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IID00034
 UniprotP24941
ProteinCyclin-dependent kinase 2
GeneCDK2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
298
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-288 Hetero dimer : IID00141Complex
 Evidence X-RAY 2jgz A Reference
       Region 2jgz A 1-288 order
Seq 1-296 Hetero tetramer : IID50253Complex
 Evidence X-RAY 3qhr C Reference
       Region 3qhr C 1-296 order
Seq 1-296 Hetero tetramer : IID50253Complex
 Evidence X-RAY 3qhw A Reference
       Region 3qhw A 1-296 order
Seq 1-296 Hetero tetramer : IID50253Complex
 Evidence X-RAY 3qhr A Reference
       Region 3qhr A 1-296 order
Seq 1-296 Hetero trimer : IID00032Complex
 Evidence X-RAY 1gy3 C Reference
       Region 1gy3 C 1-296 order
Seq 1-296 Hetero trimer : IID00032Complex
 Evidence X-RAY 1gy3 A Reference
       Region 1gy3 A 1-296 order
Seq 1-296 Hetero tetramer : IID50253Complex
 Evidence X-RAY 3qhw C Reference
       Region 3qhw C 1-296 order
Seq 1-298 Hetero tetramer : IID00032Complex
 Evidence X-RAY 4cfn C Reference
       Region 4cfn C 1-294 order
       Region 4cfn C 295-298 disorder
 Evidence X-RAY 4cfn A Reference
       Region 4cfn A 1-37 order
       Region 4cfn A 38-40 disorder
       Region 4cfn A 41-297 order
       Region 4cfn A 298-298 disorder
Seq 1-298 Hetero trimer : IID00032Complex
 Evidence X-RAY 1h28 C Reference
       Region 1h28 C 1-296 order
       Region 1h28 C 297-298 disorder
 Evidence X-RAY 1h28 A Reference
       Region 1h28 A 1-296 order
       Region 1h28 A 297-298 disorder
Seq 1-298 Hetero trimer : IID00032Complex
 Evidence X-RAY 1h26 A Reference
       Region 1h26 A 1-296 order
       Region 1h26 A 297-298 disorder
Seq 1-298 Hetero trimer : IID00032Complex
 Evidence X-RAY 2wmb A Reference
       Region 2wmb A 1-296 order
       Region 2wmb A 297-298 disorder
Seq 1-298 Hetero hexamer : IID00032Complex
 Evidence X-RAY 1urc A Reference
       Region 1urc A 1-296 order
       Region 1urc A 297-298 disorder
 Evidence X-RAY 1urc C Reference
       Region 1urc C 1-296 order
       Region 1urc C 297-298 disorder
Seq 1-298 Hetero tetramer : IID00032Complex,P30274
 Evidence X-RAY 4bcn C Reference
       Region 4bcn C 1-294 order
       Region 4bcn C 295-298 disorder
 Evidence X-RAY 4bcn A Reference
       Region 4bcn A 1-38 order
       Region 4bcn A 39-40 disorder
       Region 4bcn A 41-298 order
Seq 1-298 Hetero trimer : IID00032Complex
 Evidence X-RAY 1h25 A Reference
       Region 1h25 A 1-293 order
       Region 1h25 A 294-298 disorder
Seq 1-298 Hetero dimer : IID00032Complex
 Evidence X-RAY 2x1n A Reference
       Region 2x1n A 1-296 order
       Region 2x1n A 297-298 disorder
 Evidence X-RAY 2x1n C Reference
       Region 2x1n C 1-296 order
       Region 2x1n C 297-298 disorder
 Evidence X-RAY 2wxv A Reference
       Region 2wxv A 1-298 order
 Evidence X-RAY 2wxv C Reference
       Region 2wxv C 1-298 order
 Evidence X-RAY 2wpa C Reference
       Region 2wpa C 1-298 order
 Evidence X-RAY 2wpa A Reference
       Region 2wpa A 1-298 order
 Evidence X-RAY 2wmb C Reference
       Region 2wmb C 1-219 order
       Region 2wmb C 220-249 disorder
       Region 2wmb C 250-296 order
       Region 2wmb C 297-298 disorder
 Evidence X-RAY 2wma C Reference
       Region 2wma C 1-220 order
       Region 2wma C 221-251 disorder
       Region 2wma C 252-296 order
       Region 2wma C 297-298 disorder
 Evidence X-RAY 2wip C Reference
       Region 2wip C 1-11 order
       Region 2wip C 12-16 disorder
       Region 2wip C 17-296 order
       Region 2wip C 297-298 disorder
 Evidence X-RAY 2wip A Reference
       Region 2wip A 1-11 order
       Region 2wip A 12-16 disorder
       Region 2wip A 17-298 order
 Evidence X-RAY 2wih C Reference
       Region 2wih C 1-298 order
 Evidence X-RAY 2wih A Reference
       Region 2wih A 1-298 order
 Evidence X-RAY 2whb C Reference
       Region 2whb C 1-296 order
       Region 2whb C 297-298 disorder
 Evidence X-RAY 2whb A Reference
       Region 2whb A 1-296 order
       Region 2whb A 297-298 disorder
 Evidence X-RAY 2wfy C Reference
       Region 2wfy C 1-296 order
       Region 2wfy C 297-298 disorder
 Evidence X-RAY 2wfy A Reference
       Region 2wfy A 1-295 order
       Region 2wfy A 296-298 disorder
 Evidence X-RAY 2wev C Reference
       Region 2wev C 1-296 order
       Region 2wev C 297-298 disorder
 Evidence X-RAY 2wev A Reference
       Region 2wev A 1-296 order
       Region 2wev A 297-298 disorder
 Evidence X-RAY 1vyw C Reference
       Region 1vyw C 1-298 order
 Evidence X-RAY 1vyw A Reference
       Region 1vyw A 1-298 order
 Evidence X-RAY 2uzl C Reference
       Region 2uzl C 1-296 order
       Region 2uzl C 297-298 disorder
 Evidence X-RAY 2uzl A Reference
       Region 2uzl A 1-296 order
       Region 2uzl A 297-298 disorder
 Evidence X-RAY 2uze C Reference
       Region 2uze C 1-296 order
       Region 2uze C 297-298 disorder
 Evidence X-RAY 2uze A Reference
       Region 2uze A 1-296 order
       Region 2uze A 297-298 disorder
 Evidence X-RAY 2uzd C Reference
       Region 2uzd C 1-296 order
       Region 2uzd C 297-298 disorder
 Evidence X-RAY 2uzd A Reference
       Region 2uzd A 1-296 order
       Region 2uzd A 297-298 disorder
 Evidence X-RAY 2uzb C Reference
       Region 2uzb C 1-296 order
       Region 2uzb C 297-298 disorder
 Evidence X-RAY 2uzb A Reference
       Region 2uzb A 1-296 order
       Region 2uzb A 297-298 disorder
 Evidence X-RAY 2uue C Reference
       Region 2uue C 1-296 order
       Region 2uue C 297-298 disorder
 Evidence X-RAY 2uue A Reference
       Region 2uue A 1-296 order
       Region 2uue A 297-298 disorder
 Evidence X-RAY 1pkd C Reference
       Region 1pkd C 1-296 order
 Evidence X-RAY 1pkd A Reference
       Region 1pkd A 1-296 order
 Evidence X-RAY 1p5e C Reference
       Region 1p5e C 1-296 order
       Region 1p5e C 297-298 disorder
 Evidence X-RAY 1p5e A Reference
       Region 1p5e A 1-296 order
       Region 1p5e A 297-298 disorder
 Evidence X-RAY 1ol2 C Reference
       Region 1ol2 C 1-296 order
       Region 1ol2 C 297-298 disorder
 Evidence X-RAY 1ol2 A Reference
       Region 1ol2 A 1-296 order
       Region 1ol2 A 297-298 disorder
 Evidence X-RAY 1ol1 C Reference
       Region 1ol1 C 1-296 order
       Region 1ol1 C 297-298 disorder
 Evidence X-RAY 1ol1 A Reference
       Region 1ol1 A 1-296 order
       Region 1ol1 A 297-298 disorder
 Evidence X-RAY 1okw C Reference
       Region 1okw C 1-296 order
       Region 1okw C 297-298 disorder
 Evidence X-RAY 1okw A Reference
       Region 1okw A 1-296 order
       Region 1okw A 297-298 disorder
 Evidence X-RAY 1oiy C Reference
       Region 1oiy C 1-296 order
       Region 1oiy C 297-298 disorder
 Evidence X-RAY 1oiy A Reference
       Region 1oiy A 1-37 order
       Region 1oiy A 38-40 disorder
       Region 1oiy A 41-296 order
       Region 1oiy A 297-298 disorder
 Evidence X-RAY 1oiu C Reference
       Region 1oiu C 1-220 order
       Region 1oiu C 221-251 disorder
       Region 1oiu C 252-296 order
       Region 1oiu C 297-298 disorder
 Evidence X-RAY 1oiu A Reference
       Region 1oiu A 1-37 order
       Region 1oiu A 38-40 disorder
       Region 1oiu A 41-297 order
       Region 1oiu A 298-298 disorder
 Evidence X-RAY 1oi9 C Reference
       Region 1oi9 C 1-296 order
       Region 1oi9 C 297-298 disorder
 Evidence X-RAY 1oi9 A Reference
       Region 1oi9 A 1-37 order
       Region 1oi9 A 38-38 disorder
       Region 1oi9 A 39-296 order
       Region 1oi9 A 297-298 disorder
 Evidence X-RAY 1ogu C Reference
       Region 1ogu C 1-221 order
       Region 1ogu C 222-247 disorder
       Region 1ogu C 248-296 order
       Region 1ogu C 297-298 disorder
 Evidence X-RAY 1ogu A Reference
       Region 1ogu A 1-37 order
       Region 1ogu A 38-40 disorder
       Region 1ogu A 41-297 order
       Region 1ogu A 298-298 disorder
 Evidence X-RAY 2i40 C Reference
       Region 2i40 C 1-296 order
       Region 2i40 C 297-298 disorder
 Evidence X-RAY 2i40 A Reference
       Region 2i40 A 1-37 order
       Region 2i40 A 38-40 disorder
       Region 2i40 A 41-159 order
       Region 2i40 A 160-162 disorder
       Region 2i40 A 163-297 order
       Region 2i40 A 298-298 disorder
 Evidence X-RAY 1h27 C Reference
       Region 1h27 C 1-238 order
       Region 1h27 C 239-243 disorder
       Region 1h27 C 244-296 order
       Region 1h27 C 297-298 disorder
 Evidence X-RAY 1h26 C Reference
       Region 1h26 C 1-221 order
       Region 1h26 C 222-250 disorder
       Region 1h26 C 251-296 order
       Region 1h26 C 297-298 disorder
 Evidence X-RAY 1h25 C Reference
       Region 1h25 C 1-235 order
       Region 1h25 C 236-250 disorder
       Region 1h25 C 251-293 order
       Region 1h25 C 294-298 disorder
 Evidence X-RAY 1h24 C Reference
       Region 1h24 C 1-293 order
       Region 1h24 C 294-298 disorder
 Evidence X-RAY 1h1s C Reference
       Region 1h1s C 1-296 order
       Region 1h1s C 297-298 disorder
 Evidence X-RAY 1h1s A Reference
       Region 1h1s A 1-296 order
       Region 1h1s A 297-298 disorder
 Evidence X-RAY 1h1r C Reference
       Region 1h1r C 1-296 order
       Region 1h1r C 297-298 disorder
 Evidence X-RAY 1h1r A Reference
       Region 1h1r A 1-296 order
       Region 1h1r A 297-298 disorder
 Evidence X-RAY 1h1q C Reference
       Region 1h1q C 1-296 order
       Region 1h1q C 297-298 disorder
 Evidence X-RAY 1h1q A Reference
       Region 1h1q A 1-296 order
       Region 1h1q A 297-298 disorder
 Evidence X-RAY 1h1p C Reference
       Region 1h1p C 1-296 order
       Region 1h1p C 297-298 disorder
 Evidence X-RAY 1h1p A Reference
       Region 1h1p A 1-296 order
       Region 1h1p A 297-298 disorder
 Evidence X-RAY 4fx3 C Reference
       Region 4fx3 C 1-298 order
 Evidence X-RAY 4fx3 A Reference
       Region 4fx3 A 1-298 order
 Evidence X-RAY 1fvv C Reference
       Region 1fvv C 1-298 order
 Evidence X-RAY 1fvv A Reference
       Region 1fvv A 1-298 order
 Evidence X-RAY 1fin C Reference
       Region 1fin C 1-298 order
 Evidence X-RAY 1fin A Reference
       Region 1fin A 1-298 order
 Evidence X-RAY 3f5x C Reference
       Region 3f5x C 1-298 order
 Evidence X-RAY 3f5x A Reference
       Region 3f5x A 1-271 order
       Region 3f5x A 272-272 disorder
       Region 3f5x A 273-298 order
 Evidence X-RAY 4eos C Reference
       Region 4eos C 1-296 order
       Region 4eos C 297-297 disorder
 Evidence X-RAY 4eos A Reference
       Region 4eos A 1-38 order
       Region 4eos A 39-41 disorder
       Region 4eos A 42-297 order
 Evidence X-RAY 4eor C Reference
       Region 4eor C 1-222 order
       Region 4eor C 223-246 disorder
       Region 4eor C 247-294 order
       Region 4eor C 295-297 disorder
 Evidence X-RAY 4eor A Reference
       Region 4eor A 1-37 order
       Region 4eor A 38-41 disorder
       Region 4eor A 42-297 order
 Evidence X-RAY 4eoq C Reference
       Region 4eoq C 1-221 order
       Region 4eoq C 222-245 disorder
       Region 4eoq C 246-296 order
       Region 4eoq C 297-297 disorder
 Evidence X-RAY 4eoq A Reference
       Region 4eoq A 1-37 order
       Region 4eoq A 38-40 disorder
       Region 4eoq A 41-297 order
 Evidence X-RAY 4eop C Reference
       Region 4eop C 1-296 order
       Region 4eop C 297-297 disorder
 Evidence X-RAY 4eop A Reference
       Region 4eop A 1-39 order
       Region 4eop A 40-41 disorder
       Region 4eop A 42-297 order
 Evidence X-RAY 4eoo C Reference
       Region 4eoo C 1-296 order
       Region 4eoo C 297-297 disorder
 Evidence X-RAY 4eoo A Reference
       Region 4eoo A 1-37 order
       Region 4eoo A 38-41 disorder
       Region 4eoo A 42-297 order
 Evidence X-RAY 4eon C Reference
       Region 4eon C 1-297 order
       Region 4eon C 298-298 disorder
 Evidence X-RAY 4eon A Reference
       Region 4eon A 1-298 order
 Evidence X-RAY 4eom C Reference
       Region 4eom C 1-221 order
       Region 4eom C 222-245 disorder
       Region 4eom C 246-296 order
       Region 4eom C 297-297 disorder
 Evidence X-RAY 4eom A Reference
       Region 4eom A 1-37 order
       Region 4eom A 38-39 disorder
       Region 4eom A 40-297 order
 Evidence X-RAY 4eol C Reference
       Region 4eol C 1-297 order
 Evidence X-RAY 4eol A Reference
       Region 4eol A 1-37 order
       Region 4eol A 38-39 disorder
       Region 4eol A 40-94 order
       Region 4eol A 95-95 disorder
       Region 4eol A 96-297 order
 Evidence X-RAY 4eok C Reference
       Region 4eok C 1-297 order
 Evidence X-RAY 4eok A Reference
       Region 4eok A 1-37 order
       Region 4eok A 38-41 disorder
       Region 4eok A 42-297 order
 Evidence X-RAY 4eoj C Reference
       Region 4eoj C 1-228 order
       Region 4eoj C 229-245 disorder
       Region 4eoj C 246-296 order
       Region 4eoj C 297-298 disorder
 Evidence X-RAY 4eoj A Reference
       Region 4eoj A 1-37 order
       Region 4eoj A 38-41 disorder
       Region 4eoj A 42-298 order
 Evidence X-RAY 4eoi C Reference
       Region 4eoi C 1-296 order
       Region 4eoi C 297-298 disorder
 Evidence X-RAY 4eoi A Reference
       Region 4eoi A 1-37 order
       Region 4eoi A 38-41 disorder
       Region 4eoi A 42-298 order
 Evidence X-RAY 3eoc C Reference
       Region 3eoc C 1-37 order
       Region 3eoc C 38-40 disorder
       Region 3eoc C 41-296 order
       Region 3eoc C 297-298 disorder
 Evidence X-RAY 3eoc A Reference
       Region 3eoc A 1-37 order
       Region 3eoc A 38-40 disorder
       Region 3eoc A 41-298 order
 Evidence X-RAY 3ej1 C Reference
       Region 3ej1 C 1-37 order
       Region 3ej1 C 38-40 disorder
       Region 3ej1 C 41-297 order
       Region 3ej1 C 298-298 disorder
 Evidence X-RAY 3ej1 A Reference
       Region 3ej1 A 1-37 order
       Region 3ej1 A 38-40 disorder
       Region 3ej1 A 41-298 order
 Evidence X-RAY 3eid C Reference
       Region 3eid C 1-37 order
       Region 3eid C 38-41 disorder
       Region 3eid C 42-161 order
       Region 3eid C 162-163 disorder
       Region 3eid C 164-296 order
       Region 3eid C 297-298 disorder
 Evidence X-RAY 3eid A Reference
       Region 3eid A 1-37 order
       Region 3eid A 38-40 disorder
       Region 3eid A 41-160 order
       Region 3eid A 161-162 disorder
       Region 3eid A 163-297 order
       Region 3eid A 298-298 disorder
 Evidence X-RAY 1e9h C Reference
       Region 1e9h C 1-296 order
 Evidence X-RAY 1e9h A Reference
       Region 1e9h A 1-296 order
 Evidence X-RAY 5cyi C Reference
       Region 5cyi C 1-296 order
       Region 5cyi C 297-298 disorder
 Evidence X-RAY 5cyi A Reference
       Region 5cyi A 1-298 order
 Evidence X-RAY 2c6t C Reference
       Region 2c6t C 1-296 order
       Region 2c6t C 297-298 disorder
 Evidence X-RAY 2c6t A Reference
       Region 2c6t A 1-296 order
       Region 2c6t A 297-298 disorder
 Evidence X-RAY 2c5x C Reference
       Region 2c5x C 1-296 order
       Region 2c5x C 297-298 disorder
 Evidence X-RAY 2c5x A Reference
       Region 2c5x A 1-296 order
       Region 2c5x A 297-298 disorder
 Evidence X-RAY 2c5v C Reference
       Region 2c5v C 1-296 order
       Region 2c5v C 297-298 disorder
 Evidence X-RAY 2c5v A Reference
       Region 2c5v A 1-296 order
       Region 2c5v A 297-298 disorder
 Evidence X-RAY 2c5o C Reference
       Region 2c5o C 1-296 order
       Region 2c5o C 297-298 disorder
 Evidence X-RAY 2c5o A Reference
       Region 2c5o A 1-296 order
       Region 2c5o A 297-298 disorder
 Evidence X-RAY 2c5n C Reference
       Region 2c5n C 1-296 order
       Region 2c5n C 297-298 disorder
 Evidence X-RAY 2c5n A Reference
       Region 2c5n A 1-296 order
       Region 2c5n A 297-298 disorder
 Evidence X-RAY 2c4g C Reference
       Region 2c4g C 1-298 order
 Evidence X-RAY 2c4g A Reference
       Region 2c4g A 1-297 order
       Region 2c4g A 298-298 disorder
 Evidence X-RAY 2bpm C Reference
       Region 2bpm C 1-298 order
 Evidence X-RAY 2bpm A Reference
       Region 2bpm A 1-298 order
 Evidence X-RAY 2bkz C Reference
       Region 2bkz C 1-297 order
       Region 2bkz C 298-298 disorder
 Evidence X-RAY 2bkz A Reference
       Region 2bkz A 1-298 order
 Evidence X-RAY 4bcp C Reference
       Region 4bcp C 1-12 order
       Region 4bcp C 13-15 disorder
       Region 4bcp C 16-221 order
       Region 4bcp C 222-247 disorder
       Region 4bcp C 248-296 order
       Region 4bcp C 297-298 disorder
 Evidence X-RAY 4bcp A Reference
       Region 4bcp A 1-298 order
 Evidence X-RAY 4bcm C Reference
       Region 4bcm C 1-294 order
       Region 4bcm C 295-298 disorder
 Evidence X-RAY 4bcm A Reference
       Region 4bcm A 1-37 order
       Region 4bcm A 38-40 disorder
       Region 4bcm A 41-296 order
       Region 4bcm A 297-298 disorder
Seq 1-298 Hetero tetramer : IID00032Complex
 Evidence X-RAY 5if1 C Reference
       Region 5if1 C 1-296 order
       Region 5if1 C 297-298 disorder
 Evidence X-RAY 5if1 A Reference
       Region 5if1 A 1-298 order
 Evidence X-RAY 4cfx C Reference
       Region 4cfx C 1-298 order
 Evidence X-RAY 4cfx A Reference
       Region 4cfx A 1-298 order
Seq 1-298 Hetero trimer : IID00032Complex
 Evidence X-RAY 2cch C Reference
       Region 2cch C 1-296 order
       Region 2cch C 297-298 disorder
 Evidence X-RAY 2cch A Reference
       Region 2cch A 1-296 order
       Region 2cch A 297-298 disorder
Seq 1-298 Hetero trimer : IID00049Complex,Q5MJ70
 Evidence X-RAY 5uq3 A Reference
       Region 5uq3 A 1-18 disorder
       Region 5uq3 A 19-36 order
       Region 5uq3 A 37-40 disorder
       Region 5uq3 A 41-292 order
       Region 5uq3 A 293-298 disorder
Seq 1-298 Hetero dimer : P30274
 Evidence X-RAY 3tnw C Reference
       Region 3tnw C 1-13 order
       Region 3tnw C 14-15 disorder
       Region 3tnw C 16-294 order
       Region 3tnw C 295-298 disorder
 Evidence X-RAY 3tnw A Reference
       Region 3tnw A 1-37 order
       Region 3tnw A 38-40 disorder
       Region 3tnw A 41-298 order
 Evidence X-RAY 3my5 C Reference
       Region 3my5 C 1-220 order
       Region 3my5 C 221-250 disorder
       Region 3my5 C 251-296 order
       Region 3my5 C 297-298 disorder
 Evidence X-RAY 3my5 A Reference
       Region 3my5 A 1-37 order
       Region 3my5 A 38-40 disorder
       Region 3my5 A 41-298 order
 Evidence X-RAY 2g9x C Reference
       Region 2g9x C 1-223 order
       Region 2g9x C 224-247 disorder
       Region 2g9x C 248-298 order
 Evidence X-RAY 2g9x A Reference
       Region 2g9x A 1-298 order
 Evidence X-RAY 3dog A Reference
       Region 3dog A 1-37 order
       Region 3dog A 38-38 disorder
       Region 3dog A 39-298 order
 Evidence X-RAY 3dog C Reference
       Region 3dog C 1-221 order
       Region 3dog C 222-251 disorder
       Region 3dog C 252-297 order
       Region 3dog C 298-298 disorder
 Evidence X-RAY 3ddq A Reference
       Region 3ddq A 1-38 order
       Region 3ddq A 39-40 disorder
       Region 3ddq A 41-298 order
 Evidence X-RAY 3ddq C Reference
       Region 3ddq C 1-220 order
       Region 3ddq C 221-251 disorder
       Region 3ddq C 252-297 order
       Region 3ddq C 298-298 disorder
 Evidence X-RAY 3ddp A Reference
       Region 3ddp A 1-297 order
       Region 3ddp A 298-298 disorder
 Evidence X-RAY 3ddp C Reference
       Region 3ddp C 1-298 order
 Evidence X-RAY 3bhv C Reference
       Region 3bhv C 1-221 order
       Region 3bhv C 222-247 disorder
       Region 3bhv C 248-296 order
       Region 3bhv C 297-298 disorder
 Evidence X-RAY 3bhv A Reference
       Region 3bhv A 1-38 order
       Region 3bhv A 39-40 disorder
       Region 3bhv A 41-298 order
 Evidence X-RAY 3bhu C Reference
       Region 3bhu C 1-221 order
       Region 3bhu C 222-247 disorder
       Region 3bhu C 248-296 order
       Region 3bhu C 297-298 disorder
 Evidence X-RAY 3bhu A Reference
       Region 3bhu A 1-38 order
       Region 3bhu A 39-40 disorder
       Region 3bhu A 41-298 order
 Evidence X-RAY 3bht C Reference
       Region 3bht C 1-221 order
       Region 3bht C 222-247 disorder
       Region 3bht C 248-296 order
       Region 3bht C 297-298 disorder
 Evidence X-RAY 3bht A Reference
       Region 3bht A 1-38 order
       Region 3bht A 39-40 disorder
       Region 3bht A 41-298 order
Seq 1-298 Hetero trimer : IID00032Complex,IID00099Complex
 Evidence X-RAY 2cci C Reference
       Region 2cci C 1-296 order
       Region 2cci C 297-298 disorder
 Evidence X-RAY 2cci A Reference
       Region 2cci A 1-296 order
       Region 2cci A 297-298 disorder
Seq 1-298 Hetero tetramer : P30274
 Evidence X-RAY 4bcq C Reference
       Region 4bcq C 1-12 order
       Region 4bcq C 13-14 disorder
       Region 4bcq C 15-294 order
       Region 4bcq C 295-298 disorder
 Evidence X-RAY 4bcq A Reference
       Region 4bcq A 1-11 order
       Region 4bcq A 12-16 disorder
       Region 4bcq A 17-295 order
       Region 4bcq A 296-298 disorder
 Evidence X-RAY 4bco C Reference
       Region 4bco C 1-221 order
       Region 4bco C 222-248 disorder
       Region 4bco C 249-296 order
       Region 4bco C 297-298 disorder
 Evidence X-RAY 4bco A Reference
       Region 4bco A 1-298 order
Seq 1-298 Hetero dimer : IID00603Complex
 Evidence X-RAY 1w98 A Reference
       Region 1w98 A 1-297 order
 Evidence X-RAY 5l2w A Reference
       Region 5l2w A 1-297 order
       Region 5l2w A 298-298 disorder
Seq 1-298 Hetero trimer : IID00032Complex
 Evidence X-RAY 1okv A Reference
       Region 1okv A 1-295 order
       Region 1okv A 296-298 disorder
Seq 1-298 Hetero dimer : P89883
 Evidence X-RAY 1f5q C Reference
       Region 1f5q C 1-9 order
       Region 1f5q C 10-11 disorder
       Region 1f5q C 12-23 order
       Region 1f5q C 24-26 disorder
       Region 1f5q C 27-248 order
       Region 1f5q C 249-252 disorder
       Region 1f5q C 253-297 order
       Region 1f5q C 298-298 disorder
 Evidence X-RAY 1f5q A Reference
       Region 1f5q A 1-9 order
       Region 1f5q A 10-11 disorder
       Region 1f5q A 12-298 order
Seq 1-298 Hetero trimer : IID00032Complex
 Evidence X-RAY 2wma A Reference
       Region 2wma A 1-296 order
       Region 2wma A 297-298 disorder
Seq 1-298 Hetero dimer : IID00605Complex
 Evidence X-RAY 1fq1 B Reference
       Region 1fq1 B 1-296 order
       Region 1fq1 B 297-298 disorder
Seq 1-298 Hetero tetramer : IID00032Complex
 Evidence X-RAY 5nev C Reference
       Region 5nev C 1-296 order
       Region 5nev C 297-298 disorder
 Evidence X-RAY 5nev A Reference
       Region 5nev A 1-295 order
       Region 5nev A 296-298 disorder
 Evidence X-RAY 5lmk C Reference
       Region 5lmk C 1-220 order
       Region 5lmk C 221-251 disorder
       Region 5lmk C 252-296 order
 Evidence X-RAY 5lmk A Reference
       Region 5lmk A 1-38 order
       Region 5lmk A 39-40 disorder
       Region 5lmk A 41-298 order
 Evidence X-RAY 2iw9 C Reference
       Region 2iw9 C 1-222 order
       Region 2iw9 C 223-250 disorder
       Region 2iw9 C 251-296 order
       Region 2iw9 C 297-298 disorder
 Evidence X-RAY 2iw9 A Reference
       Region 2iw9 A 1-37 order
       Region 2iw9 A 38-41 disorder
       Region 2iw9 A 42-297 order
       Region 2iw9 A 298-298 disorder
 Evidence X-RAY 2iw8 C Reference
       Region 2iw8 C 1-220 order
       Region 2iw8 C 221-251 disorder
       Region 2iw8 C 252-296 order
       Region 2iw8 C 297-298 disorder
 Evidence X-RAY 2iw8 A Reference
       Region 2iw8 A 1-297 order
       Region 2iw8 A 298-298 disorder
 Evidence X-RAY 2iw6 C Reference
       Region 2iw6 C 1-295 order
       Region 2iw6 C 296-298 disorder
 Evidence X-RAY 2iw6 A Reference
       Region 2iw6 A 1-37 order
       Region 2iw6 A 38-40 disorder
       Region 2iw6 A 41-295 order
       Region 2iw6 A 296-298 disorder
 Evidence X-RAY 2cjm C Reference
       Region 2cjm C 1-296 order
       Region 2cjm C 297-298 disorder
 Evidence X-RAY 2cjm A Reference
       Region 2cjm A 1-36 order
       Region 2cjm A 37-41 disorder
       Region 2cjm A 42-292 order
       Region 2cjm A 293-298 disorder
 Evidence X-RAY 4cfw C Reference
       Region 4cfw C 1-296 order
       Region 4cfw C 297-298 disorder
 Evidence X-RAY 4cfw A Reference
       Region 4cfw A 1-298 order
 Evidence X-RAY 4cfv C Reference
       Region 4cfv C 1-12 order
       Region 4cfv C 13-14 disorder
       Region 4cfv C 15-221 order
       Region 4cfv C 222-251 disorder
       Region 4cfv C 252-296 order
       Region 4cfv C 297-298 disorder
 Evidence X-RAY 4cfv A Reference
       Region 4cfv A 1-298 order
 Evidence X-RAY 4cfu C Reference
       Region 4cfu C 1-221 order
       Region 4cfu C 222-247 disorder
       Region 4cfu C 248-296 order
       Region 4cfu C 297-298 disorder
 Evidence X-RAY 4cfu A Reference
       Region 4cfu A 1-38 order
       Region 4cfu A 39-40 disorder
       Region 4cfu A 41-298 order
 Evidence X-RAY 4cfm C Reference
       Region 4cfm C 1-222 order
       Region 4cfm C 223-252 disorder
       Region 4cfm C 253-296 order
       Region 4cfm C 297-298 disorder
 Evidence X-RAY 4cfm A Reference
       Region 4cfm A 1-296 order
       Region 4cfm A 297-298 disorder
 Evidence X-RAY 4bck C Reference
       Region 4bck C 1-12 order
       Region 4bck C 13-14 disorder
       Region 4bck C 15-294 order
       Region 4bck C 295-298 disorder
 Evidence X-RAY 4bck A Reference
       Region 4bck A 1-297 order
       Region 4bck A 298-298 disorder
 Evidence X-RAY 2v22 C Reference
       Region 2v22 C 1-296 order
       Region 2v22 C 297-298 disorder
 Evidence X-RAY 2v22 A Reference
       Region 2v22 A 1-296 order
       Region 2v22 A 297-298 disorder
 Evidence X-RAY 1jst C Reference
       Region 1jst C 1-298 order
 Evidence X-RAY 1jst A Reference
       Region 1jst A 1-298 order
Seq 1-298 Hetero trimer : IID00032Complex
 Evidence X-RAY 1okv C Reference
       Region 1okv C 1-296 order
       Region 1okv C 297-298 disorder
Seq 1-298 Hetero dimer : Q5MJ70
 Evidence X-RAY 5uq2 A Reference
       Region 5uq2 A 1-296 order
       Region 5uq2 A 297-298 disorder
 Evidence X-RAY 5uq1 C Reference
       Region 5uq1 C 1-289 order
       Region 5uq1 C 290-298 disorder
 Evidence X-RAY 5uq1 A Reference
       Region 5uq1 A 1-2 disorder
       Region 5uq1 A 3-21 order
       Region 5uq1 A 22-27 disorder
       Region 5uq1 A 28-296 order
       Region 5uq1 A 297-298 disorder
Seq 1-298 Hetero trimer : IID00032Complex
 Evidence X-RAY 1h27 A Reference
       Region 1h27 A 1-296 order
       Region 1h27 A 297-298 disorder
Seq 1-298 Hetero hexamer : IID00032Complex
 Evidence X-RAY 1qmz A Reference
       Region 1qmz A 1-296 order
       Region 1qmz A 297-298 disorder
 Evidence X-RAY 1qmz C Reference
       Region 1qmz C 1-296 order
       Region 1qmz C 297-298 disorder
Seq 1-298 Hetero dimer : IID00309Complex
 Evidence X-RAY 1buh A Reference
       Region 1buh A 1-39 order
       Region 1buh A 40-46 disorder
       Region 1buh A 47-294 order
       Region 1buh A 295-298 disorder
Seq 1-298 Hetero trimer : IID00032Complex,IID00049Complex
 Evidence X-RAY 1jsu A Reference
       Region 1jsu A 1-12 disorder
       Region 1jsu A 13-298 order
Seq 1-298 Monomer :
 Evidence X-RAY 5iey A Reference
       Region 5iey A 1-37 order
       Region 5iey A 38-42 disorder
       Region 5iey A 43-154 order
       Region 5iey A 155-161 disorder
       Region 5iey A 162-298 order
 Evidence X-RAY 5iex A Reference
       Region 5iex A 1-37 order
       Region 5iex A 38-42 disorder
       Region 5iex A 43-155 order
       Region 5iex A 156-163 disorder
       Region 5iex A 164-298 order
 Evidence X-RAY 1e1x A Reference
       Region 1e1x A 1-35 order
       Region 1e1x A 36-43 disorder
       Region 1e1x A 44-298 order
 Evidence X-RAY 1e1v A Reference
       Region 1e1v A 1-35 order
       Region 1e1v A 36-43 disorder
       Region 1e1v A 44-298 order
 Evidence X-RAY 1ykr A Reference
       Region 1ykr A 1-298 order
 Evidence X-RAY 1y91 A Reference
       Region 1y91 A 1-37 order
       Region 1y91 A 38-44 disorder
       Region 1y91 A 45-153 order
       Region 1y91 A 154-158 disorder
       Region 1y91 A 159-298 order
 Evidence X-RAY 1y8y A Reference
       Region 1y8y A 1-37 order
       Region 1y8y A 38-43 disorder
       Region 1y8y A 44-298 order
 Evidence X-RAY 2xnb A Reference
       Region 2xnb A 1-40 order
       Region 2xnb A 41-42 disorder
       Region 2xnb A 43-298 order
 Evidence X-RAY 2xmy A Reference
       Region 2xmy A 1-39 order
       Region 2xmy A 40-42 disorder
       Region 2xmy A 43-298 order
 Evidence X-RAY 1wcc A Reference
       Region 1wcc A 1-36 order
       Region 1wcc A 37-40 disorder
       Region 1wcc A 41-152 order
       Region 1wcc A 153-163 disorder
       Region 1wcc A 164-298 order
 Evidence X-RAY 3wbl A Reference
       Region 3wbl A 1-24 order
       Region 3wbl A 25-25 disorder
       Region 3wbl A 26-37 order
       Region 3wbl A 38-42 disorder
       Region 3wbl A 43-153 order
       Region 3wbl A 154-162 disorder
       Region 3wbl A 163-298 order
 Evidence X-RAY 1w8c A Reference
       Region 1w8c A 1-36 order
       Region 1w8c A 37-43 disorder
       Region 1w8c A 44-298 order
 Evidence X-RAY 2w1h A Reference
       Region 2w1h A 1-36 order
       Region 2w1h A 37-40 disorder
       Region 2w1h A 41-152 order
       Region 2w1h A 153-163 disorder
       Region 2w1h A 164-298 order
 Evidence X-RAY 2w17 A Reference
       Region 2w17 A 1-12 order
       Region 2w17 A 13-13 disorder
       Region 2w17 A 14-38 order
       Region 2w17 A 39-43 disorder
       Region 2w17 A 44-73 order
       Region 2w17 A 74-74 disorder
       Region 2w17 A 75-149 order
       Region 2w17 A 150-162 disorder
       Region 2w17 A 163-298 order
 Evidence X-RAY 2w06 A Reference
       Region 2w06 A 1-36 order
       Region 2w06 A 37-43 disorder
       Region 2w06 A 44-152 order
       Region 2w06 A 153-161 disorder
       Region 2w06 A 162-298 order
 Evidence X-RAY 2w05 A Reference
       Region 2w05 A 1-36 order
       Region 2w05 A 37-45 disorder
       Region 2w05 A 46-148 order
       Region 2w05 A 149-161 disorder
       Region 2w05 A 162-298 order
 Evidence X-RAY 1w0x C Reference
       Region 1w0x C 1-36 order
       Region 1w0x C 37-43 disorder
       Region 1w0x C 44-152 order
       Region 1w0x C 153-163 disorder
       Region 1w0x C 164-298 order
 Evidence X-RAY 1vyz A Reference
       Region 1vyz A 1-35 order
       Region 1vyz A 36-46 disorder
       Region 1vyz A 47-153 order
       Region 1vyz A 154-161 disorder
       Region 1vyz A 162-298 order
 Evidence X-RAY 2vv9 A Reference
       Region 2vv9 A 1-37 order
       Region 2vv9 A 38-43 disorder
       Region 2vv9 A 44-149 order
       Region 2vv9 A 150-162 disorder
       Region 2vv9 A 163-298 order
 Evidence X-RAY 2vu3 A Reference
       Region 2vu3 A 1-37 order
       Region 2vu3 A 38-46 disorder
       Region 2vu3 A 47-147 order
       Region 2vu3 A 148-151 disorder
       Region 2vu3 A 152-298 order
 Evidence X-RAY 2vtt A Reference
       Region 2vtt A 1-35 order
       Region 2vtt A 36-46 disorder
       Region 2vtt A 47-148 order
       Region 2vtt A 149-163 disorder
       Region 2vtt A 164-298 order
 Evidence X-RAY 2vts A Reference
       Region 2vts A 1-36 order
       Region 2vts A 37-44 disorder
       Region 2vts A 45-152 order
       Region 2vts A 153-160 disorder
       Region 2vts A 161-298 order
 Evidence X-RAY 2vtr A Reference
       Region 2vtr A 1-36 order
       Region 2vtr A 37-44 disorder
       Region 2vtr A 45-298 order
 Evidence X-RAY 2vtq A Reference
       Region 2vtq A 1-36 order
       Region 2vtq A 37-45 disorder
       Region 2vtq A 46-147 order
       Region 2vtq A 148-162 disorder
       Region 2vtq A 163-298 order
 Evidence X-RAY 2vtp A Reference
       Region 2vtp A 1-35 order
       Region 2vtp A 36-43 disorder
       Region 2vtp A 44-152 order
       Region 2vtp A 153-161 disorder
       Region 2vtp A 162-298 order
 Evidence X-RAY 2vto A Reference
       Region 2vto A 1-36 order
       Region 2vto A 37-43 disorder
       Region 2vto A 44-152 order
       Region 2vto A 153-160 disorder
       Region 2vto A 161-298 order
 Evidence X-RAY 2vtn A Reference
       Region 2vtn A 1-36 order
       Region 2vtn A 37-44 disorder
       Region 2vtn A 45-147 order
       Region 2vtn A 148-163 disorder
       Region 2vtn A 164-298 order
 Evidence X-RAY 2vtm A Reference
       Region 2vtm A 1-35 order
       Region 2vtm A 36-43 disorder
       Region 2vtm A 44-298 order
 Evidence X-RAY 2vtl A Reference
       Region 2vtl A 1-35 order
       Region 2vtl A 36-43 disorder
       Region 2vtl A 44-298 order
 Evidence X-RAY 2vtj A Reference
       Region 2vtj A 1-36 order
       Region 2vtj A 37-45 disorder
       Region 2vtj A 46-150 order
       Region 2vtj A 151-163 disorder
       Region 2vtj A 164-298 order
 Evidence X-RAY 2vti A Reference
       Region 2vti A 1-35 order
       Region 2vti A 36-43 disorder
       Region 2vti A 44-152 order
       Region 2vti A 153-162 disorder
       Region 2vti A 163-298 order
 Evidence X-RAY 2vth A Reference
       Region 2vth A 1-36 order
       Region 2vth A 37-45 disorder
       Region 2vth A 46-152 order
       Region 2vth A 153-163 disorder
       Region 2vth A 164-298 order
 Evidence X-RAY 2vta A Reference
       Region 2vta A 1-36 order
       Region 2vta A 37-45 disorder
       Region 2vta A 46-152 order
       Region 2vta A 153-163 disorder
       Region 2vta A 164-298 order
 Evidence X-RAY 1v1k A Reference
       Region 1v1k A 1-37 order
       Region 1v1k A 38-46 disorder
       Region 1v1k A 47-150 order
       Region 1v1k A 151-162 disorder
       Region 1v1k A 163-298 order
 Evidence X-RAY 2v0d A Reference
       Region 2v0d A 1-37 order
       Region 2v0d A 38-43 disorder
       Region 2v0d A 44-298 order
 Evidence X-RAY 2uzo A Reference
       Region 2uzo A 1-37 order
       Region 2uzo A 38-43 disorder
       Region 2uzo A 44-296 order
       Region 2uzo A 297-298 disorder
 Evidence X-RAY 2uzn A Reference
       Region 2uzn A 1-35 order
       Region 2uzn A 36-44 disorder
       Region 2uzn A 45-152 order
       Region 2uzn A 153-162 disorder
       Region 2uzn A 163-298 order
 Evidence X-RAY 1urw A Reference
       Region 1urw A 1-12 order
       Region 1urw A 13-14 disorder
       Region 1urw A 15-35 order
       Region 1urw A 36-46 disorder
       Region 1urw A 47-151 order
       Region 1urw A 152-162 disorder
       Region 1urw A 163-298 order
 Evidence X-RAY 3unk A Reference
       Region 3unk A 1-36 order
       Region 3unk A 37-39 disorder
       Region 3unk A 40-298 order
 Evidence X-RAY 3unj A Reference
       Region 3unj A 1-36 order
       Region 3unj A 37-40 disorder
       Region 3unj A 41-298 order
 Evidence X-RAY 3uli A Reference
       Region 3uli A 1-38 order
       Region 3uli A 39-43 disorder
       Region 3uli A 44-154 order
       Region 3uli A 155-161 disorder
       Region 3uli A 162-298 order
 Evidence X-RAY 3tiz A Reference
       Region 3tiz A 1-1 disorder
       Region 3tiz A 2-36 order
       Region 3tiz A 37-40 disorder
       Region 3tiz A 41-298 order
 Evidence X-RAY 3tiy A Reference
       Region 3tiy A 1-1 disorder
       Region 3tiy A 2-36 order
       Region 3tiy A 37-40 disorder
       Region 3tiy A 41-298 order
 Evidence X-RAY 3ti1 A Reference
       Region 3ti1 A 1-36 order
       Region 3ti1 A 37-40 disorder
       Region 3ti1 A 41-298 order
 Evidence X-RAY 3sw7 A Reference
       Region 3sw7 A 1-37 order
       Region 3sw7 A 38-44 disorder
       Region 3sw7 A 45-149 order
       Region 3sw7 A 150-162 disorder
       Region 3sw7 A 163-298 order
 Evidence X-RAY 3sw4 A Reference
       Region 3sw4 A 1-35 order
       Region 3sw4 A 36-44 disorder
       Region 3sw4 A 45-153 order
       Region 3sw4 A 154-163 disorder
       Region 3sw4 A 164-298 order
 Evidence X-RAY 3sqq A Reference
       Region 3sqq A 1-36 order
       Region 3sqq A 37-40 disorder
       Region 3sqq A 41-150 order
       Region 3sqq A 151-156 disorder
       Region 3sqq A 157-298 order
 Evidence X-RAY 3s2p A Reference
       Region 3s2p A 1-35 order
       Region 3s2p A 36-43 disorder
       Region 3s2p A 44-152 order
       Region 3s2p A 153-163 disorder
       Region 3s2p A 164-298 order
 Evidence X-RAY 3s1h A Reference
       Region 3s1h A 1-36 order
       Region 3s1h A 37-44 disorder
       Region 3s1h A 45-149 order
       Region 3s1h A 150-162 disorder
       Region 3s1h A 163-298 order
 Evidence X-RAY 3s0o A Reference
       Region 3s0o A 1-37 order
       Region 3s0o A 38-40 disorder
       Region 3s0o A 41-146 order
       Region 3s0o A 147-148 disorder
       Region 3s0o A 149-298 order
 Evidence X-RAY 3s00 A Reference
       Region 3s00 A 1-36 order
       Region 3s00 A 37-40 disorder
       Region 3s00 A 41-298 order
 Evidence X-RAY 3rzb A Reference
       Region 3rzb A 1-36 order
       Region 3rzb A 37-44 disorder
       Region 3rzb A 45-154 order
       Region 3rzb A 155-162 disorder
       Region 3rzb A 163-298 order
 Evidence X-RAY 3rpy A Reference
       Region 3rpy A 1-36 order
       Region 3rpy A 37-44 disorder
       Region 3rpy A 45-149 order
       Region 3rpy A 150-162 disorder
       Region 3rpy A 163-298 order
 Evidence X-RAY 3rpv A Reference
       Region 3rpv A 1-36 order
       Region 3rpv A 37-40 disorder
       Region 3rpv A 41-298 order
 Evidence X-RAY 3rpr A Reference
       Region 3rpr A 1-36 order
       Region 3rpr A 37-44 disorder
       Region 3rpr A 45-154 order
       Region 3rpr A 155-162 disorder
       Region 3rpr A 163-298 order
 Evidence X-RAY 3rpo A Reference
       Region 3rpo A 1-36 order
       Region 3rpo A 37-40 disorder
       Region 3rpo A 41-298 order
 Evidence X-RAY 3roy A Reference
       Region 3roy A 1-36 order
       Region 3roy A 37-40 disorder
       Region 3roy A 41-298 order
 Evidence X-RAY 3rni A Reference
       Region 3rni A 1-36 order
       Region 3rni A 37-40 disorder
       Region 3rni A 41-298 order
 Evidence X-RAY 3rmf A Reference
       Region 3rmf A 1-37 order
       Region 3rmf A 38-44 disorder
       Region 3rmf A 45-149 order
       Region 3rmf A 150-162 disorder
       Region 3rmf A 163-298 order
 Evidence X-RAY 3rm7 A Reference
       Region 3rm7 A 1-36 order
       Region 3rm7 A 37-40 disorder
       Region 3rm7 A 41-298 order
 Evidence X-RAY 3rm6 A Reference
       Region 3rm6 A 1-14 order
       Region 3rm6 A 15-15 disorder
       Region 3rm6 A 16-36 order
       Region 3rm6 A 37-40 disorder
       Region 3rm6 A 41-298 order
 Evidence X-RAY 3rkb A Reference
       Region 3rkb A 1-36 order
       Region 3rkb A 37-40 disorder
       Region 3rkb A 41-298 order
 Evidence X-RAY 3rk9 A Reference
       Region 3rk9 A 1-36 order
       Region 3rk9 A 37-40 disorder
       Region 3rk9 A 41-298 order
 Evidence X-RAY 3rk7 A Reference
       Region 3rk7 A 1-36 order
       Region 3rk7 A 37-40 disorder
       Region 3rk7 A 41-298 order
 Evidence X-RAY 3rk5 A Reference
       Region 3rk5 A 1-36 order
       Region 3rk5 A 37-40 disorder
       Region 3rk5 A 41-298 order
 Evidence X-RAY 4rj3 A Reference
       Region 4rj3 A 1-37 order
       Region 4rj3 A 38-44 disorder
       Region 4rj3 A 45-295 order
       Region 4rj3 A 296-298 disorder
 Evidence X-RAY 3rjc A Reference
       Region 3rjc A 1-36 order
       Region 3rjc A 37-40 disorder
       Region 3rjc A 41-298 order
 Evidence X-RAY 3ral A Reference
       Region 3ral A 1-36 order
       Region 3ral A 37-44 disorder
       Region 3ral A 45-149 order
       Region 3ral A 150-162 disorder
       Region 3ral A 163-298 order
 Evidence X-RAY 3rak A Reference
       Region 3rak A 1-36 order
       Region 3rak A 37-44 disorder
       Region 3rak A 45-149 order
       Region 3rak A 150-162 disorder
       Region 3rak A 163-298 order
 Evidence X-RAY 3rai A Reference
       Region 3rai A 1-36 order
       Region 3rai A 37-40 disorder
       Region 3rai A 41-298 order
 Evidence X-RAY 3rah A Reference
       Region 3rah A 1-36 order
       Region 3rah A 37-44 disorder
       Region 3rah A 45-154 order
       Region 3rah A 155-162 disorder
       Region 3rah A 163-298 order
 Evidence X-RAY 3r9o A Reference
       Region 3r9o A 1-36 order
       Region 3r9o A 37-44 disorder
       Region 3r9o A 45-154 order
       Region 3r9o A 155-162 disorder
       Region 3r9o A 163-298 order
 Evidence X-RAY 3r9n A Reference
       Region 3r9n A 1-36 order
       Region 3r9n A 37-44 disorder
       Region 3r9n A 45-154 order
       Region 3r9n A 155-162 disorder
       Region 3r9n A 163-298 order
 Evidence X-RAY 3r9h A Reference
       Region 3r9h A 1-36 order
       Region 3r9h A 37-40 disorder
       Region 3r9h A 41-298 order
 Evidence X-RAY 3r9d A Reference
       Region 3r9d A 1-36 order
       Region 3r9d A 37-40 disorder
       Region 3r9d A 41-298 order
 Evidence X-RAY 3r8z A Reference
       Region 3r8z A 1-36 order
       Region 3r8z A 37-40 disorder
       Region 3r8z A 41-155 order
       Region 3r8z A 156-159 disorder
       Region 3r8z A 160-298 order
 Evidence X-RAY 3r8v A Reference
       Region 3r8v A 1-36 order
       Region 3r8v A 37-40 disorder
       Region 3r8v A 41-298 order
 Evidence X-RAY 3r8u A Reference
       Region 3r8u A 1-36 order
       Region 3r8u A 37-40 disorder
       Region 3r8u A 41-298 order
 Evidence X-RAY 3r8p A Reference
       Region 3r8p A 1-36 order
       Region 3r8p A 37-40 disorder
       Region 3r8p A 41-298 order
 Evidence X-RAY 3r8m A Reference
       Region 3r8m A 1-36 order
       Region 3r8m A 37-40 disorder
       Region 3r8m A 41-153 order
       Region 3r8m A 154-161 disorder
       Region 3r8m A 162-298 order
 Evidence X-RAY 3r8l A Reference
       Region 3r8l A 1-36 order
       Region 3r8l A 37-40 disorder
       Region 3r8l A 41-298 order
 Evidence X-RAY 3r83 A Reference
       Region 3r83 A 1-36 order
       Region 3r83 A 37-40 disorder
       Region 3r83 A 41-298 order
 Evidence X-RAY 3r7y A Reference
       Region 3r7y A 1-36 order
       Region 3r7y A 37-40 disorder
       Region 3r7y A 41-298 order
 Evidence X-RAY 3r7v A Reference
       Region 3r7v A 1-36 order
       Region 3r7v A 37-40 disorder
       Region 3r7v A 41-298 order
 Evidence X-RAY 3r7u A Reference
       Region 3r7u A 1-36 order
       Region 3r7u A 37-44 disorder
       Region 3r7u A 45-154 order
       Region 3r7u A 155-162 disorder
       Region 3r7u A 163-298 order
 Evidence X-RAY 3r7i A Reference
       Region 3r7i A 1-36 order
       Region 3r7i A 37-44 disorder
       Region 3r7i A 45-154 order
       Region 3r7i A 155-162 disorder
       Region 3r7i A 163-298 order
 Evidence X-RAY 3r7e A Reference
       Region 3r7e A 1-36 order
       Region 3r7e A 37-40 disorder
       Region 3r7e A 41-298 order
 Evidence X-RAY 3r73 A Reference
       Region 3r73 A 1-36 order
       Region 3r73 A 37-40 disorder
       Region 3r73 A 41-298 order
 Evidence X-RAY 3r71 A Reference
       Region 3r71 A 1-36 order
       Region 3r71 A 37-40 disorder
       Region 3r71 A 41-298 order
 Evidence X-RAY 1r78 A Reference
       Region 1r78 A 1-37 order
       Region 1r78 A 38-46 disorder
       Region 1r78 A 47-147 order
       Region 1r78 A 148-163 disorder
       Region 1r78 A 164-298 order
 Evidence X-RAY 3r6x A Reference
       Region 3r6x A 1-36 order
       Region 3r6x A 37-40 disorder
       Region 3r6x A 41-298 order
 Evidence X-RAY 2r64 A Reference
       Region 2r64 A 1-35 order
       Region 2r64 A 36-43 disorder
       Region 2r64 A 44-152 order
       Region 2r64 A 153-163 disorder
       Region 2r64 A 164-298 order
 Evidence X-RAY 2r3r A Reference
       Region 2r3r A 1-35 order
       Region 2r3r A 36-43 disorder
       Region 2r3r A 44-298 order
 Evidence X-RAY 2r3q A Reference
       Region 2r3q A 1-35 order
       Region 2r3q A 36-46 disorder
       Region 2r3q A 47-298 order
 Evidence X-RAY 2r3p A Reference
       Region 2r3p A 1-35 order
       Region 2r3p A 36-43 disorder
       Region 2r3p A 44-298 order
 Evidence X-RAY 2r3o A Reference
       Region 2r3o A 1-35 order
       Region 2r3o A 36-43 disorder
       Region 2r3o A 44-298 order
 Evidence X-RAY 2r3n A Reference
       Region 2r3n A 1-35 order
       Region 2r3n A 36-43 disorder
       Region 2r3n A 44-148 order
       Region 2r3n A 149-162 disorder
       Region 2r3n A 163-298 order
 Evidence X-RAY 2r3m A Reference
       Region 2r3m A 1-35 order
       Region 2r3m A 36-43 disorder
       Region 2r3m A 44-150 order
       Region 2r3m A 151-161 disorder
       Region 2r3m A 162-298 order
 Evidence X-RAY 2r3l A Reference
       Region 2r3l A 1-36 order
       Region 2r3l A 37-43 disorder
       Region 2r3l A 44-149 order
       Region 2r3l A 150-164 disorder
       Region 2r3l A 165-298 order
 Evidence X-RAY 2r3k A Reference
       Region 2r3k A 1-35 order
       Region 2r3k A 36-43 disorder
       Region 2r3k A 44-150 order
       Region 2r3k A 151-162 disorder
       Region 2r3k A 163-298 order
 Evidence X-RAY 2r3j A Reference
       Region 2r3j A 1-35 order
       Region 2r3j A 36-43 disorder
       Region 2r3j A 44-150 order
       Region 2r3j A 151-161 disorder
       Region 2r3j A 162-298 order
 Evidence X-RAY 2r3i A Reference
       Region 2r3i A 1-35 order
       Region 2r3i A 36-43 disorder
       Region 2r3i A 44-298 order
 Evidence X-RAY 2r3h A Reference
       Region 2r3h A 1-35 order
       Region 2r3h A 36-44 disorder
       Region 2r3h A 45-298 order
 Evidence X-RAY 2r3g A Reference
       Region 2r3g A 1-35 order
       Region 2r3g A 36-46 disorder
       Region 2r3g A 47-298 order
 Evidence X-RAY 2r3f A Reference
       Region 2r3f A 1-35 order
       Region 2r3f A 36-43 disorder
       Region 2r3f A 44-298 order
 Evidence X-RAY 3r28 A Reference
       Region 3r28 A 1-36 order
       Region 3r28 A 37-40 disorder
       Region 3r28 A 41-298 order
 Evidence X-RAY 3r1y A Reference
       Region 3r1y A 1-36 order
       Region 3r1y A 37-40 disorder
       Region 3r1y A 41-298 order
 Evidence X-RAY 3r1s A Reference
       Region 3r1s A 1-36 order
       Region 3r1s A 37-40 disorder
       Region 3r1s A 41-298 order
 Evidence X-RAY 3r1q A Reference
       Region 3r1q A 1-36 order
       Region 3r1q A 37-40 disorder
       Region 3r1q A 41-298 order
 Evidence X-RAY 3qzi A Reference
       Region 3qzi A 1-36 order
       Region 3qzi A 37-40 disorder
       Region 3qzi A 41-298 order
 Evidence X-RAY 3qzh A Reference
       Region 3qzh A 1-36 order
       Region 3qzh A 37-40 disorder
       Region 3qzh A 41-298 order
 Evidence X-RAY 3qzg A Reference
       Region 3qzg A 1-36 order
       Region 3qzg A 37-40 disorder
       Region 3qzg A 41-298 order
 Evidence X-RAY 3qzf A Reference
       Region 3qzf A 1-36 order
       Region 3qzf A 37-40 disorder
       Region 3qzf A 41-298 order
 Evidence X-RAY 3qxp A Reference
       Region 3qxp A 1-36 order
       Region 3qxp A 37-40 disorder
       Region 3qxp A 41-298 order
 Evidence X-RAY 3qxo A Reference
       Region 3qxo A 1-36 order
       Region 3qxo A 37-40 disorder
       Region 3qxo A 41-298 order
 Evidence X-RAY 3qx4 A Reference
       Region 3qx4 A 1-36 order
       Region 3qx4 A 37-40 disorder
       Region 3qx4 A 41-298 order
 Evidence X-RAY 3qx2 A Reference
       Region 3qx2 A 1-36 order
       Region 3qx2 A 37-40 disorder
       Region 3qx2 A 41-298 order
 Evidence X-RAY 3qwk A Reference
       Region 3qwk A 1-36 order
       Region 3qwk A 37-40 disorder
       Region 3qwk A 41-298 order
 Evidence X-RAY 3qwj A Reference
       Region 3qwj A 1-36 order
       Region 3qwj A 37-40 disorder
       Region 3qwj A 41-298 order
 Evidence X-RAY 3qu0 A Reference
       Region 3qu0 A 1-36 order
       Region 3qu0 A 37-40 disorder
       Region 3qu0 A 41-298 order
 Evidence X-RAY 3qtz A Reference
       Region 3qtz A 1-36 order
       Region 3qtz A 37-40 disorder
       Region 3qtz A 41-298 order
 Evidence X-RAY 3qtx A Reference
       Region 3qtx A 1-36 order
       Region 3qtx A 37-40 disorder
       Region 3qtx A 41-298 order
 Evidence X-RAY 3qtw A Reference
       Region 3qtw A 1-36 order
       Region 3qtw A 37-40 disorder
       Region 3qtw A 41-298 order
 Evidence X-RAY 3qtu A Reference
       Region 3qtu A 1-36 order
       Region 3qtu A 37-40 disorder
       Region 3qtu A 41-298 order
 Evidence X-RAY 3qts A Reference
       Region 3qts A 1-36 order
       Region 3qts A 37-44 disorder
       Region 3qts A 45-154 order
       Region 3qts A 155-162 disorder
       Region 3qts A 163-298 order
 Evidence X-RAY 3qtr A Reference
       Region 3qtr A 1-36 order
       Region 3qtr A 37-44 disorder
       Region 3qtr A 45-154 order
       Region 3qtr A 155-162 disorder
       Region 3qtr A 163-298 order
 Evidence X-RAY 3qtq A Reference
       Region 3qtq A 1-36 order
       Region 3qtq A 37-40 disorder
       Region 3qtq A 41-298 order
 Evidence X-RAY 3qru A Reference
       Region 3qru A 1-37 order
       Region 3qru A 38-40 disorder
       Region 3qru A 41-298 order
 Evidence X-RAY 3qrt A Reference
       Region 3qrt A 1-36 order
       Region 3qrt A 37-40 disorder
       Region 3qrt A 41-298 order
 Evidence X-RAY 3qql A Reference
       Region 3qql A 1-36 order
       Region 3qql A 37-40 disorder
       Region 3qql A 41-298 order
 Evidence X-RAY 3qqk A Reference
       Region 3qqk A 1-36 order
       Region 3qqk A 37-40 disorder
       Region 3qqk A 41-298 order
 Evidence X-RAY 3qqj A Reference
       Region 3qqj A 1-36 order
       Region 3qqj A 37-40 disorder
       Region 3qqj A 41-298 order
 Evidence X-RAY 3qqh A Reference
       Region 3qqh A 1-36 order
       Region 3qqh A 37-40 disorder
       Region 3qqh A 41-298 order
 Evidence X-RAY 3qqg A Reference
       Region 3qqg A 1-36 order
       Region 3qqg A 37-40 disorder
       Region 3qqg A 41-298 order
 Evidence X-RAY 3qqf A Reference
       Region 3qqf A 1-36 order
       Region 3qqf A 37-40 disorder
       Region 3qqf A 41-298 order
 Evidence X-RAY 3ql8 A Reference
       Region 3ql8 A 1-36 order
       Region 3ql8 A 37-40 disorder
       Region 3ql8 A 41-298 order
 Evidence X-RAY 3py1 A Reference
       Region 3py1 A 1-298 order
 Evidence X-RAY 3py0 A Reference
       Region 3py0 A 1-36 order
       Region 3py0 A 37-40 disorder
       Region 3py0 A 41-298 order
 Evidence X-RAY 1pye A Reference
       Region 1pye A 1-12 order
       Region 1pye A 13-15 disorder
       Region 1pye A 16-35 order
       Region 1pye A 36-46 disorder
       Region 1pye A 47-73 order
       Region 1pye A 74-75 disorder
       Region 1pye A 76-146 order
       Region 1pye A 147-162 disorder
       Region 1pye A 163-298 order
 Evidence X-RAY 3pxz A Reference
       Region 3pxz A 1-298 order
 Evidence X-RAY 3pxy A Reference
       Region 3pxy A 1-36 order
       Region 3pxy A 37-40 disorder
       Region 3pxy A 41-298 order
 Evidence X-RAY 3pxr A Reference
       Region 3pxr A 1-36 order
       Region 3pxr A 37-40 disorder
       Region 3pxr A 41-298 order
 Evidence X-RAY 3pxq A Reference
       Region 3pxq A 1-36 order
       Region 3pxq A 37-40 disorder
       Region 3pxq A 41-298 order
 Evidence X-RAY 3pxf A Reference
       Region 3pxf A 1-298 order
 Evidence X-RAY 1pxp A Reference
       Region 1pxp A 1-36 order
       Region 1pxp A 37-40 disorder
       Region 1pxp A 41-298 order
 Evidence X-RAY 1pxo A Reference
       Region 1pxo A 1-36 order
       Region 1pxo A 37-40 disorder
       Region 1pxo A 41-298 order
 Evidence X-RAY 1pxn A Reference
       Region 1pxn A 1-36 order
       Region 1pxn A 37-40 disorder
       Region 1pxn A 41-298 order
 Evidence X-RAY 1pxm A Reference
       Region 1pxm A 1-35 order
       Region 1pxm A 36-43 disorder
       Region 1pxm A 44-298 order
 Evidence X-RAY 1pxl A Reference
       Region 1pxl A 1-35 order
       Region 1pxl A 36-43 disorder
       Region 1pxl A 44-298 order
 Evidence X-RAY 1pxk A Reference
       Region 1pxk A 1-35 order
       Region 1pxk A 36-43 disorder
       Region 1pxk A 44-298 order
 Evidence X-RAY 1pxj A Reference
       Region 1pxj A 1-36 order
       Region 1pxj A 37-40 disorder
       Region 1pxj A 41-298 order
 Evidence X-RAY 1pxi A Reference
       Region 1pxi A 1-36 order
       Region 1pxi A 37-40 disorder
       Region 1pxi A 41-298 order
 Evidence X-RAY 1pw2 A Reference
       Region 1pw2 A 1-36 order
       Region 1pw2 A 37-40 disorder
       Region 1pw2 A 41-298 order
 Evidence X-RAY 3pj8 A Reference
       Region 3pj8 A 1-36 order
       Region 3pj8 A 37-39 disorder
       Region 3pj8 A 40-154 order
       Region 3pj8 A 155-162 disorder
       Region 3pj8 A 163-298 order
 Evidence X-RAY 1pf8 A Reference
       Region 1pf8 A 1-298 order
 Evidence X-RAY 1p2a A Reference
       Region 1p2a A 1-12 order
       Region 1p2a A 13-15 disorder
       Region 1p2a A 16-37 order
       Region 1p2a A 38-47 disorder
       Region 1p2a A 48-149 order
       Region 1p2a A 150-163 disorder
       Region 1p2a A 164-298 order
 Evidence X-RAY 5osm A Reference
       Region 5osm A 1-36 order
       Region 5osm A 37-44 disorder
       Region 5osm A 45-296 order
       Region 5osm A 297-298 disorder
 Evidence X-RAY 5osj A Reference
       Region 5osj A 1-1 disorder
       Region 5osj A 2-38 order
       Region 5osj A 39-41 disorder
       Region 5osj A 42-296 order
       Region 5osj A 297-298 disorder
 Evidence X-RAY 5oo0 A Reference
       Region 5oo0 A 1-1 disorder
       Region 5oo0 A 2-36 order
       Region 5oo0 A 37-43 disorder
       Region 5oo0 A 44-296 order
       Region 5oo0 A 297-298 disorder
 Evidence X-RAY 1oit A Reference
       Region 1oit A 1-2 disorder
       Region 1oit A 3-25 order
       Region 1oit A 26-26 disorder
       Region 1oit A 27-35 order
       Region 1oit A 36-46 disorder
       Region 1oit A 47-151 order
       Region 1oit A 152-162 disorder
       Region 1oit A 163-298 order
 Evidence X-RAY 1oir A Reference
       Region 1oir A 1-37 order
       Region 1oir A 38-46 disorder
       Region 1oir A 47-296 order
       Region 1oir A 297-298 disorder
 Evidence X-RAY 1oiq A Reference
       Region 1oiq A 1-11 order
       Region 1oiq A 12-15 disorder
       Region 1oiq A 16-35 order
       Region 1oiq A 36-46 disorder
       Region 1oiq A 47-72 order
       Region 1oiq A 73-75 disorder
       Region 1oiq A 76-148 order
       Region 1oiq A 149-164 disorder
       Region 1oiq A 165-298 order
 Evidence X-RAY 3ns9 A Reference
       Region 3ns9 A 1-2 disorder
       Region 3ns9 A 3-35 order
       Region 3ns9 A 36-42 disorder
       Region 3ns9 A 43-298 order
 Evidence X-RAY 4nj3 A Reference
       Region 4nj3 A 1-37 order
       Region 4nj3 A 38-45 disorder
       Region 4nj3 A 46-149 order
       Region 4nj3 A 150-161 disorder
       Region 4nj3 A 162-298 order
 Evidence X-RAY 5mhq A Reference
       Region 5mhq A 1-37 order
       Region 5mhq A 38-46 disorder
       Region 5mhq A 47-298 order
 Evidence X-RAY 4lyn A Reference
       Region 4lyn A 1-152 order
       Region 4lyn A 153-163 disorder
       Region 4lyn A 164-298 order
 Evidence X-RAY 3lfs A Reference
       Region 3lfs A 1-36 order
       Region 3lfs A 37-44 disorder
       Region 3lfs A 45-298 order
 Evidence X-RAY 3lfq A Reference
       Region 3lfq A 1-36 order
       Region 3lfq A 37-45 disorder
       Region 3lfq A 46-298 order
 Evidence X-RAY 3lfn A Reference
       Region 3lfn A 1-36 order
       Region 3lfn A 37-40 disorder
       Region 3lfn A 41-151 order
       Region 3lfn A 152-160 disorder
       Region 3lfn A 161-298 order
 Evidence X-RAY 3le6 A Reference
       Region 3le6 A 1-35 order
       Region 3le6 A 36-44 disorder
       Region 3le6 A 45-72 order
       Region 3le6 A 73-74 disorder
       Region 3le6 A 75-294 order
       Region 3le6 A 295-298 disorder
 Evidence X-RAY 1ke9 A Reference
       Region 1ke9 A 1-36 order
       Region 1ke9 A 37-43 disorder
       Region 1ke9 A 44-152 order
       Region 1ke9 A 153-162 disorder
       Region 1ke9 A 163-298 order
 Evidence X-RAY 1ke8 A Reference
       Region 1ke8 A 1-36 order
       Region 1ke8 A 37-43 disorder
       Region 1ke8 A 44-153 order
       Region 1ke8 A 154-162 disorder
       Region 1ke8 A 163-298 order
 Evidence X-RAY 1ke7 A Reference
       Region 1ke7 A 1-36 order
       Region 1ke7 A 37-43 disorder
       Region 1ke7 A 44-152 order
       Region 1ke7 A 153-162 disorder
       Region 1ke7 A 163-298 order
 Evidence X-RAY 1ke6 A Reference
       Region 1ke6 A 1-36 order
       Region 1ke6 A 37-43 disorder
       Region 1ke6 A 44-152 order
       Region 1ke6 A 153-163 disorder
       Region 1ke6 A 164-298 order
 Evidence X-RAY 1ke5 A Reference
       Region 1ke5 A 1-36 order
       Region 1ke5 A 37-43 disorder
       Region 1ke5 A 44-152 order
       Region 1ke5 A 153-162 disorder
       Region 1ke5 A 163-298 order
 Evidence X-RAY 4kd1 A Reference
       Region 4kd1 A 1-298 order
 Evidence X-RAY 5k4j A Reference
       Region 5k4j A 1-36 order
       Region 5k4j A 37-43 disorder
       Region 5k4j A 44-151 order
       Region 5k4j A 152-161 disorder
       Region 5k4j A 162-298 order
 Evidence X-RAY 1jvp P Reference
       Region 1jvp P 1-36 order
       Region 1jvp P 37-43 disorder
       Region 1jvp P 44-152 order
       Region 1jvp P 153-162 disorder
       Region 1jvp P 163-298 order
 Evidence X-RAY 1jsv A Reference
       Region 1jsv A 1-35 order
       Region 1jsv A 36-46 disorder
       Region 1jsv A 47-298 order
 Evidence X-RAY 5jq8 A Reference
       Region 5jq8 A 1-2 disorder
       Region 5jq8 A 3-35 order
       Region 5jq8 A 36-44 disorder
       Region 5jq8 A 45-152 order
       Region 5jq8 A 153-161 disorder
       Region 5jq8 A 162-298 order
 Evidence X-RAY 5jq5 A Reference
       Region 5jq5 A 1-2 disorder
       Region 5jq5 A 3-36 order
       Region 5jq5 A 37-45 disorder
       Region 5jq5 A 46-298 order
 Evidence X-RAY 2j9m A Reference
       Region 2j9m A 1-36 order
       Region 2j9m A 37-44 disorder
       Region 2j9m A 45-148 order
       Region 2j9m A 149-163 disorder
       Region 2j9m A 164-298 order
 Evidence X-RAY 3igg A Reference
       Region 3igg A 1-35 order
       Region 3igg A 36-43 disorder
       Region 3igg A 44-298 order
 Evidence X-RAY 3ig7 A Reference
       Region 3ig7 A 1-35 order
       Region 3ig7 A 36-43 disorder
       Region 3ig7 A 44-152 order
       Region 3ig7 A 153-164 disorder
       Region 3ig7 A 165-298 order
 Evidence X-RAY 5iev A Reference
       Region 5iev A 1-37 order
       Region 5iev A 38-42 disorder
       Region 5iev A 43-153 order
       Region 5iev A 154-162 disorder
       Region 5iev A 163-298 order
 Evidence X-RAY 1hcl A Reference
       Region 1hcl A 1-36 order
       Region 1hcl A 37-40 disorder
       Region 1hcl A 41-298 order
 Evidence X-RAY 1hck A Reference
       Region 1hck A 1-36 order
       Region 1hck A 37-40 disorder
       Region 1hck A 41-298 order
 Evidence X-RAY 1h0w A Reference
       Region 1h0w A 1-36 order
       Region 1h0w A 37-43 disorder
       Region 1h0w A 44-156 order
       Region 1h0w A 157-164 disorder
       Region 1h0w A 165-298 order
 Evidence X-RAY 1h0v A Reference
       Region 1h0v A 1-36 order
       Region 1h0v A 37-43 disorder
       Region 1h0v A 44-158 order
       Region 1h0v A 159-161 disorder
       Region 1h0v A 162-298 order
 Evidence X-RAY 1h08 A Reference
       Region 1h08 A 1-35 order
       Region 1h08 A 36-43 disorder
       Region 1h08 A 44-153 order
       Region 1h08 A 154-160 disorder
       Region 1h08 A 161-298 order
 Evidence X-RAY 1h07 A Reference
       Region 1h07 A 1-36 order
       Region 1h07 A 37-43 disorder
       Region 1h07 A 44-150 order
       Region 1h07 A 151-154 disorder
       Region 1h07 A 155-296 order
       Region 1h07 A 297-298 disorder
 Evidence X-RAY 1h01 A Reference
       Region 1h01 A 1-36 order
       Region 1h01 A 37-45 disorder
       Region 1h01 A 46-296 order
       Region 1h01 A 297-298 disorder
 Evidence X-RAY 1h00 A Reference
       Region 1h00 A 1-12 order
       Region 1h00 A 13-14 disorder
       Region 1h00 A 15-35 order
       Region 1h00 A 36-43 disorder
       Region 1h00 A 44-151 order
       Region 1h00 A 152-161 disorder
       Region 1h00 A 162-298 order
 Evidence X-RAY 1gz8 A Reference
       Region 1gz8 A 1-36 order
       Region 1gz8 A 37-43 disorder
       Region 1gz8 A 44-298 order
 Evidence X-RAY 1gij A Reference
       Region 1gij A 1-36 order
       Region 1gij A 37-47 disorder
       Region 1gij A 48-149 order
       Region 1gij A 150-163 disorder
       Region 1gij A 164-298 order
 Evidence X-RAY 1gii A Reference
       Region 1gii A 1-35 order
       Region 1gii A 36-43 disorder
       Region 1gii A 44-152 order
       Region 1gii A 153-163 disorder
       Region 1gii A 164-298 order
 Evidence X-RAY 1gih A Reference
       Region 1gih A 1-36 order
       Region 1gih A 37-44 disorder
       Region 1gih A 45-149 order
       Region 1gih A 150-163 disorder
       Region 1gih A 164-298 order
 Evidence X-RAY 4gcj A Reference
       Region 4gcj A 1-298 order
 Evidence X-RAY 1g5s A Reference
       Region 1g5s A 1-36 order
       Region 1g5s A 37-45 disorder
       Region 1g5s A 46-148 order
       Region 1g5s A 149-162 disorder
       Region 1g5s A 163-298 order
 Evidence X-RAY 3fz1 A Reference
       Region 3fz1 A 1-36 order
       Region 3fz1 A 37-43 disorder
       Region 3fz1 A 44-153 order
       Region 3fz1 A 154-160 disorder
       Region 3fz1 A 161-298 order
 Evidence X-RAY 2fvd A Reference
       Region 2fvd A 1-37 order
       Region 2fvd A 38-49 disorder
       Region 2fvd A 50-149 order
       Region 2fvd A 150-151 disorder
       Region 2fvd A 152-298 order
 Evidence X-RAY 1fvt A Reference
       Region 1fvt A 1-36 order
       Region 1fvt A 37-43 disorder
       Region 1fvt A 44-153 order
       Region 1fvt A 154-162 disorder
       Region 1fvt A 163-298 order
 Evidence X-RAY 5fp6 A Reference
       Region 5fp6 A 1-147 order
       Region 5fp6 A 148-163 disorder
       Region 5fp6 A 164-294 order
       Region 5fp6 A 295-298 disorder
 Evidence X-RAY 5fp5 A Reference
       Region 5fp5 A 1-13 order
       Region 5fp5 A 14-14 disorder
       Region 5fp5 A 15-35 order
       Region 5fp5 A 36-46 disorder
       Region 5fp5 A 47-72 order
       Region 5fp5 A 73-75 disorder
       Region 5fp5 A 76-148 order
       Region 5fp5 A 149-164 disorder
       Region 5fp5 A 165-295 order
       Region 5fp5 A 296-298 disorder
 Evidence X-RAY 4fkw A Reference
       Region 4fkw A 1-37 order
       Region 4fkw A 38-42 disorder
       Region 4fkw A 43-149 order
       Region 4fkw A 150-162 disorder
       Region 4fkw A 163-298 order
 Evidence X-RAY 4fkv A Reference
       Region 4fkv A 1-37 order
       Region 4fkv A 38-42 disorder
       Region 4fkv A 43-150 order
       Region 4fkv A 151-161 disorder
       Region 4fkv A 162-298 order
 Evidence X-RAY 4fku A Reference
       Region 4fku A 1-37 order
       Region 4fku A 38-42 disorder
       Region 4fku A 43-298 order
 Evidence X-RAY 4fkt A Reference
       Region 4fkt A 1-35 order
       Region 4fkt A 36-44 disorder
       Region 4fkt A 45-152 order
       Region 4fkt A 153-161 disorder
       Region 4fkt A 162-296 order
       Region 4fkt A 297-298 disorder
 Evidence X-RAY 4fks A Reference
       Region 4fks A 1-35 order
       Region 4fks A 36-44 disorder
       Region 4fks A 45-150 order
       Region 4fks A 151-162 disorder
       Region 4fks A 163-296 order
       Region 4fks A 297-298 disorder
 Evidence X-RAY 4fkr A Reference
       Region 4fkr A 1-37 order
       Region 4fkr A 38-44 disorder
       Region 4fkr A 45-153 order
       Region 4fkr A 154-162 disorder
       Region 4fkr A 163-298 order
 Evidence X-RAY 4fkq A Reference
       Region 4fkq A 1-37 order
       Region 4fkq A 38-43 disorder
       Region 4fkq A 44-154 order
       Region 4fkq A 155-163 disorder
       Region 4fkq A 164-298 order
 Evidence X-RAY 4fkp A Reference
       Region 4fkp A 1-35 order
       Region 4fkp A 36-44 disorder
       Region 4fkp A 45-152 order
       Region 4fkp A 153-162 disorder
       Region 4fkp A 163-298 order
 Evidence X-RAY 4fko A Reference
       Region 4fko A 1-37 order
       Region 4fko A 38-44 disorder
       Region 4fko A 45-298 order
 Evidence X-RAY 4fkl A Reference
       Region 4fkl A 1-35 order
       Region 4fkl A 36-43 disorder
       Region 4fkl A 44-298 order
 Evidence X-RAY 4fkj A Reference
       Region 4fkj A 1-35 order
       Region 4fkj A 36-44 disorder
       Region 4fkj A 45-151 order
       Region 4fkj A 152-162 disorder
       Region 4fkj A 163-298 order
 Evidence X-RAY 4fki A Reference
       Region 4fki A 1-36 order
       Region 4fki A 37-44 disorder
       Region 4fki A 45-153 order
       Region 4fki A 154-156 disorder
       Region 4fki A 157-298 order
 Evidence X-RAY 4fkg A Reference
       Region 4fkg A 1-35 order
       Region 4fkg A 36-44 disorder
       Region 4fkg A 45-153 order
       Region 4fkg A 154-156 disorder
       Region 4fkg A 157-298 order
 Evidence X-RAY 4ez7 A Reference
       Region 4ez7 A 1-298 order
 Evidence X-RAY 4ez3 A Reference
       Region 4ez3 A 1-36 order
       Region 4ez3 A 37-40 disorder
       Region 4ez3 A 41-298 order
 Evidence X-RAY 3ezv A Reference
       Region 3ezv A 1-36 order
       Region 3ezv A 37-43 disorder
       Region 3ezv A 44-148 order
       Region 3ezv A 149-162 disorder
       Region 3ezv A 163-298 order
 Evidence X-RAY 3ezr A Reference
       Region 3ezr A 1-36 order
       Region 3ezr A 37-43 disorder
       Region 3ezr A 44-146 order
       Region 3ezr A 147-164 disorder
       Region 3ezr A 165-298 order
 Evidence X-RAY 2exm A Reference
       Region 2exm A 1-298 order
 Evidence X-RAY 4erw A Reference
       Region 4erw A 1-37 order
       Region 4erw A 38-42 disorder
       Region 4erw A 43-298 order
 Evidence X-RAY 4ek8 A Reference
       Region 4ek8 A 1-35 order
       Region 4ek8 A 36-44 disorder
       Region 4ek8 A 45-152 order
       Region 4ek8 A 153-161 disorder
       Region 4ek8 A 162-298 order
 Evidence X-RAY 4ek6 A Reference
       Region 4ek6 A 1-35 order
       Region 4ek6 A 36-45 disorder
       Region 4ek6 A 46-151 order
       Region 4ek6 A 152-161 disorder
       Region 4ek6 A 162-298 order
 Evidence X-RAY 4ek5 A Reference
       Region 4ek5 A 1-35 order
       Region 4ek5 A 36-44 disorder
       Region 4ek5 A 45-298 order
 Evidence X-RAY 4ek4 A Reference
       Region 4ek4 A 1-35 order
       Region 4ek4 A 36-44 disorder
       Region 4ek4 A 45-296 order
       Region 4ek4 A 297-298 disorder
 Evidence X-RAY 4ek3 A Reference
       Region 4ek3 A 1-35 order
       Region 4ek3 A 36-44 disorder
       Region 4ek3 A 45-296 order
       Region 4ek3 A 297-298 disorder
 Evidence X-RAY 2duv A Reference
       Region 2duv A 1-35 order
       Region 2duv A 36-48 disorder
       Region 2duv A 49-150 order
       Region 2duv A 151-163 disorder
       Region 2duv A 164-298 order
 Evidence X-RAY 2ds1 A Reference
       Region 2ds1 A 1-35 order
       Region 2ds1 A 36-43 disorder
       Region 2ds1 A 44-298 order
 Evidence X-RAY 1dm2 A Reference
       Region 1dm2 A 1-35 order
       Region 1dm2 A 36-44 disorder
       Region 1dm2 A 45-148 order
       Region 1dm2 A 149-163 disorder
       Region 1dm2 A 164-298 order
 Evidence X-RAY 1di8 A Reference
       Region 1di8 A 1-36 order
       Region 1di8 A 37-42 disorder
       Region 1di8 A 43-152 order
       Region 1di8 A 153-161 disorder
       Region 1di8 A 162-298 order
 Evidence X-RAY 5d1j A Reference
       Region 5d1j A 1-12 order
       Region 5d1j A 13-14 disorder
       Region 5d1j A 15-35 order
       Region 5d1j A 36-49 disorder
       Region 5d1j A 50-146 order
       Region 5d1j A 147-163 disorder
       Region 5d1j A 164-298 order
 Evidence X-RAY 4d1z A Reference
       Region 4d1z A 1-2 disorder
       Region 4d1z A 3-11 order
       Region 4d1z A 12-15 disorder
       Region 4d1z A 16-35 order
       Region 4d1z A 36-47 disorder
       Region 4d1z A 48-72 order
       Region 4d1z A 73-74 disorder
       Region 4d1z A 75-147 order
       Region 4d1z A 148-164 disorder
       Region 4d1z A 165-295 order
       Region 4d1z A 296-298 disorder
 Evidence X-RAY 4d1x A Reference
       Region 4d1x A 1-2 disorder
       Region 4d1x A 3-35 order
       Region 4d1x A 36-46 disorder
       Region 4d1x A 47-153 order
       Region 4d1x A 154-164 disorder
       Region 4d1x A 165-298 order
 Evidence X-RAY 2clx A Reference
       Region 2clx A 1-37 order
       Region 2clx A 38-42 disorder
       Region 2clx A 43-298 order
 Evidence X-RAY 1ckp A Reference
       Region 1ckp A 1-35 order
       Region 1ckp A 36-43 disorder
       Region 1ckp A 44-152 order
       Region 1ckp A 153-163 disorder
       Region 1ckp A 164-298 order
 Evidence X-RAY 2c6o A Reference
       Region 2c6o A 1-37 order
       Region 2c6o A 38-43 disorder
       Region 2c6o A 44-296 order
       Region 2c6o A 297-298 disorder
 Evidence X-RAY 2c6m A Reference
       Region 2c6m A 1-37 order
       Region 2c6m A 38-43 disorder
       Region 2c6m A 44-296 order
       Region 2c6m A 297-298 disorder
 Evidence X-RAY 2c6l A Reference
       Region 2c6l A 1-36 order
       Region 2c6l A 37-43 disorder
       Region 2c6l A 44-298 order
 Evidence X-RAY 2c6k A Reference
       Region 2c6k A 1-37 order
       Region 2c6k A 38-43 disorder
       Region 2c6k A 44-298 order
 Evidence X-RAY 2c6i A Reference
       Region 2c6i A 1-37 order
       Region 2c6i A 38-43 disorder
       Region 2c6i A 44-298 order
 Evidence X-RAY 2c69 A Reference
       Region 2c69 A 1-37 order
       Region 2c69 A 38-43 disorder
       Region 2c69 A 44-298 order
 Evidence X-RAY 2c68 A Reference
       Region 2c68 A 1-37 order
       Region 2c68 A 38-43 disorder
       Region 2c68 A 44-296 order
       Region 2c68 A 297-298 disorder
 Evidence X-RAY 2c5y A Reference
       Region 2c5y A 1-35 order
       Region 2c5y A 36-42 disorder
       Region 2c5y A 43-297 order
       Region 2c5y A 298-298 disorder
 Evidence X-RAY 4bzd A Reference
       Region 4bzd A 1-13 order
       Region 4bzd A 14-14 disorder
       Region 4bzd A 15-37 order
       Region 4bzd A 38-43 disorder
       Region 4bzd A 44-148 order
       Region 4bzd A 149-162 disorder
       Region 4bzd A 163-298 order
 Evidence X-RAY 2bts A Reference
       Region 2bts A 1-36 order
       Region 2bts A 37-45 disorder
       Region 2bts A 46-148 order
       Region 2bts A 149-163 disorder
       Region 2bts A 164-298 order
 Evidence X-RAY 2btr A Reference
       Region 2btr A 1-35 order
       Region 2btr A 36-46 disorder
       Region 2btr A 47-149 order
       Region 2btr A 150-161 disorder
       Region 2btr A 162-298 order
 Evidence X-RAY 2bhh A Reference
       Region 2bhh A 1-35 order
       Region 2bhh A 36-44 disorder
       Region 2bhh A 45-148 order
       Region 2bhh A 149-163 disorder
       Region 2bhh A 164-298 order
 Evidence X-RAY 2bhe A Reference
       Region 2bhe A 1-35 order
       Region 2bhe A 36-44 disorder
       Region 2bhe A 45-148 order
       Region 2bhe A 149-163 disorder
       Region 2bhe A 164-298 order
 Evidence X-RAY 4bgh A Reference
       Region 4bgh A 1-35 order
       Region 4bgh A 36-44 disorder
       Region 4bgh A 45-149 order
       Region 4bgh A 150-163 disorder
       Region 4bgh A 164-298 order
 Evidence X-RAY 2b55 A Reference
       Region 2b55 A 1-35 order
       Region 2b55 A 36-42 disorder
       Region 2b55 A 43-147 order
       Region 2b55 A 148-162 disorder
       Region 2b55 A 163-298 order
 Evidence X-RAY 2b54 A Reference
       Region 2b54 A 1-298 order
 Evidence X-RAY 2b53 A Reference
       Region 2b53 A 1-36 order
       Region 2b53 A 37-40 disorder
       Region 2b53 A 41-298 order
 Evidence X-RAY 2b52 A Reference
       Region 2b52 A 1-36 order
       Region 2b52 A 37-40 disorder
       Region 2b52 A 41-149 order
       Region 2b52 A 150-160 disorder
       Region 2b52 A 161-298 order
 Evidence X-RAY 1b39 A Reference
       Region 1b39 A 1-35 order
       Region 1b39 A 36-43 disorder
       Region 1b39 A 44-152 order
       Region 1b39 A 153-164 disorder
       Region 1b39 A 165-298 order
 Evidence X-RAY 1b38 A Reference
       Region 1b38 A 1-35 order
       Region 1b38 A 36-43 disorder
       Region 1b38 A 44-298 order
 Evidence X-RAY 1aq1 A Reference
       Region 1aq1 A 1-35 order
       Region 1aq1 A 36-43 disorder
       Region 1aq1 A 44-148 order
       Region 1aq1 A 149-161 disorder
       Region 1aq1 A 162-298 order
 Evidence X-RAY 5ano A Reference
       Region 5ano A 1-35 order
       Region 5ano A 36-45 disorder
       Region 5ano A 46-151 order
       Region 5ano A 152-162 disorder
       Region 5ano A 163-298 order
 Evidence X-RAY 5ank A Reference
       Region 5ank A 1-36 order
       Region 5ank A 37-45 disorder
       Region 5ank A 46-71 order
       Region 5ank A 72-75 disorder
       Region 5ank A 76-152 order
       Region 5ank A 153-164 disorder
       Region 5ank A 165-298 order
 Evidence X-RAY 5anj A Reference
       Region 5anj A 1-2 disorder
       Region 5anj A 3-157 order
       Region 5anj A 158-162 disorder
       Region 5anj A 163-298 order
 Evidence X-RAY 5ani A Reference
       Region 5ani A 1-1 disorder
       Region 5ani A 2-36 order
       Region 5ani A 37-45 disorder
       Region 5ani A 46-154 order
       Region 5ani A 155-162 disorder
       Region 5ani A 163-298 order
 Evidence X-RAY 5ang A Reference
       Region 5ang A 1-1 disorder
       Region 5ang A 2-13 order
       Region 5ang A 14-15 disorder
       Region 5ang A 16-35 order
       Region 5ang A 36-45 disorder
       Region 5ang A 46-72 order
       Region 5ang A 73-75 disorder
       Region 5ang A 76-148 order
       Region 5ang A 149-162 disorder
       Region 5ang A 163-298 order
 Evidence X-RAY 5ane A Reference
       Region 5ane A 1-36 order
       Region 5ane A 37-40 disorder
       Region 5ane A 41-298 order
 Evidence X-RAY 5and A Reference
       Region 5and A 1-1 disorder
       Region 5and A 2-35 order
       Region 5and A 36-44 disorder
       Region 5and A 45-152 order
       Region 5and A 153-163 disorder
       Region 5and A 164-294 order
       Region 5and A 295-298 disorder
 Evidence X-RAY 4acm A Reference
       Region 4acm A 1-36 order
       Region 4acm A 37-43 disorder
       Region 4acm A 44-72 order
       Region 4acm A 73-74 disorder
       Region 4acm A 75-150 order
       Region 4acm A 151-162 disorder
       Region 4acm A 163-298 order
 Evidence X-RAY 2a4l A Reference
       Region 2a4l A 1-35 order
       Region 2a4l A 36-47 disorder
       Region 2a4l A 48-298 order
 Evidence X-RAY 5a14 A Reference
       Region 5a14 A 1-40 order
       Region 5a14 A 41-42 disorder
       Region 5a14 A 43-153 order
       Region 5a14 A 154-163 disorder
       Region 5a14 A 164-296 order
       Region 5a14 A 297-298 disorder
 Evidence X-RAY 2a0c X Reference
       Region 2a0c X 1-36 order
       Region 2a0c X 37-40 disorder
       Region 2a0c X 41-298 order
Seq 1-298 Hetero dimer : IID50253Complex
 Evidence X-RAY 4ii5 C Reference
       Region 4ii5 C 1-296 order
       Region 4ii5 C 297-298 disorder
 Evidence X-RAY 4ii5 A Reference
       Region 4ii5 A 1-296 order
       Region 4ii5 A 297-298 disorder
 Evidence X-RAY 4i3z C Reference
       Region 4i3z C 1-296 order
 Evidence X-RAY 4i3z A Reference
       Region 4i3z A 1-296 order
Seq 1-298 Hetero trimer : IID00032Complex
 Evidence X-RAY 1h24 A Reference
       Region 1h24 A 1-293 order
       Region 1h24 A 294-298 disorder
SeqProS verified 153-164 Hetero dimer : IID00605Complex
       Region 1fq1 B 1-296 order
       Region 1b39 A 153-164 disorder
Seqphosphorylation
    14-14 Phosphothreonine
    15-15 Phosphotyrosine; by WEE1
    160-160 Phosphothreonine; by CAK and CCRK
    19-19 Phosphotyrosine
Seqacetylation
    1-1 N-acetylmethionine
    6-6 N6-acetyllysine
 
Prediction
NeProc
Order 1-298
AlphaFold
Disorder 14-14,38-45,47-47,147-164
Order 1-13,15-37,46-46,48-146,165-298
Pfam Hmmer
PF00069 4-286 5.8e-117
Function
Function in SwissProt
Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed:29203878).
Biological Process
See also
Diagram with PDB data
TP53/CCNA2 /CDK2CDK2/CyclinA in complex with an 11-residue recruitment peptide from p53
RB1/E2F1/TFDP1Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
RB1/CCNA1/CDK2CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein
RBL1/E2F5/TFDP1Crystal structure of the E2F5-DP1-p107 ternary complex
CDKN1B/SKP1/SKP2/CKS1BCrystal structure of Skp1-Skp2-Cks1 in complex with a p27 peptide
E2F1/CCNA2/CDK2CDK2/CyclinA in complex with a 9 residue recruitment peptide from E2F