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IID00021
 UniprotP11474
ProteinSteroid hormone receptor ERR1
GeneESRRA
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
423
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 192-423 Hetero tetramer : IID00103Complex
 Evidence X-RAY 1xb7 A Reference
       Region 1xb7 A 194-212 order
       Region 1xb7 A 213-223 disorder
       Region 1xb7 A 224-365 order
       Region 1xb7 A 366-374 disorder
       Region 1xb7 A 375-420 order
       Region 1xb7 A 421-423 disorder
 Evidence X-RAY 3d24 C Reference
       Region 3d24 C 192-213 order
       Region 3d24 C 214-222 disorder
       Region 3d24 C 223-367 order
       Region 3d24 C 368-374 disorder
       Region 3d24 C 375-423 order
 Evidence X-RAY 3d24 A Reference
       Region 3d24 A 192-193 disorder
       Region 3d24 A 194-212 order
       Region 3d24 A 213-222 disorder
       Region 3d24 A 223-365 order
       Region 3d24 A 366-373 disorder
       Region 3d24 A 374-420 order
       Region 3d24 A 421-423 disorder
Seq 193-423 Homo hexamer :
 Evidence X-RAY 2pjl B Reference
       Region 2pjl B 193-212 order
       Region 2pjl B 213-221 disorder
       Region 2pjl B 222-365 order
       Region 2pjl B 366-374 disorder
       Region 2pjl B 375-421 order
       Region 2pjl B 422-423 disorder
 Evidence X-RAY 2pjl A Reference
       Region 2pjl A 193-212 order
       Region 2pjl A 213-221 disorder
       Region 2pjl A 222-365 order
       Region 2pjl A 366-374 disorder
       Region 2pjl A 375-421 order
       Region 2pjl A 422-423 disorder
Seq 193-423 Monomer :
 Evidence X-RAY 3k6p A Reference
       Region 3k6p A 193-213 order
       Region 3k6p A 214-220 disorder
       Region 3k6p A 221-366 order
       Region 3k6p A 367-370 disorder
       Region 3k6p A 371-374 order
       Region 3k6p A 375-375 disorder
       Region 3k6p A 376-402 order
       Region 3k6p A 403-403 disorder
       Region 3k6p A 404-422 order
       Region 3k6p A 423-423 disorder
Seqphosphorylation
    19-19 Phosphoserine
    22-22 Phosphoserine
Seqacetylation
    129-129 N6-acetyllysine; by PCAF/KAT2B
    138-138 N6-acetyllysine; by PCAF/KAT2B
    160-160 N6-acetyllysine; by PCAF/KAT2B
    162-162 N6-acetyllysine; by PCAF/KAT2B
 
Prediction
NeProc
Disorder 1-74,153-220
Order 75-152,221-368,374-423
ProS 5-19,153-162,196-212
AlphaFold
Disorder 1-76,155-194,217-218,367-374,423-423
Order 77-154,195-216,219-366,375-422
Pfam Hmmer
PF00105 77-152 4.6e-52
PF00104 233-417 1.4e-53
SEG 52-67 ,169-187 ,294-325 ,349-393
Function
Function in SwissProt
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.