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IID00103
 UniprotQ9UBK2
ProteinPeroxisome proliferator-activated receptor gamma coactivator 1-alpha
GenePPARGC1A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
798
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 136-154 Hetero dimer : IID00041Complex
 Evidence X-RAY 3b1m B Reference
       Region 3b1m B 136-140 disorder
       Region 3b1m B 141-151 order
       Region 3b1m B 152-154 disorder
 Evidence X-RAY 3cs8 B Reference
       Region 3cs8 B 141-152 order
 Evidence X-RAY 3u9q B Reference
       Region 3u9q B 142-150 order
 Evidence X-RAY 3v9t C Reference
       Region 3v9t C 136-141 disorder
       Region 3v9t C 142-151 order
       Region 3v9t C 152-154 disorder
 Evidence X-RAY 3v9v C Reference
       Region 3v9v C 136-140 disorder
       Region 3v9v C 141-151 order
       Region 3v9v C 152-154 disorder
 Evidence X-RAY 5two B Reference
       Region 5two B 138-140 disorder
       Region 5two B 141-151 order
       Region 5two B 152-152 disorder
Seq 139-152 Hetero dimer : IID00072Complex
 Evidence X-RAY 4qjr B Reference
       Region 4qjr B 139-140 disorder
       Region 4qjr B 141-152 order
 Evidence X-RAY 4qk4 B Reference
       Region 4qk4 B 139-140 disorder
       Region 4qk4 B 141-152 order
Seq 139-152 Hetero dimer : IID00001Complex
 Evidence X-RAY 5unj C Reference
       Region 5unj C 139-141 disorder
       Region 5unj C 142-150 order
       Region 5unj C 151-152 disorder
Seq 141-152 Hetero dimer : IID00391Complex
 Evidence X-RAY 5q0i B Reference
       Region 5q0i B 141-152 order
Seqdisorder 101-140,153-220
 Evidence X-RAY Reference
       Region 101-140 disorder
       Region 153-220 disorder
Seq 198-219 Hetero tetramer : IID00021Complex
 Evidence X-RAY 1xb7 P Reference
       Region 1xb7 P 205-207 disorder
       Region 1xb7 P 208-216 order
 Evidence X-RAY 3d24 B Reference
       Region 3d24 B 198-204 disorder
       Region 3d24 B 205-217 order
       Region 3d24 B 218-219 disorder
 Evidence X-RAY 3d24 D Reference
       Region 3d24 D 198-204 disorder
       Region 3d24 D 205-218 order
       Region 3d24 D 219-219 disorder
SeqProS possible 141-152 LXXLL motif Hetero dimer : IID00072Complex
       Region 4qk4 B 141-152 order
       Region 4qjr B 141-152 order
SeqProS possible 141-152 LXXLL motif Hetero dimer : IID00001Complex
       Region 5unj C 142-150 order
SeqProS possible 141-152 LXXLL motif Hetero dimer : IID00391Complex
       Region 5q0i B 141-152 order
SeqProS possible 141-152 LXXLL motif Hetero dimer : IID00041Complex
       Region 3cs8 B 141-152 order
       Region 3b1m B 141-151 order
       Region 3v9t C 142-151 order
       Region 3u9q B 142-150 order
       Region 3v9v C 141-151 order
       Region 5two B 141-151 order
SeqProS verified 205-218 LLXYL motif Hetero tetramer : IID00021Complex
       Region 3d24 B 205-217 order
       Region 3d24 D 205-218 order
       Region 1xb7 P 208-216 order
       Region 153-220 disorder
Seqphosphorylation
    178-178 Phosphothreonine; by AMPK
    539-539 Phosphoserine; by AMPK
Seqacetylation
    271-271 N6-acetyllysine
    79-79 N6-acetyllysine
    146-146 N6-acetyllysine
    184-184 N6-acetyllysine
    254-254 N6-acetyllysine
    442-442 N6-acetyllysine
    278-278 N6-acetyllysine
    321-321 N6-acetyllysine
    347-347 N6-acetyllysine
    413-413 N6-acetyllysine
    779-779 N6-acetyllysine
    758-758 N6-acetyllysine
    451-451 N6-acetyllysine
 
Prediction
NeProc
Disorder 64-639,769-798
Order 1-63,640-768
ProS 76-82,93-101,139-142,187-190,208-215,251-256,280-314,346-358,376-389,406-417,453-461,491-514,523-535,598-608,769-773,778-798
AlphaFold
Disorder 1-80,100-102,105-452,469-633,739-744,752-778,797-798
Order 81-99,103-104,453-468,634-738,745-751,779-796
Pfam Hmmer
PF00076 679-745 0.00068
SEG 25-42 ,143-149 ,237-250 ,295-301 ,559-614 ,616-637 ,643-677
Function
Function in SwissProt
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.