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IID00101
 UniprotQ9NQR1
ProteinN-lysine methyltransferase KMT5A
GeneKMT5A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
393
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 194-393 Hetero dodecamer : IID50145Complex,IID50147Complex
 Evidence X-RAY 5hq2 M Reference
       Region 5hq2 M 194-233 disorder
       Region 5hq2 M 234-393 order
Seq 231-393 Monomer :
 Evidence X-RAY 5t5g A Reference
       Region 5t5g A 234-234 disorder
       Region 5t5g A 235-377 order
       Region 5t5g A 378-380 disorder
 Evidence X-RAY 5v2n A Reference
       Region 5v2n A 231-308 order
       Region 5v2n A 309-309 disorder
       Region 5v2n A 310-391 order
       Region 5v2n A 392-393 disorder
Seq 231-393 Hetero octamer : IID00058Complex
 Evidence X-RAY 1zkk A Reference
       Region 1zkk A 231-233 disorder
       Region 1zkk A 234-393 order
 Evidence X-RAY 1zkk B Reference
       Region 1zkk B 231-232 disorder
       Region 1zkk B 233-393 order
 Evidence X-RAY 1zkk C Reference
       Region 1zkk C 231-233 disorder
       Region 1zkk C 234-393 order
 Evidence X-RAY 1zkk D Reference
       Region 1zkk D 231-232 disorder
       Region 1zkk D 233-393 order
Seq 232-393 Homo dimer :
 Evidence X-RAY 4ij8 A Reference
       Region 4ij8 A 232-232 disorder
       Region 4ij8 A 233-393 order
 Evidence X-RAY 4ij8 B Reference
       Region 4ij8 B 232-243 disorder
       Region 4ij8 B 244-393 order
 Evidence X-RAY 5th7 A Reference
       Region 5th7 A 234-235 disorder
       Region 5th7 A 236-378 order
       Region 5th7 A 379-380 disorder
 Evidence X-RAY 5th7 B Reference
       Region 5th7 B 234-235 disorder
       Region 5th7 B 236-380 order
 Evidence X-RAY 5w1y A Reference
       Region 5w1y A 232-393 order
 Evidence X-RAY 5w1y B Reference
       Region 5w1y B 232-240 disorder
       Region 5w1y B 241-392 order
       Region 5w1y B 393-393 disorder
Seq 232-393 Hetero dimer : IID00058Complex
 Evidence X-RAY 2bqz A Reference
       Region 2bqz A 233-393 order
 Evidence X-RAY 2bqz E Reference
       Region 2bqz E 233-393 order
 Evidence X-RAY 3f9w A Reference
       Region 3f9w A 232-233 disorder
       Region 3f9w A 234-393 order
 Evidence X-RAY 3f9w B Reference
       Region 3f9w B 232-233 disorder
       Region 3f9w B 234-393 order
 Evidence X-RAY 3f9w C Reference
       Region 3f9w C 232-233 disorder
       Region 3f9w C 234-393 order
 Evidence X-RAY 3f9w D Reference
       Region 3f9w D 232-232 disorder
       Region 3f9w D 233-393 order
 Evidence X-RAY 3f9x A Reference
       Region 3f9x A 232-233 disorder
       Region 3f9x A 234-393 order
 Evidence X-RAY 3f9x B Reference
       Region 3f9x B 232-233 disorder
       Region 3f9x B 234-393 order
 Evidence X-RAY 3f9x C Reference
       Region 3f9x C 232-233 disorder
       Region 3f9x C 234-393 order
 Evidence X-RAY 3f9x D Reference
       Region 3f9x D 232-232 disorder
       Region 3f9x D 233-393 order
 Evidence X-RAY 3f9y A Reference
       Region 3f9y A 232-234 disorder
       Region 3f9y A 235-393 order
 Evidence X-RAY 3f9y B Reference
       Region 3f9y B 232-233 disorder
       Region 3f9y B 234-393 order
 Evidence X-RAY 3f9z A Reference
       Region 3f9z A 232-233 disorder
       Region 3f9z A 234-304 order
       Region 3f9z A 305-308 disorder
       Region 3f9z A 309-393 order
 Evidence X-RAY 3f9z B Reference
       Region 3f9z B 232-232 disorder
       Region 3f9z B 233-393 order
 Evidence X-RAY 3f9z C Reference
       Region 3f9z C 232-233 disorder
       Region 3f9z C 234-393 order
 Evidence X-RAY 3f9z D Reference
       Region 3f9z D 232-232 disorder
       Region 3f9z D 233-393 order
 Evidence X-RAY 5teg A Reference
       Region 5teg A 234-393 order
 Evidence X-RAY 5teg B Reference
       Region 5teg B 234-235 disorder
       Region 5teg B 236-393 order
Seqphosphorylation
    100-100 Phosphoserine
    181-181 Phosphothreonine
Seqacetylation
    162-162 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-4,28-239
Order 5-27,241-393
ProS 1-4,28-45,59-63,80-103,120-172,216-239
AlphaFold
Disorder 1-219
Order 220-393
Pfam Hmmer
PF00856 243-384 6.8e-40
SEG 4-38 ,55-67
Function
Function in SwissProt
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.