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IID00017
 UniprotP06400
ProteinRetinoblastoma-associated protein
GeneRB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
928
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 52-355 Monomer :
 Evidence X-RAY 2qdj A Reference
       Region 2qdj A 52-83 order
       Region 2qdj A 84-93 disorder
       Region 2qdj A 94-206 order
       Region 2qdj A 207-209 disorder
       Region 2qdj A 210-244 order
       Region 2qdj A 245-269 disorder
       Region 2qdj A 270-303 order
       Region 2qdj A 304-310 disorder
       Region 2qdj A 311-355 order
Seq 53-244,268-581,641-787 Monomer :
 Evidence X-RAY 4elj A Reference
       Region 4elj A 53-88 order
       Region 4elj A 89-93 disorder
       Region 4elj A 94-176 order
       Region 4elj A 177-184 disorder
       Region 4elj A 185-244 order
       Region 4elj A 268-269 disorder
       Region 4elj A 270-345 order
       Region 4elj A 346-370 disorder
       Region 4elj A 371-503 order
       Region 4elj A 504-507 disorder
       Region 4elj A 508-579 order
       Region 4elj A 580-581 disorder
       Region 4elj A 641-642 disorder
       Region 4elj A 643-771 order
       Region 4elj A 772-787 disorder
Seq 372-589,636-787 Hetero trimer : IID00064Complex
 Evidence X-RAY 1o9k A Reference
       Region 1o9k A 372-378 disorder
       Region 1o9k A 379-501 order
       Region 1o9k A 502-507 disorder
       Region 1o9k A 508-578 order
       Region 1o9k A 579-589 disorder
 Evidence X-RAY 1o9k C Reference
       Region 1o9k C 372-378 disorder
       Region 1o9k C 379-501 order
       Region 1o9k C 502-507 disorder
       Region 1o9k C 508-578 order
       Region 1o9k C 579-589 disorder
 Evidence X-RAY 1o9k E Reference
       Region 1o9k E 372-378 disorder
       Region 1o9k E 379-501 order
       Region 1o9k E 502-507 disorder
       Region 1o9k E 508-578 order
       Region 1o9k E 579-589 disorder
 Evidence X-RAY 1o9k G Reference
       Region 1o9k G 372-378 disorder
       Region 1o9k G 379-501 order
       Region 1o9k G 502-507 disorder
       Region 1o9k G 508-578 order
       Region 1o9k G 579-589 disorder
 Evidence X-RAY 1o9k B Reference
       Region 1o9k B 636-643 disorder
       Region 1o9k B 644-787 order
 Evidence X-RAY 1o9k D Reference
       Region 1o9k D 636-643 disorder
       Region 1o9k D 644-787 order
 Evidence X-RAY 1o9k F Reference
       Region 1o9k F 636-643 disorder
       Region 1o9k F 644-787 order
 Evidence X-RAY 1o9k H Reference
       Region 1o9k H 636-643 disorder
       Region 1o9k H 644-787 order
Seq 372-589,636-787 Hetero trimer :
 Evidence X-RAY 1gux B Reference
       Region 1gux B 636-644 disorder
       Region 1gux B 645-785 order
       Region 1gux B 786-787 disorder
 Evidence X-RAY 1gux A Reference
       Region 1gux A 372-379 disorder
       Region 1gux A 380-464 order
       Region 1gux A 465-471 disorder
       Region 1gux A 472-499 order
       Region 1gux A 500-513 disorder
       Region 1gux A 514-577 order
       Region 1gux A 578-589 disorder
Seq 378-562 Monomer :
 Evidence X-RAY 1ad6 A Reference
       Region 1ad6 A 378-562 order
Seq 379-577,645-772 Hetero trimer : IID90002Complex
 Evidence X-RAY 1gh6 B Reference
       Region 1gh6 B 379-502 order
       Region 1gh6 B 503-509 disorder
       Region 1gh6 B 510-577 order
       Region 1gh6 B 645-772 order
Seq 380-577,643-783 Hetero dimer :
 Evidence X-RAY 3pom B Reference
       Region 3pom B 380-381 disorder
       Region 3pom B 382-501 order
       Region 3pom B 502-509 disorder
       Region 3pom B 510-577 order
       Region 3pom B 643-643 disorder
       Region 3pom B 644-783 order
Seq 380-577,643-783 Hetero dimer :
 Evidence X-RAY 3pom A Reference
       Region 3pom A 380-382 disorder
       Region 3pom A 383-577 order
       Region 3pom A 643-783 order
Seq 380-581,643-785 Hetero dimer : IID00171Complex
 Evidence X-RAY 1n4m A Reference
       Region 1n4m A 380-581 order
       Region 1n4m A 643-785 order
Seq 380-581,643-785 Hetero trimer : IID00171Complex
 Evidence X-RAY 1n4m B Reference
       Region 1n4m B 380-502 order
       Region 1n4m B 503-509 disorder
       Region 1n4m B 510-581 order
       Region 1n4m B 643-785 order
Seq 380-581,643-787 Hetero pentamer : IID90003Complex
 Evidence X-RAY 2r7g C Reference
       Region 2r7g C 380-502 order
       Region 2r7g C 503-508 disorder
       Region 2r7g C 509-579 order
       Region 2r7g C 580-581 disorder
       Region 2r7g C 643-785 order
       Region 2r7g C 786-787 disorder
 Evidence X-RAY 2r7g A Reference
       Region 2r7g A 380-502 order
       Region 2r7g A 503-508 disorder
       Region 2r7g A 509-578 order
       Region 2r7g A 579-581 disorder
       Region 2r7g A 643-785 order
       Region 2r7g A 786-787 disorder
Seq 380-787 Monomer :
 Evidence X-RAY 4ell A Reference
       Region 4ell A 380-382 disorder
       Region 4ell A 383-437 order
       Region 4ell A 438-439 disorder
       Region 4ell A 440-499 order
       Region 4ell A 500-511 disorder
       Region 4ell A 512-576 order
       Region 4ell A 577-599 disorder
       Region 4ell A 600-610 order
       Region 4ell A 611-643 disorder
       Region 4ell A 644-783 order
       Region 4ell A 784-787 disorder
 Evidence X-RAY 4ell B Reference
       Region 4ell B 380-383 disorder
       Region 4ell B 384-499 order
       Region 4ell B 500-510 disorder
       Region 4ell B 511-589 order
       Region 4ell B 590-599 disorder
       Region 4ell B 600-609 order
       Region 4ell B 610-642 disorder
       Region 4ell B 643-786 order
       Region 4ell B 787-787 disorder
Seqdisorder 786-874
 Evidence NMR NMR data indicate that the isolated RbC is unstructured in solution (Supplemental Data, Section 2). Reference
       Region 786-874 disorder
Seq 802-817 Hetero tetramer : IID00123Complex
 Evidence X-RAY 4cri D Reference
       Region 4cri D 802-804 disorder
       Region 4cri D 805-810 order
       Region 4cri D 811-817 disorder
 Evidence X-RAY 4cri C Reference
       Region 4cri C 802-803 disorder
       Region 4cri C 804-810 order
       Region 4cri C 811-817 disorder
Seq 829-874 Hetero trimer : IID00064Complex,IID00076Complex
 Evidence X-RAY 2aze C Reference
       Region 2aze C 829-872 order
       Region 2aze C 873-874 disorder
Seq 858-877 Hetero dimer : IID50009Complex
 Evidence X-RAY 1pjm A Reference
       Region 1pjm A 858-877 order
Seq 868-878 Hetero trimer : IID00032Complex
 Evidence X-RAY 1h25 E Reference
       Region 1h25 E 868-868 disorder
       Region 1h25 E 869-878 order
Seq 870-882 Hetero trimer : IID00311Complex
 Evidence X-RAY 3n5u C Reference
       Region 3n5u C 870-872 disorder
       Region 3n5u C 873-879 order
       Region 3n5u C 880-882 disorder
SeqProS verified 804-810 Hetero tetramer : IID00123Complex
       Region 4cri C 804-810 order
       Region 4cri D 805-810 order
       Region 786-874 disorder
SeqProS verified 829-872 Hetero trimer : IID00064Complex,IID00076Complex
       Region 2aze C 829-872 order
       Region 786-874 disorder
SeqProS verified 858-874 NLS Hetero dimer : IID50009Complex
       Region 1pjm A 858-877 order
       Region 786-874 disorder
SeqProS verified 869-874 Hetero trimer : IID00032Complex
       Region 1h25 E 869-878 order
       Region 786-874 disorder
SeqProS predicted 873-879 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero trimer : IID00311Complex
       Region 3n5u C 873-879 order
Seqphosphorylation
    855-855 Phosphoserine
    841-841 Phosphothreonine
    823-823 Phosphothreonine
    826-826 Phosphothreonine; by CDK4
    821-821 Phosphothreonine; by CDK6
    811-811 Phosphoserine; by CDK1 and CDK3
    795-795 Phosphoserine
    807-807 Phosphoserine; by CDK1 and CDK3
    788-788 Phosphoserine
    780-780 Phosphoserine
    624-624 Phosphoserine
    608-608 Phosphoserine
    612-612 Phosphoserine; by CHEK2 and CHEK1
    567-567 Phosphoserine; by CDK2
    373-373 Phosphothreonine; by CDK1
    356-356 Phosphothreonine
    252-252 Phosphothreonine; by CDK1
    249-249 Phosphoserine; by CDK1
    37-37 Phosphoserine
Seqacetylation
    874-874 N6-acetyllysine; by PCAF
    873-873 N6-acetyllysine; by PCAF
 
Prediction
NeProc
Disorder 1-50,348-381,579-644,773-829,854-928
Order 51-178,183-347,382-501,508-578,645-772,830-853
ProS 348-369,374-381,584-623,640-644,795-810,854-860,873-880,895-918
AlphaFold
Disorder 1-52,84-93,176-184,246-264,304-312,346-372,500-510,580-598,609-642,784-902,904-905,908-908,911-912,915-928
Order 53-83,94-175,185-245,265-303,313-345,373-499,511-579,599-608,643-783,903-903,906-907,909-910,913-914
Pfam Hmmer
PF01858 373-573 6.8e-124
PF01857 645-766 1.4e-76
SEG 2-31
Function
Function in SwissProt
(Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
Biological Process
Diagram with PDB data
RB1/E2F1/TFDP1Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
RB1/CCNA1/CDK2CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein
RB1/PPP1CACrystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1
See also
Diagram with PDB data
LT_SV40/RB1RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN
E7/RB1RB POCKET BOUND TO E7 LXCXE MOTIF
E1A_ADE05/RB1Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain
E2F1/RB1Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide
E2F2/RB1Structure of Rb tumor suppressor bound to the transactivation domain of E2F-2