Search Keyword:


Search option:


IID00039
 UniprotP35222
ProteinCatenin beta-1
GeneCTNNB1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
781
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 19-44 Hetero trimer : IID00254Complex
 Evidence X-RAY 1p22 C Reference
       Region 1p22 C 19-29 disorder
       Region 1p22 C 30-40 order
       Region 1p22 C 41-44 disorder
Seq 19-44 Monomer :
 Evidence NMR 2g57 A Reference
       Region 2g57 A 19-44 order
       Region 2g57 A 19-20 high_rmsd
       Region 2g57 A 36-44 high_rmsd
Seq 30-39 Hetero trimer : P04439
 Evidence X-RAY 3fqn C Reference
       Region 3fqn C 30-33 order
       Region 3fqn C 34-35 disorder
       Region 3fqn C 36-39 order
 Evidence X-RAY 3fqr C Reference
       Region 3fqr C 30-39 order
Seq 131-670 Hetero dimer : IID00100Complex
 Evidence X-RAY 1jpw A Reference
       Region 1jpw A 131-150 disorder
       Region 1jpw A 151-549 order
       Region 1jpw A 550-559 disorder
       Region 1jpw A 560-662 order
       Region 1jpw A 663-670 disorder
 Evidence X-RAY 1jpw B Reference
       Region 1jpw B 131-150 disorder
       Region 1jpw B 151-549 order
       Region 1jpw B 550-559 disorder
       Region 1jpw B 560-662 order
       Region 1jpw B 663-670 disorder
 Evidence X-RAY 1jpw C Reference
       Region 1jpw C 131-150 disorder
       Region 1jpw C 151-549 order
       Region 1jpw C 550-559 disorder
       Region 1jpw C 560-662 order
       Region 1jpw C 663-670 disorder
Seq 133-664 Hetero dimer : IID00035Complex
 Evidence X-RAY 1th1 A Reference
       Region 1th1 A 133-144 disorder
       Region 1th1 A 145-552 order
       Region 1th1 A 553-558 disorder
       Region 1th1 A 559-664 order
 Evidence X-RAY 1th1 B Reference
       Region 1th1 B 133-145 disorder
       Region 1th1 B 146-552 order
       Region 1th1 B 553-558 disorder
       Region 1th1 B 559-664 order
Seq 133-664 Hetero dimer : IID50010Complex
 Evidence X-RAY 1g3j A Reference
       Region 1g3j A 133-133 disorder
       Region 1g3j A 134-550 order
       Region 1g3j A 551-559 disorder
       Region 1g3j A 560-664 order
 Evidence X-RAY 1g3j C Reference
       Region 1g3j C 133-222 disorder
       Region 1g3j C 223-554 order
       Region 1g3j C 555-557 disorder
       Region 1g3j C 558-664 order
Seq 133-665 Hetero dimer : IID50017Complex
 Evidence X-RAY 1qz7 A Reference
       Region 1qz7 A 133-141 disorder
       Region 1qz7 A 142-665 order
Seq 135-663 Hetero dimer : IID00100Complex
 Evidence X-RAY 1jdh A Reference
       Region 1jdh A 135-140 order
       Region 1jdh A 141-150 disorder
       Region 1jdh A 151-548 order
       Region 1jdh A 549-559 disorder
       Region 1jdh A 560-663 order
Seq 138-663 Hetero dimer : IID00001Complex
 Evidence X-RAY 3tx7 A Reference
       Region 3tx7 A 138-147 disorder
       Region 3tx7 A 148-548 order
       Region 3tx7 A 549-558 disorder
       Region 3tx7 A 559-661 order
       Region 3tx7 A 662-663 disorder
Seq 138-686 Hetero trimer : IID00002Complex,IID00100Complex
 Evidence X-RAY 2gl7 A Reference
       Region 2gl7 A 138-141 disorder
       Region 2gl7 A 142-549 order
       Region 2gl7 A 550-559 disorder
       Region 2gl7 A 560-663 order
       Region 2gl7 A 664-686 disorder
 Evidence X-RAY 2gl7 D Reference
       Region 2gl7 D 138-146 disorder
       Region 2gl7 D 147-549 order
       Region 2gl7 D 550-559 disorder
       Region 2gl7 D 560-662 order
       Region 2gl7 D 663-686 disorder
Seq 138-781 Monomer :
 Evidence X-RAY 2z6h A Reference
       Region 2z6h A 138-148 disorder
       Region 2z6h A 149-550 order
       Region 2z6h A 551-560 disorder
       Region 2z6h A 561-691 order
       Region 2z6h A 692-781 disorder
Seq 141-305 Hetero dimer : IID00002Complex
 Evidence X-RAY 3sl9 A Reference
       Region 3sl9 A 141-141 disorder
       Region 3sl9 A 142-305 order
 Evidence X-RAY 3sl9 B Reference
       Region 3sl9 B 141-305 order
 Evidence X-RAY 3sl9 E Reference
       Region 3sl9 E 141-305 order
 Evidence X-RAY 3sl9 G Reference
       Region 3sl9 G 141-147 disorder
       Region 3sl9 G 148-305 order
Seq 141-306 Monomer :
 Evidence X-RAY 3sla A Reference
       Region 3sla A 141-306 order
 Evidence X-RAY 3sla B Reference
       Region 3sla B 141-149 disorder
       Region 3sla B 150-305 order
       Region 3sla B 306-306 disorder
 Evidence X-RAY 3sla C Reference
       Region 3sla C 141-150 disorder
       Region 3sla C 151-162 order
       Region 3sla C 163-164 disorder
       Region 3sla C 165-305 order
       Region 3sla C 306-306 disorder
 Evidence X-RAY 3sla D Reference
       Region 3sla D 141-141 disorder
       Region 3sla D 142-305 order
       Region 3sla D 306-306 disorder
 Evidence X-RAY 3sla E Reference
       Region 3sla E 141-144 disorder
       Region 3sla E 145-306 order
Seq 146-664 Hetero trimer : IID00035Complex,IID00102Complex
 Evidence X-RAY 1t08 A Reference
       Region 1t08 A 146-549 order
       Region 1t08 A 550-558 disorder
       Region 1t08 A 559-664 order
Seq 148-665 Hetero dimer :
 Evidence X-RAY 4djs A Reference
       Region 4djs A 148-549 order
       Region 4djs A 550-560 disorder
       Region 4djs A 561-665 order
Seq 150-663 Hetero dimer : IID00102Complex
 Evidence X-RAY 1luj A Reference
       Region 1luj A 150-549 order
       Region 1luj A 550-562 disorder
       Region 1luj A 563-663 order
Seq 772-781 Hetero dimer : IID50015Complex
 Evidence X-RAY 3diw C Reference
       Region 3diw C 772-772 disorder
       Region 3diw C 773-781 order
 Evidence X-RAY 3diw D Reference
       Region 3diw D 772-772 disorder
       Region 3diw D 773-781 order
SeqProS possible 30-40 Same region of zebra fish homolog (Q90424, 97% identity) is disordered in the free state. Hetero trimer : IID00254Complex
       Region 1p22 C 30-40 order
SeqProS verified 141-149 Hetero trimer : IID00002Complex,IID00100Complex
       Region 2gl7 A 142-549 order
       Region 3sla B 141-149 disorder
SeqProS verified 141-149 Hetero dimer : IID00002Complex
       Region 3sl9 A 142-305 order
       Region 3sl9 B 141-305 order
       Region 3sl9 E 141-305 order
       Region 3sla B 141-149 disorder
SeqProS verified 773-781 Hetero dimer : IID50015Complex
       Region 3diw C 773-781 order
       Region 3diw D 773-781 order
       Region 2z6h A 692-781 disorder
Seqphosphorylation
    675-675 Phosphoserine
    556-556 Phosphothreonine
    552-552 Phosphoserine
    556-556 (Microbial infection) Phosphothreonine
    331-331 Phosphotyrosine; by PTK6
    333-333 Phosphotyrosine; by SRC and PTK6
    246-246 Phosphoserine; by CDK5
    191-191 Phosphoserine; by CDK5
    64-64 Phosphotyrosine; by PTK6
    142-142 Phosphotyrosine; by FYN and PTK6
    41-41 Phosphothreonine; by GSK3-beta
    45-45 Phosphoserine
    29-29 Phosphoserine; by GSK3-beta
    33-33 Phosphoserine; by GSK3-beta and HIPK2
    37-37 Phosphoserine; by GSK3-beta and HIPK2
    23-23 Phosphoserine; by GSK3-beta; alternate
Seqacetylation
    49-49 N6-acetyllysine
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-116,686-781
Order 117-552,558-685
ProS 4-9,20-74,84-116,686-735,745-781
AlphaFold
Disorder 1-88,108-108,554-559,684-781
Order 89-107,109-553,560-683
Pfam Hmmer
PF00514 224-264 6.8e-07
PF00514 350-390 1.1e-09
PF00514 431-473 5.6e-06
PF00514 583-623 8.7e-09
SEG 626-638
Function
Function in SwissProt
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle.
Biological Process
Diagram with PDB data
CTNNB1/BTRC/SKP1Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase
See also
Diagram with PDB data
AXIN1/GSK3BCrystal structure of GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide
APC/CTNNB1Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment