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IID00107
 UniprotQ9UPR3
ProteinProtein SMG5
GeneSMG5
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1016
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 853-1016 Monomer :
 Evidence X-RAY 2hwy A Reference
       Region 2hwy A 853-854 disorder
       Region 2hwy A 855-896 order
       Region 2hwy A 897-897 disorder
       Region 2hwy A 898-923 order
       Region 2hwy A 924-944 disorder
       Region 2hwy A 945-959 order
       Region 2hwy A 960-975 disorder
       Region 2hwy A 976-986 order
       Region 2hwy A 987-990 disorder
       Region 2hwy A 991-1012 order
       Region 2hwy A 1013-1016 disorder
 Evidence X-RAY 2hwy B Reference
       Region 2hwy B 853-854 disorder
       Region 2hwy B 855-896 order
       Region 2hwy B 897-897 disorder
       Region 2hwy B 898-925 order
       Region 2hwy B 926-943 disorder
       Region 2hwy B 944-959 order
       Region 2hwy B 960-977 disorder
       Region 2hwy B 978-983 order
       Region 2hwy B 984-993 disorder
       Region 2hwy B 994-997 order
       Region 2hwy B 998-998 disorder
       Region 2hwy B 999-1013 order
       Region 2hwy B 1014-1016 disorder
Seqphosphorylation
    423-423 Phosphoserine
    2-2 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-17,266-277,336-348,418-643,802-804,842-844
Order 18-154,163-265,278-335,349-417,644-739,745-801,805-841,845-1016
ProS 5-9,342-348,418-425,431-436,442-479,485-495,514-535,551-557,563-568,573-594,609-624,632-643,802-804,842-844
AlphaFold
Disorder 1-12,145-156,269-273,304-305,329-345,405-515,517-639,752-752,797-802,832-832,836-837,839-852,925-934,955-967,1015-1016
Order 13-144,157-268,274-303,306-328,346-404,516-516,640-751,753-796,803-831,833-835,838-838,853-924,935-954,968-1014
SEG 419-442 ,616-641 ,681-693 ,718-731 ,798-811 ,989-998
Function
Function in SwissProt
Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.