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IID00081
 UniprotQ15466
ProteinNuclear receptor subfamily 0 group B member 2
GeneNR0B2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
257
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 12-30 Hetero dimer : IID00001Complex
 Evidence X-RAY 1yuc D Reference
       Region 1yuc D 15-16 disorder
       Region 1yuc D 17-27 order
       Region 1yuc D 28-28 disorder
 Evidence X-RAY 1yuc C Reference
       Region 1yuc C 15-28 order
 Evidence X-RAY 4oni D Reference
       Region 4oni D 12-17 disorder
       Region 4oni D 18-27 order
       Region 4oni D 28-30 disorder
 Evidence X-RAY 4oni C Reference
       Region 4oni C 12-12 disorder
       Region 4oni C 13-28 order
       Region 4oni C 29-30 disorder
 Evidence X-RAY 4dor D Reference
       Region 4dor D 15-17 disorder
       Region 4dor D 18-27 order
       Region 4dor D 28-28 disorder
 Evidence X-RAY 4dor C Reference
       Region 4dor C 15-15 disorder
       Region 4dor C 16-27 order
       Region 4dor C 28-28 disorder
Seq 18-27 Hetero dimer : A0A1X8XLE9
 Evidence X-RAY 5ufs C Reference
       Region 5ufs C 18-27 order
 Evidence X-RAY 5ufs D Reference
       Region 5ufs D 18-27 order
Seq 18-27 Hetero dimer :
 Evidence X-RAY 2q3y B Reference
       Region 2q3y B 18-27 order
Seq 115-124 Hetero dimer : IID00020Complex
 Evidence X-RAY 2z4j B Reference
       Region 2z4j B 115-124 order
SeqProS possible 15-28 LXXLL motif Hetero dimer : IID00001Complex
       Region 1yuc C 15-28 order
       Region 1yuc D 17-27 order
       Region 4dor C 16-27 order
       Region 4dor D 18-27 order
SeqProS possible 15-28 LXXLL motif Hetero dimer : A0A1X8XLE9
       Region 5ufs C 18-27 order
       Region 5ufs D 18-27 order
SeqProS possible 15-28 LXXLL motif Hetero dimer :
       Region 2q3y B 18-27 order
SeqProS possible 115-124 LXXIL motif Hetero dimer : IID00020Complex
       Region 2z4j B 115-124 order
 
Prediction
NeProc
Disorder 1-15,117-139
Order 16-110,140-257
ProS 7-15,117-124
AlphaFold
Disorder 1-40,114-116,118-138,206-211,257-257
Order 41-113,117-117,139-205,212-256
Pfam Hmmer
PF00104 60-253 8.5e-29
SEG 78-89 ,127-133
Function
Function in SwissProt
Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity).