IID00082
 UniprotQ15596
ProteinNuclear receptor coactivator 2
GeneNCOA2
OrganismHomo sapiens
Sequence LLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1464
 order/disorder by at least rule
 order/disorder by majority rule
SeqProS possible 686-698 Hetero dimer : IID00305Complex
SeqProS possible 686-698 Hetero trimer : IID00305Complex
SeqProS possible 686-698 Hetero trimer : IID00365Complex
SeqProS possible 686-698 Hetero dimer : IID00013Complex
SeqProS possible 686-698 Hetero trimer : IID00539Complex
SeqProS possible 686-698 Hetero tetramer : IID00031Complex
SeqProS possible 686-698 Hetero tetramer : IID00031Complex,IID00041Complex
SeqProS possible 686-698 Hetero trimer : IID00305Complex
SeqProS possible 686-698 Hetero tetramer : IID00045Complex
SeqProS possible 686-698 Hetero dimer : IID00020Complex
SeqProS possible 686-698 Hetero tetramer : IID00091Complex
SeqProS possible 686-698 Hetero tetramer : IID00243Complex,IID00368Complex
SeqProS possible 686-698 Hetero tetramer : IID50155Complex
SeqProS possible 686-698 Hetero tetramer : IID00013Complex
SeqProS possible 686-698 Hetero tetramer : IID00031Complex,IID00373Complex
SeqProS possible 686-698 Hetero dimer : IID00031Complex
SeqProS possible 686-698 Hetero dimer : IID50155Complex
SeqProS possible 687-696 Hetero tetramer : IID00031Complex,IID00439Complex
SeqProS possible 734-754 Hetero dimer :
SeqProS possible 734-754 Hetero tetramer : IID00014Complex
SeqProS possible 734-754 Hetero dimer :
SeqProS possible 734-754 Hetero tetramer : IID00014Complex
SeqProS possible 734-754 Hetero dimer : IID00001Complex
SeqProS possible 734-754 Hetero dimer : IID50156Complex
SeqProS possible 734-754 Hetero dimer :
SeqProS possible 734-754 Hetero dimer : IID00013Complex
SeqProS possible 734-754 Hetero dimer :
SeqProS possible 734-754 Hetero dimer : IID00072Complex
SeqProS possible 734-754 Hetero dimer : IID00020Complex
SeqProS possible 734-754 Hetero trimer : IID00001Complex
SeqProS possible 734-754 Hetero dimer : IID00391Complex
SeqProS possible 734-754 Hetero trimer : IID00001Complex
SeqProS possible 734-754 Hetero dimer : IID00373Complex
SeqProS possible 734-754 Hetero dimer : IID00014Complex
SeqProS possible 741-753 Hetero dimer : IID50032Complex
Seqphosphorylation
Seqacetylation
 
Prediction
NeProc
AlphaFold
Pfam Hmmer
SEG 53-65 ,434-447 ,638-648 ,802-813 ,914-931 ,1181-1204 ,1245-1266 ,1292-1304
Function
Function in SwissProt
Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).