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IID00084
 UniprotQ16576
ProteinHistone-binding protein RBBP7
GeneRBBP7
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
425
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-411 Hetero dimer : IID00058Complex
 Evidence X-RAY 3cfs B Reference
       Region 3cfs B 1-6 disorder
       Region 3cfs B 7-89 order
       Region 3cfs B 90-110 disorder
       Region 3cfs B 111-410 order
       Region 3cfs B 411-411 disorder
 Evidence X-RAY 3cfv B Reference
       Region 3cfv B 1-89 order
       Region 3cfv B 90-109 disorder
       Region 3cfv B 110-410 order
       Region 3cfv B 411-411 disorder
 Evidence X-RAY 3cfv A Reference
       Region 3cfv A 1-88 order
       Region 3cfv A 89-109 disorder
       Region 3cfv A 110-409 order
       Region 3cfv A 410-411 disorder
Seqphosphorylation
    13-13 Phosphoserine
    354-354 Phosphoserine
    95-95 Phosphoserine
    10-10 Phosphothreonine
    3-3 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    159-159 N6-acetyllysine; alternate
    119-119 N6-acetyllysine
    4-4 N6-acetyllysine; alternate
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-13,92-107,411-425
Order 14-91,108-410
ProS 13-13,92-97,102-107,417-425
AlphaFold
Disorder 1-1,89-112,211-211,411-425
Order 2-88,113-210,212-410
Pfam Hmmer
PF00400 166-205 1.1e-06
PF00400 216-255 0.00016
PF00400 262-301 3.8e-09
PF00400 306-345 3.9e-07
PF00400 363-402 5.3e-06
Function
Function in SwissProt
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Biological Process
See also
Diagram with PDB data
MTA1/HDAC1The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex
EZH2/EED/SUZ12/H3C1/JARID2Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide