Search Keyword:


Search option:


IID00045
 UniprotP41235
ProteinHepatocyte nuclear factor 4-alpha
GeneHNF4A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
474
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 55-377 Hetero tetramer : IID00082Complex
 Evidence X-RAY 4iqr F Reference
       Region 4iqr F 55-57 disorder
       Region 4iqr F 58-163 order
       Region 4iqr F 164-169 disorder
       Region 4iqr F 170-377 order
 Evidence X-RAY 4iqr E Reference
       Region 4iqr E 55-57 disorder
       Region 4iqr E 58-132 order
       Region 4iqr E 133-149 disorder
       Region 4iqr E 150-377 order
 Evidence X-RAY 4iqr B Reference
       Region 4iqr B 55-57 disorder
       Region 4iqr B 58-162 order
       Region 4iqr B 163-174 disorder
       Region 4iqr B 175-377 order
 Evidence X-RAY 4iqr A Reference
       Region 4iqr A 55-57 disorder
       Region 4iqr A 58-133 order
       Region 4iqr A 134-151 disorder
       Region 4iqr A 152-377 order
Seq 58-135 Homo dimer :
 Evidence X-RAY 3cbb B Reference
       Region 3cbb B 58-135 order
 Evidence X-RAY 3cbb A Reference
       Region 3cbb A 58-133 order
       Region 3cbb A 134-135 disorder
Seq 142-377 Homo octamer :
 Evidence X-RAY 4b7w D Reference
       Region 4b7w D 142-176 disorder
       Region 4b7w D 177-376 order
       Region 4b7w D 377-377 disorder
 Evidence X-RAY 4b7w C Reference
       Region 4b7w C 142-174 disorder
       Region 4b7w C 175-376 order
       Region 4b7w C 377-377 disorder
 Evidence X-RAY 4b7w B Reference
       Region 4b7w B 142-176 disorder
       Region 4b7w B 177-376 order
       Region 4b7w B 377-377 disorder
 Evidence X-RAY 4b7w A Reference
       Region 4b7w A 142-174 disorder
       Region 4b7w A 175-376 order
       Region 4b7w A 377-377 disorder
Seq 142-378 Hetero dimer : IID00083Complex
 Evidence X-RAY 1pzl A Reference
       Region 1pzl A 142-145 disorder
       Region 1pzl A 146-166 order
       Region 1pzl A 167-172 disorder
       Region 1pzl A 173-378 order
Seq 148-377 Hetero dimer :
 Evidence X-RAY 3fs1 A Reference
       Region 3fs1 A 148-377 order
Seqphosphorylation
    142-142 Phosphoserine
    143-143 Phosphoserine
    144-144 Phosphotyrosine
    166-166 Phosphothreonine
    313-313 Phosphoserine; by AMPK
    167-167 Phosphoserine
    432-432 Phosphothreonine
    429-429 Phosphothreonine
    436-436 Phosphoserine
Seqacetylation
    458-458 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-56,131-177,381-474
Order 57-130,178-380
ProS 7-32,131-140,151-164,174-177,445-448,464-474
AlphaFold
Disorder 1-57,139-149,167-174,377-474
Order 58-138,150-166,175-376
Pfam Hmmer
PF00105 58-133 3.8e-51
PF00104 192-373 4.7e-59
SEG 337-341 ,382-393 ,426-445
Function
Function in SwissProt
Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698).
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment