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IID00088
 UniprotQ71DI3
ProteinHistone H3.2
GeneH3C15
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
136
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-136 Hetero octamer : IID00016Complex,IID00058Complex
 Evidence X-RAY 5b40 E Reference
       Region 5b40 E 1-41 disorder
       Region 5b40 E 42-136 order
 Evidence X-RAY 5b40 A Reference
       Region 5b40 A 1-41 disorder
       Region 5b40 A 42-135 order
       Region 5b40 A 136-136 disorder
 Evidence X-RAY 5b0z E Reference
       Region 5b0z E 1-37 disorder
       Region 5b0z E 38-135 order
       Region 5b0z E 136-136 disorder
 Evidence X-RAY 5b0z A Reference
       Region 5b0z A 1-38 disorder
       Region 5b0z A 39-134 order
       Region 5b0z A 135-136 disorder
 Evidence X-RAY 5b0y E Reference
       Region 5b0y E 1-37 disorder
       Region 5b0y E 38-136 order
 Evidence X-RAY 5b0y A Reference
       Region 5b0y A 1-39 disorder
       Region 5b0y A 40-135 order
       Region 5b0y A 136-136 disorder
 Evidence X-RAY 3av1 E Reference
       Region 3av1 E 1-37 disorder
       Region 3av1 E 38-136 order
 Evidence X-RAY 3av1 A Reference
       Region 3av1 A 1-39 disorder
       Region 3av1 A 40-135 order
       Region 3av1 A 136-136 disorder
Seq 2-12 Hetero dimer : IID00574Complex
 Evidence X-RAY 4ouc B Reference
       Region 4ouc B 2-8 order
       Region 4ouc B 9-12 disorder
Seq 2-16 Hetero octamer : IID00392Complex
 Evidence X-RAY 3r93 E Reference
       Region 3r93 E 2-4 disorder
       Region 3r93 E 5-16 order
 Evidence X-RAY 3r93 F Reference
       Region 3r93 F 2-2 disorder
       Region 3r93 F 3-16 order
 Evidence X-RAY 3r93 G Reference
       Region 3r93 G 2-4 disorder
       Region 3r93 G 5-16 order
 Evidence X-RAY 3r93 H Reference
       Region 3r93 H 2-4 disorder
       Region 3r93 H 5-16 order
Seq 2-16 Hetero dimer : IID00392Complex
 Evidence X-RAY 3qo2 S Reference
       Region 3qo2 S 2-16 order
 Evidence X-RAY 3qo2 R Reference
       Region 3qo2 R 2-2 disorder
       Region 3qo2 R 3-16 order
 Evidence X-RAY 3qo2 Q Reference
       Region 3qo2 Q 2-3 disorder
       Region 3qo2 Q 4-16 order
 Evidence X-RAY 3qo2 P Reference
       Region 3qo2 P 2-16 order
Seq 2-21 Hetero dimer : IID00591Complex
 Evidence X-RAY 4mzh B Reference
       Region 4mzh B 2-9 order
       Region 4mzh B 10-10 disorder
 Evidence X-RAY 4mzg C Reference
       Region 4mzg C 2-7 order
       Region 4mzg C 8-21 disorder
 Evidence X-RAY 4mzg A Reference
       Region 4mzg A 2-10 order
       Region 4mzg A 11-21 disorder
 Evidence X-RAY 4mzf A Reference
       Region 4mzf A 2-8 order
Seq 7-12 Hetero dimer : IID00327Complex
 Evidence X-RAY 3db3 B Reference
       Region 3db3 B 7-8 disorder
       Region 3db3 B 9-11 order
       Region 3db3 B 12-12 disorder
Seq 19-37 Hetero dimer : B9RU15
 Evidence X-RAY 5vac C Reference
       Region 5vac C 19-24 disorder
       Region 5vac C 25-36 order
       Region 5vac C 37-37 disorder
Seq 23-43 Hetero dimer : IID00374Complex
 Evidence X-RAY 2x4y B Reference
       Region 2x4y B 23-24 disorder
       Region 2x4y B 25-42 order
       Region 2x4y B 43-43 disorder
 Evidence X-RAY 2x4y J Reference
       Region 2x4y J 23-28 disorder
       Region 2x4y J 29-40 order
       Region 2x4y J 41-43 disorder
 Evidence X-RAY 2x4y N Reference
       Region 2x4y N 23-28 disorder
       Region 2x4y N 29-42 order
       Region 2x4y N 43-43 disorder
 Evidence X-RAY 2x4y L Reference
       Region 2x4y L 23-29 disorder
       Region 2x4y L 30-40 order
       Region 2x4y L 41-43 disorder
 Evidence X-RAY 2x4y H Reference
       Region 2x4y H 23-28 disorder
       Region 2x4y H 29-39 order
       Region 2x4y H 40-43 disorder
 Evidence X-RAY 2x4y D Reference
       Region 2x4y D 23-27 disorder
       Region 2x4y D 28-41 order
       Region 2x4y D 42-43 disorder
 Evidence X-RAY 2x4y F Reference
       Region 2x4y F 23-25 disorder
       Region 2x4y F 26-40 order
       Region 2x4y F 41-43 disorder
 Evidence X-RAY 2x4y P Reference
       Region 2x4y P 23-25 disorder
       Region 2x4y P 26-38 order
       Region 2x4y P 39-43 disorder
 Evidence X-RAY 2x4x B Reference
       Region 2x4x B 23-28 disorder
       Region 2x4x B 29-42 order
       Region 2x4x B 43-43 disorder
 Evidence X-RAY 2x4x H Reference
       Region 2x4x H 23-28 disorder
       Region 2x4x H 29-40 order
       Region 2x4x H 41-43 disorder
 Evidence X-RAY 2x4x D Reference
       Region 2x4x D 23-28 disorder
       Region 2x4x D 29-40 order
       Region 2x4x D 41-43 disorder
 Evidence X-RAY 2x4x F Reference
       Region 2x4x F 23-28 disorder
       Region 2x4x F 29-39 order
       Region 2x4x F 40-43 disorder
 Evidence X-RAY 2x4w B Reference
       Region 2x4w B 23-28 disorder
       Region 2x4w B 29-41 order
       Region 2x4w B 42-43 disorder
 Evidence X-RAY 3mo8 B Reference
       Region 3mo8 B 31-42 order
Seq 29-43 Hetero tetramer : Q9UBC3
 Evidence X-RAY 5ciu D Reference
       Region 5ciu D 29-32 disorder
       Region 5ciu D 33-39 order
       Region 5ciu D 40-43 disorder
 Evidence X-RAY 5ciu C Reference
       Region 5ciu C 29-32 disorder
       Region 5ciu C 33-39 order
       Region 5ciu C 40-43 disorder
Seq 57-136 Hetero tetramer : IID00058Complex,IID00715Complex,Q9NVP2
 Evidence X-RAY 5bo0 A Reference
       Region 5bo0 A 57-58 disorder
       Region 5bo0 A 59-135 order
       Region 5bo0 A 136-136 disorder
Seq 121-136 Hetero dimer : IID00182Complex
 Evidence NMR 2iij B Reference
       Region 2iij B 121-136 order
SeqProS verified 2-10 Hetero dimer : IID00591Complex
       Region 4mzg A 2-10 order
       Region 4mzg C 2-7 order
       Region 4mzf A 2-8 order
       Region 4mzh B 2-9 order
       Region 3av1 A 1-39 disorder
SeqProS verified 2-10 Hetero dimer : IID00574Complex
       Region 4ouc B 2-8 order
       Region 3av1 A 1-39 disorder
SeqProS verified 2-16 complex with MPP8 chromodomain Hetero dimer : IID00392Complex
       Region 3qo2 P 2-16 order
       Region 3qo2 Q 4-16 order
       Region 3qo2 R 3-16 order
       Region 3qo2 S 2-16 order
       Region 3av1 A 1-39 disorder
SeqProS verified 2-16 complex with MPP8 chromodomain Hetero octamer : IID00392Complex
       Region 3r93 E 5-16 order
       Region 3r93 F 3-16 order
       Region 3r93 G 5-16 order
       Region 3r93 H 5-16 order
       Region 3av1 A 1-39 disorder
SeqProS verified 9-11 Hetero dimer : IID00327Complex
       Region 3db3 B 9-11 order
       Region 3av1 A 1-39 disorder
SeqProS verified 30-39 Hetero dimer : IID00374Complex
       Region 3mo8 B 31-42 order
       Region 2x4x B 29-42 order
       Region 2x4x D 29-40 order
       Region 2x4x F 29-39 order
       Region 2x4x H 29-40 order
       Region 2x4y B 25-42 order
       Region 2x4y D 28-41 order
       Region 2x4y F 26-40 order
       Region 2x4y H 29-39 order
       Region 2x4y J 29-40 order
       Region 2x4y L 30-40 order
       Region 2x4y N 29-42 order
       Region 2x4y P 26-38 order
       Region 2x4w B 29-41 order
       Region 3av1 A 1-39 disorder
Seqphosphorylation
    4-4 Phosphothreonine; by HASPIN
    7-7 Phosphothreonine; by PKC
    11-11 Phosphoserine; alternate; by AURKB
    12-12 Phosphothreonine; by PKC
    29-29 Phosphoserine; alternate; by AURKB
    42-42 Phosphotyrosine
    58-58 Phosphoserine
    81-81 Phosphothreonine
    87-87 Phosphoserine
    108-108 Phosphothreonine
Seqacetylation
    5-5 N6-acetyllysine; alternate
    10-10 N6-acetyllysine; alternate
    15-15 N6-acetyllysine; alternate
    19-19 N6-acetyllysine; alternate
    24-24 N6-acetyllysine; alternate
    28-28 N6-acetyllysine; alternate
    37-37 N6-acetyllysine; alternate
    57-57 N6-acetyllysine; alternate
    80-80 N6-acetyllysine; alternate
    116-116 N6-acetyllysine; alternate
    123-123 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 1-37
Order 38-136
ProS 1-37
AlphaFold
Disorder 1-3,7-35,135-136
Order 4-6,36-134
Pfam Hmmer
PF00125 58-132 2.8e-40
Function
Function in SwissProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.