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IID00029
 UniprotP17931
ProteinGalectin-3
GeneLGALS3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
250
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 105-250 Monomer :
 Evidence X-RAY 5iuq A Reference
       Region 5iuq A 113-250 order
 Evidence X-RAY 3zsm A Reference
       Region 3zsm A 114-250 order
 Evidence X-RAY 3zsl A Reference
       Region 3zsl A 114-250 order
 Evidence X-RAY 3zsk A Reference
       Region 3zsk A 114-250 order
 Evidence X-RAY 3zsj A Reference
       Region 3zsj A 113-250 order
 Evidence X-RAY 2xg3 A Reference
       Region 2xg3 A 114-250 order
 Evidence X-RAY 4xbn A Reference
       Region 4xbn A 113-250 order
 Evidence X-RAY 3t1m A Reference
       Region 3t1m A 108-113 disorder
       Region 3t1m A 114-250 order
 Evidence X-RAY 3t1l A Reference
       Region 3t1l A 108-112 disorder
       Region 3t1l A 113-250 order
 Evidence X-RAY 4rl7 A Reference
       Region 4rl7 A 111-112 disorder
       Region 4rl7 A 113-250 order
 Evidence X-RAY 4r9d A Reference
       Region 4r9d A 111-112 disorder
       Region 4r9d A 113-250 order
 Evidence X-RAY 4r9c A Reference
       Region 4r9c A 111-112 disorder
       Region 4r9c A 113-250 order
 Evidence X-RAY 4r9b A Reference
       Region 4r9b A 111-112 disorder
       Region 4r9b A 113-250 order
 Evidence X-RAY 4r9a A Reference
       Region 4r9a A 111-112 disorder
       Region 4r9a A 113-250 order
 Evidence X-RAY 2nn8 A Reference
       Region 2nn8 A 113-250 order
 Evidence X-RAY 2nmo A Reference
       Region 2nmo A 113-250 order
 Evidence X-RAY 2nmn A Reference
       Region 2nmn A 113-250 order
 Evidence X-RAY 5nfc A Reference
       Region 5nfc A 106-112 disorder
       Region 5nfc A 113-250 order
 Evidence X-RAY 5nfb A Reference
       Region 5nfb A 106-112 disorder
       Region 5nfb A 113-250 order
 Evidence X-RAY 5nfa A Reference
       Region 5nfa A 106-112 disorder
       Region 5nfa A 113-250 order
 Evidence X-RAY 5nf9 A Reference
       Region 5nf9 A 106-112 disorder
       Region 5nf9 A 113-250 order
 Evidence X-RAY 5nf7 A Reference
       Region 5nf7 A 106-112 disorder
       Region 5nf7 A 113-250 order
 Evidence X-RAY 4lbo A Reference
       Region 4lbo A 113-250 order
 Evidence X-RAY 4lbn A Reference
       Region 4lbn A 112-250 order
 Evidence X-RAY 4lbm A Reference
       Region 4lbm A 112-250 order
 Evidence X-RAY 4lbl A Reference
       Region 4lbl A 114-250 order
 Evidence X-RAY 4lbk A Reference
       Region 4lbk A 114-250 order
 Evidence X-RAY 4lbj A Reference
       Region 4lbj A 114-250 order
 Evidence X-RAY 1kjr A Reference
       Region 1kjr A 105-112 disorder
       Region 1kjr A 113-250 order
 Evidence X-RAY 1kjl A Reference
       Region 1kjl A 105-112 disorder
       Region 1kjl A 113-250 order
 Evidence X-RAY 4jck A Reference
       Region 4jck A 108-112 disorder
       Region 4jck A 113-250 order
 Evidence X-RAY 4jc1 A Reference
       Region 4jc1 A 108-112 disorder
       Region 4jc1 A 113-250 order
 Evidence X-RAY 5h9r A Reference
       Region 5h9r A 113-250 order
 Evidence X-RAY 5h9p A Reference
       Region 5h9p A 113-250 order
 Evidence X-RAY 5exo A Reference
       Region 5exo A 112-113 disorder
       Region 5exo A 114-250 order
 Evidence X-RAY 5e8a A Reference
       Region 5e8a A 114-250 order
 Evidence X-RAY 5e89 A Reference
       Region 5e89 A 114-250 order
 Evidence X-RAY 5e88 A Reference
       Region 5e88 A 114-250 order
 Evidence X-RAY 4bm8 A Reference
       Region 4bm8 A 114-250 order
 Evidence X-RAY 4blj A Reference
       Region 4blj A 114-250 order
 Evidence X-RAY 4bli A Reference
       Region 4bli A 114-250 order
 Evidence X-RAY 3aye B Reference
       Region 3aye B 117-250 order
 Evidence X-RAY 3aye A Reference
       Region 3aye A 117-250 order
 Evidence X-RAY 3ayd A Reference
       Region 3ayd A 117-250 order
 Evidence X-RAY 3ayc B Reference
       Region 3ayc B 117-250 order
 Evidence X-RAY 3ayc A Reference
       Region 3ayc A 117-250 order
 Evidence X-RAY 3aya B Reference
       Region 3aya B 117-250 order
 Evidence X-RAY 3aya A Reference
       Region 3aya A 117-250 order
 Evidence X-RAY 1a3k A Reference
       Region 1a3k A 114-250 order
Seqphosphorylation
    6-6 Phosphoserine
    12-12 Phosphoserine
    188-188 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-106
Order 112-250
ProS 1-14,19-46,52-56,61-66,76-82,100-106
AlphaFold
Disorder 1-111
Order 112-250
Pfam Hmmer
PF00337 117-247 5.4e-57
SEG 29-113
Function
Function in SwissProt
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.