Search Keyword:


Search option:


IID00068
UniprotQ02790
ProteinPeptidyl-prolyl cis-trans isomerase FKBP4
GeneFKBP4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
459
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-140 Homo dimer :
 Evidence X-RAY 1n1a B Reference
       Region 1n1a B 1-15 disorder
       Region 1n1a B 16-71 order
       Region 1n1a B 72-75 disorder
       Region 1n1a B 76-140 order
 Evidence X-RAY 1n1a A Reference
       Region 1n1a A 1-15 disorder
       Region 1n1a A 16-71 order
       Region 1n1a A 72-75 disorder
       Region 1n1a A 76-140 order
Seq 1-140 Hetero dimer : IID00598Complex
 Evidence X-RAY 4drj A Reference
       Region 4drj A 1-18 disorder
       Region 4drj A 19-139 order
       Region 4drj A 140-140 disorder
Seq 1-260 Monomer :
 Evidence X-RAY 4tw8 B Reference
       Region 4tw8 B 21-255 order
 Evidence X-RAY 4tw8 A Reference
       Region 4tw8 A 21-255 order
 Evidence X-RAY 1q1c A Reference
       Region 1q1c A 2-20 disorder
       Region 1q1c A 21-257 order
       Region 1q1c A 258-260 disorder
 Evidence X-RAY 4lay A Reference
       Region 4lay A 1-21 disorder
       Region 4lay A 22-255 order
       Region 4lay A 256-260 disorder
 Evidence X-RAY 4lax A Reference
       Region 4lax A 16-21 disorder
       Region 4lax A 22-258 order
       Region 4lax A 259-260 disorder
 Evidence X-RAY 4law B Reference
       Region 4law B 16-21 disorder
       Region 4law B 22-255 order
       Region 4law B 256-260 disorder
 Evidence X-RAY 4law A Reference
       Region 4law A 16-20 disorder
       Region 4law A 21-255 order
       Region 4law A 256-260 disorder
 Evidence X-RAY 4lav B Reference
       Region 4lav B 16-119 order
       Region 4lav B 120-121 disorder
       Region 4lav B 122-255 order
       Region 4lav B 256-260 disorder
 Evidence X-RAY 4lav A Reference
       Region 4lav A 16-255 order
       Region 4lav A 256-260 disorder
Seq 145-459 Hetero pentamer : IID00536Complex
 Evidence X-RAY 1qz2 C Reference
       Region 1qz2 C 145-425 order
       Region 1qz2 C 426-459 disorder
 Evidence X-RAY 1qz2 B Reference
       Region 1qz2 B 145-425 order
       Region 1qz2 B 426-459 disorder
 Evidence X-RAY 1qz2 A Reference
       Region 1qz2 A 145-425 order
       Region 1qz2 A 426-459 disorder
Seq 146-459 Homo hexamer :
 Evidence X-RAY 1p5q C Reference
       Region 1p5q C 146-427 order
       Region 1p5q C 428-459 disorder
 Evidence X-RAY 1p5q B Reference
       Region 1p5q B 146-427 order
       Region 1p5q B 428-459 disorder
 Evidence X-RAY 1p5q A Reference
       Region 1p5q A 146-427 order
       Region 1p5q A 428-459 disorder
Seqphosphorylation
    451-451 Phosphoserine
    436-436 Phosphothreonine
    220-220 Phosphotyrosine
    143-143 Phosphothreonine; by CK2
    453-453 Phosphoserine
Seqacetylation
    282-282 N6-acetyllysine
    2-2 N-acetylthreonine; in peptidyl-prolyl cis-trans isomerase FKBP4
    1-1 N-acetylmethionine; in peptidyl-prolyl cis-trans isomerase FKBP4; alternate
 
Prediction
NeProc
Disorder 1-22,429-459
Order 23-428
ProS 17-22,456-459
AlphaFold
Disorder 1-16,430-459
Order 17-429
Pfam Hmmer
PF00254 41-135 8.1e-50
PF00254 158-250 1.9e-19
PF00515 319-352 1.8e-07
PF00515 353-386 5.8e-07
SEG 419-429
Function
Function in SwissProt
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.