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IID00012
 UniprotP01106
ProteinMyc proto-oncogene protein
GeneMYC
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
439
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 55-68 Hetero dimer : O00499
 Evidence NMR 1mv0 A Reference
       Region 1mv0 A 55-68 order
Seq 260-267 Hetero dimer : IID00377Complex
 Evidence X-RAY 4y7r B Reference
       Region 4y7r B 260-267 order
Seq 320-328 Hetero trimer : IID50012Complex
 Evidence X-RAY 1ee4 F Reference
       Region 1ee4 F 320-322 disorder
       Region 1ee4 F 323-326 order
       Region 1ee4 F 327-328 disorder
 Evidence X-RAY 1ee4 E Reference
       Region 1ee4 E 320-328 order
 Evidence X-RAY 1ee4 D Reference
       Region 1ee4 D 320-322 disorder
       Region 1ee4 D 323-327 order
       Region 1ee4 D 328-328 disorder
 Evidence X-RAY 1ee4 C Reference
       Region 1ee4 C 320-328 order
Seq 350-439 Homo dimer :
 Evidence X-RAY 5i4z B Reference
       Region 5i4z B 350-365 disorder
       Region 5i4z B 366-439 order
 Evidence X-RAY 5i4z A Reference
       Region 5i4z A 350-365 disorder
       Region 5i4z A 366-439 order
 Evidence X-RAY 5i50 B Reference
       Region 5i50 B 350-439 order
 Evidence X-RAY 5i50 A Reference
       Region 5i50 A 350-439 order
Seq 353-434 Hetero dimer : P61244
 Evidence X-RAY 1nkp D Reference
       Region 1nkp D 353-434 order
 Evidence X-RAY 1nkp A Reference
       Region 1nkp A 353-434 order
Seq 406-434 Hetero dimer : IID50243Complex
 Evidence NMR 2a93 A Reference
       Region 2a93 A 406-434 order
       Region 2a93 A 433-434 high_rmsd
 Evidence NMR 1a93 A Reference
       Region 1a93 A 406-434 order
Seq 410-419 Hetero trimer : P01654
 Evidence X-RAY 2or9 P Reference
       Region 2or9 P 410-419 order
SeqProS possible 260-267 Hetero dimer : IID00377Complex
       Region 4y7r B 260-267 order
SeqProS possible 320-328 Nuclear Localization Signal (NLS). Hetero trimer : IID50012Complex
       Region 1ee4 C 320-328 order
       Region 1ee4 E 320-328 order
       Region 1ee4 D 323-327 order
       Region 1ee4 F 323-326 order
Seqphosphorylation
    86-86 Phosphoserine
    344-344 Phosphoserine; by PIM2; in vitro
    176-176 Phosphoserine
    308-308 Phosphoserine
    77-77 Phosphoserine; by DYRK2
    73-73 Phosphothreonine; by GSK3; alternate
    23-23 Phosphothreonine; by RAF; in vitro
    21-21 Phosphoserine
Seqacetylation
    386-386 N6-acetyllysine; by PCAF
    290-290 N6-acetyllysine; by PCAF
    332-332 N6-acetyllysine; by PCAF
    338-338 N6-acetyllysine; by PCAF
    172-172 N6-acetyllysine; by PCAF
    163-163 N6-acetyllysine; alternate
    158-158 N6-acetyllysine; by PCAF; alternate
 
Prediction
NeProc
Disorder 1-28,40-44,49-375
Order 29-39,45-48,376-454
ProS 1-8,23-28,40-44,62-93,99-177,188-221,233-258,274-284,309-315,328-331,351-362
AlphaFold
Disorder 1-45,47-48,50-94,101-149,152-152,154-186,195-195,197-260,262-262,264-307,309-309,311-349,439-439
Order 46-46,49-49,95-100,150-151,153-153,187-194,196-196,261-261,263-263,308-308,310-310,350-438
Pfam Hmmer
PF01056 16-360 5.1e-206
PF00010 370-422 7.3e-19
PF02344 423-454 7.1e-17
SEG 48-52 ,70-88 ,222-252 ,257-283
Function
Function in SwissProt
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).