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IID00105
 UniprotQ9UBT6
ProteinDNA polymerase kappa
GenePOLK
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
870
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-528 Monomer :
 Evidence X-RAY 1t94 A Reference
       Region 1t94 A 68-70 disorder
       Region 1t94 A 71-225 order
       Region 1t94 A 226-228 disorder
       Region 1t94 A 229-253 order
       Region 1t94 A 254-275 disorder
       Region 1t94 A 276-407 order
       Region 1t94 A 408-410 disorder
       Region 1t94 A 411-411 order
       Region 1t94 A 412-413 disorder
       Region 1t94 A 414-447 order
       Region 1t94 A 448-450 disorder
       Region 1t94 A 451-472 order
       Region 1t94 A 473-473 disorder
       Region 1t94 A 474-480 order
       Region 1t94 A 481-482 disorder
       Region 1t94 A 483-515 order
       Region 1t94 A 516-526 disorder
 Evidence X-RAY 1t94 B Reference
       Region 1t94 B 68-74 disorder
       Region 1t94 B 75-224 order
       Region 1t94 B 225-280 disorder
       Region 1t94 B 281-409 order
       Region 1t94 B 410-412 disorder
       Region 1t94 B 413-473 order
       Region 1t94 B 474-475 disorder
       Region 1t94 B 476-517 order
       Region 1t94 B 518-526 disorder
 Evidence X-RAY 2oh2 A Reference
       Region 2oh2 A 19-32 disorder
       Region 2oh2 A 33-224 order
       Region 2oh2 A 225-281 disorder
       Region 2oh2 A 282-517 order
       Region 2oh2 A 518-526 disorder
 Evidence X-RAY 2oh2 B Reference
       Region 2oh2 B 19-20 disorder
       Region 2oh2 B 21-224 order
       Region 2oh2 B 225-281 disorder
       Region 2oh2 B 282-517 order
       Region 2oh2 B 518-526 disorder
 Evidence X-RAY 2w7o A Reference
       Region 2w7o A 19-32 disorder
       Region 2w7o A 33-224 order
       Region 2w7o A 225-280 disorder
       Region 2w7o A 281-519 order
       Region 2w7o A 520-526 disorder
 Evidence X-RAY 2w7o B Reference
       Region 2w7o B 19-32 disorder
       Region 2w7o B 33-223 order
       Region 2w7o B 224-281 disorder
       Region 2w7o B 282-519 order
       Region 2w7o B 520-526 disorder
 Evidence X-RAY 2w7p A Reference
       Region 2w7p A 19-32 disorder
       Region 2w7p A 33-224 order
       Region 2w7p A 225-281 disorder
       Region 2w7p A 282-520 order
       Region 2w7p A 521-526 disorder
 Evidence X-RAY 2w7p B Reference
       Region 2w7p B 19-32 disorder
       Region 2w7p B 33-223 order
       Region 2w7p B 224-281 disorder
       Region 2w7p B 282-520 order
       Region 2w7p B 521-526 disorder
 Evidence X-RAY 3in5 A Reference
       Region 3in5 A 19-24 disorder
       Region 3in5 A 25-224 order
       Region 3in5 A 225-280 disorder
       Region 3in5 A 281-518 order
       Region 3in5 A 519-526 disorder
 Evidence X-RAY 3in5 B Reference
       Region 3in5 B 19-21 disorder
       Region 3in5 B 22-223 order
       Region 3in5 B 224-283 disorder
       Region 3in5 B 284-518 order
       Region 3in5 B 519-526 disorder
 Evidence X-RAY 3pzp A Reference
       Region 3pzp A 19-24 disorder
       Region 3pzp A 25-224 order
       Region 3pzp A 225-280 disorder
       Region 3pzp A 281-520 order
       Region 3pzp A 521-528 disorder
 Evidence X-RAY 3pzp B Reference
       Region 3pzp B 19-224 order
       Region 3pzp B 225-281 disorder
       Region 3pzp B 282-518 order
       Region 3pzp B 519-528 disorder
 Evidence X-RAY 4u6p A Reference
       Region 4u6p A 1-30 disorder
       Region 4u6p A 31-224 order
       Region 4u6p A 225-281 disorder
       Region 4u6p A 282-518 order
       Region 4u6p A 519-526 disorder
 Evidence X-RAY 4u6p B Reference
       Region 4u6p B 1-30 disorder
       Region 4u6p B 31-224 order
       Region 4u6p B 225-281 disorder
       Region 4u6p B 282-518 order
       Region 4u6p B 519-526 disorder
 Evidence X-RAY 4u7c A Reference
       Region 4u7c A 27-31 disorder
       Region 4u7c A 32-224 order
       Region 4u7c A 225-280 disorder
       Region 4u7c A 281-518 order
 Evidence X-RAY 4u7c B Reference
       Region 4u7c B 27-30 disorder
       Region 4u7c B 31-224 order
       Region 4u7c B 225-281 disorder
       Region 4u7c B 282-517 order
       Region 4u7c B 518-518 disorder
 Evidence X-RAY 5t14 A Reference
       Region 5t14 A 1-30 disorder
       Region 5t14 A 31-224 order
       Region 5t14 A 225-281 disorder
       Region 5t14 A 282-518 order
       Region 5t14 A 519-527 disorder
 Evidence X-RAY 5t14 B Reference
       Region 5t14 B 1-30 disorder
       Region 5t14 B 31-224 order
       Region 5t14 B 225-281 disorder
       Region 5t14 B 282-518 order
       Region 5t14 B 519-527 disorder
 Evidence X-RAY 5w2a A Reference
       Region 5w2a A 1-30 disorder
       Region 5w2a A 31-224 order
       Region 5w2a A 225-281 disorder
       Region 5w2a A 282-518 order
       Region 5w2a A 519-526 disorder
 Evidence X-RAY 5w2a B Reference
       Region 5w2a B 1-30 disorder
       Region 5w2a B 31-224 order
       Region 5w2a B 225-281 disorder
       Region 5w2a B 282-518 order
       Region 5w2a B 519-526 disorder
 Evidence X-RAY 5w2c A Reference
       Region 5w2c A 1-30 disorder
       Region 5w2c A 31-224 order
       Region 5w2c A 225-281 disorder
       Region 5w2c A 282-518 order
       Region 5w2c A 519-526 disorder
 Evidence X-RAY 5w2c B Reference
       Region 5w2c B 1-30 disorder
       Region 5w2c B 31-224 order
       Region 5w2c B 225-281 disorder
       Region 5w2c B 282-518 order
       Region 5w2c B 519-526 disorder
Seqdisorder 21-74
 Evidence Truncated Reference
       Region 21-74 disorder
Seq 562-577 Hetero dimer : IID00284Complex
 Evidence NMR 2lsi B Reference
       Region 2lsi B 562-577 order
       Region 2lsi B 562-563 high_rmsd
Seq 563-575 Homo tetramer : IID00284Complex
 Evidence X-RAY 4ba9 A Reference
       Region 4ba9 A 563-575 order
 Evidence X-RAY 4ba9 B Reference
       Region 4ba9 B 563-575 order
 Evidence X-RAY 4ba9 C Reference
       Region 4ba9 C 563-575 order
 Evidence X-RAY 4ba9 D Reference
       Region 4ba9 D 563-575 order
Seq 563-575 Homo tetramer : IID00284Complex
 Evidence X-RAY 4ba9 E Reference
       Region 4ba9 E 563-575 order
 Evidence X-RAY 4ba9 F Reference
       Region 4ba9 F 563-575 order
Seq 564-573 Hetero tetramer : IID00284Complex
 Evidence X-RAY 4gk5 G Reference
       Region 4gk5 G 564-565 disorder
       Region 4gk5 G 566-573 order
SeqProS verified 21-74 This region is ordered in the DNA complex. The disorder-to-order transition locks pol k around the DNA. :
       Region 2oh2 B 21-224 order
       Region 5w2c A 31-224 order
       Region 5w2a A 31-224 order
       Region 5w2c B 31-224 order
       Region 5w2a B 31-224 order
       Region 5t14 B 31-224 order
       Region 5t14 A 31-224 order
       Region 21-74 disorder
SeqProS possible 562-573 This region is described to adopt alpha-helical conformation only upon binding the Rev1-CT domain (PubMed=22691049). Hetero tetramer : IID00284Complex
       Region 4gk5 G 566-573 order
SeqProS possible 562-573 This region is described to adopt alpha-helical conformation only upon binding the Rev1-CT domain (PubMed=22691049). Hetero dimer : IID00284Complex
       Region 2lsi B 562-577 order
 
Prediction
NeProc
Disorder 1-11,27-32,48-53,239-276,521-619,653-772,814-870
Order 12-26,33-47,54-238,277-520,620-652,773-813
ProS 27-32,48-53,239-276,528-535,552-558,566-581,653-656,682-694,702-744,859-870
AlphaFold
Disorder 1-18,225-281,519-529,532-621,632-634,649-776,804-870
Order 19-224,282-518,530-531,622-631,635-648,777-803
Pfam Hmmer
PF00817 106-518 1.2e-96
SEG 472-480 ,824-833
Function
Function in SwissProt
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.