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IID00087
 UniprotQ6W2J9
ProteinBCL-6 corepressor
GeneBCOR
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1755
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 498-514 Hetero tetramer : IID00372Complex
 Evidence X-RAY 3bim N Reference
       Region 3bim N 498-498 disorder
       Region 3bim N 499-514 order
 Evidence X-RAY 3bim M Reference
       Region 3bim M 498-514 order
 Evidence X-RAY 3bim J Reference
       Region 3bim J 498-514 order
 Evidence X-RAY 3bim I Reference
       Region 3bim I 498-514 order
 Evidence X-RAY 3bim P Reference
       Region 3bim P 498-514 order
 Evidence X-RAY 3bim O Reference
       Region 3bim O 498-514 order
 Evidence X-RAY 3bim L Reference
       Region 3bim L 498-498 disorder
       Region 3bim L 499-514 order
 Evidence X-RAY 3bim K Reference
       Region 3bim K 498-514 order
Seq 1634-1748 Hetero dimer : IID00621Complex
 Evidence X-RAY 4hpl A Reference
       Region 4hpl A 1634-1635 disorder
       Region 4hpl A 1636-1748 order
Seq 1634-1748 Monomer :
 Evidence NMR 2n1l A Reference
       Region 2n1l A 1634-1748 order
SeqProS possible 498-514 With the exception of the ankyrin region, BCOR is described to be disordered (PubMed=18280243). Hetero tetramer : IID00372Complex
       Region 3bim I 498-514 order
       Region 3bim J 498-514 order
       Region 3bim K 498-514 order
       Region 3bim L 499-514 order
       Region 3bim M 498-514 order
       Region 3bim N 499-514 order
       Region 3bim O 498-514 order
       Region 3bim P 498-514 order
Seqphosphorylation
    336-336 Phosphoserine
    340-340 Phosphoserine
    365-365 Phosphoserine
    367-367 Phosphoserine
    423-423 Phosphoserine
    1127-1127 Phosphoserine
    1139-1139 Phosphoserine
    1290-1290 Phosphoserine
    1345-1345 Phosphoserine
    1410-1410 Phosphoserine
Seqacetylation
    392-392 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-4,32-1453,1584-1596,1607-1635
Order 5-31,1454-1583,1597-1606,1636-1755
ProS 32-36,41-95,117-124,142-154,189-192,202-208,243-251,262-268,282-290,436-452,457-462,496-514,525-536,543-548,574-584,623-629,639-649,654-663,673-717,742-748,766-778,802-813,865-875,923-927,936-956,966-979,987-997,1012-1030,1044-1063,1073-1110,1121-1172,1197-1205,1215-1218,1233-1240,1260-1281,1360-1369,1378-1396,1406-1410,1584-1590,1607-1619,1628-1635
AlphaFold
Disorder 1-1214,1216-1218,1220-1447,1587-1645,1705-1712,1739-1755
Order 1215-1215,1219-1219,1448-1586,1646-1704,1713-1738
Pfam Hmmer
PF00023 1496-1528 2.7e-05
PF00023 1529-1561 5e-08
SEG 331-342 ,557-578 ,601-620 ,1625-1631
Function
Function in SwissProt
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).