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IID00086
 UniprotQ16695
ProteinHistone H3.1t
GeneH3-4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
136
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-136 Hetero octamer : IID00016Complex,IID00058Complex
 Evidence X-RAY 3a6n E Reference
       Region 3a6n E 1-38 disorder
       Region 3a6n E 39-136 order
 Evidence X-RAY 3a6n A Reference
       Region 3a6n A 1-38 disorder
       Region 3a6n A 39-135 order
       Region 3a6n A 136-136 disorder
Seq 2-8 Hetero trimer : IID00327Complex
 Evidence X-RAY 3t6r D Reference
       Region 3t6r D 2-6 order
       Region 3t6r D 7-8 disorder
Seq 2-22 Hetero trimer : IID00009Complex
 Evidence X-RAY 2v1d C Reference
       Region 2v1d C 2-17 order
       Region 2v1d C 18-22 disorder
Seq 17-36 Hetero trimer : IID00360Complex
 Evidence X-RAY 4v2w C Reference
       Region 4v2w C 17-25 disorder
       Region 4v2w C 26-29 order
       Region 4v2w C 30-36 disorder
Seq 26-30 Hetero dimer : IID00360Complex
 Evidence X-RAY 4v2v C Reference
       Region 4v2v C 26-30 order
 Evidence X-RAY 4v2v D Reference
       Region 4v2v D 26-30 order
Seq 31-42 Hetero dimer : IID00360Complex
 Evidence X-RAY 2ybs D Reference
       Region 2ybs D 31-42 order
 Evidence X-RAY 2ybs C Reference
       Region 2ybs C 31-42 order
 Evidence X-RAY 2ybp D Reference
       Region 2ybp D 31-42 order
 Evidence X-RAY 2ybp C Reference
       Region 2ybp C 31-42 order
SeqProS verified 2-6 Hetero trimer : IID00327Complex
       Region 3t6r D 2-6 order
       Region 3a6n A 1-38 disorder
SeqProS verified 2-17 Hetero trimer : IID00009Complex
       Region 2v1d C 2-17 order
       Region 3a6n A 1-38 disorder
SeqProS verified 26-30 Hetero trimer : IID00360Complex
       Region 4v2w C 26-29 order
       Region 3a6n A 1-38 disorder
SeqProS verified 26-30 Hetero dimer : IID00360Complex
       Region 4v2v C 26-30 order
       Region 4v2v D 26-30 order
       Region 3a6n A 1-38 disorder
SeqProS verified 31-38 Hetero dimer : IID00360Complex
       Region 2ybp C 31-42 order
       Region 2ybp D 31-42 order
       Region 2ybs C 31-42 order
       Region 2ybs D 31-42 order
       Region 3a6n A 1-38 disorder
Seqphosphorylation
    4-4 Phosphothreonine; by HASPIN
    7-7 Phosphothreonine; by PKC
    11-11 Phosphoserine; alternate; by AURKB
    12-12 Phosphothreonine; by PKC
    29-29 Phosphoserine; alternate; by AURKB
    42-42 Phosphotyrosine
    58-58 Phosphoserine
    81-81 Phosphothreonine
    87-87 Phosphoserine
    108-108 Phosphothreonine
Seqacetylation
    5-5 N6-acetyllysine; alternate
    10-10 N6-acetyllysine; alternate
    15-15 N6-acetyllysine; alternate
    19-19 N6-acetyllysine; alternate
    24-24 N6-acetyllysine; alternate
    28-28 N6-acetyllysine; alternate
    37-37 N6-acetyllysine; alternate
    57-57 N6-acetyllysine; alternate
    80-80 N6-acetyllysine; alternate
    116-116 N6-acetyllysine; alternate
    123-123 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-36
Order 37-136
ProS 1-36
AlphaFold
Disorder 1-3,7-35,135-136
Order 4-6,36-134
Pfam Hmmer
PF00125 58-132 6.4e-39
Function
Function in SwissProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.