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IID00020
 UniprotP10275
ProteinAndrogen receptor
GeneAR
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
920
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 20-31,642-920 Hetero dimer :
 Evidence X-RAY 1xow B Reference
       Region 1xow B 20-20 disorder
       Region 1xow B 21-30 order
 Evidence X-RAY 3v4a B Reference
       Region 3v4a B 21-31 order
 Evidence X-RAY 3v49 B Reference
       Region 3v49 B 21-31 order
 Evidence X-RAY 2q7k B Reference
       Region 2q7k B 20-20 disorder
       Region 2q7k B 21-30 order
 Evidence X-RAY 2q7i B Reference
       Region 2q7i B 20-20 disorder
       Region 2q7i B 21-30 order
 Evidence X-RAY 5cj6 B Reference
       Region 5cj6 B 21-30 order
 Evidence X-RAY 1xow A Reference
       Region 1xow A 672-844 order
       Region 1xow A 845-850 disorder
       Region 1xow A 851-920 order
 Evidence X-RAY 3v4a A Reference
       Region 3v4a A 672-845 order
       Region 3v4a A 846-850 disorder
       Region 3v4a A 851-920 order
 Evidence X-RAY 3v49 A Reference
       Region 3v49 A 655-671 disorder
       Region 3v49 A 672-845 order
       Region 3v49 A 846-850 disorder
       Region 3v49 A 851-920 order
 Evidence X-RAY 2q7k A Reference
       Region 2q7k A 664-671 disorder
       Region 2q7k A 672-844 order
       Region 2q7k A 845-851 disorder
       Region 2q7k A 852-920 order
 Evidence X-RAY 2q7i A Reference
       Region 2q7i A 664-671 disorder
       Region 2q7i A 672-843 order
       Region 2q7i A 844-851 disorder
       Region 2q7i A 852-920 order
 Evidence X-RAY 5cj6 A Reference
       Region 5cj6 A 642-671 disorder
       Region 5cj6 A 672-845 order
       Region 5cj6 A 846-849 disorder
       Region 5cj6 A 850-919 order
       Region 5cj6 A 920-920 disorder
Seqdisorder 142-485
 Evidence CD¸fluorescence spectroscopy¸sensitivity to protease digestion Reference
       Region 142-485 disorder
Seq 622-636 Hetero dimer : IID50009Complex
 Evidence X-RAY 3btr B Reference
       Region 3btr B 622-636 order
Seq 655-920 Monomer :
 Evidence X-RAY 1e3g A Reference
       Region 1e3g A 658-669 disorder
       Region 1e3g A 670-919 order
       Region 1e3g A 920-920 disorder
 Evidence X-RAY 3b68 A Reference
       Region 3b68 A 672-918 order
       Region 3b68 A 919-920 disorder
 Evidence X-RAY 3b67 A Reference
       Region 3b67 A 672-918 order
       Region 3b67 A 919-920 disorder
 Evidence X-RAY 3b66 A Reference
       Region 3b66 A 672-918 order
       Region 3b66 A 919-920 disorder
 Evidence X-RAY 3b65 A Reference
       Region 3b65 A 672-918 order
       Region 3b65 A 919-920 disorder
 Evidence X-RAY 3b5r A Reference
       Region 3b5r A 672-918 order
       Region 3b5r A 919-920 disorder
 Evidence X-RAY 3zqt A Reference
       Region 3zqt A 665-670 disorder
       Region 3zqt A 671-920 order
 Evidence X-RAY 1z95 A Reference
       Region 1z95 A 673-844 order
       Region 1z95 A 845-852 disorder
       Region 1z95 A 853-918 order
 Evidence X-RAY 2ylq A Reference
       Region 2ylq A 665-671 disorder
       Region 2ylq A 672-920 order
 Evidence X-RAY 2ylp A Reference
       Region 2ylp A 665-671 disorder
       Region 2ylp A 672-920 order
 Evidence X-RAY 2ylo A Reference
       Region 2ylo A 665-670 disorder
       Region 2ylo A 671-920 order
 Evidence X-RAY 2yhd A Reference
       Region 2yhd A 672-920 order
 Evidence X-RAY 1xq3 A Reference
       Region 1xq3 A 672-844 order
       Region 1xq3 A 845-850 disorder
       Region 1xq3 A 851-920 order
 Evidence X-RAY 5vo4 A Reference
       Region 5vo4 A 671-844 order
       Region 5vo4 A 845-849 disorder
       Region 5vo4 A 850-920 order
 Evidence X-RAY 5v8q A Reference
       Region 5v8q A 672-920 order
 Evidence X-RAY 5t8j A Reference
       Region 5t8j A 672-920 order
 Evidence X-RAY 5t8e A Reference
       Region 5t8e A 672-920 order
 Evidence X-RAY 3rll A Reference
       Region 3rll A 672-672 disorder
       Region 3rll A 673-844 order
       Region 3rll A 845-852 disorder
       Region 3rll A 853-918 order
 Evidence X-RAY 3rlj A Reference
       Region 3rlj A 672-918 order
 Evidence X-RAY 4ql8 A Reference
       Region 4ql8 A 663-671 disorder
       Region 4ql8 A 672-845 order
       Region 4ql8 A 846-852 disorder
       Region 4ql8 A 853-918 order
       Region 4ql8 A 919-920 disorder
 Evidence X-RAY 2pnu A Reference
       Region 2pnu A 655-670 disorder
       Region 2pnu A 671-845 order
       Region 2pnu A 846-850 disorder
       Region 2pnu A 851-920 order
 Evidence X-RAY 2pix A Reference
       Region 2pix A 670-671 disorder
       Region 2pix A 672-919 order
       Region 2pix A 920-920 disorder
 Evidence X-RAY 2piw A Reference
       Region 2piw A 670-671 disorder
       Region 2piw A 672-919 order
       Region 2piw A 920-920 disorder
 Evidence X-RAY 2piv A Reference
       Region 2piv A 670-670 disorder
       Region 2piv A 671-919 order
       Region 2piv A 920-920 disorder
 Evidence X-RAY 2piu A Reference
       Region 2piu A 670-671 disorder
       Region 2piu A 672-919 order
       Region 2piu A 920-920 disorder
 Evidence X-RAY 2pit A Reference
       Region 2pit A 670-919 order
       Region 2pit A 920-920 disorder
 Evidence X-RAY 2pir A Reference
       Region 2pir A 670-919 order
       Region 2pir A 920-920 disorder
 Evidence X-RAY 2piq A Reference
       Region 2piq A 670-670 disorder
       Region 2piq A 671-919 order
       Region 2piq A 920-920 disorder
 Evidence X-RAY 2pip L Reference
       Region 2pip L 670-670 disorder
       Region 2pip L 671-919 order
       Region 2pip L 920-920 disorder
 Evidence X-RAY 2pio A Reference
       Region 2pio A 670-671 disorder
       Region 2pio A 672-919 order
       Region 2pio A 920-920 disorder
 Evidence X-RAY 2oz7 A Reference
       Region 2oz7 A 672-920 order
 Evidence X-RAY 4ojb A Reference
       Region 4ojb A 671-671 disorder
       Region 4ojb A 672-844 order
       Region 4ojb A 845-852 disorder
       Region 4ojb A 853-919 order
       Region 4ojb A 920-920 disorder
 Evidence X-RAY 4ogh A Reference
       Region 4ogh A 671-671 disorder
       Region 4ogh A 672-844 order
       Region 4ogh A 845-851 disorder
       Region 4ogh A 852-920 order
 Evidence X-RAY 4oea A Reference
       Region 4oea A 671-844 order
       Region 4oea A 845-851 disorder
       Region 4oea A 852-919 order
       Region 4oea A 920-920 disorder
 Evidence X-RAY 4k7a A Reference
       Region 4k7a A 671-844 order
       Region 4k7a A 845-851 disorder
       Region 4k7a A 852-919 order
 Evidence X-RAY 2hvc A Reference
       Region 2hvc A 670-919 order
 Evidence X-RAY 4hlw A Reference
       Region 4hlw A 665-670 disorder
       Region 4hlw A 671-844 order
       Region 4hlw A 845-850 disorder
       Region 4hlw A 851-920 order
 Evidence X-RAY 1gs4 A Reference
       Region 1gs4 A 671-847 order
       Region 1gs4 A 848-851 disorder
       Region 1gs4 A 852-918 order
 Evidence X-RAY 2axa A Reference
       Region 2axa A 665-672 disorder
       Region 2axa A 673-844 order
       Region 2axa A 845-852 disorder
       Region 2axa A 853-918 order
       Region 2axa A 919-920 disorder
 Evidence X-RAY 2ax9 A Reference
       Region 2ax9 A 665-672 disorder
       Region 2ax9 A 673-844 order
       Region 2ax9 A 845-852 disorder
       Region 2ax9 A 853-918 order
       Region 2ax9 A 919-920 disorder
 Evidence X-RAY 2ax8 A Reference
       Region 2ax8 A 665-672 disorder
       Region 2ax8 A 673-844 order
       Region 2ax8 A 845-852 disorder
       Region 2ax8 A 853-918 order
       Region 2ax8 A 919-920 disorder
 Evidence X-RAY 2ax7 A Reference
       Region 2ax7 A 665-672 disorder
       Region 2ax7 A 673-844 order
       Region 2ax7 A 845-852 disorder
       Region 2ax7 A 853-918 order
       Region 2ax7 A 919-920 disorder
 Evidence X-RAY 2ax6 A Reference
       Region 2ax6 A 665-671 disorder
       Region 2ax6 A 672-844 order
       Region 2ax6 A 845-849 disorder
       Region 2ax6 A 850-918 order
       Region 2ax6 A 919-920 disorder
 Evidence X-RAY 2amb A Reference
       Region 2amb A 655-671 disorder
       Region 2amb A 672-847 order
       Region 2amb A 848-850 disorder
       Region 2amb A 851-920 order
 Evidence X-RAY 2ama A Reference
       Region 2ama A 655-671 disorder
       Region 2ama A 672-844 order
       Region 2ama A 845-850 disorder
       Region 2ama A 851-920 order
 Evidence X-RAY 2am9 A Reference
       Region 2am9 A 655-670 disorder
       Region 2am9 A 671-920 order
Seq 664-920 Hetero dimer :
 Evidence X-RAY 1xj7 A Reference
       Region 1xj7 A 664-919 order
       Region 1xj7 A 920-920 disorder
Seq 664-920 Hetero dimer : IID00082Complex
 Evidence X-RAY 1t63 A Reference
       Region 1t63 A 670-919 order
 Evidence X-RAY 2q7l A Reference
       Region 2q7l A 664-671 disorder
       Region 2q7l A 672-844 order
       Region 2q7l A 845-846 disorder
       Region 2q7l A 847-920 order
 Evidence X-RAY 2q7j A Reference
       Region 2q7j A 664-671 disorder
       Region 2q7j A 672-844 order
       Region 2q7j A 845-846 disorder
       Region 2q7j A 847-920 order
Seq 669-920 Hetero tetramer : Q8TBC4
 Evidence X-RAY 5jjm D Reference
       Region 5jjm D 669-669 disorder
       Region 5jjm D 670-918 order
       Region 5jjm D 919-920 disorder
 Evidence X-RAY 5jjm C Reference
       Region 5jjm C 669-918 order
       Region 5jjm C 919-920 disorder
 Evidence X-RAY 5jjm B Reference
       Region 5jjm B 669-669 disorder
       Region 5jjm B 670-920 order
 Evidence X-RAY 5jjm A Reference
       Region 5jjm A 669-920 order
Seq 670-920 Hetero dimer : IID00074Complex
 Evidence X-RAY 1t5z A Reference
       Region 1t5z A 670-919 order
       Region 1t5z A 920-920 disorder
Seq 670-920 Hetero dimer : IID00082Complex
 Evidence X-RAY 1t65 A Reference
       Region 1t65 A 670-920 order
Seq 670-920 Hetero dimer :
 Evidence X-RAY 2pkl A Reference
       Region 2pkl A 670-670 disorder
       Region 2pkl A 671-919 order
       Region 2pkl A 920-920 disorder
Seq 671-919 Hetero dimer : IID00110Complex
 Evidence X-RAY 3l3z A Reference
       Region 3l3z A 671-846 order
       Region 3l3z A 847-847 disorder
       Region 3l3z A 848-919 order
Seq 671-919 Hetero dimer : IID00110Complex
 Evidence X-RAY 3l3x A Reference
       Region 3l3x A 671-919 order
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4okx A Reference
       Region 4okx A 671-671 disorder
       Region 4okx A 672-844 order
       Region 4okx A 845-852 disorder
       Region 4okx A 853-919 order
       Region 4okx A 920-920 disorder
Seq 671-920 Hetero dimer : P41223
 Evidence X-RAY 4okb A Reference
       Region 4okb A 671-671 disorder
       Region 4okb A 672-844 order
       Region 4okb A 845-852 disorder
       Region 4okb A 853-919 order
       Region 4okb A 920-920 disorder
 Evidence X-RAY 4oh6 A Reference
       Region 4oh6 A 671-671 disorder
       Region 4oh6 A 672-844 order
       Region 4oh6 A 845-851 disorder
       Region 4oh6 A 852-920 order
 Evidence X-RAY 4oed A Reference
       Region 4oed A 671-844 order
       Region 4oed A 845-851 disorder
       Region 4oed A 852-919 order
       Region 4oed A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oil A Reference
       Region 4oil A 671-844 order
       Region 4oil A 845-851 disorder
       Region 4oil A 852-919 order
       Region 4oil A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oez A Reference
       Region 4oez A 671-844 order
       Region 4oez A 845-851 disorder
       Region 4oez A 852-919 order
       Region 4oez A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4okw A Reference
       Region 4okw A 671-671 disorder
       Region 4okw A 672-844 order
       Region 4okw A 845-852 disorder
       Region 4okw A 853-918 order
       Region 4okw A 919-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oiu A Reference
       Region 4oiu A 671-844 order
       Region 4oiu A 845-851 disorder
       Region 4oiu A 852-919 order
       Region 4oiu A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4ofr A Reference
       Region 4ofr A 671-671 disorder
       Region 4ofr A 672-844 order
       Region 4ofr A 845-849 disorder
       Region 4ofr A 850-919 order
       Region 4ofr A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oey A Reference
       Region 4oey A 671-671 disorder
       Region 4oey A 672-844 order
       Region 4oey A 845-851 disorder
       Region 4oey A 852-919 order
       Region 4oey A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oj9 A Reference
       Region 4oj9 A 671-919 order
       Region 4oj9 A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4ofu A Reference
       Region 4ofu A 671-671 disorder
       Region 4ofu A 672-844 order
       Region 4ofu A 845-851 disorder
       Region 4ofu A 852-919 order
       Region 4ofu A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4okt A Reference
       Region 4okt A 671-844 order
       Region 4okt A 845-845 disorder
       Region 4okt A 846-919 order
       Region 4okt A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oha A Reference
       Region 4oha A 671-671 disorder
       Region 4oha A 672-844 order
       Region 4oha A 845-851 disorder
       Region 4oha A 852-920 order
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4ok1 A Reference
       Region 4ok1 A 671-919 order
       Region 4ok1 A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4olm A Reference
       Region 4olm A 671-671 disorder
       Region 4olm A 672-844 order
       Region 4olm A 845-852 disorder
       Region 4olm A 853-919 order
       Region 4olm A 920-920 disorder
Seq 671-920 Hetero dimer :
 Evidence X-RAY 4oh5 A Reference
       Region 4oh5 A 671-671 disorder
       Region 4oh5 A 672-844 order
       Region 4oh5 A 845-851 disorder
       Region 4oh5 A 852-920 order
Seq 672-919 Hetero dimer : IID00081Complex
 Evidence X-RAY 2z4j A Reference
       Region 2z4j A 672-919 order
Seq 672-920 Hetero dimer :
 Evidence X-RAY 2ao6 A Reference
       Region 2ao6 A 672-844 order
       Region 2ao6 A 845-850 disorder
       Region 2ao6 A 851-919 order
       Region 2ao6 A 920-920 disorder
SeqProS predicted 622-636 The unbound state of this region is predicted to be disordered by DICHOT and Foldindex Hetero dimer : IID50009Complex
       Region 3btr B 622-636 order
Seqphosphorylation
    916-916 Phosphotyrosine; by CSK
    552-552 Phosphotyrosine; by CSK
    651-651 Phosphoserine; by STK4/MST1
    395-395 Phosphotyrosine; by CSK
    535-535 Phosphotyrosine; by CSK
    365-365 Phosphotyrosine; by CSK and TNK2
    359-359 Phosphotyrosine; by CSK
    364-364 Phosphotyrosine; by CSK
    309-309 Phosphotyrosine; by CSK
    348-348 Phosphotyrosine; by CSK
    258-258 Phosphoserine
    269-269 Phosphotyrosine; by CSK and TNK2
    96-96 Phosphoserine
    225-225 Phosphotyrosine; by CSK
    83-83 Phosphoserine; by CDK9
 
Prediction
NeProc
Disorder 40-51,84-552,628-671
Order 1-39,52-83,555-627,672-847,854-920
ProS 106-110,246-252,261-267,289-293,317-323,334-366,385-422,435-449,500-520,526-538,549-552,628-642
AlphaFold
Disorder 1-21,30-54,79-557,628-672,920-920
Order 22-29,55-78,558-627,673-919
Pfam Hmmer
PF00105 558-633 3e-42
PF00104 710-899 1.5e-44
SEG 44-91 ,150-162 ,192-199 ,203-217 ,319-341 ,374-384 ,416-434 ,451-473 ,642-657
Function
Function in SwissProt
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Isoform 3
Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.
Isoform 4
Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.
Biological Process
See also
Diagram with PDB data
NCOA3/ARCrystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3