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IID00028
 UniprotP16401
ProteinHistone H1.5
GeneH1-5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
226
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 23-27 Hetero dimer : IID00335Complex
 Evidence X-RAY 2rhi B Reference
       Region 2rhi B 23-24 disorder
       Region 2rhi B 25-27 order
Seqphosphorylation
    18-18 Phosphoserine
    11-11 Phosphothreonine; by GSK3
    2-2 Phosphoserine
    39-39 Phosphothreonine
    155-155 Phosphothreonine
    138-138 Phosphothreonine
    173-173 Phosphoserine
    189-189 Phosphoserine
Seqacetylation
    2-2 N-acetylserine; partial
    17-17 N6-acetyllysine
    49-49 N6-acetyllysine
    78-78 N6-acetyllysine
    168-168 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-41,101-226
Order 42-100
ProS 101-111
AlphaFold
Disorder 1-38,113-226
Order 39-112
Pfam Hmmer
PF00538 39-112 1.7e-33
SEG 3-16 ,20-40 ,62-71 ,112-226
Function
Function in SwissProt
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).