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IID00083
 UniprotQ15788
ProteinNuclear receptor coactivator 1
GeneNCOA1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1441
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 257-385 Hetero dimer : IID00047Complex
 Evidence NMR 5nwm A Reference
       Region 5nwm A 257-385 order
       Region 5nwm A 257-257 high_rmsd
       Region 5nwm A 371-385 high_rmsd
Seq 623-710 Hetero trimer : IID00041Complex
 Evidence X-RAY 2prg C Reference
       Region 2prg C 623-627 disorder
       Region 2prg C 628-640 order
       Region 2prg C 641-684 disorder
       Region 2prg C 685-703 order
       Region 2prg C 704-710 disorder
Seq 628-640 Hetero dimer : IID00041Complex
 Evidence X-RAY 2gtk B Reference
       Region 2gtk B 631-640 order
 Evidence X-RAY 3g9e B Reference
       Region 3g9e B 628-630 disorder
       Region 3g9e B 631-640 order
 Evidence X-RAY 2fvj B Reference
       Region 2fvj B 628-630 disorder
       Region 2fvj B 631-640 order
 Evidence X-RAY 3fur H Reference
       Region 3fur H 629-640 order
 Evidence X-RAY 3fej B Reference
       Region 3fej B 628-630 disorder
       Region 3fej B 631-640 order
Seq 629-640 Hetero tetramer : IID00031Complex,IID00041Complex
 Evidence X-RAY 3h0a E Reference
       Region 3h0a E 629-640 order
 Evidence X-RAY 3h0a B Reference
       Region 3h0a B 629-639 order
       Region 3h0a B 640-640 disorder
Seq 630-640 Hetero tetramer : IID00091Complex
 Evidence X-RAY 1zaf D Reference
       Region 1zaf D 630-640 order
 Evidence X-RAY 1zaf C Reference
       Region 1zaf C 630-640 order
 Evidence X-RAY 1yye D Reference
       Region 1yye D 630-630 disorder
       Region 1yye D 631-640 order
 Evidence X-RAY 1yye C Reference
       Region 1yye C 630-630 disorder
       Region 1yye C 631-640 order
 Evidence X-RAY 1yy4 D Reference
       Region 1yy4 D 630-631 disorder
       Region 1yy4 D 632-640 order
 Evidence X-RAY 1yy4 C Reference
       Region 1yy4 C 630-631 disorder
       Region 1yy4 C 632-640 order
 Evidence X-RAY 1x7j D Reference
       Region 1x7j D 630-630 disorder
       Region 1x7j D 631-640 order
 Evidence X-RAY 1x7j C Reference
       Region 1x7j C 630-630 disorder
       Region 1x7j C 631-640 order
 Evidence X-RAY 1x7b D Reference
       Region 1x7b D 630-630 disorder
       Region 1x7b D 631-640 order
 Evidence X-RAY 1x7b C Reference
       Region 1x7b C 630-630 disorder
       Region 1x7b C 631-640 order
 Evidence X-RAY 1x78 D Reference
       Region 1x78 D 630-631 disorder
       Region 1x78 D 632-640 order
 Evidence X-RAY 1x78 C Reference
       Region 1x78 C 630-631 disorder
       Region 1x78 C 632-640 order
 Evidence X-RAY 1x76 D Reference
       Region 1x76 D 630-631 disorder
       Region 1x76 D 632-640 order
 Evidence X-RAY 1x76 C Reference
       Region 1x76 C 630-631 disorder
       Region 1x76 C 632-640 order
 Evidence X-RAY 1u3s D Reference
       Region 1u3s D 630-631 disorder
       Region 1u3s D 632-640 order
 Evidence X-RAY 1u3s C Reference
       Region 1u3s C 630-631 disorder
       Region 1u3s C 632-640 order
 Evidence X-RAY 1u3r D Reference
       Region 1u3r D 630-631 disorder
       Region 1u3r D 632-640 order
 Evidence X-RAY 1u3r C Reference
       Region 1u3r C 630-631 disorder
       Region 1u3r C 632-640 order
 Evidence X-RAY 2nv7 D Reference
       Region 2nv7 D 631-640 order
 Evidence X-RAY 2nv7 C Reference
       Region 2nv7 C 631-640 order
Seq 676-700 Hetero tetramer : IID00031Complex,IID00041Complex
 Evidence X-RAY 1k74 E Reference
       Region 1k74 E 676-684 disorder
       Region 1k74 E 685-700 order
 Evidence X-RAY 1k74 B Reference
       Region 1k74 B 676-686 disorder
       Region 1k74 B 687-696 order
       Region 1k74 B 697-700 disorder
 Evidence X-RAY 5ji0 F Reference
       Region 5ji0 F 676-687 disorder
       Region 5ji0 F 688-696 order
       Region 5ji0 F 697-700 disorder
 Evidence X-RAY 5ji0 E Reference
       Region 5ji0 E 676-681 disorder
       Region 5ji0 E 682-700 order
 Evidence X-RAY 1fm9 E Reference
       Region 1fm9 E 676-684 disorder
       Region 1fm9 E 685-700 order
 Evidence X-RAY 1fm9 B Reference
       Region 1fm9 B 676-686 disorder
       Region 1fm9 B 687-696 order
       Region 1fm9 B 697-700 disorder
 Evidence X-RAY 1fm6 Y Reference
       Region 1fm6 Y 676-683 disorder
       Region 1fm6 Y 684-696 order
       Region 1fm6 Y 697-700 disorder
 Evidence X-RAY 1fm6 V Reference
       Region 1fm6 V 676-684 disorder
       Region 1fm6 V 685-699 order
       Region 1fm6 V 700-700 disorder
 Evidence X-RAY 1fm6 E Reference
       Region 1fm6 E 676-684 disorder
       Region 1fm6 E 685-700 order
 Evidence X-RAY 1fm6 B Reference
       Region 1fm6 B 676-686 disorder
       Region 1fm6 B 687-696 order
       Region 1fm6 B 697-700 disorder
Seq 676-700 Hetero tetramer : IID00243Complex
 Evidence X-RAY 3ipu D Reference
       Region 3ipu D 676-681 disorder
       Region 3ipu D 682-696 order
       Region 3ipu D 697-700 disorder
 Evidence X-RAY 3ipu C Reference
       Region 3ipu C 676-681 disorder
       Region 3ipu C 682-696 order
       Region 3ipu C 697-700 disorder
 Evidence X-RAY 3ips D Reference
       Region 3ips D 676-681 disorder
       Region 3ips D 682-696 order
       Region 3ips D 697-700 disorder
 Evidence X-RAY 3ips C Reference
       Region 3ips C 676-681 disorder
       Region 3ips C 682-696 order
       Region 3ips C 697-700 disorder
 Evidence X-RAY 3ipq B Reference
       Region 3ipq B 676-681 disorder
       Region 3ipq B 682-696 order
       Region 3ipq B 697-700 disorder
 Evidence X-RAY 5hjs D Reference
       Region 5hjs D 676-681 disorder
       Region 5hjs D 682-696 order
       Region 5hjs D 697-700 disorder
 Evidence X-RAY 5hjs C Reference
       Region 5hjs C 676-681 disorder
       Region 5hjs C 682-696 order
       Region 5hjs C 697-700 disorder
 Evidence X-RAY 5avl B Reference
       Region 5avl B 676-681 disorder
       Region 5avl B 682-696 order
       Region 5avl B 697-700 disorder
 Evidence X-RAY 5avi D Reference
       Region 5avi D 676-681 disorder
       Region 5avi D 682-696 order
       Region 5avi D 697-700 disorder
 Evidence X-RAY 5avi B Reference
       Region 5avi B 676-681 disorder
       Region 5avi B 682-696 order
       Region 5avi B 697-700 disorder
Seq 676-700 Hetero dimer : IID00373Complex
 Evidence X-RAY 1p8d D Reference
       Region 1p8d D 676-685 disorder
       Region 1p8d D 686-698 order
       Region 1p8d D 699-700 disorder
 Evidence X-RAY 1p8d C Reference
       Region 1p8d C 676-681 disorder
       Region 1p8d C 682-697 order
       Region 1p8d C 698-700 disorder
Seq 676-700 Hetero tetramer : IID00031Complex
 Evidence X-RAY 1rdt B Reference
       Region 1rdt B 676-686 disorder
       Region 1rdt B 687-695 order
       Region 1rdt B 696-700 disorder
Seq 676-700 Hetero dimer : IID00439Complex
 Evidence X-RAY 4dm8 D Reference
       Region 4dm8 D 676-687 disorder
       Region 4dm8 D 688-695 order
       Region 4dm8 D 696-700 disorder
 Evidence X-RAY 4dm8 C Reference
       Region 4dm8 C 676-687 disorder
       Region 4dm8 C 688-695 order
       Region 4dm8 C 696-700 disorder
 Evidence X-RAY 4dm6 F Reference
       Region 4dm6 F 676-685 disorder
       Region 4dm6 F 686-697 order
       Region 4dm6 F 698-700 disorder
 Evidence X-RAY 4dm6 E Reference
       Region 4dm6 E 676-685 disorder
       Region 4dm6 E 686-696 order
       Region 4dm6 E 697-700 disorder
Seq 676-700 Hetero dimer : IID00041Complex
 Evidence X-RAY 4hee Y Reference
       Region 4hee Y 676-683 disorder
       Region 4hee Y 684-699 order
       Region 4hee Y 700-700 disorder
 Evidence X-RAY 3vn2 C Reference
       Region 3vn2 C 685-685 disorder
       Region 3vn2 C 686-696 order
       Region 3vn2 C 697-700 disorder
 Evidence X-RAY 3v9y B Reference
       Region 3v9y B 686-696 order
       Region 3v9y B 697-700 disorder
 Evidence X-RAY 3t03 D Reference
       Region 3t03 D 683-686 disorder
       Region 3t03 D 687-699 order
       Region 3t03 D 700-700 disorder
 Evidence X-RAY 3t03 C Reference
       Region 3t03 C 683-686 disorder
       Region 3t03 C 687-694 order
       Region 3t03 C 695-700 disorder
 Evidence X-RAY 3s9s B Reference
       Region 3s9s B 685-685 disorder
       Region 3s9s B 686-695 order
       Region 3s9s B 696-697 disorder
 Evidence X-RAY 3qt0 C Reference
       Region 3qt0 C 685-696 order
       Region 3qt0 C 697-700 disorder
 Evidence X-RAY 3lmp C Reference
       Region 3lmp C 686-696 order
       Region 3lmp C 697-700 disorder
 Evidence X-RAY 2hfp B Reference
       Region 2hfp B 680-683 disorder
       Region 2hfp B 684-700 order
 Evidence X-RAY 5gtp B Reference
       Region 5gtp B 685-685 disorder
       Region 5gtp B 686-696 order
       Region 5gtp B 697-700 disorder
 Evidence X-RAY 5gto B Reference
       Region 5gto B 685-685 disorder
       Region 5gto B 686-696 order
       Region 5gto B 697-700 disorder
 Evidence X-RAY 5gtn B Reference
       Region 5gtn B 685-686 disorder
       Region 5gtn B 687-696 order
       Region 5gtn B 697-700 disorder
 Evidence X-RAY 4fgy B Reference
       Region 4fgy B 686-696 order
 Evidence X-RAY 4f9m C Reference
       Region 4f9m C 686-686 disorder
       Region 4f9m C 687-697 order
       Region 4f9m C 698-700 disorder
 Evidence X-RAY 3et3 P Reference
       Region 3et3 P 680-695 order
 Evidence X-RAY 5dwl B Reference
       Region 5dwl B 685-686 disorder
       Region 5dwl B 687-696 order
       Region 5dwl B 697-700 disorder
 Evidence X-RAY 5dvc B Reference
       Region 5dvc B 685-685 disorder
       Region 5dvc B 686-696 order
       Region 5dvc B 697-700 disorder
 Evidence X-RAY 5dv8 B Reference
       Region 5dv8 B 685-686 disorder
       Region 5dv8 B 687-696 order
       Region 5dv8 B 697-700 disorder
 Evidence X-RAY 5dv6 B Reference
       Region 5dv6 B 685-686 disorder
       Region 5dv6 B 687-696 order
       Region 5dv6 B 697-700 disorder
 Evidence X-RAY 5dv3 B Reference
       Region 5dv3 B 685-686 disorder
       Region 5dv3 B 687-696 order
       Region 5dv3 B 697-700 disorder
 Evidence X-RAY 5dsh B Reference
       Region 5dsh B 685-686 disorder
       Region 5dsh B 687-695 order
       Region 5dsh B 696-700 disorder
 Evidence X-RAY 3cwd D Reference
       Region 3cwd D 685-700 order
 Evidence X-RAY 3cwd C Reference
       Region 3cwd C 685-700 order
Seq 676-700 Hetero tetramer : IID00391Complex
 Evidence X-RAY 3bej F Reference
       Region 3bej F 676-683 disorder
       Region 3bej F 684-695 order
       Region 3bej F 696-700 disorder
 Evidence X-RAY 3bej E Reference
       Region 3bej E 676-684 disorder
       Region 3bej E 685-695 order
       Region 3bej E 696-700 disorder
Seq 676-700 Hetero dimer : IID00361Complex
 Evidence X-RAY 1nrl D Reference
       Region 1nrl D 676-681 disorder
       Region 1nrl D 682-696 order
       Region 1nrl D 697-700 disorder
 Evidence X-RAY 1nrl C Reference
       Region 1nrl C 676-681 disorder
       Region 1nrl C 682-696 order
       Region 1nrl C 697-700 disorder
Seq 676-700 Hetero tetramer : IID00361Complex
 Evidence X-RAY 5x0r D Reference
       Region 5x0r D 676-681 disorder
       Region 5x0r D 682-696 order
       Region 5x0r D 697-700 disorder
 Evidence X-RAY 5x0r C Reference
       Region 5x0r C 676-681 disorder
       Region 5x0r C 682-696 order
       Region 5x0r C 697-700 disorder
 Evidence X-RAY 5a86 D Reference
       Region 5a86 D 682-698 order
 Evidence X-RAY 5a86 C Reference
       Region 5a86 C 682-696 order
       Region 5a86 C 697-698 disorder
Seq 678-700 Hetero tetramer : IID00031Complex,IID00361Complex
 Evidence X-RAY 4j5x B Reference
       Region 4j5x B 678-680 disorder
       Region 4j5x B 681-698 order
       Region 4j5x B 699-700 disorder
 Evidence X-RAY 4j5x A Reference
       Region 4j5x A 678-681 disorder
       Region 4j5x A 682-696 order
       Region 4j5x A 697-700 disorder
 Evidence X-RAY 4j5x D Reference
       Region 4j5x D 678-685 disorder
       Region 4j5x D 686-696 order
       Region 4j5x D 697-700 disorder
 Evidence X-RAY 4j5x C Reference
       Region 4j5x C 678-685 disorder
       Region 4j5x C 686-696 order
       Region 4j5x C 697-700 disorder
Seq 678-700 Monomer : IID00361Complex
 Evidence X-RAY 3ctb A Reference
       Region 3ctb A 678-681 disorder
       Region 3ctb A 682-696 order
       Region 3ctb A 697-700 disorder
Seq 678-700 Monomer : IID00361Complex
 Evidence X-RAY 3hvl A Reference
       Region 3hvl A 678-681 disorder
       Region 3hvl A 682-696 order
       Region 3hvl A 697-700 disorder
Seq 678-700 Monomer : IID00361Complex
 Evidence X-RAY 3ctb B Reference
       Region 3ctb B 678-681 disorder
       Region 3ctb B 682-698 order
       Region 3ctb B 699-700 disorder
Seq 678-700 Monomer : IID00361Complex
 Evidence X-RAY 3hvl B Reference
       Region 3hvl B 678-681 disorder
       Region 3hvl B 682-698 order
       Region 3hvl B 699-700 disorder
Seq 678-710 Homo dimer : IID00361Complex
 Evidence X-RAY 6bns B Reference
       Region 6bns B 678-681 disorder
       Region 6bns B 682-696 order
       Region 6bns B 697-710 disorder
 Evidence X-RAY 6bns A Reference
       Region 6bns A 678-681 disorder
       Region 6bns A 682-696 order
       Region 6bns A 697-710 disorder
Seq 680-700 Hetero dimer : IID00382Complex
 Evidence X-RAY 2p54 B Reference
       Region 2p54 B 686-696 order
 Evidence X-RAY 2npa D Reference
       Region 2npa D 683-684 disorder
       Region 2npa D 685-694 order
       Region 2npa D 695-697 disorder
 Evidence X-RAY 2npa B Reference
       Region 2npa B 683-697 order
 Evidence X-RAY 1k7l H Reference
       Region 1k7l H 680-684 disorder
       Region 1k7l H 685-697 order
       Region 1k7l H 698-700 disorder
 Evidence X-RAY 1k7l F Reference
       Region 1k7l F 680-684 disorder
       Region 1k7l F 685-697 order
       Region 1k7l F 698-700 disorder
 Evidence X-RAY 1k7l D Reference
       Region 1k7l D 680-684 disorder
       Region 1k7l D 685-697 order
       Region 1k7l D 698-700 disorder
 Evidence X-RAY 1k7l B Reference
       Region 1k7l B 680-684 disorder
       Region 1k7l B 685-697 order
       Region 1k7l B 698-700 disorder
 Evidence X-RAY 3et1 Q Reference
       Region 3et1 Q 681-696 order
 Evidence X-RAY 3et1 P Reference
       Region 3et1 P 681-681 disorder
       Region 3et1 P 682-696 order
Seq 683-697 Hetero trimer : IID00382Complex
 Evidence X-RAY 5azt C Reference
       Region 5azt C 683-685 disorder
       Region 5azt C 686-696 order
       Region 5azt C 697-697 disorder
Seq 683-701 Hetero dimer : IID00091Complex
 Evidence X-RAY 3omq D Reference
       Region 3omq D 683-685 disorder
       Region 3omq D 686-695 order
       Region 3omq D 696-701 disorder
 Evidence X-RAY 3omq C Reference
       Region 3omq C 683-685 disorder
       Region 3omq C 686-695 order
       Region 3omq C 696-701 disorder
 Evidence X-RAY 3omp D Reference
       Region 3omp D 683-685 disorder
       Region 3omp D 686-695 order
       Region 3omp D 696-701 disorder
 Evidence X-RAY 3omp C Reference
       Region 3omp C 683-685 disorder
       Region 3omp C 686-695 order
       Region 3omp C 696-701 disorder
 Evidence X-RAY 3omo D Reference
       Region 3omo D 683-685 disorder
       Region 3omo D 686-695 order
       Region 3omo D 696-701 disorder
 Evidence X-RAY 3omo C Reference
       Region 3omo C 683-685 disorder
       Region 3omo C 686-695 order
       Region 3omo C 696-701 disorder
 Evidence X-RAY 3ols D Reference
       Region 3ols D 683-685 disorder
       Region 3ols D 686-695 order
       Region 3ols D 696-701 disorder
 Evidence X-RAY 3ols C Reference
       Region 3ols C 683-685 disorder
       Region 3ols C 686-695 order
       Region 3ols C 696-701 disorder
 Evidence X-RAY 3oll D Reference
       Region 3oll D 683-685 disorder
       Region 3oll D 686-695 order
       Region 3oll D 696-701 disorder
 Evidence X-RAY 3oll C Reference
       Region 3oll C 683-685 disorder
       Region 3oll C 686-695 order
       Region 3oll C 696-701 disorder
Seq 685-697 Hetero tetramer : IID00031Complex,IID00475Complex
 Evidence X-RAY 1xvp H Reference
       Region 1xvp H 685-696 order
       Region 1xvp H 697-697 disorder
 Evidence X-RAY 1xvp G Reference
       Region 1xvp G 685-696 order
       Region 1xvp G 697-697 disorder
 Evidence X-RAY 1xvp F Reference
       Region 1xvp F 685-685 disorder
       Region 1xvp F 686-697 order
 Evidence X-RAY 1xvp E Reference
       Region 1xvp E 685-686 disorder
       Region 1xvp E 687-696 order
       Region 1xvp E 697-697 disorder
 Evidence X-RAY 1xv9 H Reference
       Region 1xv9 H 685-696 order
       Region 1xv9 H 697-697 disorder
 Evidence X-RAY 1xv9 G Reference
       Region 1xv9 G 685-696 order
       Region 1xv9 G 697-697 disorder
 Evidence X-RAY 1xv9 F Reference
       Region 1xv9 F 685-685 disorder
       Region 1xv9 F 686-697 order
 Evidence X-RAY 1xv9 E Reference
       Region 1xv9 E 685-686 disorder
       Region 1xv9 E 687-696 order
       Region 1xv9 E 697-697 disorder
Seq 686-698 Hetero tetramer : IID00013Complex
 Evidence X-RAY 4tv1 D Reference
       Region 4tv1 D 686-687 disorder
       Region 4tv1 D 688-696 order
       Region 4tv1 D 697-698 disorder
 Evidence X-RAY 4tv1 C Reference
       Region 4tv1 C 686-687 disorder
       Region 4tv1 C 688-696 order
       Region 4tv1 C 697-698 disorder
 Evidence X-RAY 4tuz G Reference
       Region 4tuz G 686-687 disorder
       Region 4tuz G 688-696 order
       Region 4tuz G 697-698 disorder
 Evidence X-RAY 4tuz F Reference
       Region 4tuz F 686-687 disorder
       Region 4tuz F 688-696 order
       Region 4tuz F 697-698 disorder
 Evidence X-RAY 4mgd G Reference
       Region 4mgd G 686-686 disorder
       Region 4mgd G 687-696 order
       Region 4mgd G 697-698 disorder
 Evidence X-RAY 4mgd F Reference
       Region 4mgd F 686-687 disorder
       Region 4mgd F 688-696 order
       Region 4mgd F 697-698 disorder
 Evidence X-RAY 4mgc G Reference
       Region 4mgc G 686-687 disorder
       Region 4mgc G 688-696 order
       Region 4mgc G 697-698 disorder
 Evidence X-RAY 4mgc F Reference
       Region 4mgc F 686-687 disorder
       Region 4mgc F 688-696 order
       Region 4mgc F 697-698 disorder
 Evidence X-RAY 4mgb D Reference
       Region 4mgb D 686-686 disorder
       Region 4mgb D 687-696 order
       Region 4mgb D 697-698 disorder
 Evidence X-RAY 4mgb C Reference
       Region 4mgb C 686-687 disorder
       Region 4mgb C 688-696 order
       Region 4mgb C 697-698 disorder
 Evidence X-RAY 4mga D Reference
       Region 4mga D 686-686 disorder
       Region 4mga D 687-696 order
       Region 4mga D 697-698 disorder
 Evidence X-RAY 4mga C Reference
       Region 4mga C 686-687 disorder
       Region 4mga C 688-696 order
       Region 4mga C 697-698 disorder
 Evidence X-RAY 4mg9 G Reference
       Region 4mg9 G 686-687 disorder
       Region 4mg9 G 688-696 order
       Region 4mg9 G 697-698 disorder
 Evidence X-RAY 4mg9 F Reference
       Region 4mg9 F 686-687 disorder
       Region 4mg9 F 688-696 order
       Region 4mg9 F 697-698 disorder
 Evidence X-RAY 4mg8 D Reference
       Region 4mg8 D 686-686 disorder
       Region 4mg8 D 687-696 order
       Region 4mg8 D 697-698 disorder
 Evidence X-RAY 4mg8 C Reference
       Region 4mg8 C 686-686 disorder
       Region 4mg8 C 687-696 order
       Region 4mg8 C 697-698 disorder
 Evidence X-RAY 4mg7 D Reference
       Region 4mg7 D 686-686 disorder
       Region 4mg7 D 687-696 order
       Region 4mg7 D 697-698 disorder
 Evidence X-RAY 4mg7 C Reference
       Region 4mg7 C 686-687 disorder
       Region 4mg7 C 688-696 order
       Region 4mg7 C 697-698 disorder
 Evidence X-RAY 4mg6 D Reference
       Region 4mg6 D 686-687 disorder
       Region 4mg6 D 688-696 order
       Region 4mg6 D 697-698 disorder
 Evidence X-RAY 4mg6 C Reference
       Region 4mg6 C 686-687 disorder
       Region 4mg6 C 688-696 order
       Region 4mg6 C 697-698 disorder
 Evidence X-RAY 4mg5 D Reference
       Region 4mg5 D 686-686 disorder
       Region 4mg5 D 687-696 order
       Region 4mg5 D 697-698 disorder
 Evidence X-RAY 4mg5 C Reference
       Region 4mg5 C 686-687 disorder
       Region 4mg5 C 688-696 order
       Region 4mg5 C 697-698 disorder
 Evidence X-RAY 5jmm G Reference
       Region 5jmm G 686-686 disorder
       Region 5jmm G 687-696 order
       Region 5jmm G 697-698 disorder
 Evidence X-RAY 5jmm F Reference
       Region 5jmm F 686-687 disorder
       Region 5jmm F 688-696 order
       Region 5jmm F 697-698 disorder
Seq 686-698 Hetero dimer : IID00365Complex
 Evidence X-RAY 3kmr C Reference
       Region 3kmr C 686-686 disorder
       Region 3kmr C 687-696 order
       Region 3kmr C 697-698 disorder
Seq 686-698 Hetero tetramer : IID00439Complex
 Evidence X-RAY 4jyi G Reference
       Region 4jyi G 686-686 disorder
       Region 4jyi G 687-696 order
       Region 4jyi G 697-698 disorder
 Evidence X-RAY 4jyi F Reference
       Region 4jyi F 686-686 disorder
       Region 4jyi F 687-695 order
       Region 4jyi F 696-698 disorder
 Evidence X-RAY 4jyh G Reference
       Region 4jyh G 686-696 order
       Region 4jyh G 697-698 disorder
 Evidence X-RAY 4jyh C Reference
       Region 4jyh C 686-686 disorder
       Region 4jyh C 687-696 order
       Region 4jyh C 697-698 disorder
 Evidence X-RAY 4jyg G Reference
       Region 4jyg G 686-696 order
       Region 4jyg G 697-698 disorder
 Evidence X-RAY 4jyg F Reference
       Region 4jyg F 686-696 order
       Region 4jyg F 697-698 disorder
Seq 686-698 Hetero dimer : IID00013Complex
 Evidence X-RAY 3uud D Reference
       Region 3uud D 686-696 order
       Region 3uud D 697-698 disorder
 Evidence X-RAY 3uud C Reference
       Region 3uud C 686-687 disorder
       Region 3uud C 688-696 order
       Region 3uud C 697-698 disorder
 Evidence X-RAY 3uua G Reference
       Region 3uua G 686-687 disorder
       Region 3uua G 688-696 order
       Region 3uua G 697-698 disorder
 Evidence X-RAY 3uua F Reference
       Region 3uua F 686-687 disorder
       Region 3uua F 688-696 order
       Region 3uua F 697-698 disorder
 Evidence X-RAY 3uu7 G Reference
       Region 3uu7 G 686-687 disorder
       Region 3uu7 G 688-696 order
       Region 3uu7 G 697-698 disorder
 Evidence X-RAY 3uu7 F Reference
       Region 3uu7 F 686-687 disorder
       Region 3uu7 F 688-696 order
       Region 3uu7 F 697-698 disorder
Seq 686-700 Hetero tetramer : IID00057Complex
 Evidence X-RAY 1tfc D Reference
       Region 1tfc D 686-686 disorder
       Region 1tfc D 687-696 order
       Region 1tfc D 697-700 disorder
 Evidence X-RAY 1tfc C Reference
       Region 1tfc C 686-686 disorder
       Region 1tfc C 687-697 order
       Region 1tfc C 698-700 disorder
 Evidence X-RAY 1kv6 D Reference
       Region 1kv6 D 686-686 disorder
       Region 1kv6 D 687-697 order
       Region 1kv6 D 698-700 disorder
 Evidence X-RAY 1kv6 C Reference
       Region 1kv6 C 686-686 disorder
       Region 1kv6 C 687-696 order
       Region 1kv6 C 697-700 disorder
Seq 686-700 Hetero octamer : IID50154Complex
 Evidence X-RAY 1xiu F Reference
       Region 1xiu F 686-687 disorder
       Region 1xiu F 688-697 order
       Region 1xiu F 698-700 disorder
 Evidence X-RAY 1xiu E Reference
       Region 1xiu E 686-686 disorder
       Region 1xiu E 687-698 order
       Region 1xiu E 699-700 disorder
Seq 686-700 Hetero dimer : IID50142Complex
 Evidence X-RAY 1nq7 B Reference
       Region 1nq7 B 687-696 order
 Evidence X-RAY 1n4h B Reference
       Region 1n4h B 686-686 disorder
       Region 1n4h B 687-696 order
       Region 1n4h B 697-700 disorder
 Evidence X-RAY 1k4w B Reference
       Region 1k4w B 686-686 disorder
       Region 1k4w B 687-696 order
       Region 1k4w B 697-700 disorder
Seq 686-700 Hetero dimer : G1RH57
 Evidence X-RAY 5x8w B Reference
       Region 5x8w B 686-687 disorder
       Region 5x8w B 688-696 order
       Region 5x8w B 697-700 disorder
 Evidence X-RAY 5x8u B Reference
       Region 5x8u B 686-687 disorder
       Region 5x8u B 688-696 order
       Region 5x8u B 697-700 disorder
Seq 686-700 Hetero tetramer : IID50155Complex
 Evidence X-RAY 4rup B Reference
       Region 4rup B 686-695 order
       Region 4rup B 696-700 disorder
 Evidence X-RAY 4ruj B Reference
       Region 4ruj B 686-695 order
       Region 4ruj B 696-700 disorder
 Evidence X-RAY 5nma B Reference
       Region 5nma B 686-695 order
       Region 5nma B 696-700 disorder
Seq 686-700 Hetero dimer : IID50155Complex
 Evidence X-RAY 5nky B Reference
       Region 5nky B 686-695 order
       Region 5nky B 696-700 disorder
 Evidence X-RAY 5owd B Reference
       Region 5owd B 686-696 order
       Region 5owd B 697-700 disorder
 Evidence X-RAY 5ow9 B Reference
       Region 5ow9 B 686-695 order
       Region 5ow9 B 696-700 disorder
 Evidence X-RAY 5ow7 B Reference
       Region 5ow7 B 686-696 order
       Region 5ow7 B 697-700 disorder
 Evidence X-RAY 2hcd B Reference
       Region 2hcd B 686-695 order
       Region 2hcd B 696-700 disorder
 Evidence X-RAY 2hc4 B Reference
       Region 2hc4 B 686-695 order
       Region 2hc4 B 696-700 disorder
 Evidence X-RAY 2hbh B Reference
       Region 2hbh B 686-695 order
       Region 2hbh B 696-700 disorder
 Evidence X-RAY 4g2h B Reference
       Region 4g2h B 686-695 order
       Region 4g2h B 696-700 disorder
 Evidence X-RAY 4g21 B Reference
       Region 4g21 B 686-696 order
       Region 4g21 B 697-700 disorder
 Evidence X-RAY 4g20 B Reference
       Region 4g20 B 686-695 order
       Region 4g20 B 696-700 disorder
 Evidence X-RAY 4g1z B Reference
       Region 4g1z B 686-695 order
       Region 4g1z B 696-700 disorder
 Evidence X-RAY 4g1y B Reference
       Region 4g1y B 686-695 order
       Region 4g1y B 696-700 disorder
 Evidence X-RAY 4g1d B Reference
       Region 4g1d B 686-696 order
       Region 4g1d B 697-700 disorder
 Evidence X-RAY 5e7v B Reference
       Region 5e7v B 686-695 order
       Region 5e7v B 696-700 disorder
 Evidence X-RAY 3dr1 B Reference
       Region 3dr1 B 686-696 order
       Region 3dr1 B 697-700 disorder
Seq 687-700 Hetero dimer : IID00045Complex
 Evidence X-RAY 1pzl B Reference
       Region 1pzl B 687-700 order
Seq 741-761 Hetero dimer : IID00391Complex
 Evidence X-RAY 3dct B Reference
       Region 3dct B 741-744 disorder
       Region 3dct B 745-755 order
       Region 3dct B 756-761 disorder
 Evidence X-RAY 3rvf B Reference
       Region 3rvf B 741-744 disorder
       Region 3rvf B 745-755 order
       Region 3rvf B 756-761 disorder
 Evidence X-RAY 3ruu B Reference
       Region 3ruu B 745-755 order
 Evidence X-RAY 3rut B Reference
       Region 3rut B 745-755 order
 Evidence X-RAY 5q1i B Reference
       Region 5q1i B 744-744 disorder
       Region 5q1i B 745-756 order
       Region 5q1i B 757-757 disorder
 Evidence X-RAY 5q1h H Reference
       Region 5q1h H 744-745 disorder
       Region 5q1h H 746-755 order
       Region 5q1h H 756-757 disorder
 Evidence X-RAY 5q1h F Reference
       Region 5q1h F 744-745 disorder
       Region 5q1h F 746-754 order
       Region 5q1h F 755-757 disorder
 Evidence X-RAY 5q1h D Reference
       Region 5q1h D 744-745 disorder
       Region 5q1h D 746-755 order
       Region 5q1h D 756-757 disorder
 Evidence X-RAY 5q1h B Reference
       Region 5q1h B 744-744 disorder
       Region 5q1h B 745-755 order
       Region 5q1h B 756-757 disorder
 Evidence X-RAY 5q1g B Reference
       Region 5q1g B 744-745 disorder
       Region 5q1g B 746-754 order
       Region 5q1g B 755-757 disorder
 Evidence X-RAY 5q1f D Reference
       Region 5q1f D 744-745 disorder
       Region 5q1f D 746-755 order
       Region 5q1f D 756-757 disorder
 Evidence X-RAY 5q1f B Reference
       Region 5q1f B 744-744 disorder
       Region 5q1f B 745-755 order
       Region 5q1f B 756-757 disorder
 Evidence X-RAY 5q1e B Reference
       Region 5q1e B 744-744 disorder
       Region 5q1e B 745-755 order
       Region 5q1e B 756-757 disorder
 Evidence X-RAY 5q1d D Reference
       Region 5q1d D 744-745 disorder
       Region 5q1d D 746-756 order
       Region 5q1d D 757-757 disorder
 Evidence X-RAY 5q1d B Reference
       Region 5q1d B 744-754 order
       Region 5q1d B 755-757 disorder
 Evidence X-RAY 5q1c D Reference
       Region 5q1c D 744-745 disorder
       Region 5q1c D 746-755 order
       Region 5q1c D 756-757 disorder
 Evidence X-RAY 5q1c B Reference
       Region 5q1c B 744-745 disorder
       Region 5q1c B 746-756 order
       Region 5q1c B 757-757 disorder
 Evidence X-RAY 5q1b D Reference
       Region 5q1b D 744-745 disorder
       Region 5q1b D 746-756 order
       Region 5q1b D 757-757 disorder
 Evidence X-RAY 5q1b B Reference
       Region 5q1b B 744-744 disorder
       Region 5q1b B 745-756 order
       Region 5q1b B 757-757 disorder
 Evidence X-RAY 5q1a D Reference
       Region 5q1a D 744-745 disorder
       Region 5q1a D 746-755 order
       Region 5q1a D 756-757 disorder
 Evidence X-RAY 5q1a B Reference
       Region 5q1a B 744-755 order
       Region 5q1a B 756-757 disorder
 Evidence X-RAY 5q19 D Reference
       Region 5q19 D 744-745 disorder
       Region 5q19 D 746-755 order
       Region 5q19 D 756-757 disorder
 Evidence X-RAY 5q19 B Reference
       Region 5q19 B 744-744 disorder
       Region 5q19 B 745-755 order
       Region 5q19 B 756-757 disorder
 Evidence X-RAY 5q18 D Reference
       Region 5q18 D 744-745 disorder
       Region 5q18 D 746-756 order
       Region 5q18 D 757-757 disorder
 Evidence X-RAY 5q18 B Reference
       Region 5q18 B 744-744 disorder
       Region 5q18 B 745-756 order
       Region 5q18 B 757-757 disorder
 Evidence X-RAY 5q16 D Reference
       Region 5q16 D 744-746 disorder
       Region 5q16 D 747-755 order
       Region 5q16 D 756-757 disorder
 Evidence X-RAY 5q16 B Reference
       Region 5q16 B 744-744 disorder
       Region 5q16 B 745-754 order
       Region 5q16 B 755-757 disorder
 Evidence X-RAY 5q15 D Reference
       Region 5q15 D 744-745 disorder
       Region 5q15 D 746-755 order
       Region 5q15 D 756-757 disorder
 Evidence X-RAY 5q15 B Reference
       Region 5q15 B 744-744 disorder
       Region 5q15 B 745-755 order
       Region 5q15 B 756-757 disorder
 Evidence X-RAY 5q14 D Reference
       Region 5q14 D 744-745 disorder
       Region 5q14 D 746-756 order
       Region 5q14 D 757-757 disorder
 Evidence X-RAY 5q14 B Reference
       Region 5q14 B 744-744 disorder
       Region 5q14 B 745-756 order
       Region 5q14 B 757-757 disorder
 Evidence X-RAY 5q13 D Reference
       Region 5q13 D 744-744 disorder
       Region 5q13 D 745-755 order
       Region 5q13 D 756-757 disorder
 Evidence X-RAY 5q13 B Reference
       Region 5q13 B 744-746 disorder
       Region 5q13 B 747-756 order
       Region 5q13 B 757-757 disorder
 Evidence X-RAY 5q12 B Reference
       Region 5q12 B 744-745 disorder
       Region 5q12 B 746-756 order
       Region 5q12 B 757-757 disorder
 Evidence X-RAY 5q11 B Reference
       Region 5q11 B 744-744 disorder
       Region 5q11 B 745-756 order
       Region 5q11 B 757-757 disorder
 Evidence X-RAY 5q10 B Reference
       Region 5q10 B 744-745 disorder
       Region 5q10 B 746-755 order
       Region 5q10 B 756-757 disorder
 Evidence X-RAY 5q0z D Reference
       Region 5q0z D 744-744 disorder
       Region 5q0z D 745-755 order
       Region 5q0z D 756-757 disorder
 Evidence X-RAY 5q0z B Reference
       Region 5q0z B 744-744 disorder
       Region 5q0z B 745-755 order
       Region 5q0z B 756-757 disorder
 Evidence X-RAY 5q0y D Reference
       Region 5q0y D 744-745 disorder
       Region 5q0y D 746-756 order
       Region 5q0y D 757-757 disorder
 Evidence X-RAY 5q0y B Reference
       Region 5q0y B 744-744 disorder
       Region 5q0y B 745-755 order
       Region 5q0y B 756-757 disorder
 Evidence X-RAY 5q0x B Reference
       Region 5q0x B 744-756 order
       Region 5q0x B 757-757 disorder
 Evidence X-RAY 5q0w B Reference
       Region 5q0w B 744-744 disorder
       Region 5q0w B 745-756 order
       Region 5q0w B 757-757 disorder
 Evidence X-RAY 5q0v D Reference
       Region 5q0v D 744-745 disorder
       Region 5q0v D 746-756 order
       Region 5q0v D 757-757 disorder
 Evidence X-RAY 5q0v B Reference
       Region 5q0v B 744-756 order
       Region 5q0v B 757-757 disorder
 Evidence X-RAY 5q0u D Reference
       Region 5q0u D 744-745 disorder
       Region 5q0u D 746-756 order
       Region 5q0u D 757-757 disorder
 Evidence X-RAY 5q0u B Reference
       Region 5q0u B 744-744 disorder
       Region 5q0u B 745-756 order
       Region 5q0u B 757-757 disorder
 Evidence X-RAY 5q0t B Reference
       Region 5q0t B 744-744 disorder
       Region 5q0t B 745-755 order
       Region 5q0t B 756-757 disorder
 Evidence X-RAY 5q0s D Reference
       Region 5q0s D 744-745 disorder
       Region 5q0s D 746-755 order
       Region 5q0s D 756-757 disorder
 Evidence X-RAY 5q0s B Reference
       Region 5q0s B 744-744 disorder
       Region 5q0s B 745-755 order
       Region 5q0s B 756-757 disorder
 Evidence X-RAY 5q0r B Reference
       Region 5q0r B 744-744 disorder
       Region 5q0r B 745-756 order
       Region 5q0r B 757-757 disorder
 Evidence X-RAY 5q0q D Reference
       Region 5q0q D 744-755 order
       Region 5q0q D 756-757 disorder
 Evidence X-RAY 5q0q B Reference
       Region 5q0q B 744-746 disorder
       Region 5q0q B 747-755 order
       Region 5q0q B 756-757 disorder
 Evidence X-RAY 5q0p D Reference
       Region 5q0p D 744-757 order
 Evidence X-RAY 5q0p B Reference
       Region 5q0p B 744-744 disorder
       Region 5q0p B 745-756 order
       Region 5q0p B 757-757 disorder
 Evidence X-RAY 5q0o D Reference
       Region 5q0o D 744-745 disorder
       Region 5q0o D 746-756 order
       Region 5q0o D 757-757 disorder
 Evidence X-RAY 5q0o B Reference
       Region 5q0o B 744-744 disorder
       Region 5q0o B 745-756 order
       Region 5q0o B 757-757 disorder
 Evidence X-RAY 5q0n D Reference
       Region 5q0n D 744-745 disorder
       Region 5q0n D 746-756 order
       Region 5q0n D 757-757 disorder
 Evidence X-RAY 5q0n B Reference
       Region 5q0n B 744-744 disorder
       Region 5q0n B 745-755 order
       Region 5q0n B 756-757 disorder
 Evidence X-RAY 5q0m B Reference
       Region 5q0m B 744-745 disorder
       Region 5q0m B 746-755 order
       Region 5q0m B 756-757 disorder
 Evidence X-RAY 5q0l D Reference
       Region 5q0l D 744-744 disorder
       Region 5q0l D 745-756 order
       Region 5q0l D 757-757 disorder
 Evidence X-RAY 5q0l B Reference
       Region 5q0l B 744-744 disorder
       Region 5q0l B 745-755 order
       Region 5q0l B 756-757 disorder
 Evidence X-RAY 5q0k B Reference
       Region 5q0k B 744-756 order
       Region 5q0k B 757-757 disorder
 Evidence X-RAY 5q0j D Reference
       Region 5q0j D 744-745 disorder
       Region 5q0j D 746-755 order
       Region 5q0j D 756-757 disorder
 Evidence X-RAY 5q0j B Reference
       Region 5q0j B 744-744 disorder
       Region 5q0j B 745-755 order
       Region 5q0j B 756-757 disorder
 Evidence X-RAY 3p89 B Reference
       Region 3p89 B 745-755 order
 Evidence X-RAY 3p88 B Reference
       Region 3p88 B 745-755 order
 Evidence X-RAY 3ook D Reference
       Region 3ook D 744-745 disorder
       Region 3ook D 746-756 order
       Region 3ook D 757-757 disorder
 Evidence X-RAY 3ook B Reference
       Region 3ook B 744-744 disorder
       Region 3ook B 745-756 order
       Region 3ook B 757-757 disorder
 Evidence X-RAY 3oof D Reference
       Region 3oof D 744-756 order
       Region 3oof D 757-757 disorder
 Evidence X-RAY 3oof B Reference
       Region 3oof B 744-744 disorder
       Region 3oof B 745-756 order
       Region 3oof B 757-757 disorder
 Evidence X-RAY 3omm D Reference
       Region 3omm D 744-744 disorder
       Region 3omm D 745-756 order
       Region 3omm D 757-757 disorder
 Evidence X-RAY 3omm B Reference
       Region 3omm B 744-756 order
       Region 3omm B 757-757 disorder
 Evidence X-RAY 3omk D Reference
       Region 3omk D 744-745 disorder
       Region 3omk D 746-756 order
       Region 3omk D 757-757 disorder
 Evidence X-RAY 3omk B Reference
       Region 3omk B 744-755 order
       Region 3omk B 756-757 disorder
 Evidence X-RAY 3olf D Reference
       Region 3olf D 744-745 disorder
       Region 3olf D 746-756 order
       Region 3olf D 757-757 disorder
 Evidence X-RAY 3olf B Reference
       Region 3olf B 744-744 disorder
       Region 3olf B 745-755 order
       Region 3olf B 756-757 disorder
 Evidence X-RAY 3oki D Reference
       Region 3oki D 744-745 disorder
       Region 3oki D 746-755 order
       Region 3oki D 756-757 disorder
 Evidence X-RAY 3oki B Reference
       Region 3oki B 744-744 disorder
       Region 3oki B 745-756 order
       Region 3oki B 757-757 disorder
 Evidence X-RAY 3okh B Reference
       Region 3okh B 744-745 disorder
       Region 3okh B 746-755 order
       Region 3okh B 756-757 disorder
 Evidence X-RAY 3hc6 B Reference
       Region 3hc6 B 741-744 disorder
       Region 3hc6 B 745-755 order
       Region 3hc6 B 756-761 disorder
 Evidence X-RAY 3hc5 B Reference
       Region 3hc5 B 741-744 disorder
       Region 3hc5 B 745-755 order
       Region 3hc5 B 756-761 disorder
 Evidence X-RAY 3fxv B Reference
       Region 3fxv B 744-756 order
 Evidence X-RAY 3dcu B Reference
       Region 3dcu B 741-744 disorder
       Region 3dcu B 745-755 order
       Region 3dcu B 756-761 disorder
Seq 744-756 Hetero dimer : IID00382Complex
 Evidence X-RAY 3g8i Z Reference
       Region 3g8i Z 744-745 disorder
       Region 3g8i Z 746-753 order
       Region 3g8i Z 754-756 disorder
 Evidence X-RAY 3fei Z Reference
       Region 3fei Z 744-745 disorder
       Region 3fei Z 746-753 order
       Region 3fei Z 754-756 disorder
Seq 745-756 Hetero tetramer : IID00373Complex
 Evidence X-RAY 4dk8 D Reference
       Region 4dk8 D 745-756 order
 Evidence X-RAY 4dk8 B Reference
       Region 4dk8 B 745-756 order
 Evidence X-RAY 4dk7 D Reference
       Region 4dk7 D 745-756 order
 Evidence X-RAY 4dk7 B Reference
       Region 4dk7 B 745-756 order
Seq 920-970 Hetero dimer : IID50008Complex
 Evidence NMR 2c52 B Reference
       Region 2c52 B 920-970 order
       Region 2c52 B 925-925 high_rmsd
Seq 1427-1441 Hetero dimer : IID00702Complex
 Evidence X-RAY 4udb B Reference
       Region 4udb B 1427-1429 disorder
       Region 4udb B 1430-1441 order
 Evidence X-RAY 4uda B Reference
       Region 4uda B 1427-1431 disorder
       Region 4uda B 1432-1441 order
 Evidence X-RAY 5l7h B Reference
       Region 5l7h B 1432-1441 order
 Evidence X-RAY 5l7g B Reference
       Region 5l7g B 1432-1441 order
 Evidence X-RAY 5l7e B Reference
       Region 5l7e B 1432-1441 order
 Evidence X-RAY 2a3i B Reference
       Region 2a3i B 1430-1441 order
Seq 1429-1441 Hetero dimer : Q9XZJ5
 Evidence X-RAY 3gyu B Reference
       Region 3gyu B 1429-1431 disorder
       Region 3gyu B 1432-1441 order
 Evidence X-RAY 3gyt B Reference
       Region 3gyt B 1429-1431 disorder
       Region 3gyt B 1432-1441 order
Seq 1429-1441 Hetero dimer : IID00014Complex
 Evidence X-RAY 3bqd B Reference
       Region 3bqd B 1429-1430 disorder
       Region 3bqd B 1431-1441 order
Seq 1432-1441 Hetero dimer : IID00041Complex
 Evidence X-RAY 4y29 B Reference
       Region 4y29 B 1432-1441 order
Seq 1432-1441 Hetero dimer : IID00365Complex
 Evidence X-RAY 4dqm D Reference
       Region 4dqm D 1432-1441 order
 Evidence X-RAY 4dqm B Reference
       Region 4dqm B 1432-1441 order
SeqProS possible 628-640 LXXLL motif Hetero tetramer : IID00031Complex,IID00041Complex
       Region 3h0a B 629-639 order
       Region 3h0a E 629-640 order
SeqProS possible 628-640 LXXLL motif Hetero tetramer : IID00091Complex
       Region 1x78 C 632-640 order
       Region 1x78 D 632-640 order
       Region 1x7j C 631-640 order
       Region 1x7j D 631-640 order
       Region 1x7b C 631-640 order
       Region 1x7b D 631-640 order
       Region 1yye C 631-640 order
       Region 1yye D 631-640 order
       Region 1u3r C 632-640 order
       Region 1u3r D 632-640 order
       Region 1u3s C 632-640 order
       Region 1u3s D 632-640 order
       Region 1x76 C 632-640 order
       Region 1x76 D 632-640 order
       Region 1zaf C 630-640 order
       Region 1zaf D 630-640 order
       Region 1yy4 C 632-640 order
       Region 1yy4 D 632-640 order
       Region 2nv7 C 631-640 order
       Region 2nv7 D 631-640 order
SeqProS possible 628-640 LXXLL motif Hetero dimer : IID00041Complex
       Region 3g9e B 631-640 order
       Region 3fur H 629-640 order
       Region 2gtk B 631-640 order
       Region 3fej B 631-640 order
       Region 2fvj B 631-640 order
SeqProS possible 628-640,680-703 LXXLL motif Hetero trimer : IID00041Complex
       Region 2prg C 628-640 order
       Region 2prg C 685-703 order
SeqProS possible 680-703 LXXLL motif Hetero dimer : IID00439Complex
       Region 4dm6 E 686-696 order
       Region 4dm6 F 686-697 order
       Region 4dm8 C 688-695 order
       Region 4dm8 D 688-695 order
SeqProS possible 680-703 LXXLL motif Hetero dimer : IID00013Complex
       Region 3uu7 F 688-696 order
       Region 3uu7 G 688-696 order
       Region 3uua F 688-696 order
       Region 3uua G 688-696 order
       Region 3uud C 688-696 order
       Region 3uud D 686-696 order
SeqProS possible 680-703 LXXLL motif Hetero tetramer : IID00031Complex
       Region 1rdt B 687-695 order
SeqProS possible 680-703 LXXLL motif Hetero dimer : IID00361Complex
       Region 1nrl C 682-696 order
       Region 1nrl D 682-696 order
SeqProS possible 680-703 LXXLL motif Hetero dimer : IID00373Complex
       Region 1p8d C 682-697 order
       Region 1p8d D 686-698 order
SeqProS possible 680-703 LXXLL motif Hetero dimer : IID00382Complex
       Region 3et1 P 682-696 order
       Region 3et1 Q 681-696 order
       Region 2npa B 683-697 order
       Region 2npa D 685-694 order
       Region 2p54 B 686-696 order
       Region 1k7l B 685-697 order
       Region 1k7l D 685-697 order
       Region 1k7l F 685-697 order
       Region 1k7l H 685-697 order
SeqProS possible 680-703 LXXLL motif Hetero tetramer : IID00243Complex
       Region 3ips C 682-696 order
       Region 3ips D 682-696 order
       Region 3ipu C 682-696 order
       Region 3ipu D 682-696 order
       Region 3ipq B 682-696 order
       Region 5avl B 682-696 order
       Region 5avi B 682-696 order
       Region 5avi D 682-696 order
SeqProS possible 680-703 LXXLL motif Hetero dimer : IID00045Complex
       Region 1pzl B 687-700 order
SeqProS possible 680-703 LXXLL motif Hetero tetramer : IID00057Complex
       Region 1tfc C 687-697 order
       Region 1tfc D 687-696 order
       Region 1kv6 C 687-696 order
       Region 1kv6 D 687-697 order
SeqProS possible 680-703 LXXLL motif Hetero tetramer : IID00013Complex
       Region 4mga C 688-696 order
       Region 4mga D 687-696 order
       Region 4mg9 F 688-696 order
       Region 4mg9 G 688-696 order
       Region 4mg7 C 688-696 order
       Region 4mg7 D 687-696 order
       Region 4tv1 C 688-696 order
       Region 4tv1 D 688-696 order
       Region 4mgd F 688-696 order
       Region 4mgd G 687-696 order
       Region 4mg8 C 687-696 order
       Region 4mg8 D 687-696 order
       Region 4mg5 C 688-696 order
       Region 4mg5 D 687-696 order
       Region 4mg6 C 688-696 order
       Region 4mgc F 688-696 order
       Region 4mgc G 688-696 order
       Region 4tuz F 688-696 order
       Region 4tuz G 688-696 order
       Region 4mgb C 688-696 order
       Region 4mgb D 687-696 order
SeqProS possible 680-703 LXXLL motif Hetero tetramer : IID00031Complex,IID00475Complex
       Region 1xv9 E 687-696 order
       Region 1xv9 F 686-697 order
       Region 1xv9 G 685-696 order
       Region 1xv9 H 685-696 order
       Region 1xvp E 687-696 order
       Region 1xvp F 686-697 order
       Region 1xvp G 685-696 order
       Region 1xvp H 685-696 order
SeqProS possible 680-703 LXXLL motif Hetero dimer : IID00091Complex
       Region 3omo C 686-695 order
       Region 3omo D 686-695 order
       Region 3omp C 686-695 order
       Region 3omp D 686-695 order
       Region 3oll C 686-695 order
       Region 3oll D 686-695 order
       Region 3omq C 686-695 order
       Region 3omq D 686-695 order
       Region 3ols C 686-695 order
       Region 3ols D 686-695 order
SeqProS possible 680-703 LXXLL motif Hetero tetramer : IID00439Complex
       Region 4jyg F 686-696 order
       Region 4jyg G 686-696 order
       Region 4jyi F 687-695 order
       Region 4jyi G 687-696 order
       Region 4jyh C 687-696 order
       Region 4jyh G 686-696 order
SeqProS possible 680-703 LXXLL motif Hetero dimer : IID50142Complex
       Region 1nq7 B 687-696 order
       Region 1n4h B 687-696 order
       Region 1k4w B 687-696 order
SeqProS possible 680-703 LXXLL motif Hetero dimer : IID50155Complex
       Region 2hbh B 686-695 order
       Region 3dr1 B 686-696 order
       Region 2hc4 B 686-695 order
       Region 2hcd B 686-695 order
       Region 4g1d B 686-696 order
       Region 4g1y B 686-695 order
       Region 4g1z B 686-695 order
       Region 4g20 B 686-695 order
       Region 4g21 B 686-696 order
       Region 4g2h B 686-695 order
SeqProS possible 680-703 LXXLL motif Hetero tetramer : IID00031Complex,IID00361Complex
       Region 4j5x A 682-696 order
       Region 4j5x B 681-698 order
       Region 4j5x C 686-696 order
       Region 4j5x D 686-696 order
SeqProS possible 680-703 LXXLL motif : IID00361Complex
       Region 3ctb A 682-696 order
SeqProS possible 680-703 LXXLL motif : IID00361Complex
       Region 3hvl B 682-698 order
SeqProS possible 680-703 LXXLL motif Hetero octamer : IID50154Complex
       Region 1xiu E 687-698 order
       Region 1xiu F 688-697 order
SeqProS possible 680-703 LXXLL motif Hetero tetramer : IID00361Complex
       Region 5a86 C 682-696 order
       Region 5a86 D 682-698 order
SeqProS possible 680-703 LXXLL motif Hetero dimer : IID00041Complex
       Region 2hfp B 684-700 order
       Region 3et3 P 680-695 order
       Region 3cwd C 685-700 order
       Region 3cwd D 685-700 order
       Region 3lmp C 686-696 order
       Region 3s9s B 686-695 order
       Region 3t03 C 687-694 order
       Region 3t03 D 687-699 order
       Region 3v9y B 686-696 order
       Region 3vn2 C 686-696 order
       Region 4f9m C 687-697 order
       Region 4fgy B 686-696 order
       Region 4hee Y 684-699 order
SeqProS possible 680-703 LXXLL motif : IID00361Complex
       Region 3hvl A 682-696 order
SeqProS possible 680-703 LXXLL motif Hetero tetramer : IID00031Complex,IID00041Complex
       Region 1k74 B 687-696 order
       Region 1k74 E 685-700 order
       Region 1fm9 E 685-700 order
       Region 1fm6 B 687-696 order
       Region 1fm6 E 685-700 order
       Region 1fm6 V 685-699 order
       Region 1fm6 Y 684-696 order
SeqProS possible 680-703 LXXLL motif Hetero tetramer : IID00391Complex
       Region 3bej E 685-695 order
       Region 3bej F 684-695 order
SeqProS possible 680-703 LXXLL motif Hetero dimer : IID00365Complex
       Region 3kmr C 687-696 order
SeqProS possible 680-703 LXXLL motif Hetero tetramer : IID50155Complex
       Region 4rup B 686-695 order
       Region 4ruj B 686-695 order
SeqProS possible 680-703 LXXLL motif : IID00361Complex
       Region 3ctb B 682-698 order
SeqProS possible 744-756 LXXLL motif Hetero tetramer : IID00373Complex
       Region 4dk7 B 745-756 order
       Region 4dk7 D 745-756 order
       Region 4dk8 B 745-756 order
       Region 4dk8 D 745-756 order
SeqProS possible 744-756 LXXLL motif Hetero dimer : IID00382Complex
       Region 3fei Z 746-753 order
       Region 3g8i Z 746-753 order
SeqProS possible 744-756 LXXLL motif Hetero dimer : IID00391Complex
       Region 3dct B 745-755 order
       Region 3fxv B 744-756 order
       Region 3hc5 B 745-755 order
       Region 3dcu B 745-755 order
       Region 3hc6 B 745-755 order
       Region 3p88 B 745-755 order
       Region 3p89 B 745-755 order
       Region 3olf B 745-755 order
       Region 3olf D 746-756 order
       Region 3rvf B 745-755 order
       Region 3ook B 745-756 order
       Region 3ook D 746-756 order
       Region 3oki B 745-756 order
       Region 3oki D 746-755 order
       Region 3omm B 744-756 order
       Region 3omm D 745-756 order
       Region 3ruu B 745-755 order
       Region 3rut B 745-755 order
       Region 3oof B 745-756 order
       Region 3oof D 744-756 order
       Region 3omk B 744-755 order
       Region 3omk D 746-756 order
SeqProS possible 1431-1441 LXXLL motif Hetero dimer : IID00041Complex
       Region 4y29 B 1432-1441 order
SeqProS possible 1431-1441 LXXLL motif Hetero dimer : IID00365Complex
       Region 4dqm B 1432-1441 order
       Region 4dqm D 1432-1441 order
SeqProS possible 1431-1441 LXXLL motif Hetero dimer : IID00014Complex
       Region 3bqd B 1431-1441 order
SeqProS possible 1431-1441 LXXLL motif Hetero dimer : Q9XZJ5
       Region 3gyu B 1432-1441 order
Seqphosphorylation
    1185-1185 Phosphoserine
    22-22 Phosphoserine
    372-372 Phosphoserine
    395-395 Phosphoserine
    517-517 Phosphoserine
    558-558 Phosphoserine
    569-569 Phosphoserine
    698-698 Phosphoserine
    1033-1033 Phosphoserine
    1179-1179 Phosphothreonine
    1372-1372 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-43,58-73,87-103,178-185,371-1441
Order 44-57,74-86,104-172,186-370
ProS 1-43,58-73,90-103,178-185,624-638,684-711,743-757,812-821,1067-1070,1355-1370,1392-1411,1433-1441
AlphaFold
Disorder 1-29,52-64,83-111,171-192,204-215,227-241,251-259,367-928,960-960,962-1055,1057-1057,1061-1063,1065-1106,1133-1441
Order 30-51,65-82,112-170,193-203,216-226,242-250,260-366,929-959,961-961,1056-1056,1058-1060,1064-1064,1107-1132
Pfam Hmmer
PF07469 1149-1199 2.5e-21
PF07469 1212-1268 2e-23
SEG 422-444 ,454-475 ,659-682 ,771-779 ,783-796 ,1053-1074 ,1119-1138 ,1168-1181 ,1250-1275 ,1327-1345 ,1385-1392 ,1425-1439
Function
Function in SwissProt
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Biological Process
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment
See also
Diagram with PDB data
STAT6/NCOA1Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6
Crebbp/NCOA3Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR