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IID00090
 UniprotQ92540
ProteinProtein SMG7
GeneSMG7
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1137
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-497 Monomer :
 Evidence X-RAY 1ya0 B Reference
       Region 1ya0 B 1-119 order
       Region 1ya0 B 120-141 disorder
       Region 1ya0 B 142-349 order
       Region 1ya0 B 350-352 disorder
       Region 1ya0 B 353-438 order
       Region 1ya0 B 439-446 disorder
       Region 1ya0 B 447-497 order
 Evidence X-RAY 1ya0 A Reference
       Region 1ya0 A 1-111 order
       Region 1ya0 A 112-142 disorder
       Region 1ya0 A 143-349 order
       Region 1ya0 A 350-350 disorder
       Region 1ya0 A 351-407 order
       Region 1ya0 A 408-408 disorder
       Region 1ya0 A 409-440 order
       Region 1ya0 A 441-446 disorder
       Region 1ya0 A 447-497 order
Seqphosphorylation
    897-897 Phosphoserine
    781-781 Phosphoserine
    624-624 Phosphothreonine
    520-520 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 494-1137
Order 1-131,144-493
ProS 544-549,730-734,799-802,819-831,864-877,921-924,944-956,976-986,998-1006,1016-1038,1043-1047,1054-1061,1068-1074,1093-1137
AlphaFold
Disorder 1-1,118-137,349-357,438-447,494-1117,1119-1119,1122-1122,1124-1137
Order 2-117,138-348,358-437,448-493,1118-1118,1120-1121,1123-1123
SEG 450-458 ,581-606 ,656-674 ,723-770 ,922-939 ,999-1025 ,1117-1131
Function
Function in SwissProt
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.