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IID00018
 UniprotP09012
ProteinU1 small nuclear ribonucleoprotein A
GeneSNRPA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
282
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-102 Hetero trimer :
 Evidence X-RAY 5fj4 F Reference
       Region 5fj4 F 1-5 disorder
       Region 5fj4 F 6-102 order
 Evidence X-RAY 5fj4 E Reference
       Region 5fj4 E 1-5 disorder
       Region 5fj4 E 6-102 order
 Evidence X-RAY 5fj4 B Reference
       Region 5fj4 B 1-5 disorder
       Region 5fj4 B 6-102 order
 Evidence X-RAY 5fj4 A Reference
       Region 5fj4 A 1-5 disorder
       Region 5fj4 A 6-102 order
 Evidence X-RAY 4c4w F Reference
       Region 4c4w F 1-6 disorder
       Region 4c4w F 7-102 order
 Evidence X-RAY 4c4w E Reference
       Region 4c4w E 1-5 disorder
       Region 4c4w E 6-102 order
 Evidence X-RAY 4c4w B Reference
       Region 4c4w B 1-6 disorder
       Region 4c4w B 7-101 order
       Region 4c4w B 102-102 disorder
 Evidence X-RAY 4c4w A Reference
       Region 4c4w A 1-5 disorder
       Region 4c4w A 6-101 order
       Region 4c4w A 102-102 disorder
Seq 1-117 Monomer :
 Evidence NMR 1fht A Reference
       Region 1fht A 2-117 order
       Region 1fht A 2-5 high_rmsd
       Region 1fht A 100-117 high_rmsd
 Evidence X-RAY 3egz A Reference
       Region 3egz A 1-5 disorder
       Region 3egz A 6-96 order
       Region 3egz A 97-98 disorder
 Evidence NMR 1aud A Reference
       Region 1aud A 2-102 order
       Region 1aud A 2-5 high_rmsd
       Region 1aud A 102-102 high_rmsd
 Evidence X-RAY 1zzn A Reference
       Region 1zzn A 1-3 disorder
       Region 1zzn A 4-98 order
 Evidence X-RAY 4yb1 P Reference
       Region 4yb1 P 7-97 order
 Evidence X-RAY 4w92 B Reference
       Region 4w92 B 6-87 order
       Region 4w92 B 88-88 disorder
       Region 4w92 B 89-96 order
 Evidence X-RAY 4w90 B Reference
       Region 4w90 B 6-6 disorder
       Region 4w90 B 7-96 order
 Evidence X-RAY 1vc6 A Reference
       Region 1vc6 A 1-3 disorder
       Region 1vc6 A 4-98 order
       Region 1vc6 A 99-100 disorder
 Evidence X-RAY 1vc5 A Reference
       Region 1vc5 A 1-3 disorder
       Region 1vc5 A 4-98 order
       Region 1vc5 A 99-100 disorder
 Evidence X-RAY 1vc0 A Reference
       Region 1vc0 A 1-3 disorder
       Region 1vc0 A 4-98 order
       Region 1vc0 A 99-100 disorder
 Evidence X-RAY 1vbz A Reference
       Region 1vbz A 1-3 disorder
       Region 1vbz A 4-98 order
       Region 1vbz A 99-100 disorder
 Evidence X-RAY 1vby A Reference
       Region 1vby A 1-3 disorder
       Region 1vby A 4-98 order
       Region 1vby A 99-100 disorder
 Evidence X-RAY 1vbx A Reference
       Region 1vbx A 1-3 disorder
       Region 1vbx A 4-98 order
       Region 1vbx A 99-100 disorder
 Evidence X-RAY 1urn C Reference
       Region 1urn C 2-97 order
       Region 1urn C 98-98 disorder
 Evidence X-RAY 1urn B Reference
       Region 1urn B 2-97 order
       Region 1urn B 98-98 disorder
 Evidence X-RAY 1urn A Reference
       Region 1urn A 2-97 order
       Region 1urn A 98-98 disorder
 Evidence X-RAY 3ud4 P Reference
       Region 3ud4 P 1-6 disorder
       Region 3ud4 P 7-93 order
       Region 3ud4 P 94-98 disorder
 Evidence X-RAY 3ud3 P Reference
       Region 3ud3 P 1-6 disorder
       Region 3ud3 P 7-93 order
       Region 3ud3 P 94-98 disorder
 Evidence X-RAY 3ucz P Reference
       Region 3ucz P 1-6 disorder
       Region 3ucz P 7-97 order
       Region 3ucz P 98-98 disorder
 Evidence X-RAY 3ucu P Reference
       Region 3ucu P 1-6 disorder
       Region 3ucu P 7-93 order
       Region 3ucu P 94-98 disorder
 Evidence X-RAY 1u6b A Reference
       Region 1u6b A 1-3 disorder
       Region 1u6b A 4-98 order
 Evidence X-RAY 1sjf A Reference
       Region 1sjf A 1-3 disorder
       Region 1sjf A 4-98 order
       Region 1sjf A 99-100 disorder
 Evidence X-RAY 1sj4 P Reference
       Region 1sj4 P 1-3 disorder
       Region 1sj4 P 4-98 order
       Region 1sj4 P 99-100 disorder
 Evidence X-RAY 1sj3 P Reference
       Region 1sj3 P 1-3 disorder
       Region 1sj3 P 4-98 order
       Region 1sj3 P 99-100 disorder
 Evidence X-RAY 3r1l D Reference
       Region 3r1l D 1-5 disorder
       Region 3r1l D 6-98 order
 Evidence X-RAY 3r1l A Reference
       Region 3r1l A 1-6 disorder
       Region 3r1l A 7-98 order
 Evidence X-RAY 3r1h D Reference
       Region 3r1h D 1-5 disorder
       Region 3r1h D 6-98 order
 Evidence X-RAY 3r1h A Reference
       Region 3r1h A 1-6 disorder
       Region 3r1h A 7-98 order
 Evidence X-RAY 4prf A Reference
       Region 4prf A 1-3 disorder
       Region 4prf A 4-98 order
       Region 4prf A 99-100 disorder
 Evidence X-RAY 4pr6 A Reference
       Region 4pr6 A 4-96 order
 Evidence X-RAY 3p49 B Reference
       Region 3p49 B 1-5 disorder
       Region 3p49 B 6-97 order
       Region 3p49 B 98-98 disorder
 Evidence X-RAY 2oj3 A Reference
       Region 2oj3 A 2-3 disorder
       Region 2oj3 A 4-98 order
       Region 2oj3 A 99-100 disorder
 Evidence X-RAY 2oih A Reference
       Region 2oih A 2-3 disorder
       Region 2oih A 4-98 order
       Region 2oih A 99-100 disorder
 Evidence X-RAY 1oia B Reference
       Region 1oia B 1-5 disorder
       Region 1oia B 6-91 order
       Region 1oia B 92-95 disorder
 Evidence X-RAY 1oia A Reference
       Region 1oia A 1-2 disorder
       Region 1oia A 3-92 order
       Region 1oia A 93-95 disorder
 Evidence X-RAY 2nz4 D Reference
       Region 2nz4 D 5-6 disorder
       Region 2nz4 D 7-96 order
       Region 2nz4 D 97-98 disorder
 Evidence X-RAY 2nz4 C Reference
       Region 2nz4 C 5-7 disorder
       Region 2nz4 C 8-97 order
       Region 2nz4 C 98-98 disorder
 Evidence X-RAY 2nz4 B Reference
       Region 2nz4 B 5-98 order
 Evidence X-RAY 2nz4 A Reference
       Region 2nz4 A 5-6 disorder
       Region 2nz4 A 7-96 order
       Region 2nz4 A 97-98 disorder
 Evidence X-RAY 1nu4 B Reference
       Region 1nu4 B 2-5 disorder
       Region 1nu4 B 6-98 order
 Evidence X-RAY 1nu4 A Reference
       Region 1nu4 A 2-6 disorder
       Region 1nu4 A 7-97 order
       Region 1nu4 A 98-98 disorder
 Evidence X-RAY 3mxh P Reference
       Region 3mxh P 1-6 disorder
       Region 3mxh P 7-93 order
       Region 3mxh P 94-98 disorder
 Evidence X-RAY 3muv P Reference
       Region 3muv P 1-6 disorder
       Region 3muv P 7-96 order
       Region 3muv P 97-98 disorder
 Evidence X-RAY 3mut P Reference
       Region 3mut P 1-6 disorder
       Region 3mut P 7-96 order
       Region 3mut P 97-98 disorder
 Evidence X-RAY 3mur P Reference
       Region 3mur P 1-6 disorder
       Region 3mur P 7-96 order
       Region 3mur P 97-98 disorder
 Evidence X-RAY 3mum P Reference
       Region 3mum P 1-6 disorder
       Region 3mum P 7-93 order
       Region 3mum P 94-98 disorder
 Evidence X-RAY 1m5v F Reference
       Region 1m5v F 1-3 disorder
       Region 1m5v F 4-97 order
       Region 1m5v F 98-100 disorder
 Evidence X-RAY 1m5v C Reference
       Region 1m5v C 1-3 disorder
       Region 1m5v C 4-97 order
       Region 1m5v C 98-100 disorder
 Evidence X-RAY 1m5p F Reference
       Region 1m5p F 1-5 disorder
       Region 1m5p F 6-97 order
       Region 1m5p F 98-100 disorder
 Evidence X-RAY 1m5p C Reference
       Region 1m5p C 1-5 disorder
       Region 1m5p C 6-97 order
       Region 1m5p C 98-100 disorder
 Evidence X-RAY 1m5o F Reference
       Region 1m5o F 1-3 disorder
       Region 1m5o F 4-98 order
       Region 1m5o F 99-100 disorder
 Evidence X-RAY 1m5o C Reference
       Region 1m5o C 1-5 disorder
       Region 1m5o C 6-97 order
       Region 1m5o C 98-100 disorder
 Evidence X-RAY 1m5k C Reference
       Region 1m5k C 1-5 disorder
       Region 1m5k C 6-97 order
       Region 1m5k C 98-100 disorder
 Evidence X-RAY 1m5k F Reference
       Region 1m5k F 1-5 disorder
       Region 1m5k F 6-97 order
       Region 1m5k F 98-100 disorder
 Evidence X-RAY 3l3c D Reference
       Region 3l3c D 7-96 order
 Evidence X-RAY 3l3c C Reference
       Region 3l3c C 7-96 order
 Evidence X-RAY 3l3c B Reference
       Region 3l3c B 7-96 order
 Evidence X-RAY 3l3c A Reference
       Region 3l3c A 7-96 order
 Evidence X-RAY 3iwn D Reference
       Region 3iwn D 6-96 order
 Evidence X-RAY 3iwn C Reference
       Region 3iwn C 6-96 order
 Evidence X-RAY 3irw P Reference
       Region 3irw P 1-6 disorder
       Region 3irw P 7-96 order
       Region 3irw P 97-98 disorder
 Evidence X-RAY 3iin A Reference
       Region 3iin A 4-98 order
 Evidence X-RAY 3g9c D Reference
       Region 3g9c D 1-6 disorder
       Region 3g9c D 7-96 order
       Region 3g9c D 97-98 disorder
 Evidence X-RAY 3g9c C Reference
       Region 3g9c C 1-6 disorder
       Region 3g9c C 7-96 order
       Region 3g9c C 97-98 disorder
 Evidence X-RAY 3g9c B Reference
       Region 3g9c B 1-6 disorder
       Region 3g9c B 7-96 order
       Region 3g9c B 97-98 disorder
 Evidence X-RAY 3g9c A Reference
       Region 3g9c A 1-6 disorder
       Region 3g9c A 7-96 order
       Region 3g9c A 97-98 disorder
 Evidence X-RAY 3g96 D Reference
       Region 3g96 D 1-6 disorder
       Region 3g96 D 7-96 order
       Region 3g96 D 97-98 disorder
 Evidence X-RAY 3g96 C Reference
       Region 3g96 C 1-6 disorder
       Region 3g96 C 7-96 order
       Region 3g96 C 97-98 disorder
 Evidence X-RAY 3g96 B Reference
       Region 3g96 B 1-6 disorder
       Region 3g96 B 7-96 order
       Region 3g96 B 97-98 disorder
 Evidence X-RAY 3g96 A Reference
       Region 3g96 A 1-6 disorder
       Region 3g96 A 7-96 order
       Region 3g96 A 97-98 disorder
 Evidence X-RAY 3g8t D Reference
       Region 3g8t D 1-6 disorder
       Region 3g8t D 7-94 order
       Region 3g8t D 95-98 disorder
 Evidence X-RAY 3g8t C Reference
       Region 3g8t C 1-6 disorder
       Region 3g8t C 7-96 order
       Region 3g8t C 97-98 disorder
 Evidence X-RAY 3g8t B Reference
       Region 3g8t B 1-6 disorder
       Region 3g8t B 7-96 order
       Region 3g8t B 97-98 disorder
 Evidence X-RAY 3g8t A Reference
       Region 3g8t A 1-6 disorder
       Region 3g8t A 7-96 order
       Region 3g8t A 97-98 disorder
 Evidence X-RAY 3g8s D Reference
       Region 3g8s D 1-6 disorder
       Region 3g8s D 7-96 order
       Region 3g8s D 97-98 disorder
 Evidence X-RAY 3g8s C Reference
       Region 3g8s C 1-6 disorder
       Region 3g8s C 7-96 order
       Region 3g8s C 97-98 disorder
 Evidence X-RAY 3g8s B Reference
       Region 3g8s B 1-4 disorder
       Region 3g8s B 5-98 order
 Evidence X-RAY 3g8s A Reference
       Region 3g8s A 1-6 disorder
       Region 3g8s A 7-96 order
       Region 3g8s A 97-98 disorder
 Evidence X-RAY 1drz A Reference
       Region 1drz A 2-3 disorder
       Region 1drz A 4-98 order
 Evidence X-RAY 5ddr C Reference
       Region 5ddr C 2-2 disorder
       Region 5ddr C 3-96 order
       Region 5ddr C 97-98 disorder
 Evidence X-RAY 5ddr D Reference
       Region 5ddr D 2-4 disorder
       Region 5ddr D 5-98 order
 Evidence X-RAY 5ddq C Reference
       Region 5ddq C 2-3 disorder
       Region 5ddq C 4-97 order
       Region 5ddq C 98-98 disorder
 Evidence X-RAY 5ddq D Reference
       Region 5ddq D 2-2 disorder
       Region 5ddq D 3-95 order
       Region 5ddq D 96-98 disorder
 Evidence X-RAY 5ddo C Reference
       Region 5ddo C 2-5 disorder
       Region 5ddo C 6-92 order
       Region 5ddo C 93-98 disorder
 Evidence X-RAY 5ddo G Reference
       Region 5ddo G 2-6 disorder
       Region 5ddo G 7-92 order
       Region 5ddo G 93-98 disorder
 Evidence X-RAY 3cun B Reference
       Region 3cun B 1-5 disorder
       Region 3cun B 6-96 order
       Region 3cun B 97-98 disorder
 Evidence X-RAY 3cun A Reference
       Region 3cun A 1-6 disorder
       Region 3cun A 7-97 order
       Region 3cun A 98-98 disorder
 Evidence X-RAY 3cul B Reference
       Region 3cul B 1-5 disorder
       Region 3cul B 6-96 order
 Evidence X-RAY 3cul A Reference
       Region 3cul A 1-5 disorder
       Region 3cul A 6-96 order
 Evidence X-RAY 3bo4 A Reference
       Region 3bo4 A 4-98 order
 Evidence X-RAY 3bo3 A Reference
       Region 3bo3 A 4-98 order
 Evidence X-RAY 3bo2 A Reference
       Region 3bo2 A 4-98 order
Seq 1-282 Hetero nonamer :
 Evidence X-RAY 3pgw P Reference
       Region 3pgw P 1-1 disorder
       Region 3pgw P 2-114 order
       Region 3pgw P 115-282 disorder
 Evidence X-RAY 3pgw A Reference
       Region 3pgw A 1-4 disorder
       Region 3pgw A 5-112 order
       Region 3pgw A 113-282 disorder
Seq 2-98 Homo dimer :
 Evidence X-RAY 5ddp D Reference
       Region 5ddp D 2-2 disorder
       Region 5ddp D 3-96 order
       Region 5ddp D 97-98 disorder
 Evidence X-RAY 5ddp C Reference
       Region 5ddp C 2-3 disorder
       Region 5ddp C 4-96 order
       Region 5ddp C 97-98 disorder
Seq 2-102 Homo dimer :
 Evidence X-RAY 3k0j D Reference
       Region 3k0j D 2-5 disorder
       Region 3k0j D 6-48 order
       Region 3k0j D 49-50 disorder
       Region 3k0j D 51-89 order
       Region 3k0j D 90-97 disorder
 Evidence X-RAY 3k0j B Reference
       Region 3k0j B 2-5 disorder
       Region 3k0j B 6-97 order
 Evidence X-RAY 3k0j C Reference
       Region 3k0j C 2-3 disorder
       Region 3k0j C 4-89 order
       Region 3k0j C 90-97 disorder
 Evidence X-RAY 3k0j A Reference
       Region 3k0j A 2-5 disorder
       Region 3k0j A 6-97 order
 Evidence X-RAY 3hhn D Reference
       Region 3hhn D 2-5 disorder
       Region 3hhn D 6-98 order
 Evidence X-RAY 3hhn B Reference
       Region 3hhn B 2-6 disorder
       Region 3hhn B 7-98 order
 Evidence NMR 1dz5 B Reference
       Region 1dz5 B 2-102 order
       Region 1dz5 B 2-5 high_rmsd
       Region 1dz5 B 20-22 high_rmsd
 Evidence NMR 1dz5 A Reference
       Region 1dz5 A 2-102 order
       Region 1dz5 A 2-6 high_rmsd
Seq 195-282 Monomer :
 Evidence NMR 2u1a A Reference
       Region 2u1a A 195-282 order
       Region 2u1a A 195-206 high_rmsd
       Region 2u1a A 272-272 high_rmsd
       Region 2u1a A 281-282 high_rmsd
Seqphosphorylation
    131-131 Phosphothreonine
Seqacetylation
    2-2 N-acetylalanine
    60-60 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-5,104-199
Order 6-103,200-282
ProS 104-107,134-154,160-199
AlphaFold
Disorder 1-5,105-161,167-172,174-203
Order 6-104,162-166,173-173,204-282
Pfam Hmmer
PF00076 12-84 3.5e-12
PF00076 210-277 5.8e-15
SEG 103-114 ,125-148 ,157-201
Function
Function in SwissProt
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.