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IID00042
 UniprotP38398
ProteinBreast cancer type 1 susceptibility protein
GeneBRCA1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1863
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-110 Hetero dimer : Q99728
 Evidence NMR 1jm7 A Reference
       Region 1jm7 A 1-103 order
       Region 1jm7 A 103-103 high_rmsd
       Region 1jm7 A 104-110 disorder
Seqdisorder 100-1649
 Evidence NMR¸CD Reference
       Region 100-219 disorder
       Region 170-360 disorder
       Region 219-408 disorder
       Region 219-758 disorder
       Region 219-498 disorder
       Region 360-498 disorder
       Region 360-758 disorder
       Region 408-540 disorder
       Region 444-1057 disorder
       Region 498-663 disorder
       Region 540-758 disorder
       Region 663-894 disorder
       Region 758-936 disorder
       Region 758-1057 disorder
       Region 894-1057 disorder
       Region 936-1113 disorder
       Region 1057-1234 disorder
       Region 1113-1316 disorder
       Region 1234-1443 disorder
       Region 1316-1538 disorder
       Region 1443-1649 disorder
Seq 1646-1859 Hetero dimer : Q6UWZ7
 Evidence X-RAY 4y2g A Reference
       Region 4y2g A 1646-1859 order
 Evidence X-RAY 4y18 F Reference
       Region 4y18 F 1646-1859 order
 Evidence X-RAY 4y18 E Reference
       Region 4y18 E 1646-1859 order
 Evidence X-RAY 4y18 D Reference
       Region 4y18 D 1646-1858 order
       Region 4y18 D 1859-1859 disorder
 Evidence X-RAY 4y18 C Reference
       Region 4y18 C 1646-1859 order
 Evidence X-RAY 4y18 B Reference
       Region 4y18 B 1646-1859 order
 Evidence X-RAY 4y18 H Reference
       Region 4y18 H 1646-1648 disorder
       Region 4y18 H 1649-1859 order
 Evidence X-RAY 4y18 G Reference
       Region 4y18 G 1646-1648 disorder
       Region 4y18 G 1649-1859 order
 Evidence X-RAY 4y18 A Reference
       Region 4y18 A 1646-1859 order
 Evidence X-RAY 4u4a C Reference
       Region 4u4a C 1646-1647 disorder
       Region 4u4a C 1648-1859 order
 Evidence X-RAY 4u4a B Reference
       Region 4u4a B 1646-1859 order
 Evidence X-RAY 4u4a A Reference
       Region 4u4a A 1646-1859 order
 Evidence X-RAY 4jlu A Reference
       Region 4jlu A 1649-1859 order
Seq 1646-1859 Hetero dimer : IID00181Complex
 Evidence X-RAY 1t29 A Reference
       Region 1t29 A 1646-1648 disorder
       Region 1t29 A 1649-1859 order
 Evidence X-RAY 1t15 A Reference
       Region 1t15 A 1646-1648 disorder
       Region 1t15 A 1649-1859 order
Seq 1646-1859 Hetero tetramer : Q6UWZ7
 Evidence X-RAY 4y18 F Reference
       Region 4y18 F 1646-1859 order
 Evidence X-RAY 4y18 D Reference
       Region 4y18 D 1646-1858 order
       Region 4y18 D 1859-1859 disorder
 Evidence X-RAY 4y18 E Reference
       Region 4y18 E 1646-1859 order
 Evidence X-RAY 4y18 C Reference
       Region 4y18 C 1646-1859 order
 Evidence X-RAY 4y18 B Reference
       Region 4y18 B 1646-1859 order
 Evidence X-RAY 4y18 A Reference
       Region 4y18 A 1646-1859 order
 Evidence X-RAY 4y18 H Reference
       Region 4y18 H 1646-1648 disorder
       Region 4y18 H 1649-1859 order
 Evidence X-RAY 4y18 G Reference
       Region 4y18 G 1646-1648 disorder
       Region 4y18 G 1649-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1t2v C Reference
       Region 1t2v C 1646-1648 disorder
       Region 1t2v C 1649-1799 order
       Region 1t2v C 1800-1804 disorder
       Region 1t2v C 1805-1816 order
       Region 1t2v C 1817-1820 disorder
       Region 1t2v C 1821-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 3pxe B Reference
       Region 3pxe B 1646-1646 disorder
       Region 3pxe B 1647-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1y98 A Reference
       Region 1y98 A 1646-1648 disorder
       Region 1y98 A 1649-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1t2v A Reference
       Region 1t2v A 1646-1648 disorder
       Region 1t2v A 1649-1799 order
       Region 1t2v A 1800-1802 disorder
       Region 1t2v A 1803-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 3pxe A Reference
       Region 3pxe A 1646-1646 disorder
       Region 3pxe A 1647-1801 order
       Region 3pxe A 1802-1803 disorder
       Region 3pxe A 1804-1859 order
Seq 1646-1859 Hetero dimer : Q8WXE1
 Evidence X-RAY 4igk B Reference
       Region 4igk B 1646-1815 order
       Region 4igk B 1816-1818 disorder
       Region 4igk B 1819-1859 order
 Evidence X-RAY 4igk A Reference
       Region 4igk A 1646-1815 order
       Region 4igk A 1816-1818 disorder
       Region 4igk A 1819-1859 order
Seq 1646-1859 Hetero dimer : IID00610Complex
 Evidence X-RAY 3coj G Reference
       Region 3coj G 1646-1647 disorder
       Region 3coj G 1648-1693 order
       Region 3coj G 1694-1694 disorder
       Region 3coj G 1695-1814 order
       Region 3coj G 1815-1819 disorder
       Region 3coj G 1820-1859 order
 Evidence X-RAY 3coj F Reference
       Region 3coj F 1646-1648 disorder
       Region 3coj F 1649-1693 order
       Region 3coj F 1694-1694 disorder
       Region 3coj F 1695-1816 order
       Region 3coj F 1817-1819 disorder
       Region 3coj F 1820-1859 order
 Evidence X-RAY 3coj E Reference
       Region 3coj E 1646-1648 disorder
       Region 3coj E 1649-1693 order
       Region 3coj E 1694-1694 disorder
       Region 3coj E 1695-1816 order
       Region 3coj E 1817-1819 disorder
       Region 3coj E 1820-1859 order
 Evidence X-RAY 3coj D Reference
       Region 3coj D 1646-1648 disorder
       Region 3coj D 1649-1693 order
       Region 3coj D 1694-1694 disorder
       Region 3coj D 1695-1816 order
       Region 3coj D 1817-1819 disorder
       Region 3coj D 1820-1859 order
 Evidence X-RAY 3coj C Reference
       Region 3coj C 1646-1647 disorder
       Region 3coj C 1648-1693 order
       Region 3coj C 1694-1694 disorder
       Region 3coj C 1695-1816 order
       Region 3coj C 1817-1819 disorder
       Region 3coj C 1820-1859 order
 Evidence X-RAY 3coj B Reference
       Region 3coj B 1646-1647 disorder
       Region 3coj B 1648-1693 order
       Region 3coj B 1694-1694 disorder
       Region 3coj B 1695-1816 order
       Region 3coj B 1817-1819 disorder
       Region 3coj B 1820-1859 order
 Evidence X-RAY 3coj A Reference
       Region 3coj A 1646-1647 disorder
       Region 3coj A 1648-1693 order
       Region 3coj A 1694-1694 disorder
       Region 3coj A 1695-1816 order
       Region 3coj A 1817-1819 disorder
       Region 3coj A 1820-1859 order
 Evidence X-RAY 3coj X Reference
       Region 3coj X 1646-1647 disorder
       Region 3coj X 1648-1693 order
       Region 3coj X 1694-1694 disorder
       Region 3coj X 1695-1816 order
       Region 3coj X 1817-1819 disorder
       Region 3coj X 1820-1859 order
Seq 1646-1859 Hetero dimer : IID00611Complex
 Evidence X-RAY 4ifi A Reference
       Region 4ifi A 1646-1648 disorder
       Region 4ifi A 1649-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 3pxe D Reference
       Region 3pxe D 1646-1648 disorder
       Region 3pxe D 1649-1797 order
       Region 3pxe D 1798-1802 disorder
       Region 3pxe D 1803-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1t2v B Reference
       Region 1t2v B 1646-1816 order
       Region 1t2v B 1817-1820 disorder
       Region 1t2v B 1821-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1t2v D Reference
       Region 1t2v D 1646-1646 disorder
       Region 1t2v D 1647-1816 order
       Region 1t2v D 1817-1820 disorder
       Region 1t2v D 1821-1828 order
       Region 1t2v D 1829-1829 disorder
       Region 1t2v D 1830-1856 order
       Region 1t2v D 1857-1859 disorder
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 3pxe C Reference
       Region 3pxe C 1646-1646 disorder
       Region 3pxe C 1647-1802 order
       Region 3pxe C 1803-1804 disorder
       Region 3pxe C 1805-1859 order
Seq 1646-1859 Hetero dimer :
 Evidence X-RAY 1t2v E Reference
       Region 1t2v E 1646-1648 disorder
       Region 1t2v E 1649-1859 order
Seq 1646-1859 Monomer :
 Evidence X-RAY 1t2u A Reference
       Region 1t2u A 1646-1648 disorder
       Region 1t2u A 1649-1816 order
       Region 1t2u A 1817-1820 disorder
       Region 1t2u A 1821-1859 order
 Evidence X-RAY 3pxd A Reference
       Region 3pxd A 1646-1648 disorder
       Region 3pxd A 1649-1816 order
       Region 3pxd A 1817-1818 disorder
       Region 3pxd A 1819-1859 order
 Evidence X-RAY 3pxc X Reference
       Region 3pxc X 1646-1648 disorder
       Region 3pxc X 1649-1693 order
       Region 3pxc X 1694-1694 disorder
       Region 3pxc X 1695-1816 order
       Region 3pxc X 1817-1820 disorder
       Region 3pxc X 1821-1859 order
 Evidence X-RAY 3pxb A Reference
       Region 3pxb A 1646-1648 disorder
       Region 3pxb A 1649-1816 order
       Region 3pxb A 1817-1819 disorder
       Region 3pxb A 1820-1859 order
 Evidence X-RAY 3pxa A Reference
       Region 3pxa A 1646-1648 disorder
       Region 3pxa A 1649-1816 order
       Region 3pxa A 1817-1820 disorder
       Region 3pxa A 1821-1859 order
 Evidence X-RAY 4ofb A Reference
       Region 4ofb A 1646-1648 disorder
       Region 4ofb A 1649-1816 order
       Region 4ofb A 1817-1818 disorder
       Region 4ofb A 1819-1859 order
 Evidence X-RAY 1n5o X Reference
       Region 1n5o X 1646-1648 disorder
       Region 1n5o X 1649-1693 order
       Region 1n5o X 1694-1694 disorder
       Region 1n5o X 1695-1816 order
       Region 1n5o X 1817-1819 disorder
       Region 1n5o X 1820-1859 order
 Evidence X-RAY 3k16 A Reference
       Region 3k16 A 1646-1648 disorder
       Region 3k16 A 1649-1859 order
 Evidence X-RAY 3k15 A Reference
       Region 3k15 A 1646-1648 disorder
       Region 3k15 A 1649-1859 order
 Evidence X-RAY 3k0k A Reference
       Region 3k0k A 1646-1648 disorder
       Region 3k0k A 1649-1859 order
 Evidence X-RAY 3k0h A Reference
       Region 3k0h A 1646-1648 disorder
       Region 3k0h A 1649-1859 order
 Evidence X-RAY 1jnx X Reference
       Region 1jnx X 1646-1648 disorder
       Region 1jnx X 1649-1693 order
       Region 1jnx X 1694-1694 disorder
       Region 1jnx X 1695-1816 order
       Region 1jnx X 1817-1819 disorder
       Region 1jnx X 1820-1859 order
 Evidence X-RAY 2ing X Reference
       Region 2ing X 1649-1693 order
       Region 2ing X 1694-1694 disorder
       Region 2ing X 1695-1816 order
       Region 2ing X 1817-1818 disorder
       Region 2ing X 1819-1859 order
Seq 1755-1863 Monomer :
 Evidence NMR 1oqa A Reference
       Region 1oqa A 1755-1863 order
       Region 1oqa A 1755-1756 high_rmsd
       Region 1oqa A 1856-1863 high_rmsd
Seqphosphorylation
    1524-1524 Phosphoserine; by ATM
    1394-1394 Phosphothreonine; by ATR; in vitro
    1542-1542 Phosphoserine
    1423-1423 Phosphoserine; by ATM and ATR
    1457-1457 Phosphoserine; by ATR; in vitro
    1387-1387 Phosphoserine; by ATM and ATR
    1342-1342 Phosphoserine
    1336-1336 Phosphoserine
    1328-1328 Phosphoserine
    1218-1218 Phosphoserine
    1280-1280 Phosphoserine; by ATR; in vitro
    1211-1211 Phosphoserine
    1217-1217 Phosphoserine
    1189-1189 Phosphoserine
    1191-1191 Phosphoserine
    1009-1009 Phosphoserine
    1143-1143 Phosphoserine; by ATR; in vitro
    988-988 Phosphoserine; by CHEK2
    840-840 Phosphoserine
    725-725 Phosphoserine
    753-753 Phosphoserine
    551-551 Phosphoserine
    694-694 Phosphoserine
    708-708 Phosphoserine
    434-434 Phosphoserine
    398-398 Phosphoserine
    423-423 Phosphoserine
    395-395 Phosphoserine
    114-114 Phosphoserine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-3,108-466,474-850,877-950,959-1396,1425-1646
Order 4-107,467-473,851-876,951-958,1397-1424,1647-1863
ProS 117-133,143-150,175-207,219-250,257-353,361-466,474-486,493-573,578-798,802-850,882-950,959-979,990-998,1010-1108,1115-1202,1223-1235,1264-1272,1285-1299,1325-1334,1341-1383,1474-1480,1487-1492,1499-1524,1534-1539,1544-1573,1588-1592,1618-1625
AlphaFold
Disorder 1-6,55-58,102-1391,1421-1648,1800-1802,1817-1818,1860-1863
Order 7-54,59-101,1392-1420,1649-1799,1803-1816,1819-1859
Pfam Hmmer
PF00097 24-64 9.3e-12
PF00533 1642-1723 3.9e-12
PF00533 1756-1842 2e-12
SEG 394-405 ,533-544 ,643-654 ,729-736 ,1209-1223 ,1254-1268 ,1425-1437 ,1572-1587 ,1673-1686
Function
Function in SwissProt
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:12887909, PubMed:10500182, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:12183412, PubMed:11836499, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719).
Biological Process
See also
Diagram with PDB data
PALB2/BRCA2Crystal Structure of a PALB2 / BRCA2 complex
BRIP1/BRCA1Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase