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IID00067
 UniprotQ02548
ProteinPaired box protein Pax-5
GenePAX5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
391
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-149 Hetero dimer : IID50005Complex
 Evidence X-RAY 1k78 I Reference
       Region 1k78 I 1-83 disorder
       Region 1k78 I 84-141 order
       Region 1k78 I 142-149 disorder
 Evidence X-RAY 1k78 A Reference
       Region 1k78 A 1-18 disorder
       Region 1k78 A 19-142 order
       Region 1k78 A 143-149 disorder
Seq 1-149 Hetero dimer : IID50005Complex
 Evidence X-RAY 1mdm A Reference
       Region 1mdm A 1-18 disorder
       Region 1mdm A 19-142 order
       Region 1mdm A 143-149 disorder
 Evidence X-RAY 1k78 E Reference
       Region 1k78 E 1-18 disorder
       Region 1k78 E 19-142 order
       Region 1k78 E 143-149 disorder
 
Prediction
NeProc
Disorder 1-2,146-391
Order 3-145
ProS 1-2,146-149,155-159,176-187,198-206,213-276,354-359,368-371,387-391
AlphaFold
Disorder 1-16,145-178,188-227,241-391
Order 17-144,179-187,228-240
Pfam Hmmer
PF00292 16-140 1.1e-90
SEG 157-189 ,369-388
Function
Function in SwissProt
Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238).
(Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172).