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IID00043
 UniprotP38936
ProteinCyclin-dependent kinase inhibitor 1
GeneCDKN1A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
164
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-94
 Evidence NMR Reference
       Region 1-94 disorder
       Region 9-84 disorder
Seqdisorder 1-164
 Evidence CD Reference
       Region 1-164 disorder
Seq 9-85 Hetero trimer : P11802,P24385
 Evidence X-RAY 6p8h C Reference
       Region 6p8h C 9-13 disorder
       Region 6p8h C 14-67 order
       Region 6p8h C 68-85 disorder
Seqdisorder 125-164
 Evidence NMR Reference
       Region 125-164 disorder
Seq 139-152 Monomer :
 Evidence NMR 6cej A Reference
       Region 6cej A 139-152 order
       Region 6cej A 139-140 high_rmsd
       Region 6cej A 152-152 high_rmsd
 Evidence NMR 6civ C Reference
       Region 6civ C 139-152 order
 Evidence NMR 6cix B Reference
       Region 6cix B 139-152 order
Seq 139-152 Hetero decamer : IID00022Complex
 Evidence X-RAY 6cbi H Reference
       Region 6cbi H 139-141 disorder
       Region 6cbi H 142-152 order
 Evidence X-RAY 6cbi I Reference
       Region 6cbi I 139-143 disorder
       Region 6cbi I 144-151 order
       Region 6cbi I 152-152 disorder
 Evidence X-RAY 6cbi J Reference
       Region 6cbi J 139-141 disorder
       Region 6cbi J 142-152 order
 Evidence X-RAY 6cbi K Reference
       Region 6cbi K 139-141 disorder
       Region 6cbi K 142-152 order
Seq 139-160 Hetero hexamer : IID50102Complex
 Evidence X-RAY 2zvv X Reference
       Region 2zvv X 139-142 disorder
       Region 2zvv X 143-153 order
       Region 2zvv X 154-160 disorder
 Evidence X-RAY 2zvv Y Reference
       Region 2zvv Y 139-141 disorder
       Region 2zvv Y 142-158 order
       Region 2zvv Y 159-160 disorder
Seq 139-160 Hetero hexamer : IID00022Complex
 Evidence X-RAY 5e0u D Reference
       Region 5e0u D 139-142 disorder
       Region 5e0u D 143-160 order
 Evidence X-RAY 5e0u E Reference
       Region 5e0u E 139-141 disorder
       Region 5e0u E 142-160 order
 Evidence X-RAY 5e0u F Reference
       Region 5e0u F 139-142 disorder
       Region 5e0u F 143-160 order
Seq 139-160 Hetero hexamer : IID00022Complex
 Evidence X-RAY 1axc B Reference
       Region 1axc B 139-142 disorder
       Region 1axc B 143-160 order
 Evidence X-RAY 1axc D Reference
       Region 1axc D 139-142 disorder
       Region 1axc D 143-160 order
 Evidence X-RAY 1axc F Reference
       Region 1axc F 139-142 disorder
       Region 1axc F 143-160 order
 Evidence X-RAY 4rjf B Reference
       Region 4rjf B 139-140 disorder
       Region 4rjf B 141-160 order
 Evidence X-RAY 4rjf D Reference
       Region 4rjf D 139-141 disorder
       Region 4rjf D 142-160 order
 Evidence X-RAY 4rjf F Reference
       Region 4rjf F 139-142 disorder
       Region 4rjf F 143-160 order
 Evidence X-RAY 7kq1 B Reference
       Region 7kq1 B 141-155 order
 Evidence X-RAY 7kq1 D Reference
       Region 7kq1 D 141-155 order
 Evidence X-RAY 7kq1 F Reference
       Region 7kq1 F 141-141 disorder
       Region 7kq1 F 142-154 order
       Region 7kq1 F 155-155 disorder
Seq 139-160 Hetero hexamer : IID50110Complex
 Evidence X-RAY 2zvw I Reference
       Region 2zvw I 139-142 disorder
       Region 2zvw I 143-153 order
       Region 2zvw I 154-160 disorder
 Evidence X-RAY 2zvw J Reference
       Region 2zvw J 139-142 disorder
       Region 2zvw J 143-153 order
       Region 2zvw J 154-160 disorder
 Evidence X-RAY 2zvw K Reference
       Region 2zvw K 139-142 disorder
       Region 2zvw K 143-153 order
       Region 2zvw K 154-160 disorder
 Evidence X-RAY 2zvw L Reference
       Region 2zvw L 139-142 disorder
       Region 2zvw L 143-153 order
       Region 2zvw L 154-160 disorder
 Evidence X-RAY 2zvw M Reference
       Region 2zvw M 139-142 disorder
       Region 2zvw M 143-153 order
       Region 2zvw M 154-160 disorder
 Evidence X-RAY 2zvw N Reference
       Region 2zvw N 139-142 disorder
       Region 2zvw N 143-153 order
       Region 2zvw N 154-160 disorder
 Evidence X-RAY 2zvw O Reference
       Region 2zvw O 139-142 disorder
       Region 2zvw O 143-153 order
       Region 2zvw O 154-160 disorder
 Evidence X-RAY 2zvw P Reference
       Region 2zvw P 139-142 disorder
       Region 2zvw P 143-153 order
       Region 2zvw P 154-160 disorder
Seq 141-155 Hetero hexamer : IID00022Complex
 Evidence X-RAY 7kq0 B Reference
       Region 7kq0 B 141-141 disorder
       Region 7kq0 B 142-154 order
       Region 7kq0 B 155-155 disorder
 Evidence X-RAY 7kq0 D Reference
       Region 7kq0 D 141-141 disorder
       Region 7kq0 D 142-155 order
 Evidence X-RAY 7kq0 F Reference
       Region 7kq0 F 141-142 disorder
       Region 7kq0 F 143-155 order
SeqProS verified 14-67 Hetero trimer : P11802,P24385
       Region 6p8h C 14-67 order
       Region 1-94 disorder
SeqProS verified 141-155 Hetero hexamer : IID00022Complex
       Region 7kq0 B 142-154 order
       Region 7kq0 D 142-155 order
       Region 7kq0 F 143-155 order
       Region 125-164 disorder
SeqProS verified 141-160 Hetero hexamer : IID00022Complex
       Region 4rjf B 141-160 order
       Region 4rjf D 142-160 order
       Region 4rjf F 143-160 order
       Region 7kq1 B 141-155 order
       Region 7kq1 D 141-155 order
       Region 7kq1 F 142-154 order
       Region 1axc B 143-160 order
       Region 1axc D 143-160 order
       Region 1axc F 143-160 order
       Region 125-164 disorder
SeqProS verified 142-152 Hetero decamer : IID00022Complex
       Region 6cbi H 142-152 order
       Region 6cbi I 144-151 order
       Region 6cbi J 142-152 order
       Region 6cbi K 142-152 order
       Region 125-164 disorder
SeqProS verified 142-158 Hetero hexamer : IID50102Complex
       Region 2zvv X 143-153 order
       Region 2zvv Y 142-158 order
       Region 125-164 disorder
SeqProS verified 142-160 Hetero hexamer : IID00022Complex
       Region 5e0u D 143-160 order
       Region 5e0u E 142-160 order
       Region 5e0u F 143-160 order
       Region 125-164 disorder
SeqProS verified 143-153 Hetero hexamer : IID50110Complex
       Region 2zvw I 143-153 order
       Region 2zvw J 143-153 order
       Region 2zvw K 143-153 order
       Region 2zvw L 143-153 order
       Region 2zvw M 143-153 order
       Region 2zvw N 143-153 order
       Region 2zvw O 143-153 order
       Region 2zvw P 143-153 order
       Region 125-164 disorder
Seqphosphorylation
    146-146 Phosphoserine; by PKC and NUAK1
    146-146 Phosphoserine; by PKC and NUAK1
    80-80 Phosphothreonine; by LKB1
    114-114 Phosphoserine; by GSK3-beta
    130-130 Phosphoserine
    145-145 Phosphothreonine; by PKA
    160-160 Phosphoserine; by PKC; in vitro
    80-80 Phosphothreonine; by LKB1
    114-114 Phosphoserine; by GSK3-beta
    130-130 Phosphoserine
    145-145 Phosphothreonine; by PKA
    160-160 Phosphoserine; by PKC; in vitro
Seqacetylation
    2-2 N-acetylserine
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-13,77-164
Order 14-76
ProS 77-80,112-116,145-161
AlphaFold
Disorder 1-13,82-141,149-164
Order 14-81,142-148
Pfam Hmmer
PF02234 19-69 1e-20
SEG 81-96
Function
Function in SwissProt
Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
Biological Process
Diagram with PDB data
CDKN1A/PCNAHuman PCNA