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IID00043
 UniprotP38936
ProteinCyclin-dependent kinase inhibitor 1
GeneCDKN1A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
164
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-94
 Evidence NMR Reference
       Region 1-94 disorder
       Region 9-84 disorder
Seqdisorder 1-164
 Evidence CD Reference
       Region 1-164 disorder
Seqdisorder 125-164
 Evidence NMR Reference
       Region 125-164 disorder
Seq 139-160 Hetero hexamer : IID50102Complex
 Evidence X-RAY 2zvv Y Reference
       Region 2zvv Y 139-141 disorder
       Region 2zvv Y 142-158 order
       Region 2zvv Y 159-160 disorder
 Evidence X-RAY 2zvv X Reference
       Region 2zvv X 139-142 disorder
       Region 2zvv X 143-153 order
       Region 2zvv X 154-160 disorder
Seq 139-160 Hetero hexamer : IID00022Complex
 Evidence X-RAY 5e0u F Reference
       Region 5e0u F 139-142 disorder
       Region 5e0u F 143-160 order
 Evidence X-RAY 5e0u E Reference
       Region 5e0u E 139-141 disorder
       Region 5e0u E 142-160 order
 Evidence X-RAY 5e0u D Reference
       Region 5e0u D 139-142 disorder
       Region 5e0u D 143-160 order
Seq 139-160 Hetero hexamer : IID50110Complex
 Evidence X-RAY 2zvw P Reference
       Region 2zvw P 139-142 disorder
       Region 2zvw P 143-153 order
       Region 2zvw P 154-160 disorder
 Evidence X-RAY 2zvw O Reference
       Region 2zvw O 139-142 disorder
       Region 2zvw O 143-153 order
       Region 2zvw O 154-160 disorder
 Evidence X-RAY 2zvw N Reference
       Region 2zvw N 139-142 disorder
       Region 2zvw N 143-153 order
       Region 2zvw N 154-160 disorder
 Evidence X-RAY 2zvw M Reference
       Region 2zvw M 139-142 disorder
       Region 2zvw M 143-153 order
       Region 2zvw M 154-160 disorder
 Evidence X-RAY 2zvw L Reference
       Region 2zvw L 139-142 disorder
       Region 2zvw L 143-153 order
       Region 2zvw L 154-160 disorder
 Evidence X-RAY 2zvw K Reference
       Region 2zvw K 139-142 disorder
       Region 2zvw K 143-153 order
       Region 2zvw K 154-160 disorder
 Evidence X-RAY 2zvw J Reference
       Region 2zvw J 139-142 disorder
       Region 2zvw J 143-153 order
       Region 2zvw J 154-160 disorder
 Evidence X-RAY 2zvw I Reference
       Region 2zvw I 139-142 disorder
       Region 2zvw I 143-153 order
       Region 2zvw I 154-160 disorder
Seq 139-160 Hetero hexamer : IID00022Complex
 Evidence X-RAY 4rjf F Reference
       Region 4rjf F 139-142 disorder
       Region 4rjf F 143-160 order
 Evidence X-RAY 4rjf D Reference
       Region 4rjf D 139-141 disorder
       Region 4rjf D 142-160 order
 Evidence X-RAY 4rjf B Reference
       Region 4rjf B 139-140 disorder
       Region 4rjf B 141-160 order
 Evidence X-RAY 1axc F Reference
       Region 1axc F 139-142 disorder
       Region 1axc F 143-160 order
 Evidence X-RAY 1axc D Reference
       Region 1axc D 139-142 disorder
       Region 1axc D 143-160 order
 Evidence X-RAY 1axc B Reference
       Region 1axc B 139-142 disorder
       Region 1axc B 143-160 order
SeqProS verified 141-160 Hetero hexamer : IID00022Complex
       Region 4rjf B 141-160 order
       Region 4rjf D 142-160 order
       Region 4rjf F 143-160 order
       Region 1axc B 143-160 order
       Region 1axc D 143-160 order
       Region 1axc F 143-160 order
       Region 125-164 disorder
SeqProS verified 142-158 Hetero hexamer : IID50102Complex
       Region 2zvv X 143-153 order
       Region 2zvv Y 142-158 order
       Region 125-164 disorder
SeqProS verified 142-160 Hetero hexamer : IID00022Complex
       Region 5e0u D 143-160 order
       Region 5e0u E 142-160 order
       Region 5e0u F 143-160 order
       Region 125-164 disorder
SeqProS verified 143-153 Hetero hexamer : IID50110Complex
       Region 2zvw I 143-153 order
       Region 2zvw J 143-153 order
       Region 2zvw K 143-153 order
       Region 2zvw L 143-153 order
       Region 2zvw M 143-153 order
       Region 2zvw N 143-153 order
       Region 2zvw O 143-153 order
       Region 2zvw P 143-153 order
       Region 125-164 disorder
Seqphosphorylation
    80-80 Phosphothreonine; by LKB1
    114-114 Phosphoserine; by GSK3-beta
    145-145 Phosphothreonine; by PKA
    130-130 Phosphoserine
    146-146 Phosphoserine; by PKC and NUAK1
    160-160 Phosphoserine; by PKC; in vitro
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-13,77-164
Order 14-76
ProS 77-80,112-116,145-161
AlphaFold
Disorder 1-13,82-141,149-164
Order 14-81,142-148
Pfam Hmmer
PF02234 19-69 1e-20
SEG 81-96
Function
Function in SwissProt
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657).
Biological Process
Diagram with PDB data
CDKN1A/PCNAHuman PCNA