Search Keyword:


Search option:


IID00104
 UniprotQ9UBT2
ProteinSUMO-activating enzyme subunit 2
GeneUBA2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
640
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-640 Hetero trimer : IID00378Complex,IID00397Complex
 Evidence X-RAY 3kyc B Reference
       Region 3kyc B 1-4 disorder
       Region 3kyc B 5-217 order
       Region 3kyc B 218-234 disorder
       Region 3kyc B 235-291 order
       Region 3kyc B 292-304 disorder
       Region 3kyc B 305-548 order
       Region 3kyc B 549-606 disorder
       Region 3kyc B 607-640 order
 Evidence X-RAY 3kyd B Reference
       Region 3kyd B 1-3 disorder
       Region 3kyd B 4-197 order
       Region 3kyd B 198-239 disorder
       Region 3kyd B 240-290 order
       Region 3kyd B 291-308 disorder
       Region 3kyd B 309-336 order
       Region 3kyd B 337-344 disorder
       Region 3kyd B 345-548 order
       Region 3kyd B 549-549 disorder
Seq 1-640 Hetero dimer : IID00397Complex
 Evidence X-RAY 1y8q B Reference
       Region 1y8q B 1-5 disorder
       Region 1y8q B 6-218 order
       Region 1y8q B 219-239 disorder
       Region 1y8q B 240-290 order
       Region 1y8q B 291-304 disorder
       Region 1y8q B 305-550 order
       Region 1y8q B 551-640 disorder
 Evidence X-RAY 1y8q D Reference
       Region 1y8q D 1-3 disorder
       Region 1y8q D 4-218 order
       Region 1y8q D 219-237 disorder
       Region 1y8q D 238-290 order
       Region 1y8q D 291-304 disorder
       Region 1y8q D 305-550 order
       Region 1y8q D 551-640 disorder
Seq 1-640 Hetero trimer : IID00378Complex,IID00397Complex
 Evidence X-RAY 1y8r B Reference
       Region 1y8r B 1-3 disorder
       Region 1y8r B 4-218 order
       Region 1y8r B 219-239 disorder
       Region 1y8r B 240-290 order
       Region 1y8r B 291-304 disorder
       Region 1y8r B 305-550 order
       Region 1y8r B 551-640 disorder
 Evidence X-RAY 1y8r E Reference
       Region 1y8r E 1-3 disorder
       Region 1y8r E 4-218 order
       Region 1y8r E 219-237 disorder
       Region 1y8r E 238-290 order
       Region 1y8r E 291-304 disorder
       Region 1y8r E 305-550 order
       Region 1y8r E 551-640 disorder
Seq 166-382 Hetero dimer : P63279
 Evidence NMR 2px9 A Reference
       Region 2px9 A 166-382 order
       Region 2px9 A 222-235 high_rmsd
       Region 2px9 A 294-300 high_rmsd
Seq 445-561 Hetero dimer : P63279
 Evidence X-RAY 4w5v B Reference
       Region 4w5v B 445-549 order
       Region 4w5v B 550-561 disorder
 Evidence X-RAY 5fq2 B Reference
       Region 5fq2 B 446-446 disorder
       Region 5fq2 B 447-547 order
SeqProS verified 198-217,337-344,607-640 The 198-217 and 337-344 are disordered in the closed form due to the conformational change in the Cys domain. The 607-640 is disordered without SUMO. (PubMed=20164921) Hetero trimer : IID00378Complex,IID00397Complex
       Region 3kyc B 5-217 order
       Region 3kyc B 305-548 order
       Region 3kyc B 607-640 order
       Region 3kyd B 198-239 disorder
       Region 3kyd B 337-344 disorder
       Region 1y8r E 551-640 disorder
Seqphosphorylation
    207-207 Phosphoserine
    507-507 Phosphoserine
    592-592 Phosphoserine
Seqacetylation
    271-271 N6-acetyllysine; alternate
    613-613 N6-acetyllysine; alternate
 
Prediction
NeProc
Disorder 202-214,292-304,546-602,631-640
Order 1-201,215-291,305-545,603-630
ProS 208-214,546-550,633-640
AlphaFold
Disorder 1-5,217-237,291-304,549-610,612-612
Order 6-216,238-290,305-548,611-611,613-640
Pfam Hmmer
PF00899 16-151 3.9e-50
PF02134 343-413 1.5e-39
SEG 12-29 ,211-228 ,590-607
Function
Function in SwissProt
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.