B This region binds to an antibody. Reference
       Region 2vyr B 16-24 disorder
       Region 2vyr B 25-109 order
       Region 2vyr B 110-116 disorder
 Evidence X-RAY 2vyr A This region binds to an antibody. Reference
       Region 2vyr A 16-24 disorder
       Region 2vyr A 25-109 order
       Region 2vyr A 110-116 disorder
Seq 23-111 Hetero dimer : IID00015Complex
 Evidence X-RAY 7el4 A Reference
       Region 7el4 A 23-25 disorder
       Region 7el4 A 26-108 order
       Region 7el4 A 109-111 disorder
Seq 23-111 Hetero dimer :
 Evidence X-RAY 8ia5 A Reference
       Region 8ia5 A 23-108 order
       Region 8ia5 A 109-111 disorder
Seq 23-111 Hetero dimer :
 Evidence X-RAY 3fdo A This region binds to a peptide. Reference
       Region 3fdo A 23-111 order
Seq 23-111 Hetero dimer :
 Evidence X-RAY 3jzq A Reference
       Region 3jzq A 23-24 disorder
       Region 3jzq A 25-108 order
       Region 3jzq A 109-111 disorder
Seq 23-111 Hetero dimer :
 Evidence X-RAY 3jzp A This region binds to a peptide. Reference
       Region 3jzp A 23-109 order
       Region 3jzp A 110-111 disorder
Seq 23-111 Hetero dimer :
 Evidence X-RAY 3jzo A Reference
       Region 3jzo A 23-109 order
       Region 3jzo A 110-111 disorder
Seq 23-111 Hetero dimer :
 Evidence X-RAY 3jzq B Reference
       Region 3jzq B 23-24 disorder
       Region 3jzq B 25-111 order
Seq 23-111 Hetero dimer : IID00015Complex
 Evidence X-RAY 3dab A Reference
       Region 3dab A 23-109 order
       Region 3dab A 110-111 disorder
 Evidence X-RAY 3dab C Reference
       Region 3dab C 23-107 order
       Region 3dab C 108-111 disorder
 Evidence X-RAY 3dab E Reference
       Region 3dab E 23-107 order
       Region 3dab E 108-111 disorder
 Evidence X-RAY 3dab G Reference
       Region 3dab G 23-109 order
       Region 3dab G 110-111 disorder
 Evidence NMR 2mwy A Reference
       Region 2mwy A 23-111 order
Seq 24-108 Hetero dimer :
 Evidence X-RAY 4rxz B Reference
       Region 4rxz B 24-24 disorder
       Region 4rxz B 25-108 order
Seq 24-108 Hetero dimer :
 Evidence X-RAY 5uml E Reference
       Region 5uml E 24-25 disorder
       Region 5uml E 26-108 order
Seq 24-108 Hetero dimer :
 Evidence X-RAY 3eqy A Reference
       Region 3eqy A 24-24 disorder
       Region 3eqy A 25-108 order
Seq 24-108 Hetero dimer :
 Evidence X-RAY 5uml G Reference
       Region 5uml G 24-25 disorder
       Region 5uml G 26-108 order
Seq 24-108 Hetero dimer :
 Evidence X-RAY 5uml B Reference
       Region 5uml B 24-24 disorder
       Region 5uml B 25-108 order
Seq 24-108 Hetero dimer :
 Evidence X-RAY 3eqy B Reference
       Region 3eqy B 24-24 disorder
       Region 3eqy B 25-108 order
Seq 24-108 Hetero dimer :
 Evidence X-RAY 4rxz A Reference
       Region 4rxz A 24-24 disorder
       Region 4rxz A 25-108 order
Seq 24-108 Hetero dimer :
 Evidence X-RAY 5uml A Reference
       Region 5uml A 24-24 disorder
       Region 5uml A 25-108 order
Seq 300-339 Monomer :
 Evidence NMR 2cr8 A Reference
       Region 2cr8 A 300-339 order
       Region 2cr8 A 300-300 high_rmsd
       Region 2cr8 A 330-339 high_rmsd
Seq 335-374 Hetero tetramer : IID00301Complex
 Evidence X-RAY 6yr7 Q Reference
       Region 6yr7 Q 335-338 disorder
       Region 6yr7 Q 339-346 order
       Region 6yr7 Q 347-374 disorder
 Evidence X-RAY 6yr7 C Reference
       Region 6yr7 C 335-338 disorder
       Region 6yr7 C 339-346 order
       Region 6yr7 C 347-374 disorder
Seq 361-374 Hetero octamer : IID00301Complex
 Evidence X-RAY 6yr5 R Reference
       Region 6yr5 R 361-364 disorder
       Region 6yr5 R 365-370 order
       Region 6yr5 R 371-374 disorder
 Evidence X-RAY 6yr5 Q Reference
       Region 6yr5 Q 361-364 disorder
       Region 6yr5 Q 365-371 order
       Region 6yr5 Q 372-374 disorder
 Evidence X-RAY 6yr5 P Reference
       Region 6yr5 P 361-363 disorder
       Region 6yr5 P 364-373 order
       Region 6yr5 P 374-374 disorder
 Evidence X-RAY 6yr5 O Reference
       Region 6yr5 O 361-362 disorder
       Region 6yr5 O 363-371 order
       Region 6yr5 O 372-374 disorder
Seq 395-404 Hetero dimer : IID00176Complex
 Evidence X-RAY 3mqr B Reference
       Region 3mqr B 395-397 disorder
       Region 3mqr B 398-401 order
       Region 3mqr B 402-404 disorder
Seq 427-490 Hetero tetramer : IID00163Complex,P0CG47
 Evidence X-RAY 5mnj D Reference
       Region 5mnj D 427-427 disorder
       Region 5mnj D 428-490 order
 Evidence X-RAY 5mnj H Reference
       Region 5mnj H 427-490 order
Seq 428-490 Hetero tetramer : IID00163Complex
 Evidence X-RAY 2vje B Reference
       Region 2vje B 428-429 disorder
       Region 2vje B 430-490 order
 Evidence X-RAY 2vje D Reference
       Region 2vje D 428-428 disorder
       Region 2vje D 429-490 order
 Evidence X-RAY 2vjf B Reference
       Region 2vjf B 428-490 order
 Evidence X-RAY 2vjf D Reference
       Region 2vjf D 428-490 order
Seq 428-490 Hetero dimer :
 Evidence NMR 7mla A Reference
       Region 7mla A 428-490 order
SeqProS predicted 339-346 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : IID00301Complex
       Region 6yr7 C 339-346 order
       Region 6yr7 Q 339-346 order
SeqProS predicted 363-373 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero octamer : IID00301Complex
       Region 6yr5 O 363-371 order
       Region 6yr5 P 364-373 order
       Region 6yr5 Q 365-371 order
       Region 6yr5 R 365-370 order
SeqProS predicted 398-401 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00176Complex
       Region 3mqr B 398-401 order
Seqphosphorylation
    342-342 Phosphoserine; by CHEK2
    367-367 Phosphoserine; by CHEK1 and CHEK2
 
Prediction
NeProc
Disorder 1-21,111-297,338-432
Order 22-110,298-337,433-490
ProS 14-21,125-129,155-168,185-212,220-257,273-293,356-378,415-423
AlphaFold
Disorder 1-24,110-301,330-433
Order 25-109,302-329,434-490
Pfam Hmmer
PF02201 26-101 7.1e-15
SEG 108-125 ,282-303
Function
Function in SwissProt
Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
Biological Process
Diagram with PDB data
MDM4/USP7Crystal Structure of the USP7:HdmX(AHSS) complex
See also
Diagram with PDB data
TP53/MDM4Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
MDM2/MDM4Crystal Structure of the MDM2-MDMX RING Domain Heterodimer