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IID00091
 UniprotQ92731
ProteinEstrogen receptor beta
GeneESR2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
530
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-103
 Evidence CD Reference
       Region 1-103 disorder
Seqdisorder 1-103
 Evidence NMR Reference
       Region 1-103 disorder
Seq 255-509 Monomer :
 Evidence X-RAY 1qkm A Reference
       Region 1qkm A 255-259 disorder
       Region 1qkm A 260-285 order
       Region 1qkm A 286-291 disorder
       Region 1qkm A 292-414 order
       Region 1qkm A 415-419 disorder
       Region 1qkm A 420-500 order
       Region 1qkm A 501-509 disorder
 Evidence X-RAY 1nde A Reference
       Region 1nde A 256-260 disorder
       Region 1nde A 261-286 order
       Region 1nde A 287-288 disorder
       Region 1nde A 289-411 order
       Region 1nde A 412-415 disorder
       Region 1nde A 416-482 order
       Region 1nde A 483-485 disorder
       Region 1nde A 486-500 order
       Region 1nde A 501-501 disorder
 Evidence X-RAY 1l2j B Reference
       Region 1l2j B 256-280 order
       Region 1l2j B 281-293 disorder
       Region 1l2j B 294-410 order
       Region 1l2j B 411-412 disorder
       Region 1l2j B 413-479 order
       Region 1l2j B 480-484 disorder
       Region 1l2j B 485-497 order
       Region 1l2j B 498-505 disorder
 Evidence X-RAY 1l2j A Reference
       Region 1l2j A 256-260 disorder
       Region 1l2j A 261-284 order
       Region 1l2j A 285-289 disorder
       Region 1l2j A 290-408 order
       Region 1l2j A 409-412 disorder
       Region 1l2j A 413-501 order
       Region 1l2j A 502-505 disorder
Seq 256-509 Homo dimer :
 Evidence X-RAY 2yly B Reference
       Region 2yly B 260-282 order
       Region 2yly B 283-288 disorder
       Region 2yly B 289-409 order
       Region 2yly B 410-419 disorder
       Region 2yly B 421-421 disorder
       Region 2yly B 422-498 order
       Region 2yly B 499-500 disorder
 Evidence X-RAY 2yly A Reference
       Region 2yly A 260-260 disorder
       Region 2yly A 261-282 order
       Region 2yly A 283-288 disorder
       Region 2yly A 289-409 order
       Region 2yly A 410-419 disorder
       Region 2yly A 421-421 disorder
       Region 2yly A 422-497 order
       Region 2yly A 498-500 disorder
 Evidence X-RAY 2jj3 B Reference
       Region 2jj3 B 256-259 disorder
       Region 2jj3 B 260-285 order
       Region 2jj3 B 286-291 disorder
       Region 2jj3 B 292-414 order
       Region 2jj3 B 415-421 disorder
       Region 2jj3 B 422-480 order
       Region 2jj3 B 481-482 disorder
       Region 2jj3 B 483-500 order
       Region 2jj3 B 501-505 disorder
 Evidence X-RAY 2jj3 A Reference
       Region 2jj3 A 256-260 disorder
       Region 2jj3 A 261-285 order
       Region 2jj3 A 286-291 disorder
       Region 2jj3 A 292-414 order
       Region 2jj3 A 415-421 disorder
       Region 2jj3 A 422-480 order
       Region 2jj3 A 481-482 disorder
       Region 2jj3 A 483-498 order
       Region 2jj3 A 499-505 disorder
 Evidence X-RAY 2z4b B Reference
       Region 2z4b B 256-259 disorder
       Region 2z4b B 260-285 order
       Region 2z4b B 286-291 disorder
       Region 2z4b B 292-414 order
       Region 2z4b B 415-421 disorder
       Region 2z4b B 422-480 order
       Region 2z4b B 481-484 disorder
       Region 2z4b B 485-500 order
       Region 2z4b B 501-505 disorder
 Evidence X-RAY 2z4b A Reference
       Region 2z4b A 256-260 disorder
       Region 2z4b A 261-285 order
       Region 2z4b A 286-291 disorder
       Region 2z4b A 292-414 order
       Region 2z4b A 415-421 disorder
       Region 2z4b A 422-480 order
       Region 2z4b A 481-484 disorder
       Region 2z4b A 485-498 order
       Region 2z4b A 499-505 disorder
 Evidence X-RAY 1u3q D Reference
       Region 1u3q D 261-262 disorder
       Region 1u3q D 263-411 order
       Region 1u3q D 412-420 disorder
       Region 1u3q D 421-497 order
       Region 1u3q D 498-500 disorder
 Evidence X-RAY 1u3q B Reference
       Region 1u3q B 261-410 order
       Region 1u3q B 411-420 disorder
       Region 1u3q B 421-497 order
       Region 1u3q B 498-500 disorder
 Evidence X-RAY 1u3q C Reference
       Region 1u3q C 261-262 disorder
       Region 1u3q C 263-411 order
       Region 1u3q C 412-420 disorder
       Region 1u3q C 421-497 order
       Region 1u3q C 498-500 disorder
 Evidence X-RAY 1u3q A Reference
       Region 1u3q A 261-262 disorder
       Region 1u3q A 263-411 order
       Region 1u3q A 412-420 disorder
       Region 1u3q A 421-497 order
       Region 1u3q A 498-500 disorder
 Evidence X-RAY 5toa B Reference
       Region 5toa B 262-412 order
       Region 5toa B 413-421 disorder
       Region 5toa B 422-501 order
       Region 5toa B 502-509 disorder
 Evidence X-RAY 5toa A Reference
       Region 5toa A 262-285 order
       Region 5toa A 286-286 disorder
       Region 5toa A 287-411 order
       Region 5toa A 412-420 disorder
       Region 5toa A 421-501 order
       Region 5toa A 502-509 disorder
 Evidence X-RAY 2qtu B Reference
       Region 2qtu B 256-259 disorder
       Region 2qtu B 260-285 order
       Region 2qtu B 286-291 disorder
       Region 2qtu B 292-414 order
       Region 2qtu B 415-421 disorder
       Region 2qtu B 422-480 order
       Region 2qtu B 481-486 disorder
       Region 2qtu B 487-500 order
       Region 2qtu B 501-505 disorder
 Evidence X-RAY 2qtu A Reference
       Region 2qtu A 256-260 disorder
       Region 2qtu A 261-285 order
       Region 2qtu A 286-291 disorder
       Region 2qtu A 292-414 order
       Region 2qtu A 415-421 disorder
       Region 2qtu A 422-480 order
       Region 2qtu A 481-486 disorder
       Region 2qtu A 487-498 order
       Region 2qtu A 499-505 disorder
 Evidence X-RAY 2i0g B Reference
       Region 2i0g B 256-259 disorder
       Region 2i0g B 260-285 order
       Region 2i0g B 286-291 disorder
       Region 2i0g B 292-414 order
       Region 2i0g B 415-421 disorder
       Region 2i0g B 422-480 order
       Region 2i0g B 481-484 disorder
       Region 2i0g B 485-498 order
       Region 2i0g B 499-505 disorder
 Evidence X-RAY 2i0g A Reference
       Region 2i0g A 256-260 disorder
       Region 2i0g A 261-285 order
       Region 2i0g A 286-291 disorder
       Region 2i0g A 292-414 order
       Region 2i0g A 415-421 disorder
       Region 2i0g A 422-480 order
       Region 2i0g A 481-484 disorder
       Region 2i0g A 485-498 order
       Region 2i0g A 499-505 disorder
 Evidence X-RAY 2giu A Reference
       Region 2giu A 260-285 order
       Region 2giu A 286-291 disorder
       Region 2giu A 292-369 order
       Region 2giu A 370-370 disorder
       Region 2giu A 371-414 order
       Region 2giu A 415-419 disorder
       Region 2giu A 420-479 order
       Region 2giu A 480-483 disorder
       Region 2giu A 484-500 order
 Evidence X-RAY 2fsz B Reference
       Region 2fsz B 257-259 disorder
       Region 2fsz B 260-410 order
       Region 2fsz B 411-422 disorder
       Region 2fsz B 423-479 order
       Region 2fsz B 480-482 disorder
       Region 2fsz B 483-501 order
       Region 2fsz B 502-502 disorder
 Evidence X-RAY 2fsz A Reference
       Region 2fsz A 257-263 disorder
       Region 2fsz A 264-410 order
       Region 2fsz A 411-422 disorder
       Region 2fsz A 423-479 order
       Region 2fsz A 480-482 disorder
       Region 2fsz A 483-501 order
       Region 2fsz A 502-502 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j26 A Reference
       Region 4j26 A 261-409 order
       Region 4j26 A 410-419 disorder
       Region 4j26 A 420-498 order
       Region 4j26 A 499-500 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j24 A Reference
       Region 4j24 A 261-261 disorder
       Region 4j24 A 262-409 order
       Region 4j24 A 410-421 disorder
       Region 4j24 A 422-498 order
       Region 4j24 A 499-500 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j26 B Reference
       Region 4j26 B 261-410 order
       Region 4j26 B 411-419 disorder
       Region 4j26 B 420-498 order
       Region 4j26 B 499-500 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j24 D Reference
       Region 4j24 D 261-263 disorder
       Region 4j24 D 264-409 order
       Region 4j24 D 410-422 disorder
       Region 4j24 D 423-497 order
       Region 4j24 D 498-500 disorder
Seq 261-500 Hetero dimer : IID00083Complex
 Evidence X-RAY 3omq B Reference
       Region 3omq B 261-263 disorder
       Region 3omq B 264-416 order
       Region 3omq B 417-424 disorder
       Region 3omq B 425-495 order
       Region 3omq B 496-500 disorder
 Evidence X-RAY 3omq A Reference
       Region 3omq A 261-263 disorder
       Region 3omq A 264-415 order
       Region 3omq A 416-420 disorder
       Region 3omq A 421-497 order
       Region 3omq A 498-500 disorder
 Evidence X-RAY 3omp B Reference
       Region 3omp B 261-263 disorder
       Region 3omp B 264-416 order
       Region 3omp B 417-424 disorder
       Region 3omp B 425-495 order
       Region 3omp B 496-500 disorder
 Evidence X-RAY 3omp A Reference
       Region 3omp A 261-263 disorder
       Region 3omp A 264-415 order
       Region 3omp A 416-420 disorder
       Region 3omp A 421-497 order
       Region 3omp A 498-500 disorder
 Evidence X-RAY 3omo B Reference
       Region 3omo B 261-263 disorder
       Region 3omo B 264-416 order
       Region 3omo B 417-424 disorder
       Region 3omo B 425-495 order
       Region 3omo B 496-500 disorder
 Evidence X-RAY 3omo A Reference
       Region 3omo A 261-263 disorder
       Region 3omo A 264-415 order
       Region 3omo A 416-420 disorder
       Region 3omo A 421-497 order
       Region 3omo A 498-500 disorder
 Evidence X-RAY 3ols B Reference
       Region 3ols B 261-263 disorder
       Region 3ols B 264-416 order
       Region 3ols B 417-424 disorder
       Region 3ols B 425-495 order
       Region 3ols B 496-500 disorder
 Evidence X-RAY 3ols A Reference
       Region 3ols A 261-263 disorder
       Region 3ols A 264-415 order
       Region 3ols A 416-420 disorder
       Region 3ols A 421-497 order
       Region 3ols A 498-500 disorder
 Evidence X-RAY 3oll B Reference
       Region 3oll B 261-261 disorder
       Region 3oll B 262-417 order
       Region 3oll B 418-420 disorder
       Region 3oll B 421-498 order
       Region 3oll B 499-500 disorder
 Evidence X-RAY 3oll A Reference
       Region 3oll A 261-261 disorder
       Region 3oll A 262-417 order
       Region 3oll A 418-419 disorder
       Region 3oll A 420-498 order
       Region 3oll A 499-500 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j24 B Reference
       Region 4j24 B 261-410 order
       Region 4j24 B 411-420 disorder
       Region 4j24 B 421-498 order
       Region 4j24 B 499-500 disorder
Seq 261-500 Hetero dimer :
 Evidence X-RAY 4j24 C Reference
       Region 4j24 C 261-261 disorder
       Region 4j24 C 262-409 order
       Region 4j24 C 410-421 disorder
       Region 4j24 C 422-498 order
       Region 4j24 C 499-500 disorder
Seq 261-500 Hetero tetramer : IID00082Complex
 Evidence X-RAY 2yjd B Reference
       Region 2yjd B 261-262 disorder
       Region 2yjd B 263-409 order
       Region 2yjd B 410-421 disorder
       Region 2yjd B 422-497 order
       Region 2yjd B 498-500 disorder
 Evidence X-RAY 2yjd A Reference
       Region 2yjd A 261-262 disorder
       Region 2yjd A 263-409 order
       Region 2yjd A 410-421 disorder
       Region 2yjd A 422-497 order
       Region 2yjd A 498-500 disorder
Seq 261-501 Hetero dimer :
 Evidence X-RAY 1u9e B Reference
       Region 1u9e B 261-262 disorder
       Region 1u9e B 263-410 order
       Region 1u9e B 411-421 disorder
       Region 1u9e B 422-501 order
Seq 261-501 Hetero dimer :
 Evidence X-RAY 1u9e A Reference
       Region 1u9e A 261-262 disorder
       Region 1u9e A 263-409 order
       Region 1u9e A 410-421 disorder
       Region 1u9e A 422-497 order
       Region 1u9e A 498-501 disorder
Seq 261-530 Hetero tetramer : IID00083Complex
 Evidence X-RAY 1zaf B Reference
       Region 1zaf B 263-410 order
       Region 1zaf B 411-420 disorder
       Region 1zaf B 421-500 order
 Evidence X-RAY 1zaf A Reference
       Region 1zaf A 263-410 order
       Region 1zaf A 411-420 disorder
       Region 1zaf A 421-500 order
 Evidence X-RAY 1yye B Reference
       Region 1yye B 263-410 order
       Region 1yye B 411-420 disorder
       Region 1yye B 421-496 order
       Region 1yye B 497-530 disorder
 Evidence X-RAY 1yye A Reference
       Region 1yye A 263-410 order
       Region 1yye A 411-420 disorder
       Region 1yye A 421-500 order
       Region 1yye A 501-530 disorder
 Evidence X-RAY 1yy4 B Reference
       Region 1yy4 B 263-410 order
       Region 1yy4 B 411-420 disorder
       Region 1yy4 B 421-497 order
       Region 1yy4 B 498-530 disorder
 Evidence X-RAY 1yy4 A Reference
       Region 1yy4 A 263-410 order
       Region 1yy4 A 411-420 disorder
       Region 1yy4 A 421-497 order
       Region 1yy4 A 498-530 disorder
 Evidence X-RAY 1x7j B Reference
       Region 1x7j B 261-262 disorder
       Region 1x7j B 263-410 order
       Region 1x7j B 411-420 disorder
       Region 1x7j B 421-497 order
       Region 1x7j B 498-500 disorder
 Evidence X-RAY 1x7j A Reference
       Region 1x7j A 261-262 disorder
       Region 1x7j A 263-410 order
       Region 1x7j A 411-420 disorder
       Region 1x7j A 421-497 order
       Region 1x7j A 498-500 disorder
 Evidence X-RAY 1x7b B Reference
       Region 1x7b B 261-262 disorder
       Region 1x7b B 263-410 order
       Region 1x7b B 411-420 disorder
       Region 1x7b B 421-497 order
       Region 1x7b B 498-500 disorder
 Evidence X-RAY 1x7b A Reference
       Region 1x7b A 261-262 disorder
       Region 1x7b A 263-410 order
       Region 1x7b A 411-420 disorder
       Region 1x7b A 421-500 order
 Evidence X-RAY 1x78 B Reference
       Region 1x78 B 261-262 disorder
       Region 1x78 B 263-410 order
       Region 1x78 B 411-420 disorder
       Region 1x78 B 421-500 order
 Evidence X-RAY 1x78 A Reference
       Region 1x78 A 261-262 disorder
       Region 1x78 A 263-410 order
       Region 1x78 A 411-420 disorder
       Region 1x78 A 421-500 order
 Evidence X-RAY 1x76 B Reference
       Region 1x76 B 261-262 disorder
       Region 1x76 B 263-410 order
       Region 1x76 B 411-420 disorder
       Region 1x76 B 421-497 order
       Region 1x76 B 498-500 disorder
 Evidence X-RAY 1x76 A Reference
       Region 1x76 A 261-262 disorder
       Region 1x76 A 263-410 order
       Region 1x76 A 411-420 disorder
       Region 1x76 A 421-497 order
       Region 1x76 A 498-500 disorder
 Evidence X-RAY 1u3s B Reference
       Region 1u3s B 261-262 disorder
       Region 1u3s B 263-409 order
       Region 1u3s B 410-421 disorder
       Region 1u3s B 422-497 order
       Region 1u3s B 498-500 disorder
 Evidence X-RAY 1u3s A Reference
       Region 1u3s A 261-262 disorder
       Region 1u3s A 263-411 order
       Region 1u3s A 412-419 disorder
       Region 1u3s A 420-497 order
       Region 1u3s A 498-500 disorder
 Evidence X-RAY 1u3r B Reference
       Region 1u3r B 261-262 disorder
       Region 1u3r B 263-409 order
       Region 1u3r B 410-421 disorder
       Region 1u3r B 422-501 order
 Evidence X-RAY 1u3r A Reference
       Region 1u3r A 261-262 disorder
       Region 1u3r A 263-410 order
       Region 1u3r A 411-417 disorder
       Region 1u3r A 418-500 order
       Region 1u3r A 501-501 disorder
 Evidence X-RAY 2nv7 B Reference
       Region 2nv7 B 263-410 order
       Region 2nv7 B 411-420 disorder
       Region 2nv7 B 421-497 order
       Region 2nv7 B 498-500 disorder
 Evidence X-RAY 2nv7 A Reference
       Region 2nv7 A 263-410 order
       Region 2nv7 A 411-420 disorder
       Region 2nv7 A 421-500 order
Seq 262-509 Hetero tetramer : Q9HCD5
 Evidence X-RAY 4zi1 A Reference
       Region 4zi1 A 262-408 order
       Region 4zi1 A 409-419 disorder
       Region 4zi1 A 420-502 order
       Region 4zi1 A 503-509 disorder
Seqphosphorylation
    105-105 Phosphoserine
    87-87 Phosphoserine
 
Prediction
NeProc
Disorder 1-145,219-275,283-286,502-530
Order 146-218,276-282,287-412,420-501
ProS 9-17,24-56,77-91,105-110,219-227,263-275,283-286
AlphaFold
Disorder 1-145,180-180,217-261,408-419,500-530
Order 146-179,181-216,262-407,420-499
Pfam Hmmer
PF00105 147-222 6.4e-47
PF00104 303-494 4.6e-50
SEG 5-21
Function
Function in SwissProt
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560).
Isoform 2
Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment