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IID00063
 UniprotQ00688
ProteinPeptidyl-prolyl cis-trans isomerase FKBP3
GeneFKBP3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
224
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-73 Monomer :
 Evidence NMR 2kfv A Reference
       Region 2kfv A 1-73 order
       Region 2kfv A 1-3 high_rmsd
Seq 1-224 Monomer :
 Evidence NMR 2mph A Reference
       Region 2mph A 1-224 order
       Region 2mph A 1-3 high_rmsd
       Region 2mph A 19-19 high_rmsd
       Region 2mph A 75-110 high_rmsd
       Region 2mph A 120-123 high_rmsd
       Region 2mph A 141-141 high_rmsd
       Region 2mph A 154-154 high_rmsd
       Region 2mph A 195-212 high_rmsd
       Region 2mph A 224-224 high_rmsd
Seq 109-224 Hetero dimer : IID00598Complex
 Evidence X-RAY 5gpg A Reference
       Region 5gpg A 109-150 order
       Region 5gpg A 151-157 disorder
       Region 5gpg A 158-224 order
Seq 109-224 Monomer :
 Evidence X-RAY 1pbk A Reference
       Region 1pbk A 109-224 order
 Evidence X-RAY 5d75 A Reference
       Region 5d75 A 109-224 order
Seqphosphorylation
    152-152 Phosphoserine
    36-36 Phosphoserine
Seqacetylation
    170-170 N6-acetyllysine
    99-99 N6-acetyllysine
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-9,77-107
Order 10-76,108-224
ProS 9-9
AlphaFold
Disorder 1-7,73-108,151-158
Order 8-72,109-150,159-224
Pfam Hmmer
PF00254 119-221 3.5e-47
Function
Function in SwissProt
FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.