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IID00071
 UniprotQ12830
ProteinNucleosome-remodeling factor subunit BPTF
GeneBPTF
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
3046
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2865-2921 Monomer :
 Evidence NMR 2fui A Reference
       Region 2fui A 2865-2921 order
       Region 2fui A 2865-2866 high_rmsd
       Region 2fui A 2920-2921 high_rmsd
Seq 2865-2921 Hetero dimer : Q7M3Z9
 Evidence NMR 2fuu A Reference
       Region 2fuu A 2865-2921 order
       Region 2fuu A 2865-2866 high_rmsd
       Region 2fuu A 2920-2921 high_rmsd
Seq 2865-3033 Homo dimer :
 Evidence X-RAY 2f6n B Reference
       Region 2f6n B 2865-2866 disorder
       Region 2f6n B 2867-3029 order
       Region 2f6n B 3030-3033 disorder
 Evidence X-RAY 2f6n A Reference
       Region 2f6n A 2865-2866 disorder
       Region 2f6n A 2867-3032 order
       Region 2f6n A 3033-3033 disorder
Seq 2865-3033 Hetero dimer : IID00062Complex
 Evidence X-RAY 2ri7 A Reference
       Region 2ri7 A 2865-2865 disorder
       Region 2ri7 A 2866-3033 order
Seq 2865-3033 Hetero tetramer :
 Evidence X-RAY 2fsa A Reference
       Region 2fsa A 2865-3032 order
       Region 2fsa A 3033-3033 disorder
 Evidence X-RAY 2fsa B Reference
       Region 2fsa B 2865-2865 disorder
       Region 2fsa B 2866-3032 order
       Region 2fsa B 3033-3033 disorder
 Evidence X-RAY 2fsa C Reference
       Region 2fsa C 2865-2866 disorder
       Region 2fsa C 2867-3032 order
       Region 2fsa C 3033-3033 disorder
Seq 2865-3033 Hetero tetramer :
 Evidence X-RAY 2f6j A Reference
       Region 2f6j A 2865-3032 order
       Region 2f6j A 3033-3033 disorder
 Evidence X-RAY 2f6j B Reference
       Region 2f6j B 2865-2865 disorder
       Region 2f6j B 2866-3032 order
       Region 2f6j B 3033-3033 disorder
 Evidence X-RAY 2f6j C Reference
       Region 2f6j C 2865-2866 disorder
       Region 2f6j C 2867-3032 order
       Region 2f6j C 3033-3033 disorder
Seq 2865-3033 Hetero dimer : IID00058Complex
 Evidence X-RAY 3qzv A Reference
       Region 3qzv A 2865-2866 disorder
       Region 3qzv A 2867-3033 order
Seq 2914-3037 Monomer :
 Evidence X-RAY 3uv2 A Reference
       Region 3uv2 A 2914-2918 disorder
       Region 3uv2 A 2919-3037 order
 Evidence X-RAY 5h6y A Reference
       Region 5h6y A 2921-3036 order
Seq 2924-3033 Hetero dimer : IID00058Complex
 Evidence X-RAY 3qzt A Reference
       Region 3qzt A 2924-2924 disorder
       Region 3qzt A 2925-3032 order
       Region 3qzt A 3033-3033 disorder
 Evidence X-RAY 3qzs B Reference
       Region 3qzs B 2924-3033 order
 Evidence X-RAY 3qzs A Reference
       Region 3qzs A 2924-3033 order
Seqphosphorylation
    216-216 Phosphoserine
    572-572 Phosphoserine
    763-763 Phosphoserine
    817-817 Phosphoserine
    1064-1064 Phosphothreonine
    1231-1231 Phosphoserine
    1300-1300 Phosphoserine
    1303-1303 Phosphothreonine
    1310-1310 Phosphoserine
    2098-2098 Phosphoserine
    2465-2465 Phosphoserine
Seqacetylation
    880-880 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-125,170-214,563-572,608-822,1063-1158,1204-1828,1976-2012,2051-2619,2655-2700,2738-2847,3037-3046
Order 126-169,215-562,573-607,823-1062,1159-1203,1829-1975,2013-2050,2620-2654,2701-2737,2848-3036
ProS 5-9,20-24,33-52,120-125,186-189,197-205,764-769,775-794,802-807,816-822,1067-1077,1087-1097,1153-1158,1204-1207,1238-1247,1264-1267,1282-1291,1308-1313,1351-1358,1368-1373,1385-1392,1410-1413,1456-1464,1481-1484,1498-1520,1533-1538,1543-1554,1559-1576,1589-1604,1701-1705,1757-1764,1782-1802,1807-1817,2004-2012,2135-2139,2292-2295,2669-2683,2740-2779,2824-2847,3037-3040
AlphaFold
Disorder 1-224,302-310,349-350,385-385,449-449,452-454,456-456,484-488,564-837,973-983,1002-1186,1190-1190,1205-1829,1874-1883,1928-1932,1972-2004,2045-2627,2629-2631,2634-2634,2637-2638,2640-2642,2644-2645,2648-2683,2686-2686,2784-2866,2917-2925,3037-3046
Order 225-301,311-348,351-384,386-448,450-451,455-455,457-483,489-563,838-972,984-1001,1187-1189,1191-1204,1830-1873,1884-1927,1933-1971,2005-2044,2628-2628,2632-2633,2635-2636,2639-2639,2643-2643,2646-2647,2684-2685,2687-2783,2867-2916,2926-3036
Pfam Hmmer
PF02791 240-300 1.1e-31
PF00628 392-437 5.9e-16
PF00628 2869-2918 1.4e-11
PF00439 2932-3019 4.8e-29
SEG 12-31 ,37-50 ,62-120 ,127-185 ,190-203 ,574-586 ,604-615 ,706-723 ,982-1000 ,1175-1185 ,1205-1219 ,1372-1386 ,1513-1524 ,1606-1617 ,1708-1727 ,1750-1759 ,1781-1804 ,1932-1948 ,2054-2072 ,2118-2134 ,2140-2153 ,2165-2173 ,2257-2270 ,2289-2311 ,2341-2362 ,2391-2431 ,2486-2505 ,2508-2538 ,2548-2587 ,2590-2603 ,2623-2648 ,2710-2723 ,2789-2818 ,2834-2867
Function
Function in SwissProt
Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.