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IID00058
 UniprotP62805
ProteinHistone H4
GeneH4C1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
103
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-103 Hetero octamer : IID00016Complex,IID00019Complex,IID00239Complex,P06899
 Evidence X-RAY 5b32 F Reference
       Region 5b32 F 1-19 disorder
       Region 5b32 F 20-102 order
       Region 5b32 F 103-103 disorder
 Evidence X-RAY 5b32 B Reference
       Region 5b32 B 1-25 disorder
       Region 5b32 B 26-103 order
Seq 1-103 Hetero tetramer : IID00062Complex,IID00182Complex,IID00715Complex
 Evidence X-RAY 5c3i W Reference
       Region 5c3i W 1-24 disorder
       Region 5c3i W 25-101 order
       Region 5c3i W 102-103 disorder
 Evidence X-RAY 5c3i S Reference
       Region 5c3i S 1-24 disorder
       Region 5c3i S 25-102 order
       Region 5c3i S 103-103 disorder
 Evidence X-RAY 5c3i O Reference
       Region 5c3i O 1-24 disorder
       Region 5c3i O 25-102 order
       Region 5c3i O 103-103 disorder
 Evidence X-RAY 5c3i G Reference
       Region 5c3i G 1-24 disorder
       Region 5c3i G 25-101 order
       Region 5c3i G 102-103 disorder
 Evidence X-RAY 5c3i K Reference
       Region 5c3i K 1-26 disorder
       Region 5c3i K 27-102 order
       Region 5c3i K 103-103 disorder
Seq 1-103 Hetero nonamer : IID00016Complex,IID00062Complex,P06899
 Evidence X-RAY 5gtc F Reference
       Region 5gtc F 1-17 disorder
       Region 5gtc F 18-103 order
 Evidence X-RAY 5gtc B Reference
       Region 5gtc B 1-25 disorder
       Region 5gtc B 26-103 order
Seq 1-103 Hetero octamer : IID00016Complex,IID00062Complex,P06899
 Evidence X-RAY 4ym5 F Reference
       Region 4ym5 F 1-16 disorder
       Region 4ym5 F 17-103 order
 Evidence X-RAY 4ym5 B Reference
       Region 4ym5 B 1-24 disorder
       Region 4ym5 B 25-103 order
 Evidence X-RAY 5xf5 F Reference
       Region 5xf5 F 1-16 disorder
       Region 5xf5 F 17-103 order
 Evidence X-RAY 5xf5 B Reference
       Region 5xf5 B 1-21 disorder
       Region 5xf5 B 22-103 order
 Evidence X-RAY 5xf4 F Reference
       Region 5xf4 F 1-16 disorder
       Region 5xf4 F 17-103 order
 Evidence X-RAY 5xf4 B Reference
       Region 5xf4 B 1-21 disorder
       Region 5xf4 B 22-103 order
 Evidence X-RAY 5xf3 F Reference
       Region 5xf3 F 1-16 disorder
       Region 5xf3 F 17-103 order
 Evidence X-RAY 5xf3 B Reference
       Region 5xf3 B 1-21 disorder
       Region 5xf3 B 22-103 order
 Evidence X-RAY 3w97 F Reference
       Region 3w97 F 1-19 disorder
       Region 3w97 F 20-103 order
 Evidence X-RAY 3w97 B Reference
       Region 3w97 B 1-25 disorder
       Region 3w97 B 26-103 order
 Evidence X-RAY 5jrg F Reference
       Region 5jrg F 1-17 disorder
       Region 5jrg F 18-103 order
 Evidence X-RAY 5jrg B Reference
       Region 5jrg B 1-25 disorder
       Region 5jrg B 26-103 order
 Evidence X-RAY 5cpk F Reference
       Region 5cpk F 1-19 disorder
       Region 5cpk F 20-102 order
       Region 5cpk F 103-103 disorder
 Evidence X-RAY 5cpk B Reference
       Region 5cpk B 1-24 disorder
       Region 5cpk B 25-103 order
 Evidence X-RAY 5cpi F Reference
       Region 5cpi F 1-19 disorder
       Region 5cpi F 20-102 order
       Region 5cpi F 103-103 disorder
 Evidence X-RAY 5cpi B Reference
       Region 5cpi B 1-25 disorder
       Region 5cpi B 26-103 order
 Evidence X-RAY 5b2j F Reference
       Region 5b2j F 1-18 disorder
       Region 5b2j F 19-103 order
 Evidence X-RAY 5b2j B Reference
       Region 5b2j B 1-21 disorder
       Region 5b2j B 22-103 order
 Evidence X-RAY 5b2i F Reference
       Region 5b2i F 1-18 disorder
       Region 5b2i F 19-103 order
 Evidence X-RAY 5b2i B Reference
       Region 5b2i B 1-21 disorder
       Region 5b2i B 22-103 order
 Evidence X-RAY 5b24 F Reference
       Region 5b24 F 1-19 disorder
       Region 5b24 F 20-103 order
 Evidence X-RAY 5b24 B Reference
       Region 5b24 B 1-25 disorder
       Region 5b24 B 26-103 order
 Evidence X-RAY 3azm F Reference
       Region 3azm F 1-19 disorder
       Region 3azm F 20-103 order
 Evidence X-RAY 3azm B Reference
       Region 3azm B 1-25 disorder
       Region 3azm B 26-102 order
       Region 3azm B 103-103 disorder
 Evidence X-RAY 3azj F Reference
       Region 3azj F 1-19 disorder
       Region 3azj F 20-102 order
       Region 3azj F 103-103 disorder
 Evidence X-RAY 3azj B Reference
       Region 3azj B 1-24 disorder
       Region 3azj B 25-103 order
 Evidence X-RAY 3azg F Reference
       Region 3azg F 1-19 disorder
       Region 3azg F 20-103 order
 Evidence X-RAY 3azg B Reference
       Region 3azg B 1-25 disorder
       Region 3azg B 26-103 order
 Evidence X-RAY 3ayw F Reference
       Region 3ayw F 1-19 disorder
       Region 3ayw F 20-103 order
 Evidence X-RAY 3ayw B Reference
       Region 3ayw B 1-25 disorder
       Region 3ayw B 26-103 order
 Evidence X-RAY 5avc F Reference
       Region 5avc F 1-16 disorder
       Region 5avc F 17-103 order
 Evidence X-RAY 5avc B Reference
       Region 5avc B 1-21 disorder
       Region 5avc B 22-103 order
 Evidence X-RAY 5avb F Reference
       Region 5avb F 1-16 disorder
       Region 5avb F 17-103 order
 Evidence X-RAY 5avb B Reference
       Region 5avb B 1-21 disorder
       Region 5avb B 22-103 order
 Evidence X-RAY 5av9 F Reference
       Region 5av9 F 1-17 disorder
       Region 5av9 F 18-103 order
 Evidence X-RAY 5av9 B Reference
       Region 5av9 B 1-21 disorder
       Region 5av9 B 22-103 order
 Evidence X-RAY 5av8 F Reference
       Region 5av8 F 1-17 disorder
       Region 5av8 F 18-103 order
 Evidence X-RAY 5av8 B Reference
       Region 5av8 B 1-21 disorder
       Region 5av8 B 22-103 order
 Evidence X-RAY 5av6 F Reference
       Region 5av6 F 1-17 disorder
       Region 5av6 F 18-103 order
 Evidence X-RAY 5av6 B Reference
       Region 5av6 B 1-21 disorder
       Region 5av6 B 22-103 order
 Evidence X-RAY 5av5 F Reference
       Region 5av5 F 1-17 disorder
       Region 5av5 F 18-103 order
 Evidence X-RAY 5av5 B Reference
       Region 5av5 B 1-21 disorder
       Region 5av5 B 22-103 order
 Evidence X-RAY 3afa F Reference
       Region 3afa F 1-19 disorder
       Region 3afa F 20-103 order
 Evidence X-RAY 3afa B Reference
       Region 3afa B 1-25 disorder
       Region 3afa B 26-103 order
Seq 1-103 Hetero octamer : IID00016Complex,IID00062Complex,P06899
 Evidence X-RAY 5cpj F Reference
       Region 5cpj F 1-19 disorder
       Region 5cpj F 20-103 order
 Evidence X-RAY 5cpj B Reference
       Region 5cpj B 1-25 disorder
       Region 5cpj B 26-103 order
 Evidence X-RAY 3azn F Reference
       Region 3azn F 1-19 disorder
       Region 3azn F 20-103 order
 Evidence X-RAY 3azn B Reference
       Region 3azn B 1-25 disorder
       Region 3azn B 26-103 order
 Evidence X-RAY 3azl F Reference
       Region 3azl F 1-17 disorder
       Region 3azl F 18-103 order
 Evidence X-RAY 3azl B Reference
       Region 3azl B 1-25 disorder
       Region 3azl B 26-103 order
 Evidence X-RAY 3azk F Reference
       Region 3azk F 1-19 disorder
       Region 3azk F 20-103 order
 Evidence X-RAY 3azk B Reference
       Region 3azk B 1-25 disorder
       Region 3azk B 26-103 order
 Evidence X-RAY 3azi F Reference
       Region 3azi F 1-19 disorder
       Region 3azi F 20-103 order
 Evidence X-RAY 3azi B Reference
       Region 3azi B 1-25 disorder
       Region 3azi B 26-103 order
 Evidence X-RAY 3azh F Reference
       Region 3azh F 1-18 disorder
       Region 3azh F 19-102 order
       Region 3azh F 103-103 disorder
 Evidence X-RAY 3azh B Reference
       Region 3azh B 1-25 disorder
       Region 3azh B 26-103 order
 Evidence X-RAY 3azf F Reference
       Region 3azf F 1-19 disorder
       Region 3azf F 20-103 order
 Evidence X-RAY 3azf B Reference
       Region 3azf B 1-25 disorder
       Region 3azf B 26-103 order
 Evidence X-RAY 3aze F Reference
       Region 3aze F 1-18 disorder
       Region 3aze F 19-103 order
 Evidence X-RAY 3aze B Reference
       Region 3aze B 1-25 disorder
       Region 3aze B 26-102 order
       Region 3aze B 103-103 disorder
Seq 1-103 Hetero octamer : IID00062Complex,IID00614Complex,P06899
 Evidence X-RAY 3waa F Reference
       Region 3waa F 1-19 disorder
       Region 3waa F 20-103 order
 Evidence X-RAY 3waa B Reference
       Region 3waa B 1-25 disorder
       Region 3waa B 26-103 order
Seq 1-103 Hetero tetradecamer : IID00016Complex,IID00062Complex,P06899
 Evidence X-RAY 5gse P Reference
       Region 5gse P 1-21 disorder
       Region 5gse P 22-102 order
       Region 5gse P 103-103 disorder
 Evidence X-RAY 5gse L Reference
       Region 5gse L 1-25 disorder
       Region 5gse L 26-94 order
       Region 5gse L 95-103 disorder
 Evidence X-RAY 5gse F Reference
       Region 5gse F 1-23 disorder
       Region 5gse F 24-102 order
       Region 5gse F 103-103 disorder
 Evidence X-RAY 5gse B Reference
       Region 5gse B 1-21 disorder
       Region 5gse B 22-103 order
Seq 1-103 Hetero octamer : IID00016Complex,IID00239Complex,P06899
 Evidence X-RAY 5x7x F Reference
       Region 5x7x F 1-17 disorder
       Region 5x7x F 18-103 order
 Evidence X-RAY 5x7x B Reference
       Region 5x7x B 1-25 disorder
       Region 5x7x B 26-102 order
       Region 5x7x B 103-103 disorder
Seq 1-103 Hetero octamer : IID00016Complex,IID00239Complex,P06899
 Evidence X-RAY 3av2 F Reference
       Region 3av2 F 1-19 disorder
       Region 3av2 F 20-103 order
 Evidence X-RAY 3av2 B Reference
       Region 3av2 B 1-25 disorder
       Region 3av2 B 26-103 order
Seq 1-103 Hetero octamer : IID00016Complex,IID00019Complex,IID00062Complex,P06899
 Evidence X-RAY 5b31 F Reference
       Region 5b31 F 1-19 disorder
       Region 5b31 F 20-102 order
       Region 5b31 F 103-103 disorder
 Evidence X-RAY 5b31 B Reference
       Region 5b31 B 1-25 disorder
       Region 5b31 B 26-103 order
Seq 1-103 Hetero trimer : IID00272Complex,IID00283Complex
 Evidence X-RAY 3r45 B Reference
       Region 3r45 B 1-23 disorder
       Region 3r45 B 24-97 order
       Region 3r45 B 98-103 disorder
Seq 1-103 Hetero octamer : IID00016Complex,P06899,Q6NXT2
 Evidence X-RAY 4z5t F Reference
       Region 4z5t F 1-24 disorder
       Region 4z5t F 25-103 order
 Evidence X-RAY 4z5t B Reference
       Region 4z5t B 1-20 disorder
       Region 4z5t B 21-103 order
Seq 1-103 Hetero octamer : IID00016Complex,IID00239Complex,P06899
 Evidence X-RAY 5ay8 F Reference
       Region 5ay8 F 1-24 disorder
       Region 5ay8 F 25-103 order
 Evidence X-RAY 5ay8 B Reference
       Region 5ay8 B 1-25 disorder
       Region 5ay8 B 26-103 order
Seq 1-103 Hetero octamer : A0A1X8XL64,IID00016Complex,P06899
 Evidence X-RAY 5gxq F Reference
       Region 5gxq F 1-19 disorder
       Region 5gxq F 20-103 order
 Evidence X-RAY 5gxq B Reference
       Region 5gxq B 1-25 disorder
       Region 5gxq B 26-103 order
Seq 1-103 Hetero octamer : IID00016Complex,IID00239Complex,IID00272Complex,P06899
 Evidence X-RAY 3wtp F Reference
       Region 3wtp F 1-18 disorder
       Region 3wtp F 19-103 order
 Evidence X-RAY 3wtp B Reference
       Region 3wtp B 1-25 disorder
       Region 3wtp B 26-103 order
Seq 1-103 Hetero octamer : IID00016Complex,IID00062Complex,P06899
 Evidence X-RAY 4ym6 F Reference
       Region 4ym6 F 1-19 disorder
       Region 4ym6 F 20-103 order
 Evidence X-RAY 4ym6 B Reference
       Region 4ym6 B 1-25 disorder
       Region 4ym6 B 26-103 order
 Evidence X-RAY 3w99 F Reference
       Region 3w99 F 17-19 disorder
       Region 3w99 F 20-103 order
 Evidence X-RAY 3w99 B Reference
       Region 3w99 B 17-25 disorder
       Region 3w99 B 26-103 order
 Evidence X-RAY 3w98 F Reference
       Region 3w98 F 1-19 disorder
       Region 3w98 F 20-103 order
 Evidence X-RAY 3w98 B Reference
       Region 3w98 B 1-25 disorder
       Region 3w98 B 26-101 order
       Region 3w98 B 102-103 disorder
 Evidence X-RAY 3w96 F Reference
       Region 3w96 F 1-20 disorder
       Region 3w96 F 21-102 order
       Region 3w96 F 103-103 disorder
 Evidence X-RAY 3w96 B Reference
       Region 3w96 B 1-26 disorder
       Region 3w96 B 27-103 order
Seq 1-103 Hetero octamer : IID00019Complex,IID00239Complex,P06899
 Evidence X-RAY 5b33 F Reference
       Region 5b33 F 1-19 disorder
       Region 5b33 F 20-103 order
 Evidence X-RAY 5b33 B Reference
       Region 5b33 B 1-25 disorder
       Region 5b33 B 26-103 order
Seq 1-103 Hetero octamer : IID00010Complex,IID00016Complex,IID00062Complex
 Evidence X-RAY 2cv5 F Reference
       Region 2cv5 F 1-18 disorder
       Region 2cv5 F 19-103 order
 Evidence X-RAY 2cv5 B Reference
       Region 2cv5 B 1-25 disorder
       Region 2cv5 B 26-103 order
Seq 1-103 Hetero pentamer : IID00062Complex,Q9Y5B9
 Evidence X-RAY 4z2m J Reference
       Region 4z2m J 1-24 disorder
       Region 4z2m J 25-94 order
       Region 4z2m J 95-103 disorder
 Evidence X-RAY 4z2m H Reference
       Region 4z2m H 1-23 disorder
       Region 4z2m H 24-94 order
       Region 4z2m H 95-103 disorder
Seq 1-103 Hetero tetramer : IID00272Complex
 Evidence X-RAY 3nqu B Reference
       Region 3nqu B 1-25 disorder
       Region 3nqu B 26-92 order
       Region 3nqu B 93-103 disorder
 Evidence X-RAY 3nqj B Reference
       Region 3nqj B 21-24 disorder
       Region 3nqj B 25-93 order
       Region 3nqj B 94-103 disorder
Seq 1-103 Hetero octamer : IID00016Complex,IID00088Complex,P06899
 Evidence X-RAY 5b40 F Reference
       Region 5b40 F 1-22 disorder
       Region 5b40 F 23-102 order
       Region 5b40 F 103-103 disorder
 Evidence X-RAY 5b40 B Reference
       Region 5b40 B 1-25 disorder
       Region 5b40 B 26-103 order
 Evidence X-RAY 5b0z F Reference
       Region 5b0z F 1-20 disorder
       Region 5b0z F 21-103 order
 Evidence X-RAY 5b0z B Reference
       Region 5b0z B 1-25 disorder
       Region 5b0z B 26-103 order
 Evidence X-RAY 5b0y F Reference
       Region 5b0y F 1-19 disorder
       Region 5b0y F 20-103 order
 Evidence X-RAY 5b0y B Reference
       Region 5b0y B 1-25 disorder
       Region 5b0y B 26-103 order
 Evidence X-RAY 3av1 F Reference
       Region 3av1 F 1-19 disorder
       Region 3av1 F 20-103 order
 Evidence X-RAY 3av1 B Reference
       Region 3av1 B 1-25 disorder
       Region 3av1 B 26-103 order
Seq 1-103 Hetero trimer : IID00239Complex,IID00398Complex
 Evidence X-RAY 4hga C Reference
       Region 4hga C 1-27 disorder
       Region 4hga C 28-102 order
       Region 4hga C 103-103 disorder
 Evidence X-RAY 4h9s D Reference
       Region 4h9s D 21-27 disorder
       Region 4h9s D 28-101 order
       Region 4h9s D 102-103 disorder
 Evidence X-RAY 4h9s C Reference
       Region 4h9s C 21-27 disorder
       Region 4h9s C 28-101 order
       Region 4h9s C 102-103 disorder
 Evidence X-RAY 4h9r B Reference
       Region 4h9r B 2-20 disorder
       Region 4h9r B 21-103 order
 Evidence X-RAY 4h9q B Reference
       Region 4h9q B 2-20 disorder
       Region 4h9q B 21-103 order
 Evidence X-RAY 4h9p B Reference
       Region 4h9p B 2-20 disorder
       Region 4h9p B 21-103 order
 Evidence X-RAY 4h9o B Reference
       Region 4h9o B 2-20 disorder
       Region 4h9o B 21-103 order
 Evidence X-RAY 4h9n B Reference
       Region 4h9n B 2-20 disorder
       Region 4h9n B 21-103 order
Seq 1-103 Hetero octamer : IID00016Complex,IID00272Complex,P06899
 Evidence X-RAY 3an2 F Reference
       Region 3an2 F 1-24 disorder
       Region 3an2 F 25-103 order
 Evidence X-RAY 3an2 B Reference
       Region 3an2 B 1-25 disorder
       Region 3an2 B 26-103 order
Seq 1-103 Hetero octamer : IID00016Complex,IID00086Complex,P06899
 Evidence X-RAY 3a6n F Reference
       Region 3a6n F 1-19 disorder
       Region 3a6n F 20-103 order
 Evidence X-RAY 3a6n B Reference
       Region 3a6n B 1-22 disorder
       Region 3a6n B 23-103 order
Seq 1-103 Hetero tetramer : IID00062Complex,IID00182Complex,IID00715Complex
 Evidence X-RAY 5c3i C Reference
       Region 5c3i C 1-24 disorder
       Region 5c3i C 25-102 order
       Region 5c3i C 103-103 disorder
Seq 1-103 Hetero octamer : IID00016Complex,IID00062Complex,Q96A08
 Evidence X-RAY 3wkj F Reference
       Region 3wkj F 1-19 disorder
       Region 3wkj F 20-103 order
 Evidence X-RAY 3wkj B Reference
       Region 3wkj B 1-25 disorder
       Region 3wkj B 26-103 order
Seq 1-103 Hetero octamer : IID00019Complex,IID00062Complex,P06899
 Evidence X-RAY 3wa9 F Reference
       Region 3wa9 F 1-19 disorder
       Region 3wa9 F 20-103 order
 Evidence X-RAY 3wa9 B Reference
       Region 3wa9 B 1-25 disorder
       Region 3wa9 B 26-103 order
Seq 2-6 Hetero dimer : Q86UY6
 Evidence X-RAY 4u9w H Reference
       Region 4u9w H 2-6 order
 Evidence X-RAY 4u9w G Reference
       Region 4u9w G 2-6 order
 Evidence X-RAY 4u9w E Reference
       Region 4u9w E 2-6 order
 Evidence X-RAY 4u9w F Reference
       Region 4u9w F 2-6 order
Seq 2-11 Hetero dimer : IID00374Complex
 Evidence NMR 2rs9 A Reference
       Region 2rs9 A 2-11 order
Seq 2-11 Hetero trimer : IID00374Complex
 Evidence X-RAY 5ffw C Reference
       Region 5ffw C 2-11 order
Seq 2-12 Hetero trimer : IID00545Complex
 Evidence X-RAY 4yyn Z Reference
       Region 4yyn Z 2-12 order
 Evidence X-RAY 4yym Z Reference
       Region 4yym Z 2-5 disorder
       Region 4yym Z 6-12 order
Seq 2-12 Hetero dimer : IID00111Complex
 Evidence X-RAY 3uvw B Reference
       Region 3uvw B 2-12 order
Seq 2-12 Hetero trimer : Q9H8M2
 Evidence X-RAY 4yyj F Reference
       Region 4yyj F 2-4 disorder
       Region 4yyj F 5-10 order
       Region 4yyj F 11-12 disorder
Seq 2-12 Hetero dimer : Q9H8M2
 Evidence X-RAY 4yyh Y Reference
       Region 4yyh Y 2-6 disorder
       Region 4yyh Y 7-10 order
       Region 4yyh Y 11-12 disorder
 Evidence X-RAY 4yyh Z Reference
       Region 4yyh Z 2-6 disorder
       Region 4yyh Z 7-10 order
       Region 4yyh Z 11-12 disorder
 Evidence X-RAY 4yyg B Reference
       Region 4yyg B 2-6 disorder
       Region 4yyg B 7-9 order
       Region 4yyg B 10-12 disorder
 Evidence X-RAY 4yyd Z Reference
       Region 4yyd Z 2-2 disorder
       Region 4yyd Z 3-12 order
 Evidence X-RAY 4yy6 Z Reference
       Region 4yy6 Z 2-2 disorder
       Region 4yy6 Z 3-12 order
Seq 2-12 Hetero trimer : Q9H8M2
 Evidence X-RAY 4yyk F Reference
       Region 4yyk F 2-4 disorder
       Region 4yyk F 5-10 order
       Region 4yyk F 11-12 disorder
 Evidence X-RAY 4yyk C Reference
       Region 4yyk C 2-4 disorder
       Region 4yyk C 5-10 order
       Region 4yyk C 11-12 disorder
 Evidence X-RAY 4yyj C Reference
       Region 4yyj C 2-4 disorder
       Region 4yyj C 5-10 order
       Region 4yyj C 11-12 disorder
 Evidence X-RAY 4yyi F Reference
       Region 4yyi F 2-4 disorder
       Region 4yyi F 5-10 order
       Region 4yyi F 11-12 disorder
 Evidence X-RAY 4yyi C Reference
       Region 4yyi C 2-4 disorder
       Region 4yyi C 5-10 order
       Region 4yyi C 11-12 disorder
Seq 2-16 Hetero trimer : IID00360Complex
 Evidence X-RAY 5fwe D Reference
       Region 5fwe D 2-4 order
       Region 5fwe D 5-16 disorder
 Evidence X-RAY 5fwe C Reference
       Region 5fwe C 2-14 disorder
       Region 5fwe C 15-16 order
Seq 2-21 Hetero trimer : IID00405Complex
 Evidence X-RAY 5fa5 C Reference
       Region 5fa5 C 2-3 disorder
       Region 5fa5 C 4-4 order
       Region 5fa5 C 5-21 disorder
Seq 2-21 Hetero dimer : IID00418Complex
 Evidence NMR 2kwo B Reference
       Region 2kwo B 2-21 order
Seq 2-22 Hetero tetramer : IID50227Complex
 Evidence X-RAY 4m38 F Reference
       Region 4m38 F 2-3 disorder
       Region 4m38 F 4-5 order
       Region 4m38 F 6-22 disorder
 Evidence X-RAY 4m38 E Reference
       Region 4m38 E 2-5 order
       Region 4m38 E 6-22 disorder
Seq 2-22 Hetero dodecamer : IID00405Complex
 Evidence X-RAY 4gqb C Reference
       Region 4gqb C 2-9 order
       Region 4gqb C 10-22 disorder
Seq 2-103 Hetero octamer : IID00062Complex,P70696,Q8CGP4
 Evidence X-RAY 3x1t F Reference
       Region 3x1t F 2-16 disorder
       Region 3x1t F 17-103 order
 Evidence X-RAY 3x1t B Reference
       Region 3x1t B 2-22 disorder
       Region 3x1t B 23-103 order
Seq 2-103 Hetero octamer : IID00016Complex,IID00062Complex,P70696
 Evidence X-RAY 3x1v F Reference
       Region 3x1v F 2-16 disorder
       Region 3x1v F 17-103 order
 Evidence X-RAY 3x1v B Reference
       Region 3x1v B 2-24 disorder
       Region 3x1v B 25-103 order
Seq 2-103 Hetero octamer : IID00062Complex,P62807,Q96QV6
 Evidence X-RAY 5gt0 F Reference
       Region 5gt0 F 2-17 disorder
       Region 5gt0 F 18-103 order
 Evidence X-RAY 5gt0 B Reference
       Region 5gt0 B 2-24 disorder
       Region 5gt0 B 25-103 order
Seq 2-103 Hetero octamer : IID00062Complex,P20671,Q96A08
 Evidence X-RAY 5gt3 F Reference
       Region 5gt3 F 2-18 disorder
       Region 5gt3 F 19-103 order
 Evidence X-RAY 5gt3 B Reference
       Region 5gt3 B 2-22 disorder
       Region 5gt3 B 23-103 order
Seq 2-103 Hetero tetramer : IID00088Complex,IID00715Complex,Q9NVP2
 Evidence X-RAY 5bo0 B Reference
       Region 5bo0 B 2-17 disorder
       Region 5bo0 B 18-103 order
Seq 2-103 Hetero octamer : IID00062Complex,Q96A08,Q96QV6
 Evidence X-RAY 5gsu F Reference
       Region 5gsu F 2-17 disorder
       Region 5gsu F 18-103 order
 Evidence X-RAY 5gsu B Reference
       Region 5gsu B 2-24 disorder
       Region 5gsu B 25-103 order
Seq 2-103 Hetero octamer : IID00239Complex,IID00715Complex,Q96HA7
 Evidence X-RAY 5ja4 B Reference
       Region 5ja4 B 2-12 disorder
       Region 5ja4 B 13-101 order
       Region 5ja4 B 102-103 disorder
Seq 2-103 Hetero tetramer : IID00239Complex,IID00398Complex,Q1HVJ0
 Evidence X-RAY 5kdm B Reference
       Region 5kdm B 2-26 disorder
       Region 5kdm B 27-103 order
Seq 2-103 Hetero octamer : IID00062Complex,P33778,Q8CGP4
 Evidence X-RAY 3x1u F Reference
       Region 3x1u F 2-16 disorder
       Region 3x1u F 17-103 order
 Evidence X-RAY 3x1u B Reference
       Region 3x1u B 2-20 disorder
       Region 3x1u B 21-103 order
Seq 2-103 Hetero tetramer : IID00239Complex,IID00715Complex,Q9NVP2
 Evidence X-RAY 5bnx B Reference
       Region 5bnx B 2-17 disorder
       Region 5bnx B 18-103 order
Seq 2-103 Hetero octamer : IID00016Complex,IID00062Complex,P33778
 Evidence X-RAY 3x1s F Reference
       Region 3x1s F 2-19 disorder
       Region 3x1s F 20-103 order
 Evidence X-RAY 3x1s B Reference
       Region 3x1s B 2-25 disorder
       Region 3x1s B 26-103 order
Seq 2-103 Hetero hexamer : IID00239Complex,IID00715Complex
 Evidence X-RAY 5bnv E Reference
       Region 5bnv E 2-26 disorder
       Region 5bnv E 27-95 order
       Region 5bnv E 96-103 disorder
 Evidence X-RAY 5bnv B Reference
       Region 5bnv B 2-19 disorder
       Region 5bnv B 20-98 order
       Region 5bnv B 99-103 disorder
Seq 4-16 Hetero dimer : IID00570Complex
 Evidence X-RAY 4quu B Reference
       Region 4quu B 4-9 order
       Region 4quu B 10-16 disorder
Seq 5-18 Hetero dimer : IID00374Complex
 Evidence X-RAY 4qyd B Reference
       Region 4qyd B 5-6 disorder
       Region 4qyd B 7-14 order
       Region 4qyd B 15-18 disorder
Seq 6-26 Hetero dimer : IID00092Complex
 Evidence X-RAY 4n4f C Reference
       Region 4n4f C 6-7 disorder
       Region 4n4f C 8-13 order
       Region 4n4f C 14-26 disorder
Seq 8-18 Hetero trimer : IID00111Complex
 Evidence X-RAY 3uw9 F Reference
       Region 3uw9 F 8-8 disorder
       Region 3uw9 F 9-14 order
       Region 3uw9 F 15-18 disorder
 Evidence X-RAY 3uw9 E Reference
       Region 3uw9 E 8-8 disorder
       Region 3uw9 E 9-13 order
       Region 3uw9 E 14-18 disorder
Seq 8-18 Hetero dimer : IID00071Complex
 Evidence X-RAY 3qzv C Reference
       Region 3qzv C 8-13 order
       Region 3qzv C 14-18 disorder
Seq 10-16 Hetero dimer : IID00570Complex
 Evidence X-RAY 4qut B Reference
       Region 4qut B 10-14 order
       Region 4qut B 15-16 disorder
Seq 10-24 Hetero dimer : IID00418Complex
 Evidence NMR 2kwn B Reference
       Region 2kwn B 10-24 order
Seq 12-22 Hetero dimer : IID00111Complex
 Evidence X-RAY 3uvx B Reference
       Region 3uvx B 12-18 order
       Region 3uvx B 19-22 disorder
Seq 13-22 Hetero dimer : IID00071Complex
 Evidence X-RAY 3qzt B Reference
       Region 3qzt B 13-14 disorder
       Region 3qzt B 15-20 order
       Region 3qzt B 21-22 disorder
 Evidence X-RAY 3qzs D Reference
       Region 3qzs D 13-14 disorder
       Region 3qzs D 15-22 order
 Evidence X-RAY 3qzs C Reference
       Region 3qzs C 13-14 disorder
       Region 3qzs C 15-22 order
Seq 14-28 Hetero dimer : IID00530Complex
 Evidence X-RAY 3jpx B Reference
       Region 3jpx B 14-18 disorder
       Region 3jpx B 19-24 order
       Region 3jpx B 25-28 disorder
 Evidence X-RAY 3ij1 B Reference
       Region 3ij1 B 16-17 disorder
       Region 3ij1 B 18-24 order
       Region 3ij1 B 25-26 disorder
Seq 14-28 Hetero dimer : IID00092Complex
 Evidence NMR 2rny B Reference
       Region 2rny B 14-28 order
Seq 14-28 Hetero dimer : IID00092Complex
 Evidence X-RAY 4n3w C Reference
       Region 4n3w C 14-17 disorder
       Region 4n3w C 18-22 order
       Region 4n3w C 23-28 disorder
Seq 15-20 Hetero dimer : IID00289Complex
 Evidence X-RAY 3o36 E Reference
       Region 3o36 E 15-17 order
       Region 3o36 E 18-20 disorder
Seq 15-20 Hetero dimer :
 Evidence X-RAY 3o36 D Reference
       Region 3o36 D 15-20 disorder
Seq 15-28 Hetero dimer : IID00123Complex
 Evidence NMR 2lvm B Reference
       Region 2lvm B 15-28 order
Seq 16-25 Hetero octamer : IID00101Complex
 Evidence X-RAY 1zkk H Reference
       Region 1zkk H 16-16 disorder
       Region 1zkk H 17-24 order
       Region 1zkk H 25-25 disorder
 Evidence X-RAY 1zkk G Reference
       Region 1zkk G 16-16 disorder
       Region 1zkk G 17-25 order
 Evidence X-RAY 1zkk F Reference
       Region 1zkk F 16-16 disorder
       Region 1zkk F 17-25 order
 Evidence X-RAY 1zkk E Reference
       Region 1zkk E 16-16 disorder
       Region 1zkk E 17-24 order
       Region 1zkk E 25-25 disorder
Seq 16-26 Hetero dimer : IID00101Complex
 Evidence X-RAY 5teg E Reference
       Region 5teg E 17-17 disorder
       Region 5teg E 18-24 order
 Evidence X-RAY 5teg D Reference
       Region 5teg D 17-24 order
 Evidence X-RAY 3f9z H Reference
       Region 3f9z H 16-16 disorder
       Region 3f9z H 17-24 order
       Region 3f9z H 25-25 disorder
 Evidence X-RAY 3f9z G Reference
       Region 3f9z G 16-16 disorder
       Region 3f9z G 17-23 order
       Region 3f9z G 24-25 disorder
 Evidence X-RAY 3f9z E Reference
       Region 3f9z E 16-16 disorder
       Region 3f9z E 17-25 order
 Evidence X-RAY 3f9z F Reference
       Region 3f9z F 16-16 disorder
       Region 3f9z F 17-24 order
       Region 3f9z F 25-25 disorder
 Evidence X-RAY 3f9y F Reference
       Region 3f9y F 16-16 disorder
       Region 3f9y F 17-24 order
       Region 3f9y F 25-25 disorder
 Evidence X-RAY 3f9y E Reference
       Region 3f9y E 16-16 disorder
       Region 3f9y E 17-23 order
       Region 3f9y E 24-25 disorder
 Evidence X-RAY 3f9x H Reference
       Region 3f9x H 16-16 disorder
       Region 3f9x H 17-24 order
       Region 3f9x H 25-25 disorder
 Evidence X-RAY 3f9x G Reference
       Region 3f9x G 16-16 disorder
       Region 3f9x G 17-25 order
 Evidence X-RAY 3f9x E Reference
       Region 3f9x E 16-16 disorder
       Region 3f9x E 17-25 order
 Evidence X-RAY 3f9x F Reference
       Region 3f9x F 16-16 disorder
       Region 3f9x F 17-24 order
       Region 3f9x F 25-25 disorder
 Evidence X-RAY 3f9w H Reference
       Region 3f9w H 16-16 disorder
       Region 3f9w H 17-24 order
       Region 3f9w H 25-25 disorder
 Evidence X-RAY 3f9w G Reference
       Region 3f9w G 16-16 disorder
       Region 3f9w G 17-25 order
 Evidence X-RAY 3f9w E Reference
       Region 3f9w E 16-16 disorder
       Region 3f9w E 17-25 order
 Evidence X-RAY 3f9w F Reference
       Region 3f9w F 16-16 disorder
       Region 3f9w F 17-24 order
       Region 3f9w F 25-25 disorder
 Evidence X-RAY 2bqz F Reference
       Region 2bqz F 18-26 order
 Evidence X-RAY 2bqz B Reference
       Region 2bqz B 18-26 order
Seq 16-26 Hetero dimer : IID00111Complex
 Evidence X-RAY 3uvy B Reference
       Region 3uvy B 16-25 order
       Region 3uvy B 26-26 disorder
Seq 16-26 Hetero pentamer : IID00335Complex
 Evidence X-RAY 2rje P Reference
       Region 2rje P 16-16 disorder
       Region 2rje P 17-25 order
       Region 2rje P 26-26 disorder
 Evidence X-RAY 2rje Q Reference
       Region 2rje Q 16-18 disorder
       Region 2rje Q 19-26 order
Seq 16-26 Hetero tetramer : Q7Z4V5
 Evidence X-RAY 3qby H Reference
       Region 3qby H 16-18 disorder
       Region 3qby H 19-21 order
       Region 3qby H 22-26 disorder
Seq 17-26 Hetero dimer : IID00123Complex
 Evidence X-RAY 2ig0 B Reference
       Region 2ig0 B 17-19 disorder
       Region 2ig0 B 20-21 order
       Region 2ig0 B 22-26 disorder
Seq 17-26 Hetero dimer : IID00360Complex
 Evidence X-RAY 2qqs C Reference
       Region 2qqs C 17-17 disorder
       Region 2qqs C 18-22 order
       Region 2qqs C 23-26 disorder
 Evidence X-RAY 2qqs D Reference
       Region 2qqs D 17-17 disorder
       Region 2qqs D 18-24 order
       Region 2qqs D 25-26 disorder
Seq 25-42 Hetero dimer : IID00084Complex
 Evidence X-RAY 3cfv F Reference
       Region 3cfv F 25-28 disorder
       Region 3cfv F 29-42 order
 Evidence X-RAY 3cfv E Reference
       Region 3cfv E 25-42 order
 Evidence X-RAY 3cfs E Reference
       Region 3cfs E 28-42 order
SeqProS verified 2-12 Hetero dodecamer : IID00405Complex
       Region 4gqb C 2-9 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-12 Hetero dimer : IID00111Complex
       Region 3uvw B 2-12 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-12 Hetero tetramer : IID50227Complex
       Region 4m38 E 2-5 order
       Region 4m38 F 4-5 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-12 Hetero dimer : IID00374Complex
       Region 2rs9 A 2-11 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-14 Hetero trimer : Q9H8M2
       Region 4yyj F 5-10 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-14 Hetero trimer : IID00545Complex
       Region 4yyn Z 2-12 order
       Region 4yym Z 6-12 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-14 Hetero dimer : Q9H8M2
       Region 4yyg B 7-9 order
       Region 4yyh Y 7-10 order
       Region 4yyh Z 7-10 order
       Region 4yy6 Z 3-12 order
       Region 4yyd Z 3-12 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-14 Hetero dimer : Q86UY6
       Region 4u9w E 2-6 order
       Region 4u9w F 2-6 order
       Region 4u9w G 2-6 order
       Region 4u9w H 2-6 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-14 Hetero dimer : IID00570Complex
       Region 4quu B 4-9 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-14 Hetero dimer : IID00374Complex
       Region 4qyd B 7-14 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-14 Hetero dimer : IID00092Complex
       Region 4n4f C 8-13 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-14 Hetero dimer : IID00570Complex
       Region 4qut B 10-14 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-14 Hetero trimer : Q9H8M2
       Region 4yyk C 5-10 order
       Region 4yyk F 5-10 order
       Region 4yyi C 5-10 order
       Region 4yyi F 5-10 order
       Region 4yyj C 5-10 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-4,15-16 Hetero trimer : IID00360Complex
       Region 5fwe D 2-4 order
       Region 5fwe C 15-16 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 2-21 Hetero dimer : IID00418Complex
       Region 2kwo B 2-21 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 8-13 Hetero dimer : IID00071Complex
       Region 3qzv C 8-13 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 9-14 Hetero trimer : IID00111Complex
       Region 3uw9 E 9-13 order
       Region 3uw9 F 9-14 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 10-24 Hetero dimer : IID00418Complex
       Region 2kwn B 10-24 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 12-18 Hetero dimer : IID00111Complex
       Region 3uvx B 12-18 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 14-25 Hetero dimer : IID00092Complex
       Region 2rny B 14-28 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 15-17 Hetero dimer : IID00289Complex
       Region 3o36 E 15-17 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 15-22 Hetero dimer : IID00071Complex
       Region 3qzt B 15-20 order
       Region 3qzs C 15-22 order
       Region 3qzs D 15-22 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 15-25 Hetero dimer : IID00123Complex
       Region 2lvm B 15-28 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 16-25 Hetero dimer : IID00111Complex
       Region 3uvy B 16-25 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 17-25 Hetero pentamer : IID00335Complex
       Region 2rje P 17-25 order
       Region 2rje Q 19-26 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 17-25 Hetero dimer : IID00101Complex
       Region 3f9y E 17-23 order
       Region 3f9y F 17-24 order
       Region 3f9z E 17-25 order
       Region 3f9z F 17-24 order
       Region 3f9z G 17-23 order
       Region 3f9z H 17-24 order
       Region 3f9w E 17-25 order
       Region 3f9w F 17-24 order
       Region 3f9w G 17-25 order
       Region 3f9w H 17-24 order
       Region 3f9x E 17-25 order
       Region 3f9x F 17-24 order
       Region 3f9x G 17-25 order
       Region 3f9x H 17-24 order
       Region 2bqz B 18-26 order
       Region 2bqz F 18-26 order
       Region 5teg D 17-24 order
       Region 5teg E 18-24 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 17-25 Hetero octamer : IID00101Complex
       Region 1zkk E 17-24 order
       Region 1zkk F 17-25 order
       Region 1zkk G 17-25 order
       Region 1zkk H 17-24 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 18-24 Hetero dimer : IID00530Complex
       Region 3ij1 B 18-24 order
       Region 3jpx B 19-24 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 18-24 Hetero dimer : IID00360Complex
       Region 2qqs C 18-22 order
       Region 2qqs D 18-24 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 18-24 Hetero dimer : IID00123Complex
       Region 2ig0 B 20-21 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 18-24 Hetero dimer : IID00092Complex
       Region 4n3w C 18-22 order
       Region 2cv5 B 1-25 disorder
SeqProS verified 19-21 Hetero tetramer : Q7Z4V5
       Region 3qby H 19-21 order
       Region 2cv5 B 1-25 disorder
Seqphosphorylation
    2-2 Phosphoserine
    48-48 Phosphoserine; by PAK2
    52-52 Phosphotyrosine
    81-81 Phosphothreonine
    89-89 Phosphotyrosine
Seqacetylation
    2-2 N-acetylserine
    6-6 N6-acetyl-N6-methyllysine; alternate
    6-6 N6-acetyllysine; alternate
    9-9 N6-acetyllysine; alternate
    13-13 N6-acetyl-N6-methyllysine; alternate
    13-13 N6-acetyllysine; alternate
    17-17 N6-acetyllysine; alternate
    32-32 N6-acetyllysine; alternate
    92-92 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-18
Order 19-103
ProS 1-18
AlphaFold
Disorder 1-15,103-103
Order 16-102
Pfam Hmmer
PF00125 25-94 2.3e-17
SEG 3-21
Function
Function in SwissProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Biological Process
See also
Diagram with PDB data
TP53/TP53BP1Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide