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IID00100
 UniprotQ9NQB0
ProteinTranscription factor 7-like 2
GeneTCF7L2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
619
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-53 Hetero trimer : IID00039Complex
 Evidence X-RAY 2gl7 B Reference
       Region 2gl7 B 1-11 disorder
       Region 2gl7 B 12-28 order
       Region 2gl7 B 29-37 disorder
       Region 2gl7 B 38-50 order
       Region 2gl7 B 51-53 disorder
 Evidence X-RAY 2gl7 E Reference
       Region 2gl7 E 1-11 disorder
       Region 2gl7 E 12-28 order
       Region 2gl7 E 29-39 disorder
       Region 2gl7 E 40-50 order
       Region 2gl7 E 51-53 disorder
Seqdisorder 1-130
 Evidence CD Reference
       Region 1-130 disorder
       Region 1-53 disorder
Seq 6-54 Hetero dimer : IID00039Complex
 Evidence X-RAY 1jpw D Reference
       Region 1jpw D 6-12 disorder
       Region 1jpw D 13-25 order
       Region 1jpw D 26-39 disorder
       Region 1jpw D 40-50 order
       Region 1jpw D 51-54 disorder
 Evidence X-RAY 1jpw E Reference
       Region 1jpw E 6-12 disorder
       Region 1jpw E 13-25 order
       Region 1jpw E 26-39 disorder
       Region 1jpw E 40-50 order
       Region 1jpw E 51-54 disorder
 Evidence X-RAY 1jpw F Reference
       Region 1jpw F 6-12 disorder
       Region 1jpw F 13-25 order
       Region 1jpw F 26-39 disorder
       Region 1jpw F 40-50 order
       Region 1jpw F 51-54 disorder
Seq 12-49 Hetero dimer : IID00039Complex
 Evidence X-RAY 1jdh B Reference
       Region 1jdh B 12-49 order
SeqProS verified 12-49 Hetero dimer : IID00039Complex
       Region 1jdh B 12-49 order
       Region 1-53 disorder
SeqProS verified 13-35,40-50 Hetero dimer : IID00039Complex
       Region 1jpw D 13-25 order
       Region 1jpw E 13-25 order
       Region 1jpw F 13-25 order
       Region 1jpw D 40-50 order
       Region 1jpw E 40-50 order
       Region 1jpw F 40-50 order
       Region 1-53 disorder
SeqProS verified 13-35,40-50 Hetero trimer : IID00039Complex
       Region 2gl7 B 12-28 order
       Region 2gl7 E 12-28 order
       Region 2gl7 B 38-50 order
       Region 2gl7 E 40-50 order
       Region 1-53 disorder
Seqphosphorylation
    201-201 Phosphothreonine; by NLK
    212-212 Phosphothreonine; by NLK
 
Prediction
NeProc
Disorder 1-348,425-619
Order 349-424
ProS 1-28,35-53,89-119,126-161,186-210,450-457,473-493,505-508,602-619
AlphaFold
Disorder 1-38,48-347,424-461,490-551,553-619
Order 39-47,348-423,462-489,552-552
Pfam Hmmer
PF08347 1-259 2.8e-155
PF00505 350-418 4.1e-30
SEG 4-16 ,58-74 ,188-199 ,230-244 ,332-352 ,425-433 ,494-521 ,542-560 ,572-603
Function
Function in SwissProt
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.