Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
459
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Region 1n1a B 1-15 disorder
Region 1n1a B 16-71 order
Region 1n1a B 72-75 disorder
Region 1n1a B 76-140 order
Region 1n1a A 1-15 disorder
Region 1n1a A 16-71 order
Region 1n1a A 72-75 disorder
Region 1n1a A 76-140 order
Seq 1-140 Hetero dimer : IID00598 Complex
Region 4drj A 1-18 disorder
Region 4drj A 19-139 order
Region 4drj A 140-140 disorder
Region 4tw8 B 21-255 order
Region 4tw8 A 21-255 order
Region 1q1c A 2-20 disorder
Region 1q1c A 21-257 order
Region 1q1c A 258-260 disorder
Region 4lay A 1-21 disorder
Region 4lay A 22-255 order
Region 4lay A 256-260 disorder
Region 4lax A 16-21 disorder
Region 4lax A 22-258 order
Region 4lax A 259-260 disorder
Region 4law B 16-21 disorder
Region 4law B 22-255 order
Region 4law B 256-260 disorder
Region 4law A 16-20 disorder
Region 4law A 21-255 order
Region 4law A 256-260 disorder
Region 4lav B 16-119 order
Region 4lav B 120-121 disorder
Region 4lav B 122-255 order
Region 4lav B 256-260 disorder
Region 4lav A 16-255 order
Region 4lav A 256-260 disorder
Seq 145-459 Hetero pentamer : IID00536 Complex
Region 1qz2 C 145-425 order
Region 1qz2 C 426-459 disorder
Region 1qz2 B 145-425 order
Region 1qz2 B 426-459 disorder
Region 1qz2 A 145-425 order
Region 1qz2 A 426-459 disorder
Seq 146-459 Homo hexamer :
Region 1p5q C 146-427 order
Region 1p5q C 428-459 disorder
Region 1p5q B 146-427 order
Region 1p5q B 428-459 disorder
Region 1p5q A 146-427 order
Region 1p5q A 428-459 disorder
143-143 Phosphothreonine; by CK2
2-2 N-acetylthreonine; in peptidyl-prolyl cis-trans isomerase FKBP4
1-1 N-acetylmethionine; in peptidyl-prolyl cis-trans isomerase FKBP4; alternate
Function
Function in SwissProt
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.