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IID00073
 UniprotQ13451
ProteinPeptidyl-prolyl cis-trans isomerase FKBP5
GeneFKBP5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
457
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-140 Hetero dimer : IID00598Complex
 Evidence X-RAY 4dri A Reference
       Region 4dri A 1-19 disorder
       Region 4dri A 20-140 order
 Evidence X-RAY 4drh D Reference
       Region 4drh D 1-9 disorder
       Region 4drh D 10-140 order
 Evidence X-RAY 4drh A Reference
       Region 4drh A 1-8 disorder
       Region 4drh A 9-140 order
Seq 1-140 Monomer :
 Evidence X-RAY 4tw6 A Reference
       Region 4tw6 A 16-140 order
 Evidence X-RAY 5div A Reference
       Region 5div A 16-139 order
 Evidence X-RAY 4w9q A Reference
       Region 4w9q A 16-140 order
 Evidence X-RAY 4w9p E Reference
       Region 4w9p E 16-139 order
       Region 4w9p E 140-140 disorder
 Evidence X-RAY 4w9p A Reference
       Region 4w9p A 16-18 disorder
       Region 4w9p A 19-139 order
       Region 4w9p A 140-140 disorder
 Evidence X-RAY 4w9o E Reference
       Region 4w9o E 16-139 order
       Region 4w9o E 140-140 disorder
 Evidence X-RAY 4w9o A Reference
       Region 4w9o A 16-16 disorder
       Region 4w9o A 17-139 order
       Region 4w9o A 140-140 disorder
 Evidence X-RAY 4tx0 A Reference
       Region 4tx0 A 16-140 order
 Evidence X-RAY 4tw7 A Reference
       Region 4tw7 A 16-140 order
 Evidence X-RAY 4r0x A Reference
       Region 4r0x A 20-140 order
 Evidence X-RAY 3o5r A Reference
       Region 3o5r A 16-140 order
 Evidence X-RAY 3o5q A Reference
       Region 3o5q A 16-140 order
 Evidence X-RAY 3o5p A Reference
       Region 3o5p A 16-140 order
 Evidence X-RAY 3o5o A Reference
       Region 3o5o A 16-140 order
 Evidence X-RAY 3o5m B Reference
       Region 3o5m B 16-139 order
       Region 3o5m B 140-140 disorder
 Evidence X-RAY 3o5m A Reference
       Region 3o5m A 16-139 order
       Region 3o5m A 140-140 disorder
 Evidence X-RAY 3o5l A Reference
       Region 3o5l A 16-140 order
 Evidence X-RAY 3o5k D Reference
       Region 3o5k D 16-140 order
 Evidence X-RAY 3o5k C Reference
       Region 3o5k C 16-140 order
 Evidence X-RAY 3o5k B Reference
       Region 3o5k B 16-139 order
       Region 3o5k B 140-140 disorder
 Evidence X-RAY 3o5k A Reference
       Region 3o5k A 16-139 order
       Region 3o5k A 140-140 disorder
 Evidence X-RAY 3o5j A Reference
       Region 3o5j A 16-139 order
       Region 3o5j A 140-140 disorder
 Evidence X-RAY 3o5i B Reference
       Region 3o5i B 16-140 order
 Evidence X-RAY 3o5i A Reference
       Region 3o5i A 16-140 order
 Evidence X-RAY 3o5g A Reference
       Region 3o5g A 16-140 order
 Evidence X-RAY 3o5f A Reference
       Region 3o5f A 1-14 disorder
       Region 3o5f A 15-139 order
       Region 3o5f A 140-140 disorder
 Evidence X-RAY 3o5e A Reference
       Region 3o5e A 1-12 disorder
       Region 3o5e A 13-140 order
 Evidence X-RAY 4jfm A Reference
       Region 4jfm A 16-140 order
 Evidence X-RAY 4jfl A Reference
       Region 4jfl A 16-140 order
 Evidence X-RAY 4jfk A Reference
       Region 4jfk A 16-140 order
 Evidence X-RAY 4jfj A Reference
       Region 4jfj A 16-140 order
 Evidence X-RAY 4jfi A Reference
       Region 4jfi A 16-139 order
 Evidence X-RAY 4drq A Reference
       Region 4drq A 16-140 order
 Evidence X-RAY 4drp A Reference
       Region 4drp A 16-140 order
 Evidence X-RAY 4dro A Reference
       Region 4dro A 16-140 order
 Evidence X-RAY 4drn A Reference
       Region 4drn A 16-140 order
 Evidence X-RAY 4drm A Reference
       Region 4drm A 16-140 order
 Evidence X-RAY 4drk B Reference
       Region 4drk B 16-139 order
       Region 4drk B 140-140 disorder
 Evidence X-RAY 4drk A Reference
       Region 4drk A 16-140 order
 Evidence X-RAY 5diu A Reference
       Region 5diu A 16-140 order
 Evidence X-RAY 5dit A Reference
       Region 5dit A 16-140 order
 Evidence X-RAY 5bxj A Reference
       Region 5bxj A 16-139 order
       Region 5bxj A 140-140 disorder
Seq 1-260 Monomer :
 Evidence X-RAY 3o5d B Reference
       Region 3o5d B 1-12 disorder
       Region 3o5d B 13-254 order
       Region 3o5d B 255-260 disorder
 Evidence X-RAY 3o5d A Reference
       Region 3o5d A 1-12 disorder
       Region 3o5d A 13-254 order
       Region 3o5d A 255-260 disorder
Seq 1-457 Monomer :
 Evidence X-RAY 5omp A Reference
       Region 5omp A 1-12 disorder
       Region 5omp A 13-424 order
       Region 5omp A 425-457 disorder
 Evidence X-RAY 1kt0 A Reference
       Region 1kt0 A 1-32 disorder
       Region 1kt0 A 33-37 order
       Region 1kt0 A 38-45 disorder
       Region 1kt0 A 46-61 order
       Region 1kt0 A 62-66 disorder
       Region 1kt0 A 67-69 order
       Region 1kt0 A 70-75 disorder
       Region 1kt0 A 76-381 order
       Region 1kt0 A 382-385 disorder
       Region 1kt0 A 386-412 order
       Region 1kt0 A 413-457 disorder
Seq 1-457 Hetero dimer : Q96HX7
 Evidence X-RAY 5njx A Reference
       Region 5njx A 1-12 disorder
       Region 5njx A 13-425 order
       Region 5njx A 426-457 disorder
Seqphosphorylation
    445-445 Phosphoserine
    13-13 Phosphoserine
Seqacetylation
    155-155 N6-acetyllysine
    28-28 N6-acetyllysine
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-18,411-457
Order 19-410
ProS 411-419,451-457
AlphaFold
Disorder 1-12,430-457
Order 13-429
Pfam Hmmer
PF00254 41-135 1.2e-48
PF00254 156-248 1.8e-22
PF00515 317-350 6.8e-08
PF00515 351-384 6.8e-07
Function
Function in SwissProt
Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277).