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IID00098
 UniprotQ96NY9
ProteinCrossover junction endonuclease MUS81
GeneMUS81
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
551
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 127-230 Monomer :
 Evidence NMR 2mc3 A Reference
       Region 2mc3 A 127-127 disorder
       Region 2mc3 A 128-230 order
       Region 2mc3 A 128-128 high_rmsd
       Region 2mc3 A 175-178 high_rmsd
       Region 2mc3 A 229-230 high_rmsd
Seq 246-551 Hetero dimer : IID00096Complex
 Evidence X-RAY 2zix A Reference
       Region 2zix A 246-258 disorder
       Region 2zix A 259-280 order
       Region 2zix A 281-283 disorder
       Region 2zix A 284-316 order
       Region 2zix A 317-320 disorder
       Region 2zix A 321-432 order
       Region 2zix A 433-448 disorder
       Region 2zix A 449-551 order
 Evidence X-RAY 4p0p A Reference
       Region 4p0p A 246-255 disorder
       Region 4p0p A 256-280 order
       Region 4p0p A 281-284 disorder
       Region 4p0p A 285-437 order
       Region 4p0p A 438-446 disorder
       Region 4p0p A 447-551 order
 Evidence X-RAY 4p0q A Reference
       Region 4p0q A 246-255 disorder
       Region 4p0q A 256-279 order
       Region 4p0q A 280-281 disorder
       Region 4p0q A 282-437 order
       Region 4p0q A 438-446 disorder
       Region 4p0q A 447-551 order
 Evidence X-RAY 4p0r A Reference
       Region 4p0r A 246-255 disorder
       Region 4p0r A 256-280 order
       Region 4p0r A 281-284 disorder
       Region 4p0r A 285-437 order
       Region 4p0r A 438-446 disorder
       Region 4p0r A 447-463 order
       Region 4p0r A 464-471 disorder
       Region 4p0r A 472-551 order
 Evidence X-RAY 4p0r C Reference
       Region 4p0r C 246-255 disorder
       Region 4p0r C 256-280 order
       Region 4p0r C 281-284 disorder
       Region 4p0r C 285-437 order
       Region 4p0r C 438-446 disorder
       Region 4p0r C 447-463 order
       Region 4p0r C 464-471 disorder
       Region 4p0r C 472-551 order
 Evidence X-RAY 4p0s A Reference
       Region 4p0s A 246-255 disorder
       Region 4p0s A 256-280 order
       Region 4p0s A 281-284 disorder
       Region 4p0s A 285-437 order
       Region 4p0s A 438-446 disorder
       Region 4p0s A 447-463 order
       Region 4p0s A 464-471 disorder
       Region 4p0s A 472-551 order
 Evidence X-RAY 4p0s C Reference
       Region 4p0s C 246-255 disorder
       Region 4p0s C 256-280 order
       Region 4p0s C 281-284 disorder
       Region 4p0s C 285-437 order
       Region 4p0s C 438-446 disorder
       Region 4p0s C 447-463 order
       Region 4p0s C 464-471 disorder
       Region 4p0s C 472-551 order
 Evidence X-RAY 4p0s E Reference
       Region 4p0s E 246-255 disorder
       Region 4p0s E 256-280 order
       Region 4p0s E 281-284 disorder
       Region 4p0s E 285-437 order
       Region 4p0s E 438-446 disorder
       Region 4p0s E 447-463 order
       Region 4p0s E 464-471 disorder
       Region 4p0s E 472-551 order
 Evidence X-RAY 4p0s G Reference
       Region 4p0s G 246-255 disorder
       Region 4p0s G 256-280 order
       Region 4p0s G 281-284 disorder
       Region 4p0s G 285-437 order
       Region 4p0s G 438-446 disorder
       Region 4p0s G 447-463 order
       Region 4p0s G 464-471 disorder
       Region 4p0s G 472-551 order
Seqphosphorylation
    101-101 Phosphoserine
    95-95 Phosphoserine
 
Prediction
NeProc
Disorder 1-9,98-122,174-255
Order 10-97,123-173,256-551
ProS 5-9,98-102,122-122,174-255
AlphaFold
Disorder 1-15,88-129,152-152,154-154,170-181,199-200,221-257,279-283,371-376,434-446,465-467
Order 16-87,130-151,153-153,155-169,182-198,201-220,258-278,284-370,377-433,447-464,468-551
Pfam Hmmer
PF02732 270-372 5.3e-19
SEG 33-40 ,47-59 ,243-254
Function
Function in SwissProt
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.