IID00104
 UniprotQ9UBT2
ProteinSUMO-activating enzyme subunit 2
GeneUBA2
OrganismHomo sapiens
Sequence LLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
640
 order/disorder by at least rule
 order/disorder by majority rule
SeqProS verified 198-217,337-344,607-640 Hetero trimer : IID00378Complex,IID00397Complex
Seqphosphorylation
Seqacetylation
 
Prediction
NeProc
AlphaFold
Pfam Hmmer
SEG 12-29 ,211-228 ,590-607
Function
Function in SwissProt
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.