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IID00095
 UniprotQ969R5
ProteinLethal(3)malignant brain tumor-like protein 2
GeneL3MBTL2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
705
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 82-124 Monomer :
 Evidence NMR 2w0t A Reference
       Region 2w0t A 82-124 order
       Region 2w0t A 82-82 high_rmsd
       Region 2w0t A 123-124 high_rmsd
Seq 170-625 Monomer :
 Evidence X-RAY 3cey B Reference
       Region 3cey B 170-172 disorder
       Region 3cey B 173-222 order
       Region 3cey B 223-227 disorder
       Region 3cey B 228-359 order
       Region 3cey B 360-362 disorder
       Region 3cey B 363-389 order
       Region 3cey B 390-407 disorder
       Region 3cey B 408-464 order
       Region 3cey B 465-472 disorder
       Region 3cey B 473-503 order
       Region 3cey B 504-506 disorder
       Region 3cey B 507-605 order
       Region 3cey B 606-625 disorder
 Evidence X-RAY 3cey A Reference
       Region 3cey A 170-171 disorder
       Region 3cey A 172-222 order
       Region 3cey A 223-227 disorder
       Region 3cey A 228-359 order
       Region 3cey A 360-362 disorder
       Region 3cey A 363-390 order
       Region 3cey A 391-407 disorder
       Region 3cey A 408-464 order
       Region 3cey A 465-472 disorder
       Region 3cey A 473-501 order
       Region 3cey A 502-506 disorder
       Region 3cey A 507-528 order
       Region 3cey A 529-533 disorder
       Region 3cey A 534-604 order
       Region 3cey A 605-625 disorder
Seq 170-625 Homo dimer :
 Evidence X-RAY 3f70 B Reference
       Region 3f70 B 170-171 disorder
       Region 3f70 B 172-391 order
       Region 3f70 B 392-407 disorder
       Region 3f70 B 408-464 order
       Region 3f70 B 465-472 disorder
       Region 3f70 B 473-502 order
       Region 3f70 B 503-506 disorder
       Region 3f70 B 507-609 order
       Region 3f70 B 610-625 disorder
 Evidence X-RAY 3f70 A Reference
       Region 3f70 A 170-171 disorder
       Region 3f70 A 172-225 order
       Region 3f70 A 226-227 disorder
       Region 3f70 A 228-359 order
       Region 3f70 A 360-363 disorder
       Region 3f70 A 364-386 order
       Region 3f70 A 387-418 disorder
       Region 3f70 A 419-464 order
       Region 3f70 A 465-472 disorder
       Region 3f70 A 473-609 order
       Region 3f70 A 610-625 disorder
Seqphosphorylation
    76-76 Phosphothreonine
    13-13 Phosphoserine
    67-67 Phosphoserine
    338-338 Phosphoserine
    683-683 Phosphoserine
    688-688 Phosphoserine
    689-689 Phosphoserine
 
Prediction
NeProc
Disorder 1-83,112-176,612-705
Order 84-111,177-607
ProS 4-9,23-35,56-61,80-83,112-120,140-146,151-161,172-176,623-649,665-702
AlphaFold
Disorder 1-85,121-177,392-396,405-405,467-469,606-705
Order 86-120,178-391,397-404,406-466,470-605
Pfam Hmmer
PF02820 214-291 9.3e-13
PF02820 327-396 2.2e-31
PF02820 432-509 1.1e-22
PF02820 540-611 9.8e-45
SEG 8-26 ,38-60 ,111-126 ,614-642
Function
Function in SwissProt
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.