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IID00016
 UniprotP04908
ProteinHistone H2A type 1-B/E
GeneH2AC4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
130
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-130 Hetero octamer : IID00058Complex,IID00062Complex,P06899
 Evidence X-RAY 5cpj G Reference
       Region 5cpj G 1-15 disorder
       Region 5cpj G 16-118 order
       Region 5cpj G 119-130 disorder
 Evidence X-RAY 5cpj C Reference
       Region 5cpj C 1-14 disorder
       Region 5cpj C 15-119 order
       Region 5cpj C 120-130 disorder
 Evidence X-RAY 3azn G Reference
       Region 3azn G 1-15 disorder
       Region 3azn G 16-119 order
       Region 3azn G 120-130 disorder
 Evidence X-RAY 3azn C Reference
       Region 3azn C 1-11 disorder
       Region 3azn C 12-119 order
       Region 3azn C 120-130 disorder
 Evidence X-RAY 3azl G Reference
       Region 3azl G 1-14 disorder
       Region 3azl G 15-119 order
       Region 3azl G 120-130 disorder
 Evidence X-RAY 3azl C Reference
       Region 3azl C 1-11 disorder
       Region 3azl C 12-119 order
       Region 3azl C 120-130 disorder
 Evidence X-RAY 3azk G Reference
       Region 3azk G 1-14 disorder
       Region 3azk G 15-119 order
       Region 3azk G 120-130 disorder
 Evidence X-RAY 3azk C Reference
       Region 3azk C 1-11 disorder
       Region 3azk C 12-119 order
       Region 3azk C 120-130 disorder
 Evidence X-RAY 3azi G Reference
       Region 3azi G 1-15 disorder
       Region 3azi G 16-119 order
       Region 3azi G 120-130 disorder
 Evidence X-RAY 3azi C Reference
       Region 3azi C 1-11 disorder
       Region 3azi C 12-119 order
       Region 3azi C 120-130 disorder
 Evidence X-RAY 3azh G Reference
       Region 3azh G 1-15 disorder
       Region 3azh G 16-119 order
       Region 3azh G 120-130 disorder
 Evidence X-RAY 3azh C Reference
       Region 3azh C 1-13 disorder
       Region 3azh C 14-119 order
       Region 3azh C 120-130 disorder
 Evidence X-RAY 3azf G Reference
       Region 3azf G 1-15 disorder
       Region 3azf G 16-119 order
       Region 3azf G 120-130 disorder
 Evidence X-RAY 3azf C Reference
       Region 3azf C 1-11 disorder
       Region 3azf C 12-119 order
       Region 3azf C 120-130 disorder
 Evidence X-RAY 3aze G Reference
       Region 3aze G 1-15 disorder
       Region 3aze G 16-119 order
       Region 3aze G 120-130 disorder
 Evidence X-RAY 3aze C Reference
       Region 3aze C 1-11 disorder
       Region 3aze C 12-119 order
       Region 3aze C 120-130 disorder
Seq 1-130 Hetero octamer : IID00010Complex,IID00058Complex,IID00062Complex
 Evidence X-RAY 2cv5 G Reference
       Region 2cv5 G 1-15 disorder
       Region 2cv5 G 16-119 order
       Region 2cv5 G 120-130 disorder
 Evidence X-RAY 2cv5 C Reference
       Region 2cv5 C 1-11 disorder
       Region 2cv5 C 12-119 order
       Region 2cv5 C 120-130 disorder
Seq 1-130 Hetero octamer : IID00058Complex,IID00239Complex,P06899
 Evidence X-RAY 5x7x G Reference
       Region 5x7x G 1-14 disorder
       Region 5x7x G 15-119 order
       Region 5x7x G 120-130 disorder
 Evidence X-RAY 5x7x C Reference
       Region 5x7x C 1-11 disorder
       Region 5x7x C 12-119 order
       Region 5x7x C 120-130 disorder
Seq 1-130 Hetero octamer : IID00058Complex,IID00062Complex,P06899
 Evidence X-RAY 4ym5 G Reference
       Region 4ym5 G 1-16 disorder
       Region 4ym5 G 17-119 order
       Region 4ym5 G 120-130 disorder
 Evidence X-RAY 4ym5 C Reference
       Region 4ym5 C 1-14 disorder
       Region 4ym5 C 15-119 order
       Region 4ym5 C 120-130 disorder
 Evidence X-RAY 5xf5 G Reference
       Region 5xf5 G 1-14 disorder
       Region 5xf5 G 15-120 order
       Region 5xf5 G 121-130 disorder
 Evidence X-RAY 5xf5 C Reference
       Region 5xf5 C 1-14 disorder
       Region 5xf5 C 15-120 order
       Region 5xf5 C 121-130 disorder
 Evidence X-RAY 5xf4 G Reference
       Region 5xf4 G 1-14 disorder
       Region 5xf4 G 15-120 order
       Region 5xf4 G 121-130 disorder
 Evidence X-RAY 5xf4 C Reference
       Region 5xf4 C 1-14 disorder
       Region 5xf4 C 15-120 order
       Region 5xf4 C 121-130 disorder
 Evidence X-RAY 5xf3 G Reference
       Region 5xf3 G 1-14 disorder
       Region 5xf3 G 15-120 order
       Region 5xf3 G 121-130 disorder
 Evidence X-RAY 5xf3 C Reference
       Region 5xf3 C 1-14 disorder
       Region 5xf3 C 15-120 order
       Region 5xf3 C 121-130 disorder
 Evidence X-RAY 3w97 G Reference
       Region 3w97 G 1-16 disorder
       Region 3w97 G 17-119 order
       Region 3w97 G 120-130 disorder
 Evidence X-RAY 3w97 C Reference
       Region 3w97 C 1-13 disorder
       Region 3w97 C 14-119 order
       Region 3w97 C 120-130 disorder
 Evidence X-RAY 5jrg G Reference
       Region 5jrg G 1-10 disorder
       Region 5jrg G 11-119 order
       Region 5jrg G 120-130 disorder
 Evidence X-RAY 5jrg C Reference
       Region 5jrg C 1-12 disorder
       Region 5jrg C 13-119 order
       Region 5jrg C 120-130 disorder
 Evidence X-RAY 5cpk G Reference
       Region 5cpk G 1-15 disorder
       Region 5cpk G 16-119 order
       Region 5cpk G 120-130 disorder
 Evidence X-RAY 5cpk C Reference
       Region 5cpk C 1-13 disorder
       Region 5cpk C 14-119 order
       Region 5cpk C 120-130 disorder
 Evidence X-RAY 5cpi G Reference
       Region 5cpi G 1-15 disorder
       Region 5cpi G 16-119 order
       Region 5cpi G 120-130 disorder
 Evidence X-RAY 5cpi C Reference
       Region 5cpi C 1-11 disorder
       Region 5cpi C 12-119 order
       Region 5cpi C 120-130 disorder
 Evidence X-RAY 5b2j G Reference
       Region 5b2j G 1-14 disorder
       Region 5b2j G 15-119 order
       Region 5b2j G 120-130 disorder
 Evidence X-RAY 5b2j C Reference
       Region 5b2j C 1-13 disorder
       Region 5b2j C 14-119 order
       Region 5b2j C 120-130 disorder
 Evidence X-RAY 5b2i G Reference
       Region 5b2i G 1-14 disorder
       Region 5b2i G 15-119 order
       Region 5b2i G 120-130 disorder
 Evidence X-RAY 5b2i C Reference
       Region 5b2i C 1-13 disorder
       Region 5b2i C 14-119 order
       Region 5b2i C 120-130 disorder
 Evidence X-RAY 5b24 G Reference
       Region 5b24 G 1-15 disorder
       Region 5b24 G 16-119 order
       Region 5b24 G 120-130 disorder
 Evidence X-RAY 5b24 C Reference
       Region 5b24 C 1-11 disorder
       Region 5b24 C 12-119 order
       Region 5b24 C 120-130 disorder
 Evidence X-RAY 3azm G Reference
       Region 3azm G 1-15 disorder
       Region 3azm G 16-119 order
       Region 3azm G 120-130 disorder
 Evidence X-RAY 3azm C Reference
       Region 3azm C 1-13 disorder
       Region 3azm C 14-119 order
       Region 3azm C 120-130 disorder
 Evidence X-RAY 3azj G Reference
       Region 3azj G 1-15 disorder
       Region 3azj G 16-111 order
       Region 3azj G 112-130 disorder
 Evidence X-RAY 3azj C Reference
       Region 3azj C 1-11 disorder
       Region 3azj C 12-111 order
       Region 3azj C 112-130 disorder
 Evidence X-RAY 3azg G Reference
       Region 3azg G 1-15 disorder
       Region 3azg G 16-119 order
       Region 3azg G 120-130 disorder
 Evidence X-RAY 3azg C Reference
       Region 3azg C 1-11 disorder
       Region 3azg C 12-119 order
       Region 3azg C 120-130 disorder
 Evidence X-RAY 3ayw G Reference
       Region 3ayw G 1-16 disorder
       Region 3ayw G 17-119 order
       Region 3ayw G 120-130 disorder
 Evidence X-RAY 3ayw C Reference
       Region 3ayw C 1-11 disorder
       Region 3ayw C 12-119 order
       Region 3ayw C 120-130 disorder
 Evidence X-RAY 5avc G Reference
       Region 5avc G 1-14 disorder
       Region 5avc G 15-119 order
       Region 5avc G 120-130 disorder
 Evidence X-RAY 5avc C Reference
       Region 5avc C 1-13 disorder
       Region 5avc C 14-119 order
       Region 5avc C 120-130 disorder
 Evidence X-RAY 5avb G Reference
       Region 5avb G 1-14 disorder
       Region 5avb G 15-119 order
       Region 5avb G 120-130 disorder
 Evidence X-RAY 5avb C Reference
       Region 5avb C 1-13 disorder
       Region 5avb C 14-119 order
       Region 5avb C 120-130 disorder
 Evidence X-RAY 5av9 G Reference
       Region 5av9 G 1-14 disorder
       Region 5av9 G 15-119 order
       Region 5av9 G 120-130 disorder
 Evidence X-RAY 5av9 C Reference
       Region 5av9 C 1-13 disorder
       Region 5av9 C 14-119 order
       Region 5av9 C 120-130 disorder
 Evidence X-RAY 5av8 G Reference
       Region 5av8 G 1-14 disorder
       Region 5av8 G 15-119 order
       Region 5av8 G 120-130 disorder
 Evidence X-RAY 5av8 C Reference
       Region 5av8 C 1-13 disorder
       Region 5av8 C 14-119 order
       Region 5av8 C 120-130 disorder
 Evidence X-RAY 5av6 G Reference
       Region 5av6 G 1-14 disorder
       Region 5av6 G 15-119 order
       Region 5av6 G 120-130 disorder
 Evidence X-RAY 5av6 C Reference
       Region 5av6 C 1-13 disorder
       Region 5av6 C 14-119 order
       Region 5av6 C 120-130 disorder
 Evidence X-RAY 5av5 G Reference
       Region 5av5 G 1-14 disorder
       Region 5av5 G 15-119 order
       Region 5av5 G 120-130 disorder
 Evidence X-RAY 5av5 C Reference
       Region 5av5 C 1-13 disorder
       Region 5av5 C 14-119 order
       Region 5av5 C 120-130 disorder
 Evidence X-RAY 3afa G Reference
       Region 3afa G 1-15 disorder
       Region 3afa G 16-119 order
       Region 3afa G 120-130 disorder
 Evidence X-RAY 3afa C Reference
       Region 3afa C 1-11 disorder
       Region 3afa C 12-119 order
       Region 3afa C 120-130 disorder
Seq 1-130 Hetero octamer : IID00058Complex,IID00062Complex,P06899
 Evidence X-RAY 4ym6 G Reference
       Region 4ym6 G 1-15 disorder
       Region 4ym6 G 16-119 order
       Region 4ym6 G 120-130 disorder
 Evidence X-RAY 4ym6 C Reference
       Region 4ym6 C 1-11 disorder
       Region 4ym6 C 12-119 order
       Region 4ym6 C 120-130 disorder
 Evidence X-RAY 3w99 G Reference
       Region 3w99 G 1-17 disorder
       Region 3w99 G 18-119 order
       Region 3w99 G 120-130 disorder
 Evidence X-RAY 3w99 C Reference
       Region 3w99 C 1-14 disorder
       Region 3w99 C 15-119 order
       Region 3w99 C 120-130 disorder
 Evidence X-RAY 3w98 G Reference
       Region 3w98 G 1-15 disorder
       Region 3w98 G 16-119 order
       Region 3w98 G 120-130 disorder
 Evidence X-RAY 3w98 C Reference
       Region 3w98 C 1-13 disorder
       Region 3w98 C 14-119 order
       Region 3w98 C 120-130 disorder
 Evidence X-RAY 3w96 G Reference
       Region 3w96 G 11-16 disorder
       Region 3w96 G 17-119 order
       Region 3w96 G 120-130 disorder
 Evidence X-RAY 3w96 C Reference
       Region 3w96 C 11-12 disorder
       Region 3w96 C 13-119 order
       Region 3w96 C 120-130 disorder
Seq 1-130 Hetero octamer : IID00058Complex,IID00239Complex,IID00272Complex,P06899
 Evidence X-RAY 3wtp G Reference
       Region 3wtp G 1-14 disorder
       Region 3wtp G 15-117 order
       Region 3wtp G 118-130 disorder
 Evidence X-RAY 3wtp C Reference
       Region 3wtp C 1-12 disorder
       Region 3wtp C 13-119 order
       Region 3wtp C 120-130 disorder
Seq 1-130 Hetero octamer : IID00019Complex,IID00058Complex,IID00062Complex,P06899
 Evidence X-RAY 5b31 C Reference
       Region 5b31 C 1-13 disorder
       Region 5b31 C 14-120 order
       Region 5b31 C 121-130 disorder
Seq 1-130 Hetero dimer : P06899
 Evidence NMR 2rvq C Reference
       Region 2rvq C 1-130 order
       Region 2rvq C 1-47 high_rmsd
       Region 2rvq C 99-130 high_rmsd
Seq 1-130 Hetero octamer : IID00058Complex,IID00088Complex,P06899
 Evidence X-RAY 5b40 G Reference
       Region 5b40 G 1-15 disorder
       Region 5b40 G 16-119 order
       Region 5b40 G 120-130 disorder
 Evidence X-RAY 5b40 C Reference
       Region 5b40 C 1-14 disorder
       Region 5b40 C 15-118 order
       Region 5b40 C 119-130 disorder
 Evidence X-RAY 5b0z G Reference
       Region 5b0z G 1-15 disorder
       Region 5b0z G 16-119 order
       Region 5b0z G 120-130 disorder
 Evidence X-RAY 5b0z C Reference
       Region 5b0z C 1-11 disorder
       Region 5b0z C 12-119 order
       Region 5b0z C 120-130 disorder
 Evidence X-RAY 5b0y G Reference
       Region 5b0y G 1-15 disorder
       Region 5b0y G 16-119 order
       Region 5b0y G 120-130 disorder
 Evidence X-RAY 5b0y C Reference
       Region 5b0y C 1-14 disorder
       Region 5b0y C 15-119 order
       Region 5b0y C 120-130 disorder
 Evidence X-RAY 3av1 G Reference
       Region 3av1 G 1-15 disorder
       Region 3av1 G 16-119 order
       Region 3av1 G 120-130 disorder
 Evidence X-RAY 3av1 C Reference
       Region 3av1 C 1-14 disorder
       Region 3av1 C 15-119 order
       Region 3av1 C 120-130 disorder
Seq 1-130 Hetero octamer : IID00058Complex,IID00239Complex,P06899
 Evidence X-RAY 5ay8 G Reference
       Region 5ay8 G 1-15 disorder
       Region 5ay8 G 16-119 order
       Region 5ay8 G 120-130 disorder
 Evidence X-RAY 5ay8 C Reference
       Region 5ay8 C 1-14 disorder
       Region 5ay8 C 15-119 order
       Region 5ay8 C 120-130 disorder
Seq 1-130 Hetero octamer : A0A1X8XL64,IID00058Complex,P06899
 Evidence X-RAY 5gxq G Reference
       Region 5gxq G 1-15 disorder
       Region 5gxq G 16-119 order
       Region 5gxq G 120-130 disorder
 Evidence X-RAY 5gxq C Reference
       Region 5gxq C 1-11 disorder
       Region 5gxq C 12-119 order
       Region 5gxq C 120-130 disorder
Seq 1-130 Hetero nonamer : IID00058Complex,IID00062Complex,P06899,Q9QR71
 Evidence X-RAY 5gtc G Reference
       Region 5gtc G 1-12 disorder
       Region 5gtc G 13-119 order
       Region 5gtc G 120-130 disorder
 Evidence X-RAY 5gtc C Reference
       Region 5gtc C 1-11 disorder
       Region 5gtc C 12-119 order
       Region 5gtc C 120-130 disorder
Seq 1-130 Hetero octamer : IID00058Complex,IID00062Complex,Q96A08
 Evidence X-RAY 3wkj G Reference
       Region 3wkj G 1-15 disorder
       Region 3wkj G 16-119 order
       Region 3wkj G 120-130 disorder
 Evidence X-RAY 3wkj C Reference
       Region 3wkj C 1-12 disorder
       Region 3wkj C 13-119 order
       Region 3wkj C 120-130 disorder
Seq 1-130 Hetero octamer : IID00058Complex,IID00086Complex,P06899
 Evidence X-RAY 3a6n G Reference
       Region 3a6n G 1-15 disorder
       Region 3a6n G 16-119 order
       Region 3a6n G 120-130 disorder
 Evidence X-RAY 3a6n C Reference
       Region 3a6n C 1-14 disorder
       Region 3a6n C 15-119 order
       Region 3a6n C 120-130 disorder
Seq 1-130 Hetero octamer : IID00058Complex,IID00272Complex,P06899
 Evidence X-RAY 3an2 G Reference
       Region 3an2 G 1-15 disorder
       Region 3an2 G 16-115 order
       Region 3an2 G 116-130 disorder
 Evidence X-RAY 3an2 C Reference
       Region 3an2 C 1-16 disorder
       Region 3an2 C 17-113 order
       Region 3an2 C 114-130 disorder
Seq 1-130 Hetero octamer : IID00058Complex,P06899,Q6NXT2
 Evidence X-RAY 4z5t G Reference
       Region 4z5t G 1-15 disorder
       Region 4z5t G 16-119 order
       Region 4z5t G 120-130 disorder
 Evidence X-RAY 4z5t C Reference
       Region 4z5t C 1-14 disorder
       Region 4z5t C 15-119 order
       Region 4z5t C 120-130 disorder
Seq 1-130 Hetero octamer : IID00019Complex,IID00058Complex,IID00239Complex,P06899
 Evidence X-RAY 5b32 C Reference
       Region 5b32 C 1-11 disorder
       Region 5b32 C 12-119 order
       Region 5b32 C 120-130 disorder
Seq 1-130 Hetero octamer : IID00058Complex,IID00239Complex,P06899
 Evidence X-RAY 3av2 G Reference
       Region 3av2 G 1-15 disorder
       Region 3av2 G 16-119 order
       Region 3av2 G 120-130 disorder
 Evidence X-RAY 3av2 C Reference
       Region 3av2 C 1-14 disorder
       Region 3av2 C 15-119 order
       Region 3av2 C 120-130 disorder
Seq 1-130 Hetero tetradecamer : IID00058Complex,IID00062Complex,P06899
 Evidence X-RAY 5gse M Reference
       Region 5gse M 1-12 disorder
       Region 5gse M 13-118 order
       Region 5gse M 119-130 disorder
 Evidence X-RAY 5gse G Reference
       Region 5gse G 1-9 disorder
       Region 5gse G 10-118 order
       Region 5gse G 119-130 disorder
 Evidence X-RAY 5gse C Reference
       Region 5gse C 1-16 disorder
       Region 5gse C 17-118 order
       Region 5gse C 119-130 disorder
Seq 2-130 Hetero octamer : IID00058Complex,IID00062Complex,P70696
 Evidence X-RAY 3x1v G Reference
       Region 3x1v G 2-11 disorder
       Region 3x1v G 12-120 order
       Region 3x1v G 121-130 disorder
 Evidence X-RAY 3x1v C Reference
       Region 3x1v C 2-13 disorder
       Region 3x1v C 14-119 order
       Region 3x1v C 120-130 disorder
Seq 2-130 Hetero octamer : IID00058Complex,IID00062Complex,P33778
 Evidence X-RAY 3x1s G Reference
       Region 3x1s G 2-15 disorder
       Region 3x1s G 16-119 order
       Region 3x1s G 120-130 disorder
 Evidence X-RAY 3x1s C Reference
       Region 3x1s C 2-14 disorder
       Region 3x1s C 15-119 order
       Region 3x1s C 120-130 disorder
Seqphosphorylation
    2-2 Phosphoserine; by RPS6KA5
    121-121 Phosphothreonine; by DCAF1
Seqacetylation
    6-6 N6-acetyllysine; alternate
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-22,119-130
Order 23-118
ProS 1-7,19-22
AlphaFold
Disorder 1-10,123-130
Order 11-122
Pfam Hmmer
PF00125 18-91 2.5e-32
SEG 2-23
Function
Function in SwissProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.