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IID00057
 UniprotP62508
ProteinEstrogen-related receptor gamma
GeneESRRG
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
458
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 222-458 Homo dimer :
 Evidence X-RAY 2zkc A Reference
       Region 2zkc A 222-231 disorder
       Region 2zkc A 232-457 order
       Region 2zkc A 458-458 disorder
 Evidence X-RAY 2zbs A Reference
       Region 2zbs A 222-231 disorder
       Region 2zbs A 232-458 order
 Evidence X-RAY 2zas A Reference
       Region 2zas A 222-231 disorder
       Region 2zas A 232-458 order
 Evidence X-RAY 1vjb B Reference
       Region 1vjb B 229-232 disorder
       Region 1vjb B 233-442 order
       Region 1vjb B 443-458 disorder
 Evidence X-RAY 1vjb A Reference
       Region 1vjb A 229-233 disorder
       Region 1vjb A 234-441 order
       Region 1vjb A 442-458 disorder
 Evidence X-RAY 2gpu A Reference
       Region 2gpu A 229-233 disorder
       Region 2gpu A 234-455 order
       Region 2gpu A 456-458 disorder
 Evidence X-RAY 2gp7 D Reference
       Region 2gp7 D 229-234 disorder
       Region 2gp7 D 235-458 order
 Evidence X-RAY 2gp7 C Reference
       Region 2gp7 C 229-234 disorder
       Region 2gp7 C 235-458 order
 Evidence X-RAY 2gp7 B Reference
       Region 2gp7 B 229-233 disorder
       Region 2gp7 B 234-458 order
 Evidence X-RAY 2gp7 A Reference
       Region 2gp7 A 229-234 disorder
       Region 2gp7 A 235-458 order
 Evidence X-RAY 2ewp E Reference
       Region 2ewp E 233-236 disorder
       Region 2ewp E 237-403 order
       Region 2ewp E 404-408 disorder
       Region 2ewp E 409-455 order
       Region 2ewp E 456-458 disorder
 Evidence X-RAY 2ewp D Reference
       Region 2ewp D 233-234 disorder
       Region 2ewp D 235-455 order
       Region 2ewp D 456-458 disorder
 Evidence X-RAY 2ewp C Reference
       Region 2ewp C 233-233 disorder
       Region 2ewp C 234-456 order
       Region 2ewp C 457-458 disorder
 Evidence X-RAY 2ewp B Reference
       Region 2ewp B 233-456 order
       Region 2ewp B 457-458 disorder
 Evidence X-RAY 2ewp A Reference
       Region 2ewp A 233-456 order
       Region 2ewp A 457-458 disorder
 Evidence X-RAY 2e2r A Reference
       Region 2e2r A 222-231 disorder
       Region 2e2r A 232-458 order
Seq 229-458 Hetero nonamer : IID00109Complex
 Evidence X-RAY 2gpv F Reference
       Region 2gpv F 229-232 disorder
       Region 2gpv F 233-440 order
       Region 2gpv F 441-458 disorder
 Evidence X-RAY 2gpv E Reference
       Region 2gpv E 229-233 disorder
       Region 2gpv E 234-441 order
       Region 2gpv E 442-458 disorder
 Evidence X-RAY 2gpv D Reference
       Region 2gpv D 229-232 disorder
       Region 2gpv D 233-441 order
       Region 2gpv D 442-458 disorder
 Evidence X-RAY 2gpv C Reference
       Region 2gpv C 229-232 disorder
       Region 2gpv C 233-455 order
       Region 2gpv C 456-458 disorder
 Evidence X-RAY 2gpv B Reference
       Region 2gpv B 229-232 disorder
       Region 2gpv B 233-455 order
       Region 2gpv B 456-458 disorder
 Evidence X-RAY 2gpv A Reference
       Region 2gpv A 229-231 disorder
       Region 2gpv A 232-455 order
       Region 2gpv A 456-458 disorder
Seq 229-458 Monomer :
 Evidence X-RAY 2p7z A Reference
       Region 2p7z A 229-234 disorder
       Region 2p7z A 235-441 order
       Region 2p7z A 442-458 disorder
 Evidence X-RAY 2p7g A Reference
       Region 2p7g A 229-234 disorder
       Region 2p7g A 235-456 order
       Region 2p7g A 457-458 disorder
 Evidence X-RAY 2p7a A Reference
       Region 2p7a A 229-233 disorder
       Region 2p7a A 234-456 order
       Region 2p7a A 457-458 disorder
Seq 229-458 Hetero tetramer : IID00083Complex
 Evidence X-RAY 1tfc B Reference
       Region 1tfc B 229-232 disorder
       Region 1tfc B 233-457 order
       Region 1tfc B 458-458 disorder
 Evidence X-RAY 1tfc A Reference
       Region 1tfc A 229-232 disorder
       Region 1tfc A 233-458 order
 Evidence X-RAY 1kv6 B Reference
       Region 1kv6 B 229-234 disorder
       Region 1kv6 B 235-456 order
       Region 1kv6 B 457-458 disorder
 Evidence X-RAY 1kv6 A Reference
       Region 1kv6 A 229-234 disorder
       Region 1kv6 A 235-456 order
       Region 1kv6 A 457-458 disorder
Seq 229-458 Hetero tetramer : IID00050Complex
 Evidence X-RAY 2gpp B Reference
       Region 2gpp B 229-232 disorder
       Region 2gpp B 233-456 order
       Region 2gpp B 457-458 disorder
 Evidence X-RAY 2gpp A Reference
       Region 2gpp A 229-232 disorder
       Region 2gpp A 233-457 order
       Region 2gpp A 458-458 disorder
 Evidence X-RAY 2gpo A Reference
       Region 2gpo A 229-234 disorder
       Region 2gpo A 235-458 order
Seqphosphorylation
    45-45 Phosphoserine
 
Prediction
NeProc
Disorder 1-124,199-233
Order 125-198,234-458
ProS 1-33,40-50,199-206
AlphaFold
Disorder 1-125,201-234
Order 126-200,235-458
Pfam Hmmer
PF00105 126-201 6.2e-51
PF00104 273-453 1.1e-57
SEG 57-70
Function
Function in SwissProt
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment