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IID00050
 UniprotP48552
ProteinNuclear receptor-interacting protein 1
GeneNRIP1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1158
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 366-390 Hetero tetramer : IID00057Complex
 Evidence X-RAY 2gpp D Reference
       Region 2gpp D 366-377 disorder
       Region 2gpp D 378-390 order
 Evidence X-RAY 2gpp C Reference
       Region 2gpp C 366-377 disorder
       Region 2gpp C 378-388 order
       Region 2gpp C 389-390 disorder
 Evidence X-RAY 2gpo C Reference
       Region 2gpo C 366-377 disorder
       Region 2gpo C 378-387 order
       Region 2gpo C 388-390 disorder
Seq 493-512 Hetero dimer : IID00305Complex
 Evidence X-RAY 4s14 C Reference
       Region 4s14 C 499-507 order
       Region 4s14 C 508-510 disorder
 Evidence X-RAY 5nu1 Q Reference
       Region 5nu1 Q 493-498 disorder
       Region 5nu1 Q 499-507 order
       Region 5nu1 Q 508-512 disorder
 Evidence X-RAY 5nu1 P Reference
       Region 5nu1 P 493-498 disorder
       Region 5nu1 P 499-506 order
       Region 5nu1 P 507-512 disorder
 Evidence X-RAY 5ntw S Reference
       Region 5ntw S 493-498 disorder
       Region 5ntw S 499-507 order
       Region 5ntw S 508-512 disorder
 Evidence X-RAY 5ntw R Reference
       Region 5ntw R 493-498 disorder
       Region 5ntw R 499-507 order
       Region 5ntw R 508-512 disorder
 Evidence X-RAY 5ntw Q Reference
       Region 5ntw Q 493-498 disorder
       Region 5ntw Q 499-508 order
       Region 5ntw Q 509-512 disorder
 Evidence X-RAY 5ntw P Reference
       Region 5ntw P 493-498 disorder
       Region 5ntw P 499-507 order
       Region 5ntw P 508-512 disorder
 Evidence X-RAY 5ntn S Reference
       Region 5ntn S 493-498 disorder
       Region 5ntn S 499-507 order
       Region 5ntn S 508-512 disorder
 Evidence X-RAY 5ntn R Reference
       Region 5ntn R 493-498 disorder
       Region 5ntn R 499-506 order
       Region 5ntn R 507-512 disorder
 Evidence X-RAY 5ntn Q Reference
       Region 5ntn Q 493-498 disorder
       Region 5ntn Q 499-506 order
       Region 5ntn Q 507-512 disorder
 Evidence X-RAY 5ntn P Reference
       Region 5ntn P 493-498 disorder
       Region 5ntn P 499-506 order
       Region 5ntn P 507-512 disorder
 Evidence X-RAY 5nti S Reference
       Region 5nti S 493-498 disorder
       Region 5nti S 499-507 order
       Region 5nti S 508-512 disorder
 Evidence X-RAY 5nti R Reference
       Region 5nti R 493-498 disorder
       Region 5nti R 499-506 order
       Region 5nti R 507-512 disorder
 Evidence X-RAY 5nti Q Reference
       Region 5nti Q 493-498 disorder
       Region 5nti Q 499-506 order
       Region 5nti Q 507-512 disorder
 Evidence X-RAY 5nti P Reference
       Region 5nti P 493-498 disorder
       Region 5nti P 499-506 order
       Region 5nti P 507-512 disorder
Seq 499-510 Hetero dimer : IID00550Complex
 Evidence X-RAY 4s15 D Reference
       Region 4s15 D 499-507 order
       Region 4s15 D 508-510 disorder
 Evidence X-RAY 4s15 C Reference
       Region 4s15 C 499-507 order
       Region 4s15 C 508-510 disorder
SeqProS possible 378-390 LXXLL motif Hetero tetramer : IID00057Complex
       Region 2gpp C 378-388 order
       Region 2gpp D 378-390 order
       Region 2gpo C 378-387 order
SeqProS possible 499-507 LXXLL motif Hetero dimer : IID00550Complex
       Region 4s15 C 499-507 order
       Region 4s15 D 499-507 order
SeqProS possible 499-508 LXXLL motif Hetero dimer : IID00305Complex
       Region 4s14 C 499-507 order
       Region 5nti P 499-506 order
       Region 5nti Q 499-506 order
       Region 5nti R 499-506 order
       Region 5nti S 499-507 order
       Region 5nu1 P 499-506 order
       Region 5nu1 Q 499-507 order
       Region 5ntn P 499-506 order
       Region 5ntn Q 499-506 order
       Region 5ntn R 499-506 order
       Region 5ntn S 499-507 order
       Region 5ntw P 499-507 order
       Region 5ntw Q 499-508 order
       Region 5ntw R 499-507 order
       Region 5ntw S 499-507 order
Seqphosphorylation
    487-487 Phosphoserine
    518-518 Phosphoserine
    356-356 Phosphoserine
    378-378 Phosphoserine
    207-207 Phosphothreonine
    218-218 Phosphoserine
    542-542 Phosphoserine
    104-104 Phosphoserine
    564-564 Phosphoserine
    671-671 Phosphoserine
    807-807 Phosphoserine
    1001-1001 Phosphoserine
Seqacetylation
    158-158 N6-acetyllysine
    528-528 N6-acetyllysine
    481-481 N6-acetyllysine
    446-446 N6-acetyllysine
    286-286 N6-acetyllysine
    310-310 N6-acetyllysine
    111-111 N6-acetyllysine; alternate
    606-606 N6-acetyllysine
    931-931 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-1158
ProS 4-40,49-54,77-96,106-150,173-184,203-208,280-286,379-384,399-403,421-429,436-444,468-473,498-509,597-605,627-637,663-668,703-717,798-804,813-834,859-870,925-948,981-984,1029-1033,1041-1092,1101-1123,1138-1154
AlphaFold
Disorder 1-15,26-130,159-234,249-260,305-378,385-497,506-626,637-703,716-817,819-820,823-823,825-933,943-1063,1075-1158
Order 16-25,131-158,235-248,261-304,379-384,498-505,627-636,704-715,818-818,821-822,824-824,934-942,1064-1074
SEG 182-198 ,332-343 ,548-560 ,706-717
Function
Function in SwissProt
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (By similarity). Plays a role in renal development (PubMed:28381549).