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IID00093
 UniprotQ92837
ProteinProto-oncogene FRAT1
GeneFRAT1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
279
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-279 Hetero dimer : IID00052Complex
 Evidence X-RAY 3zrk Y Reference
       Region 3zrk Y 197-200 disorder
       Region 3zrk Y 201-222 order
       Region 3zrk Y 223-226 disorder
 Evidence X-RAY 3zrk X Reference
       Region 3zrk X 197-198 disorder
       Region 3zrk X 199-222 order
       Region 3zrk X 223-226 disorder
 Evidence X-RAY 5oy4 Y Reference
       Region 5oy4 Y 1-198 disorder
       Region 5oy4 Y 199-222 order
       Region 5oy4 Y 223-279 disorder
 Evidence X-RAY 5oy4 X Reference
       Region 5oy4 X 1-198 disorder
       Region 5oy4 X 199-223 order
       Region 5oy4 X 224-279 disorder
 Evidence X-RAY 1gng Y Reference
       Region 1gng Y 188-197 disorder
       Region 1gng Y 198-222 order
       Region 1gng Y 223-226 disorder
 Evidence X-RAY 1gng X Reference
       Region 1gng X 188-197 disorder
       Region 1gng X 198-222 order
       Region 1gng X 223-226 disorder
 Evidence X-RAY 4afj Y Reference
       Region 4afj Y 197-199 disorder
       Region 4afj Y 200-222 order
       Region 4afj Y 223-226 disorder
 Evidence X-RAY 4afj X Reference
       Region 4afj X 197-199 disorder
       Region 4afj X 200-222 order
       Region 4afj X 223-226 disorder
Seq 197-226 Hetero tetramer : IID00052Complex
 Evidence X-RAY 3zrm Y Reference
       Region 3zrm Y 197-200 disorder
       Region 3zrm Y 201-222 order
       Region 3zrm Y 223-226 disorder
 Evidence X-RAY 3zrm X Reference
       Region 3zrm X 197-198 disorder
       Region 3zrm X 199-221 order
       Region 3zrm X 222-226 disorder
 Evidence X-RAY 3zrl Y Reference
       Region 3zrl Y 197-200 disorder
       Region 3zrl Y 201-222 order
       Region 3zrl Y 223-226 disorder
 Evidence X-RAY 3zrl X Reference
       Region 3zrl X 197-198 disorder
       Region 3zrl X 199-221 order
       Region 3zrl X 222-226 disorder
SeqProS possible 198-222 This region is flanked by disordered regions. Hetero dimer : IID00052Complex
       Region 1gng X 198-222 order
       Region 1gng Y 198-222 order
       Region 3zrk X 199-222 order
       Region 3zrk Y 201-222 order
       Region 4afj X 200-222 order
       Region 4afj Y 200-222 order
SeqProS possible 198-222 This region is flanked by disordered regions. Hetero tetramer : IID00052Complex
       Region 3zrm X 199-221 order
       Region 3zrm Y 201-222 order
       Region 3zrl X 199-221 order
       Region 3zrl Y 201-222 order
Seqphosphorylation
    88-88 Phosphoserine
    249-249 Phosphoserine
    252-252 Phosphoserine
 
Prediction
NeProc
Disorder 1-22,37-40,59-196,229-279
Order 23-36,41-58,197-228
ProS 1-5,37-40,91-94,109-123,168-196,251-279
AlphaFold
Disorder 1-23,25-25,27-29,31-31,54-197,230-276,278-279
Order 24-24,26-26,30-30,32-53,198-229,277-277
Pfam Hmmer
PF05350 1-240 3e-146
SEG 6-22 ,59-83 ,89-100 ,247-256
Function
Function in SwissProt
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.