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IID00089
 UniprotQ86VP6
ProteinCullin-associated NEDD8-dissociated protein 1
GeneCAND1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1230
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-1230 Hetero trimer : IID50217Complex,Q13620
 Evidence X-RAY 4a0c A Reference
       Region 4a0c A 1-3 disorder
       Region 4a0c A 4-118 order
       Region 4a0c A 119-123 disorder
       Region 4a0c A 124-307 order
       Region 4a0c A 308-343 disorder
       Region 4a0c A 344-409 order
       Region 4a0c A 410-420 disorder
       Region 4a0c A 421-786 order
       Region 4a0c A 787-792 disorder
       Region 4a0c A 793-1216 order
       Region 4a0c A 1217-1230 disorder
 Evidence X-RAY 4a0c B Reference
       Region 4a0c B 1-2 disorder
       Region 4a0c B 3-119 order
       Region 4a0c B 120-122 disorder
       Region 4a0c B 123-307 order
       Region 4a0c B 308-343 disorder
       Region 4a0c B 344-407 order
       Region 4a0c B 408-421 disorder
       Region 4a0c B 422-786 order
       Region 4a0c B 787-790 disorder
       Region 4a0c B 791-1068 order
       Region 4a0c B 1069-1071 disorder
       Region 4a0c B 1072-1216 order
       Region 4a0c B 1217-1230 disorder
Seq 1-1230 Hetero trimer : IID00059Complex,IID00133Complex
 Evidence X-RAY 1u6g C Reference
       Region 1u6g C 1-3 disorder
       Region 1u6g C 4-118 order
       Region 1u6g C 119-123 disorder
       Region 1u6g C 124-206 order
       Region 1u6g C 207-210 disorder
       Region 1u6g C 211-307 order
       Region 1u6g C 308-343 disorder
       Region 1u6g C 344-408 order
       Region 1u6g C 409-420 disorder
       Region 1u6g C 421-786 order
       Region 1u6g C 787-790 disorder
       Region 1u6g C 791-1210 order
       Region 1u6g C 1211-1230 disorder
Seqphosphorylation
    335-335 Phosphoserine
    558-558 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
    55-55 N6-acetyllysine
    971-971 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-4,316-341,413-422,1220-1230
Order 5-141,147-315,342-412,423-918,924-1219
ProS 326-341,1227-1230
AlphaFold
Disorder 1-5,120-123,313-343,407-422,786-791,1071-1071,1190-1192,1219-1230
Order 6-119,124-312,344-406,423-785,792-1070,1072-1189,1193-1218
Pfam Hmmer
PF08623 1039-1205 1.9e-98
SEG 117-128 ,310-346 ,481-496
Function
Function in SwissProt
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.