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IID00096
 UniprotQ96AY2
ProteinCrossover junction endonuclease EME1
GeneEME1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
570
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 178-570 Hetero dimer : IID00098Complex
 Evidence X-RAY 2zix B Reference
       Region 2zix B 246-246 disorder
       Region 2zix B 247-295 order
       Region 2zix B 296-304 disorder
       Region 2zix B 305-329 order
       Region 2zix B 330-341 disorder
       Region 2zix B 342-367 order
       Region 2zix B 368-403 disorder
       Region 2zix B 404-447 order
       Region 2zix B 448-449 disorder
       Region 2zix B 450-536 order
       Region 2zix B 537-540 disorder
       Region 2zix B 541-568 order
       Region 2zix B 569-570 disorder
 Evidence X-RAY 4p0s H Reference
       Region 4p0s H 178-232 disorder
       Region 4p0s H 233-329 order
       Region 4p0s H 330-341 disorder
       Region 4p0s H 342-370 order
       Region 4p0s H 371-402 disorder
       Region 4p0s H 403-534 order
       Region 4p0s H 535-540 disorder
       Region 4p0s H 541-566 order
       Region 4p0s H 567-570 disorder
 Evidence X-RAY 4p0s F Reference
       Region 4p0s F 178-232 disorder
       Region 4p0s F 233-329 order
       Region 4p0s F 330-341 disorder
       Region 4p0s F 342-370 order
       Region 4p0s F 371-402 disorder
       Region 4p0s F 403-534 order
       Region 4p0s F 535-540 disorder
       Region 4p0s F 541-566 order
       Region 4p0s F 567-570 disorder
 Evidence X-RAY 4p0s D Reference
       Region 4p0s D 178-232 disorder
       Region 4p0s D 233-329 order
       Region 4p0s D 330-341 disorder
       Region 4p0s D 342-370 order
       Region 4p0s D 371-402 disorder
       Region 4p0s D 403-534 order
       Region 4p0s D 535-540 disorder
       Region 4p0s D 541-566 order
       Region 4p0s D 567-570 disorder
 Evidence X-RAY 4p0s B Reference
       Region 4p0s B 178-232 disorder
       Region 4p0s B 233-329 order
       Region 4p0s B 330-341 disorder
       Region 4p0s B 342-370 order
       Region 4p0s B 371-402 disorder
       Region 4p0s B 403-534 order
       Region 4p0s B 535-540 disorder
       Region 4p0s B 541-566 order
       Region 4p0s B 567-570 disorder
 Evidence X-RAY 4p0r D Reference
       Region 4p0r D 178-232 disorder
       Region 4p0r D 233-329 order
       Region 4p0r D 330-341 disorder
       Region 4p0r D 342-370 order
       Region 4p0r D 371-402 disorder
       Region 4p0r D 403-534 order
       Region 4p0r D 535-540 disorder
       Region 4p0r D 541-566 order
       Region 4p0r D 567-570 disorder
 Evidence X-RAY 4p0r B Reference
       Region 4p0r B 178-232 disorder
       Region 4p0r B 233-329 order
       Region 4p0r B 330-341 disorder
       Region 4p0r B 342-370 order
       Region 4p0r B 371-402 disorder
       Region 4p0r B 403-534 order
       Region 4p0r B 535-540 disorder
       Region 4p0r B 541-566 order
       Region 4p0r B 567-570 disorder
 Evidence X-RAY 4p0q B Reference
       Region 4p0q B 178-232 disorder
       Region 4p0q B 233-329 order
       Region 4p0q B 330-341 disorder
       Region 4p0q B 342-370 order
       Region 4p0q B 371-402 disorder
       Region 4p0q B 403-534 order
       Region 4p0q B 535-540 disorder
       Region 4p0q B 541-566 order
       Region 4p0q B 567-570 disorder
 Evidence X-RAY 4p0p B Reference
       Region 4p0p B 178-238 disorder
       Region 4p0p B 239-329 order
       Region 4p0p B 330-341 disorder
       Region 4p0p B 342-370 order
       Region 4p0p B 371-402 disorder
       Region 4p0p B 403-534 order
       Region 4p0p B 535-540 disorder
       Region 4p0p B 541-566 order
       Region 4p0p B 567-570 disorder
Seq 246-367,403-570 Hetero dimer : E7F6N8,Q7SXA9
 Evidence X-RAY 2ziv B Reference
       Region 2ziv B 246-246 disorder
       Region 2ziv B 247-295 order
       Region 2ziv B 296-304 disorder
       Region 2ziv B 305-329 order
       Region 2ziv B 330-341 disorder
       Region 2ziv B 342-367 order
       Region 2ziv B 403-447 order
       Region 2ziv B 448-450 disorder
       Region 2ziv B 451-536 order
       Region 2ziv B 537-539 disorder
       Region 2ziv B 540-568 order
       Region 2ziv B 569-570 disorder
Seq 246-570 Hetero dimer : Q7SXA9
 Evidence X-RAY 2ziw B Reference
       Region 2ziw B 246-249 disorder
       Region 2ziw B 250-294 order
       Region 2ziw B 295-306 disorder
       Region 2ziw B 307-319 order
       Region 2ziw B 320-348 disorder
       Region 2ziw B 349-357 order
       Region 2ziw B 358-359 disorder
       Region 2ziw B 360-368 order
       Region 2ziw B 369-403 disorder
       Region 2ziw B 404-447 order
       Region 2ziw B 448-450 disorder
       Region 2ziw B 451-534 order
       Region 2ziw B 535-543 disorder
       Region 2ziw B 544-567 order
       Region 2ziw B 568-570 disorder
 Evidence X-RAY 2ziu B Reference
       Region 2ziu B 246-246 disorder
       Region 2ziu B 247-295 order
       Region 2ziu B 296-304 disorder
       Region 2ziu B 305-329 order
       Region 2ziu B 330-341 disorder
       Region 2ziu B 342-367 order
       Region 2ziu B 368-403 disorder
       Region 2ziu B 404-447 order
       Region 2ziu B 448-450 disorder
       Region 2ziu B 451-536 order
       Region 2ziu B 537-540 disorder
       Region 2ziu B 541-568 order
       Region 2ziu B 569-570 disorder
Seqphosphorylation
    85-85 Phosphoserine
    12-12 Phosphoserine
    15-15 Phosphoserine
    84-84 Phosphoserine
    87-87 Phosphoserine
    111-111 Phosphoserine
    117-117 Phosphoserine
    150-150 Phosphothreonine
 
Prediction
NeProc
Disorder 1-233,302-307,377-398
Order 234-301,308-376,399-570
ProS 8-27,43-51,76-85,93-103,121-149,161-172,208-214,219-233,302-307,377-381,393-398
AlphaFold
Disorder 1-213,299-304,330-340,369-369,371-401,460-466,568-570
Order 214-298,305-329,341-368,370-370,402-459,467-567
SEG 3-21 ,84-92 ,260-274
Function
Function in SwissProt
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.