Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
432
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Region 4bcn D 171-176 disorder
Region 4bcn D 177-431 order
Seq 171-432 Hetero tetramer : IID00034 Complex
Region 4bcn B 171-175 disorder
Region 4bcn B 176-432 order
Seq 171-432 Hetero tetramer : IID00034 Complex
Region 5nev D 174-174 disorder
Region 5nev D 175-429 order
Region 5nev D 430-432 disorder
Region 5nev B 174-174 disorder
Region 5nev B 175-429 order
Region 5nev B 430-432 disorder
Region 5lmk D 175-175 disorder
Region 5lmk D 176-432 order
Region 5lmk B 175-432 order
Region 2iw9 D 174-177 disorder
Region 2iw9 D 178-432 order
Region 2iw9 B 174-175 disorder
Region 2iw9 B 176-282 order
Region 2iw9 B 283-284 disorder
Region 2iw9 B 285-432 order
Region 2iw8 D 174-177 disorder
Region 2iw8 D 178-432 order
Region 2iw8 B 174-175 disorder
Region 2iw8 B 176-282 order
Region 2iw8 B 283-284 disorder
Region 2iw8 B 285-432 order
Region 2iw6 D 174-177 disorder
Region 2iw6 D 178-432 order
Region 2iw6 B 174-175 disorder
Region 2iw6 B 176-432 order
Region 2cjm D 175-175 disorder
Region 2cjm D 176-432 order
Region 2cjm B 175-175 disorder
Region 2cjm B 176-432 order
Region 4cfw D 175-175 disorder
Region 4cfw D 176-432 order
Region 4cfw B 175-432 order
Region 4cfv D 172-432 order
Region 4cfv B 172-432 order
Region 4cfu D 173-432 order
Region 4cfu B 172-432 order
Region 4cfm D 175-432 order
Region 4cfm B 175-432 order
Region 4bck D 171-177 disorder
Region 4bck D 178-430 order
Region 4bck D 431-432 disorder
Region 4bck B 171-175 disorder
Region 4bck B 176-432 order
Region 2v22 D 174-174 disorder
Region 2v22 D 175-432 order
Region 2v22 B 174-174 disorder
Region 2v22 B 175-432 order
Region 1jst D 175-432 order
Region 1jst B 175-432 order
Seq 171-432 Hetero dimer : IID00034 Complex
Region 2x1n B 172-174 disorder
Region 2x1n B 175-432 order
Region 2x1n D 172-174 disorder
Region 2x1n D 175-432 order
Region 2wxv B 173-175 disorder
Region 2wxv B 176-432 order
Region 2wxv D 173-175 disorder
Region 2wxv D 176-432 order
Region 2wpa D 173-178 disorder
Region 2wpa D 179-432 order
Region 2wpa B 173-174 disorder
Region 2wpa B 175-432 order
Region 2wmb D 174-174 disorder
Region 2wmb D 175-432 order
Region 2wma D 174-174 disorder
Region 2wma D 175-432 order
Region 2wip D 173-177 disorder
Region 2wip D 178-432 order
Region 2wip B 173-174 disorder
Region 2wip B 175-432 order
Region 2wih D 173-175 disorder
Region 2wih D 176-322 order
Region 2wih D 323-323 disorder
Region 2wih D 324-432 order
Region 2wih B 173-175 disorder
Region 2wih B 176-432 order
Region 2whb D 173-174 disorder
Region 2whb D 175-432 order
Region 2whb B 173-174 disorder
Region 2whb B 175-432 order
Region 2wfy D 173-432 order
Region 2wfy B 173-175 disorder
Region 2wfy B 176-432 order
Region 2wev D 173-174 disorder
Region 2wev D 175-432 order
Region 2wev B 173-174 disorder
Region 2wev B 175-432 order
Region 1vyw D 174-177 disorder
Region 1vyw D 178-432 order
Region 1vyw B 174-174 disorder
Region 1vyw B 175-432 order
Region 2uzl D 175-175 disorder
Region 2uzl D 176-432 order
Region 2uzl B 175-175 disorder
Region 2uzl B 176-432 order
Region 2uze D 175-432 order
Region 2uze B 175-432 order
Region 2uzd D 175-432 order
Region 2uzd B 175-432 order
Region 2uzb D 175-432 order
Region 2uzb B 175-432 order
Region 2uue D 174-174 disorder
Region 2uue D 175-432 order
Region 2uue B 174-174 disorder
Region 2uue B 175-432 order
Region 1pkd D 175-432 order
Region 1pkd B 175-432 order
Region 1p5e D 175-432 order
Region 1p5e B 175-432 order
Region 1ol2 D 173-174 disorder
Region 1ol2 D 175-432 order
Region 1ol2 B 173-174 disorder
Region 1ol2 B 175-432 order
Region 1ol1 D 173-174 disorder
Region 1ol1 D 175-432 order
Region 1ol1 B 173-174 disorder
Region 1ol1 B 175-432 order
Region 1okw D 173-174 disorder
Region 1okw D 175-432 order
Region 1okw B 173-174 disorder
Region 1okw B 175-432 order
Region 1oiy D 174-174 disorder
Region 1oiy D 175-432 order
Region 1oiy B 174-174 disorder
Region 1oiy B 175-432 order
Region 1oiu D 174-176 disorder
Region 1oiu D 177-432 order
Region 1oiu B 174-176 disorder
Region 1oiu B 177-432 order
Region 1oi9 D 174-177 disorder
Region 1oi9 D 178-430 order
Region 1oi9 D 431-432 disorder
Region 1oi9 B 174-174 disorder
Region 1oi9 B 175-432 order
Region 1ogu D 174-177 disorder
Region 1ogu D 178-432 order
Region 1ogu B 174-177 disorder
Region 1ogu B 178-282 order
Region 1ogu B 283-284 disorder
Region 1ogu B 285-432 order
Region 2i40 D 173-177 disorder
Region 2i40 D 178-432 order
Region 2i40 B 173-174 disorder
Region 2i40 B 175-431 order
Region 2i40 B 432-432 disorder
Region 1h27 D 174-174 disorder
Region 1h27 D 175-432 order
Region 1h26 D 174-174 disorder
Region 1h26 D 175-432 order
Region 1h25 D 174-174 disorder
Region 1h25 D 175-432 order
Region 1h24 D 174-174 disorder
Region 1h24 D 175-432 order
Region 1h1s D 175-432 order
Region 1h1s B 175-432 order
Region 1h1r D 175-432 order
Region 1h1r B 175-432 order
Region 1h1q D 175-432 order
Region 1h1q B 175-432 order
Region 1h1p D 175-432 order
Region 1h1p B 175-432 order
Region 4fx3 D 175-432 order
Region 4fx3 B 175-175 disorder
Region 4fx3 B 176-432 order
Region 1fvv D 173-432 order
Region 1fvv B 173-432 order
Region 1fin D 173-432 order
Region 1fin B 173-432 order
Region 3f5x D 177-177 disorder
Region 3f5x D 178-432 order
Region 3f5x B 177-432 order
Region 4eos D 175-429 order
Region 4eos D 430-432 disorder
Region 4eos B 175-175 disorder
Region 4eos B 176-432 order
Region 4eor D 175-429 order
Region 4eor D 430-432 disorder
Region 4eor B 175-175 disorder
Region 4eor B 176-432 order
Region 4eoq D 175-175 disorder
Region 4eoq D 176-429 order
Region 4eoq D 430-432 disorder
Region 4eoq B 175-175 disorder
Region 4eoq B 176-432 order
Region 4eop D 175-429 order
Region 4eop D 430-432 disorder
Region 4eop B 175-175 disorder
Region 4eop B 176-432 order
Region 4eoo D 175-175 disorder
Region 4eoo D 176-429 order
Region 4eoo D 430-432 disorder
Region 4eoo B 175-432 order
Region 4eon D 175-431 order
Region 4eon D 432-432 disorder
Region 4eon B 175-175 disorder
Region 4eon B 176-432 order
Region 4eom D 175-175 disorder
Region 4eom D 176-429 order
Region 4eom D 430-432 disorder
Region 4eom B 175-175 disorder
Region 4eom B 176-432 order
Region 4eol D 175-175 disorder
Region 4eol D 176-431 order
Region 4eol D 432-432 disorder
Region 4eol B 175-175 disorder
Region 4eol B 176-432 order
Region 4eok D 175-175 disorder
Region 4eok D 176-431 order
Region 4eok D 432-432 disorder
Region 4eok B 175-432 order
Region 4eoj D 175-175 disorder
Region 4eoj D 176-431 order
Region 4eoj D 432-432 disorder
Region 4eoj B 175-175 disorder
Region 4eoj B 176-432 order
Region 4eoi D 175-177 disorder
Region 4eoi D 178-432 order
Region 4eoi B 175-432 order
Region 3eoc D 173-175 disorder
Region 3eoc D 176-432 order
Region 3eoc B 173-175 disorder
Region 3eoc B 176-432 order
Region 3ej1 D 173-175 disorder
Region 3ej1 D 176-432 order
Region 3ej1 B 173-174 disorder
Region 3ej1 B 175-432 order
Region 3eid D 173-177 disorder
Region 3eid D 178-432 order
Region 3eid B 173-175 disorder
Region 3eid B 176-432 order
Region 1e9h D 175-432 order
Region 1e9h B 175-432 order
Region 5cyi D 174-176 disorder
Region 5cyi D 177-432 order
Region 5cyi B 174-174 disorder
Region 5cyi B 175-432 order
Region 2c6t D 175-432 order
Region 2c6t B 175-432 order
Region 2c5x D 174-174 disorder
Region 2c5x D 175-432 order
Region 2c5x B 174-174 disorder
Region 2c5x B 175-432 order
Region 2c5v D 174-174 disorder
Region 2c5v D 175-432 order
Region 2c5v B 174-174 disorder
Region 2c5v B 175-432 order
Region 2c5o D 173-174 disorder
Region 2c5o D 175-432 order
Region 2c5o B 173-174 disorder
Region 2c5o B 175-432 order
Region 2c5n D 174-174 disorder
Region 2c5n D 175-432 order
Region 2c5n B 174-174 disorder
Region 2c5n B 175-432 order
Region 2c4g D 173-174 disorder
Region 2c4g D 175-432 order
Region 2c4g B 173-174 disorder
Region 2c4g B 175-432 order
Region 2bpm D 174-177 disorder
Region 2bpm D 178-432 order
Region 2bpm B 174-174 disorder
Region 2bpm B 175-432 order
Region 2bkz D 174-177 disorder
Region 2bkz D 178-432 order
Region 2bkz B 174-175 disorder
Region 2bkz B 176-432 order
Region 4bcp D 171-175 disorder
Region 4bcp D 176-432 order
Region 4bcp B 171-175 disorder
Region 4bcp B 176-432 order
Region 4bcm D 171-175 disorder
Region 4bcm D 176-321 order
Region 4bcm D 322-330 disorder
Region 4bcm D 331-363 order
Region 4bcm D 364-371 disorder
Region 4bcm D 372-428 order
Region 4bcm D 429-432 disorder
Region 4bcm B 171-175 disorder
Region 4bcm B 176-432 order
Seq 173-432 Hetero trimer : IID00034 Complex ,
IID00049 Complex
Region 1jsu B 173-174 disorder
Region 1jsu B 175-432 order
Seq 173-432 Hetero hexamer : IID00034 Complex
Region 1urc B 173-174 disorder
Region 1urc B 175-432 order
Region 1urc D 173-174 disorder
Region 1urc D 175-432 order
Seq 173-432 Hetero tetramer : IID00034 Complex
Region 5if1 D 174-175 disorder
Region 5if1 D 176-432 order
Region 5if1 B 174-175 disorder
Region 5if1 B 176-432 order
Region 4cfx D 173-432 order
Region 4cfx B 173-432 order
Seq 173-432 Hetero trimer : IID00034 Complex
Region 1okv B 173-174 disorder
Region 1okv B 175-432 order
Seq 173-432 Hetero trimer : IID00034 Complex
Region 1okv D 173-432 order
Seq 173-432 Hetero trimer : IID00034 Complex ,
IID00099 Complex
Region 2cch D 173-175 disorder
Region 2cch D 176-431 order
Region 2cch D 432-432 disorder
Region 2cch B 173-432 order
Seq 174-432 Hetero trimer : IID00034 Complex ,
IID00130 Complex
Region 1h28 D 174-174 disorder
Region 1h28 D 175-432 order
Region 1h28 B 174-174 disorder
Region 1h28 B 175-432 order
Seq 174-432 Hetero trimer : IID00034 Complex ,
IID00064 Complex
Region 1h24 B 174-174 disorder
Region 1h24 B 175-432 order
Seq 174-432 Hetero trimer : IID00017 Complex ,
IID00034 Complex
Region 1h25 B 174-174 disorder
Region 1h25 B 175-432 order
Seq 174-432 Hetero trimer : IID00034 Complex
Region 2wma B 174-174 disorder
Region 2wma B 175-432 order
Seq 174-432 Hetero hexamer : IID00034 Complex
Region 1qmz B 174-174 disorder
Region 1qmz B 175-432 order
Region 1qmz D 174-174 disorder
Region 1qmz D 175-432 order
Seq 174-432 Hetero trimer : IID00034 Complex ,
IID00049 Complex
Region 1h27 B 174-174 disorder
Region 1h27 B 175-432 order
Seq 174-432 Hetero trimer : IID00034 Complex
Region 2wmb B 174-174 disorder
Region 2wmb B 175-432 order
Seq 174-432 Hetero trimer : IID00015 Complex ,
IID00034 Complex
Region 1h26 B 174-174 disorder
Region 1h26 B 175-432 order
Seq 175-432 Hetero trimer : IID00034 Complex ,
IID00099 Complex
Region 2cci D 175-432 order
Region 2cci B 175-432 order
Seq 175-432 Hetero trimer : IID00034 Complex
Region 1gy3 B 175-432 order
Seq 175-432 Hetero trimer : IID00034 Complex
Region 1gy3 D 175-432 order
Seq 175-432 Hetero tetramer : IID00034 Complex
Region 4cfn D 175-175 disorder
Region 4cfn D 176-282 order
Region 4cfn D 283-284 disorder
Region 4cfn D 285-432 order
Region 4cfn B 175-176 disorder
Region 4cfn B 177-282 order
Region 4cfn B 283-284 disorder
Region 4cfn B 285-432 order
Prediction
ProS 27-37,46-59,99-104,142-168,427-432
Function
Function in SwissProt
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
Biological Process
See also
Diagram with PDB data
TP53/CCNA2 /CDK2 CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
RB1/CCNA1/CDK2 CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein
RBL1/E2F5/TFDP1 Crystal structure of the E2F5-DP1-p107
ternary complex
E2F1/CCNA2/CDK2 CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F