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IID00072
 UniprotQ13285
ProteinSteroidogenic factor 1
GeneNR5A1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
461
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 218-461 Hetero dimer : IID00103Complex
 Evidence X-RAY 4qk4 A Reference
       Region 4qk4 A 218-461 order
 Evidence X-RAY 4qjr A Reference
       Region 4qjr A 218-461 order
Seq 221-461 Hetero dimer : IID00082Complex
 Evidence X-RAY 1zdt B Reference
       Region 1zdt B 221-459 order
       Region 1zdt B 460-461 disorder
 Evidence X-RAY 1zdt A Reference
       Region 1zdt A 221-248 order
       Region 1zdt A 249-255 disorder
       Region 1zdt A 256-460 order
       Region 1zdt A 461-461 disorder
Seq 222-461 Hetero dimer :
 Evidence X-RAY 1yow A Reference
       Region 1yow A 222-250 order
       Region 1yow A 251-258 disorder
       Region 1yow A 259-458 order
       Region 1yow A 459-461 disorder
Seqphosphorylation
    203-203 Phosphoserine; by CDK7
Seqacetylation
    72-72 N6-acetyllysine
    38-38 N6-acetyllysine
    34-34 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-2,87-257
Order 3-86,258-461
ProS 1-2,87-113,159-171,187-212,224-248
AlphaFold
Disorder 1-10,88-88,90-92,117-221,250-259,448-449,459-461
Order 11-87,89-89,93-116,222-249,260-447,450-458
Pfam Hmmer
PF00105 11-86 4.7e-53
PF00104 270-455 2.1e-46
SEG 124-142 ,146-170 ,224-239 ,347-367
Function
Function in SwissProt
Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.